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73 results

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Page 1
Oral versus intravenous empirical antibiotics in children and adolescents with uncomplicated bone and joint infections: a nationwide, randomised, controlled, non-inferiority trial in Denmark.
Nielsen AB, Holm M, Lindhard MS, Glenthøj JP, Borch L, Hartling U, Schmidt LS, Rytter MJH, Rasmussen AH, Damkjær M, Lemvik G, Petersen JJH, Søndergaard MJ, Thaarup J, Kristensen K, Jensen LH, Hansen LH, Lawaetz MC, Gottliebsen M, Horsager TH, Zaharov T, Hoffmann TU, Nygaard T, Justesen US, Stensballe LG, Vissing NH, Blanche P, Schmiegelow K, Nygaard U. Nielsen AB, et al. Lancet Child Adolesc Health. 2024 Sep;8(9):625-635. doi: 10.1016/S2352-4642(24)00133-0. Epub 2024 Jul 15. Lancet Child Adolesc Health. 2024. PMID: 39025092 Clinical Trial.
High-dose oral antibiotics were coformulated amoxicillin (100 mg/kg per day) and clavulanic acid (12.5 mg/kg per day) in three doses for patients younger than 5 years or dicloxacillin (200 mg/kg per day) in four doses for patients aged 5 years or older. After a minimum of …
High-dose oral antibiotics were coformulated amoxicillin (100 mg/kg per day) and clavulanic acid (12.5 mg/kg per day) in three doses for pat …
Dicloxacillin induces CYP2C19, CYP2C9 and CYP3A4 in vivo and in vitro.
Stage TB, Graff M, Wong S, Rasmussen LL, Nielsen F, Pottegård A, Brøsen K, Kroetz DL, Khojasteh SC, Damkier P. Stage TB, et al. Br J Clin Pharmacol. 2018 Mar;84(3):510-519. doi: 10.1111/bcp.13467. Epub 2018 Jan 10. Br J Clin Pharmacol. 2018. PMID: 29105855 Free PMC article. Clinical Trial.
AIM: The aim of this study was to study potential cytochrome P450 (CYP) induction by dicloxacillin. METHODS: We performed an open-label, randomized, two-phase, five-drug clinical pharmacokinetic cocktail crossover study in 12 healthy men with and without pretreatment with …
AIM: The aim of this study was to study potential cytochrome P450 (CYP) induction by dicloxacillin. METHODS: We performed an open-lab …
Safety and pharmacokinetics of dicloxacillin in healthy Chinese volunteers following single and multiple oral doses.
Wu G, Zheng Y, Zhou H, Hu X, Liu J, Zhai Y, Zhu M, Wu L, Shentu J. Wu G, et al. Drug Des Devel Ther. 2015 Oct 16;9:5687-95. doi: 10.2147/DDDT.S92117. eCollection 2015. Drug Des Devel Ther. 2015. PMID: 26527863 Free PMC article. Clinical Trial.
No appreciable accumulation of drug occurred with multiple oral doses of dicloxacillin. No serious adverse events were reported. Adverse events were generally mild. CONCLUSION: Dicloxacillin was safe and well tolerated in the volunteers and displayed linear increase …
No appreciable accumulation of drug occurred with multiple oral doses of dicloxacillin. No serious adverse events were reported. Adve …
Dicloxacillin is an inducer of intestinal P-glycoprotein but neither dicloxacillin nor flucloxacillin increases the risk of stroke/systemic embolism in direct oral anticoagulant users.
Iversen DB, Dunvald AD, Ernst MT, Abtahi S, Souverein P, Klungel O, Jeppesen GB, Nielsen F, Brøsen K, Hammer HS, Pötz O, Damkier P, Järvinen E, Pottegård A, Stage TB. Iversen DB, et al. Br J Clin Pharmacol. 2024 Dec;90(12):3252-3262. doi: 10.1111/bcp.16190. Epub 2024 Aug 19. Br J Clin Pharmacol. 2024. PMID: 39160000 Free PMC article. Clinical Trial.
CONCLUSIONS: Dicloxacillin increases expression of intestinal P-gp, leading to reduced oral absorption of dabigatran. However, concomitant use of dicloxacillin/flucloxacillin was not associated with stroke and systemic embolism among DOAC users, suggesting no clinic …
CONCLUSIONS: Dicloxacillin increases expression of intestinal P-gp, leading to reduced oral absorption of dabigatran. However, concom …
Clinical safety and tolerance of azithromycin in children.
