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From structure to clinic: Design of a muscarinic M1 receptor agonist with potential to treatment of Alzheimer's disease.
Brown AJH, Bradley SJ, Marshall FH, Brown GA, Bennett KA, Brown J, Cansfield JE, Cross DM, de Graaf C, Hudson BD, Dwomoh L, Dias JM, Errey JC, Hurrell E, Liptrot J, Mattedi G, Molloy C, