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Table representation of search results timeline featuring number of search results per year.

Year Number of Results
1966 2
1967 8
1968 6
1969 6
1970 7
1971 8
1972 2
1973 9
1974 3
1975 7
1976 7
1977 6
1978 7
1979 6
1980 6
1981 5
1982 6
1983 4
1984 6
1985 12
1986 9
1987 15
1988 11
1989 12
1990 12
1991 22
1992 18
1993 24
1994 28
1995 29
1996 31
1997 20
1998 19
1999 18
2000 24
2001 17
2002 17
2003 16
2004 14
2005 10
2006 25
2007 19
2008 20
2009 11
2010 15
2011 15
2012 14
2013 12
2014 7
2015 11
2016 8
2017 16
2018 8
2019 14
2020 8
2021 7
2022 0
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666 results
Results by year
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Page 1
Effect of Doxepin Mouthwash or Diphenhydramine-Lidocaine-Antacid Mouthwash vs Placebo on Radiotherapy-Related Oral Mucositis Pain: The Alliance A221304 Randomized Clinical Trial.
Sio TT, Le-Rademacher JG, Leenstra JL, Loprinzi CL, Rine G, Curtis A, Singh AK, Martenson JA Jr, Novotny PJ, Tan AD, Qin R, Ko SJ, Reiter PL, Miller RC. Sio TT, et al. JAMA. 2019 Apr 16;321(15):1481-1490. doi: 10.1001/jama.2019.3504. JAMA. 2019. PMID: 30990550 Free PMC article. Clinical Trial.
In a randomized study, doxepin mouthwash was shown to reduce oral mucositis-related pain. A common mouthwash comprising diphenhydramine-lidocaine-antacid is also widely used. OBJECTIVE: To evaluate the effect of doxepin mouthwash or diphenhydramine-lidocaine-antacid …
In a randomized study, doxepin mouthwash was shown to reduce oral mucositis-related pain. A common mouthwash comprising diphenhydramine
Efficacy and Safety of a Fixed Combination of Cinnarizine 20 mg and Dimenhydrinate 40 mg vs Betahistine Dihydrochloride 16 mg in Patients with Peripheral Vestibular Vertigo: A Prospective, Multinational, Multicenter, Double-Blind, Randomized, Non-inferiority Clinical Trial.
Scholtz AW, Hahn A, Stefflova B, Medzhidieva D, Ryazantsev SV, Paschinin A, Kunelskaya N, Schumacher K, Weisshaar G. Scholtz AW, et al. Clin Drug Investig. 2019 Nov;39(11):1045-1056. doi: 10.1007/s40261-019-00858-6. Clin Drug Investig. 2019. PMID: 31571128 Free PMC article. Clinical Trial.
A randomized trial comparing physostigmine vs lorazepam for treatment of antimuscarinic (anticholinergic) toxidrome.
Wang GS, Baker K, Ng P, Janis GC, Leonard J, Mistry RD, Heard K. Wang GS, et al. Clin Toxicol (Phila). 2021 Aug;59(8):698-704. doi: 10.1080/15563650.2020.1854281. Epub 2020 Dec 9. Clin Toxicol (Phila). 2021. PMID: 33295809 Clinical Trial.
RESULTS: Ten (53%) subjects were enrolled in the lorazepam arm, 9 (47%) in the physostigmine arm. Diphenhydramine was the most common agent ingested (16, 84%). Fewer patients receiving physostigmine had delirium after the initial bolus (44% vs 100%, p = 0.01) and at the 4t …
RESULTS: Ten (53%) subjects were enrolled in the lorazepam arm, 9 (47%) in the physostigmine arm. Diphenhydramine was the most common …
Intravenous Cetirizine Versus Intravenous Diphenhydramine for the Treatment of Acute Urticaria: A Phase III Randomized Controlled Noninferiority Trial.
Abella BS, Berger WE, Blaiss MS, Stiell IG, Herres JP, Moellman JJ, Suner S, Kessler A, Klausner HA, Caterino JM, Du J. Abella BS, et al. Ann Emerg Med. 2020 Oct;76(4):489-500. doi: 10.1016/j.annemergmed.2020.05.025. Epub 2020 Jul 9. Ann Emerg Med. 2020. PMID: 32653333 Clinical Trial.
RESULTS: Among 262 enrolled patients, the 2-hour pruritus score change from baseline for intravenous cetirizine was statistically noninferior to that for intravenous diphenhydramine (-1.6 versus -1.5; 95% confidence interval -0.1 to 0.3), and in favor of cetirizine. ...CON …
RESULTS: Among 262 enrolled patients, the 2-hour pruritus score change from baseline for intravenous cetirizine was statistically noninferio …
Valerian-hops combination and diphenhydramine for treating insomnia: a randomized placebo-controlled clinical trial.