Hopkins S. Hopkins S. J Antimicrob Chemother. 1993 Jun;31 Suppl E:111-7. doi: 10.1093/jac/31.suppl_e.111. J Antimicrob Chemother. 1993. PMID: 8396082 Review.
The studies compared azithromycin with standard regimens of various comparator agents: co-amoxiclav, amoxycillin, penicillin V, erythromycin, dicloxacillin and flucloxacillin, in the treatment of otitis media, pharyngitis and skin infections. ...
The studies compared azithromycin with standard regimens of various comparator agents: co-amoxiclav, amoxycillin, penicillin V, erythromycin …
Dicloxacillin and flucloxacillin: pharmacokinetics, protein binding and serum bactericidal titers in healthy subjects after oral administration.
Røder BL, Frimodt-Møller N, Espersen F, Rasmussen SN. Røder BL, et al. Infection. 1995 Mar-Apr;23(2):107-12. doi: 10.1007/BF01833876. Infection. 1995. PMID: 7622258 Clinical Trial.
The pharmacokinetics of dicloxacillin and flucloxacillin were studied in 12 healthy volunteers after oral administration. The participants received a single dose of either dicloxacillin (0.5 g, 0.75 g or 1.0 g) or flucloxacillin (0.75 g) in a cross-over fashion. ...
The pharmacokinetics of dicloxacillin and flucloxacillin were studied in 12 healthy volunteers after oral administration. The partici …
Mupirocin: a topical antibiotic with a unique structure and mechanism of action.
Parenti MA, Hatfield SM, Leyden JJ. Parenti MA, et al. Clin Pharm. 1987 Oct;6(10):761-70. Clin Pharm. 1987. PMID: 3146455 Review.
Several controlled clinical trials documented that mupirocin was significantly better than the polyethylene glycol vehicle alone or ampicillin and as effective as cloxacillin, dicloxacillin, or erythromycin in producing clinical and bacteriological cures in patients with i …
Several controlled clinical trials documented that mupirocin was significantly better than the polyethylene glycol vehicle alone or ampicill …
Antibiotic prophylaxis in open and closed fractures: a controlled clinical trial.
Bergman BR. Bergman BR. Acta Orthop Scand. 1982 Feb;53(1):57-62. doi: 10.3109/17453678208992179. Acta Orthop Scand. 1982. PMID: 7064681 Clinical Trial.
Of the patients with Grade I wounds, 17 received dicloxacillin, 21 benzyl penicillin and 17 saline. No major infections occurred. Twelve patients with Grade II & III wounds were treated with dicloxacillin, 10 with benzyl penicillin and 13 with saline. ...Fifty-e …
Of the patients with Grade I wounds, 17 received dicloxacillin, 21 benzyl penicillin and 17 saline. No major infections occurred. Twe …
Should probenecid be used to reduce the dicloxacillin dosage in orthopaedic infections? A study of the dicloxacillin-saving effect of probenecid.
Krogsgaard MR, Hansen BA, Slotsbjerg T, Jensen P. Krogsgaard MR, et al. Pharmacol Toxicol. 1994 Mar;74(3):181-4. doi: 10.1111/j.1600-0773.1994.tb01096.x. Pharmacol Toxicol. 1994. PMID: 8008725 Clinical Trial.
In this cross-over study, the serum concentrations of dicloxacillin were measured in 9 patients after administration of dicloxacillin 500 mg 3 times a day (dicloxacillin 500 mg) and after co-administration of 250 mg dicloxacillin and 250 mg probenecid …
In this cross-over study, the serum concentrations of dicloxacillin were measured in 9 patients after administration of dicloxacil …
Microdialysis as a tool to determine the local tissue concentration of dicloxacillin in man.
Hansen KK, Nielsen F, Stage TB, Jørgensen U, Skov O, Rasmussen LE. Hansen KK, et al. Br J Clin Pharmacol. 2018 Mar;84(3):533-541. doi: 10.1111/bcp.13468. Epub 2017 Dec 7. Br J Clin Pharmacol. 2018. PMID: 29105799 Free PMC article. Clinical Trial.
They were given 2 g dicloxacillin intravenously. Samples from blood and MD fluid were collected. The unbound dicloxacillin was isolated from plasma. ...RESULTS: The maximum concentration was reached in muscle tissue after 0.5 h and in adipose tissue after 0.8 h. AUC …
They were given 2 g dicloxacillin intravenously. Samples from blood and MD fluid were collected. The unbound dicloxacillin was …
73 results