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Table representation of search results timeline featuring number of search results per year.

Year Number of Results
1948 1
1949 14
1950 48
1951 86
1952 82
1953 45
1954 44
1955 34
1956 18
1957 22
1958 17
1959 18
1960 18
1961 7
1962 17
1963 31
1964 29
1965 35
1966 53
1967 50
1968 46
1969 55
1970 67
1971 59
1972 61
1973 79
1974 70
1975 73
1976 76
1977 87
1978 79
1979 79
1980 95
1981 100
1982 101
1983 97
1984 117
1985 89
1986 100
1987 98
1988 72
1989 76
1990 63
1991 59
1992 67
1993 67
1994 65
1995 60
1996 47
1997 55
1998 51
1999 47
2000 47
2001 29
2002 40
2003 45
2004 63
2005 50
2006 61
2007 74
2008 57
2009 59
2010 75
2011 78
2012 75
2013 97
2014 105
2015 85
2016 105
2017 92
2018 101
2019 101
2020 150
2021 174
2022 199
2023 161
2024 212
2025 12

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5,118 results

Results by year

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Page 1
Disulfiram ameliorates nonalcoholic steatohepatitis by modulating the gut microbiota and bile acid metabolism.
Lei Y, Tang L, Chen Q, Wu L, He W, Tu D, Wang S, Chen Y, Liu S, Xie Z, Wei H, Yang S, Tang B. Lei Y, et al. Nat Commun. 2022 Nov 11;13(1):6862. doi: 10.1038/s41467-022-34671-1. Nat Commun. 2022. PMID: 36369291 Free PMC article. Clinical Trial.
Here, we investigate the potential for repurposing disulfiram (DSF), a drug commonly used to treat chronic alcoholism, for NASH. Using a mouse model, we show that DSF ameliorates NASH in a gut microbiota-dependent manner. ...
Here, we investigate the potential for repurposing disulfiram (DSF), a drug commonly used to treat chronic alcoholism, for NASH. Usin …
Photothermally Triggered Copper Payload Release for Cuproptosis-Promoted Cancer Synergistic Therapy.
Zhou J, Yu Q, Song J, Li S, Li XL, Kang BK, Chen HY, Xu JJ. Zhou J, et al. Angew Chem Int Ed Engl. 2023 Mar 13;62(12):e202213922. doi: 10.1002/anie.202213922. Epub 2023 Feb 10. Angew Chem Int Ed Engl. 2023. PMID: 36585379
In this study, we constructed a photothermally triggered nanoplatform (Au@MSN-Cu/PEG/DSF) to realize on-demand delivery for synergistic therapy. The released disulfiram (DSF) chelated with Cu(2+) in situ to generate highly cytotoxic bis(diethyldithiocarbamate)copper (CuET) …
In this study, we constructed a photothermally triggered nanoplatform (Au@MSN-Cu/PEG/DSF) to realize on-demand delivery for synergistic ther …
[Disulfiram therapy].
Widenius T, Salaspuro M. Widenius T, et al. Duodecim. 1994;110(2):153-8. Duodecim. 1994. PMID: 7555786 Review. Finnish. No abstract available.
FDA-approved disulfiram as a novel treatment for aggressive leukemia.
Karsa M, Xiao L, Ronca E, Bongers A, Spurling D, Karsa A, Cantilena S, Mariana A, Failes TW, Arndt GM, Cheung LC, Kotecha RS, Sutton R, Lock RB, Williams O, de Boer J, Haber M, Norris MD, Henderson MJ, Somers K. Karsa M, et al. J Mol Med (Berl). 2024 Apr;102(4):507-519. doi: 10.1007/s00109-023-02414-4. Epub 2024 Feb 13. J Mol Med (Berl). 2024. PMID: 38349407 Free PMC article.
KEY MESSAGES: Disulfiram induces rapid apoptosis in leukemia cells by boosting oxidative stress. Disulfiram inhibits leukemia cell growth more potently than solid cancer cell growth. Disulfiram can enhance the antileukemic efficacy of chemotherapies. Disul …
KEY MESSAGES: Disulfiram induces rapid apoptosis in leukemia cells by boosting oxidative stress. Disulfiram inhibits leukemia …
