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Year Number of Results
1966 2
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1968 6
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1970 7
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1973 9
1974 3
1975 7
1976 7
1977 6
1978 7
1979 6
1980 6
1981 5
1982 6
1983 4
1984 6
1985 12
1986 9
1987 15
1988 11
1989 12
1990 12
1991 22
1992 18
1993 24
1994 28
1995 29
1996 31
1997 20
1998 19
1999 18
2000 24
2001 17
2002 17
2003 16
2004 14
2005 10
2006 25
2007 19
2008 20
2009 11
2010 15
2011 15
2012 14
2013 12
2014 7
2015 11
2016 8
2017 16
2018 8
2019 14
2020 8
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2022 5
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685 results

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Page 1
Effect of Doxepin Mouthwash or Diphenhydramine-Lidocaine-Antacid Mouthwash vs Placebo on Radiotherapy-Related Oral Mucositis Pain: The Alliance A221304 Randomized Clinical Trial.
Sio TT, Le-Rademacher JG, Leenstra JL, Loprinzi CL, Rine G, Curtis A, Singh AK, Martenson JA Jr, Novotny PJ, Tan AD, Qin R, Ko SJ, Reiter PL, Miller RC. Sio TT, et al. JAMA. 2019 Apr 16;321(15):1481-1490. doi: 10.1001/jama.2019.3504. JAMA. 2019. PMID: 30990550 Free PMC article. Clinical Trial.
In a randomized study, doxepin mouthwash was shown to reduce oral mucositis-related pain. A common mouthwash comprising diphenhydramine-lidocaine-antacid is also widely used. OBJECTIVE: To evaluate the effect of doxepin mouthwash or diphenhydramine-lidocaine-antacid …
In a randomized study, doxepin mouthwash was shown to reduce oral mucositis-related pain. A common mouthwash comprising diphenhydramine …
Valerian-hops combination and diphenhydramine for treating insomnia: a randomized placebo-controlled clinical trial.
Morin CM, Koetter U, Bastien C, Ware JC, Wooten V. Morin CM, et al. Sleep. 2005 Nov;28(11):1465-71. doi: 10.1093/sleep/28.11.1465. Sleep. 2005. PMID: 16335333 Clinical Trial.
There were no significant residual effects and no serious adverse events with either valerian or diphenhydramine and no rebound insomnia following their discontinuation. CONCLUSIONS: The findings show a modest hypnotic effect for a valerian-hops combination and diphenhy …
There were no significant residual effects and no serious adverse events with either valerian or diphenhydramine and no rebound insom …
Nelson's eye.
[No authors listed] [No authors listed] Lancet. 1979 Jun 16;1(8129):1280. Lancet. 1979. PMID: 87735 Clinical Trial. No abstract available.
A randomized trial of intravenous ketorolac versus intravenous metoclopramide plus diphenhydramine for tension-type and all nonmigraine, noncluster recurrent headaches.
Friedman BW, Adewunmi V, Campbell C, Solorzano C, Esses D, Bijur PE, Gallagher EJ. Friedman BW, et al. Ann Emerg Med. 2013 Oct;62(4):311-318.e4. doi: 10.1016/j.annemergmed.2013.03.017. Epub 2013 Apr 6. Ann Emerg Med. 2013. PMID: 23567060 Free PMC article. Clinical Trial.
STUDY OBJECTIVE: We compare metoclopramide 20 mg intravenously, combined with diphenhydramine 25 mg intravenously, with ketorolac 30 mg intravenously in adults with tension-type headache and all nonmigraine, noncluster recurrent headaches. ...CONCLUSION: For adults who pre …
STUDY OBJECTIVE: We compare metoclopramide 20 mg intravenously, combined with diphenhydramine 25 mg intravenously, with ketorolac 30 …
Randomized Trial of Adding Parenteral Acetaminophen to Prochlorperazine and Diphenhydramine to Treat Headache in the Emergency Department.
Meyering SH, Stringer RW, Hysell MK. Meyering SH, et al. West J Emerg Med. 2017 Apr;18(3):373-381. doi: 10.5811/westjem.2016.12.29218. Epub 2017 Feb 27. West J Emerg Med. 2017. PMID: 28435487 Free PMC article. Clinical Trial.