Morin CM, Koetter U, Bastien C, Ware JC, Wooten V. Morin CM, et al. Sleep. 2005 Nov;28(11):1465-71. doi: 10.1093/sleep/28.11.1465. Sleep. 2005. PMID: 16335333 Clinical Trial.
There were no significant residual effects and no serious adverse events with either valerian or diphenhydramine and no rebound insomnia following their discontinuation. ...Overall, these findings indicate that a valerian-hops combination and diphenhydramine might b …
There were no significant residual effects and no serious adverse events with either valerian or diphenhydramine and no rebound insom …
Subjective and behavioral effects of diphenhydramine, lorazepam and methocarbamol: evaluation of abuse liability.
Preston KL, Wolf B, Guarino JJ, Griffiths RR. Preston KL, et al. J Pharmacol Exp Ther. 1992 Aug;262(2):707-20. J Pharmacol Exp Ther. 1992. PMID: 1501118 Clinical Trial.
Diphenhydramine produced the most side effects. The present study clearly differentiated the behavioral and subjective profiles of diphenhydramine, lorazepam and methocarbamol. Consistent with its recognized low abuse liability, diphenhydramine produced fewer
Diphenhydramine produced the most side effects. The present study clearly differentiated the behavioral and subjective profiles of
A randomized trial of intravenous ketorolac versus intravenous metoclopramide plus diphenhydramine for tension-type and all nonmigraine, noncluster recurrent headaches.
Friedman BW, Adewunmi V, Campbell C, Solorzano C, Esses D, Bijur PE, Gallagher EJ. Friedman BW, et al. Ann Emerg Med. 2013 Oct;62(4):311-318.e4. doi: 10.1016/j.annemergmed.2013.03.017. Epub 2013 Apr 6. Ann Emerg Med. 2013. PMID: 23567060 Free PMC article. Clinical Trial.
STUDY OBJECTIVE: We compare metoclopramide 20 mg intravenously, combined with diphenhydramine 25 mg intravenously, with ketorolac 30 mg intravenously in adults with tension-type headache and all nonmigraine, noncluster recurrent headaches. ...CONCLUSION: For adults who pre …
STUDY OBJECTIVE: We compare metoclopramide 20 mg intravenously, combined with diphenhydramine 25 mg intravenously, with ketorolac 30 …
The effects of licorice containing diphenhydramine solution on recurrent aphthous stomatitis: A double-blind, randomized clinical trial.
Akbari N, Asadimehr N, Kiani Z. Akbari N, et al. Complement Ther Med. 2020 May;50:102401. doi: 10.1016/j.ctim.2020.102401. Epub 2020 Apr 15. Complement Ther Med. 2020. PMID: 32444056 Clinical Trial.
OBJECTIVES: The aim of this study was to compare the efficacy of the diphenhydramine solution (DS) and diphenhydramine-containing glycyrrhiza glabra (DSG) in the treatment of recurrent aphthous stomatitis (RAS). ...INTERVENTION: DSG was made by adding 5% hydroethano …
OBJECTIVES: The aim of this study was to compare the efficacy of the diphenhydramine solution (DS) and diphenhydramine-contain …
Prophylactic Administration of Diphenhydramine/Acetaminophen and Ondansetron Reduced Postoperative Nausea and Vomiting and Pain Following Laparoscopic Sleeve Gastrectomy: a Randomized Controlled Trial.
Pourfakhr P, Aghabagheri M, Zabihi Mahmoudabadi H, Najjari K, Talebpour M, Khajavi MR. Pourfakhr P, et al. Obes Surg. 2021 Oct;31(10):4371-4375. doi: 10.1007/s11695-021-05589-2. Epub 2021 Jul 27. Obes Surg. 2021. PMID: 34313917 Clinical Trial.
Intraoperative multimodal antiemetic prophylaxis is essential to improve postoperative outcomes. This study investigated the effect of adding diphenhydramine to acetaminophen and ondansetron in reducing postoperative nausea and vomiting and pain following laparoscopic slee …
Intraoperative multimodal antiemetic prophylaxis is essential to improve postoperative outcomes. This study investigated the effect of addin …
Pharmacodynamic response profiles of anxiolytic and sedative drugs.
Chen X, Broeyer F, de Kam M, Baas J, Cohen A, van Gerven J. Chen X, et al. Br J Clin Pharmacol. 2017 May;83(5):1028-1038. doi: 10.1111/bcp.13204. Epub 2017 Mar 17. Br J Clin Pharmacol. 2017. PMID: 27922194 Free PMC article. Clinical Trial.
RESULTS: Compared to placebo, VAS(calmness) increased with alprazolam (2.0 mm) and pregabalin (2.5 mm) but not with diphenhydramine. Saccadic peak velocity (SPV) declined after alprazolam (-57 s(-1) ) and pregabalin (-28 s(-1) ), more than with diphenhydramine (-14 …
RESULTS: Compared to placebo, VAS(calmness) increased with alprazolam (2.0 mm) and pregabalin (2.5 mm) but not with diphenhydramine. …
666 results