PharmGKB summary: disulfiram pathway.
Gonzalez-Suarez AD, Thorn CF, Whirl-Carrillo M, Klein TE. Gonzalez-Suarez AD, et al. Pharmacogenet Genomics. 2023 Dec 1;33(9):207-216. doi: 10.1097/FPC.0000000000000509. Epub 2023 Sep 20. Pharmacogenet Genomics. 2023. PMID: 37728645 Free PMC article. No abstract available.
Systematic review of disulfiram as an antibacterial agent: what is the evidence?
Meneguello JE, Murase LS, de Souza JVP, de Oliveira CG, Ghiraldi-Lopes LD, Teixeira JJV, Scodro RBL, Ferracioli KRC, Siqueira VLD, Campanerut-Sá PAZ, Cardoso RF. Meneguello JE, et al. Int J Antimicrob Agents. 2022 May;59(5):106578. doi: 10.1016/j.ijantimicag.2022.106578. Epub 2022 Apr 1. Int J Antimicrob Agents. 2022. PMID: 35367599 Review.
The search strategy retrieved a total of 870 studies, of which 31 were included and 19 approached disulfiram as the primary aim and 12 included it as a secondary finding from other investigational objectives. ...We evaluated the potency and selectivity of disulfiram …
The search strategy retrieved a total of 870 studies, of which 31 were included and 19 approached disulfiram as the primary aim and 1 …
Disulfiram: A novel repurposed drug for cancer therapy.
Zeng M, Wu B, Wei W, Jiang Z, Li P, Quan Y, Hu X. Zeng M, et al. Chin Med J (Engl). 2024 Jun 20;137(12):1389-1398. doi: 10.1097/CM9.0000000000002909. Epub 2024 Jan 26. Chin Med J (Engl). 2024. PMID: 38275022 Free PMC article. Review.
Drug repurposing, which identifies new therapeutic uses for approved drugs, is a promising approach with the advantages of reducing research costs, shortening development time, and increasing efficiency and safety. Disulfiram (DSF), a Food and Drug Administration (FDA)-app …
Drug repurposing, which identifies new therapeutic uses for approved drugs, is a promising approach with the advantages of reducing research …
Disulfiram treatment of alcoholism.
Wright C, Moore RD. Wright C, et al. Am J Med. 1990 Jun;88(6):647-55. doi: 10.1016/0002-9343(90)90534-k. Am J Med. 1990. PMID: 2189310 Free article. Review.
PURPOSE: For 40 years, disulfiram has been the alcohol-aversive drug used most frequently by American physicians in the treatment of alcohol dependency disorders. ...Disulfiram has no proven effect on the long-term outcome of alcoholism....
PURPOSE: For 40 years, disulfiram has been the alcohol-aversive drug used most frequently by American physicians in the treatment of …
Disulfiram and encephalopathy.
Wilson WH. Wilson WH. Hosp Community Psychiatry. 1984 May;35(5):496-7. doi: 10.1176/ps.35.5.496. Hosp Community Psychiatry. 1984. PMID: 6724545 No abstract available.
Antifungal potential of disulfiram.
Khan S, Singhal S, Mathur T, Upadhyay DJ, Rattan A. Khan S, et al. Nihon Ishinkin Gakkai Zasshi. 2007;48(3):109-13. doi: 10.3314/jjmm.48.109. Nihon Ishinkin Gakkai Zasshi. 2007. PMID: 17667894 Free article. Review.
Disulfiram, an alcohol antagonistic drug has been on the market since 1949 with 80% bioavailability and an established safety profile. ...Interestingly, disulfiram also showed fungicidal activity on Aspergillus spp. with MIC50 and MIC90 of 2 and 8 microg/ml, respect …
Disulfiram, an alcohol antagonistic drug has been on the market since 1949 with 80% bioavailability and an established safety profile …
5,118 results