Secondary outcomes measures included assessment of decreased requirement of "rescue" pain medicines, defined as any analgesic medications outside of diphenhydramine, prochlorperazine and acetaminophen, with particular interest to potential opioid-sparing effects with paren …
Secondary outcomes measures included assessment of decreased requirement of "rescue" pain medicines, defined as any analgesic medications ou …
Diphenhydramine as Adjuvant Therapy for Acute Migraine: An Emergency Department-Based Randomized Clinical Trial.
Friedman BW, Cabral L, Adewunmi V, Solorzano C, Esses D, Bijur PE, Gallagher EJ. Friedman BW, et al. Ann Emerg Med. 2016 Jan;67(1):32-39.e3. doi: 10.1016/j.annemergmed.2015.07.495. Epub 2015 Aug 29. Ann Emerg Med. 2016. PMID: 26320523 Free PMC article. Clinical Trial.
We determine whether administration of diphenhydramine 50 mg intravenously+metoclopramide 10 mg intravenously results in greater rates of sustained headache relief than placebo+metoclopramide 10 mg intravenously. ...Median ED length of stay was 122 minutes (interquartile r …
We determine whether administration of diphenhydramine 50 mg intravenously+metoclopramide 10 mg intravenously results in greater rate …
A clinical trial of trimethobenzamide/diphenhydramine versus sumatriptan for acute migraines.
Friedman BW, Hochberg M, Esses D, Bijur PE, Corbo J, Paternoster J, Solorzano C, Toosi B, Lipton RB, Gallagher EJ. Friedman BW, et al. Headache. 2006 Jun;46(6):934-41. doi: 10.1111/j.1526-4610.2006.00467.x. Headache. 2006. PMID: 16732839 Clinical Trial.
Open-label studies suggest that the combination of trimethobenzamide and diphenhydramine (TMB/DPH) may provide effective relief in a high proportion of migraineurs. ...
Open-label studies suggest that the combination of trimethobenzamide and diphenhydramine (TMB/DPH) may provide effective relief in a …
Comparison of diphenhydramine and modafinil on arousal and autonomic functions in healthy volunteers.
Hou RH, Langley RW, Szabadi E, Bradshaw CM. Hou RH, et al. J Psychopharmacol. 2007 Aug;21(6):567-78. doi: 10.1177/0269881106071022. Epub 2006 Nov 8. J Psychopharmacol. 2007. PMID: 17092978 Clinical Trial.
Comparison of pre-post medication changes in pupil diameter showed a decrease after diphenhydramine and an increase after modafinil. Diphenhydramine reduced salivation, and modafinil increased systolic blood pressure. ...Hyposalivation by diphenhydramine is l …
Comparison of pre-post medication changes in pupil diameter showed a decrease after diphenhydramine and an increase after modafinil. …
Diphenhydramine, Sodium Bicarbonate, or Combination for Acute Peripheral Vertigo: A Randomized Clinical Trial.
Chi CY, Chen YC, Cheng MT, Chang KC, Chen YP, Tsai MS, Chang WT, Ma MH, Huang CH, Chiang WC. Chi CY, et al. JAMA Netw Open. 2025 Nov 3;8(11):e2541472. doi: 10.1001/jamanetworkopen.2025.41472. JAMA Netw Open. 2025. PMID: 41196596 Free PMC article. Clinical Trial.
IMPORTANCE: Intravenous diphenhydramine is commonly used to treat acute peripheral vertigo but may cause sedation. ...OBJECTIVE: To evaluate the efficacy and safety of diphenhydramine, sodium bicarbonate, and their combination in treating acute peripheral vertigo am …
IMPORTANCE: Intravenous diphenhydramine is commonly used to treat acute peripheral vertigo but may cause sedation. ...OBJECTIVE: To e …
Pharmacokinetics and pharmacodynamics of diphenhydramine 25 mg in young and elderly volunteers.
Scavone JM, Greenblatt DJ, Harmatz JS, Engelhardt N, Shader RI. Scavone JM, et al. J Clin Pharmacol. 1998 Jul;38(7):603-9. doi: 10.1002/j.1552-4604.1998.tb04466.x. J Clin Pharmacol. 1998. PMID: 9702844 Clinical Trial.
Effects on psychomotor performance, sedation, mood, and memory did not differ between diphenhydramine and placebo in either group. Thus, the pharmacokinetics of single 25-mg oral doses of diphenhydramine are not influenced by age or gender. This dose of diphenhyd …
Effects on psychomotor performance, sedation, mood, and memory did not differ between diphenhydramine and placebo in either group. Th …
685 results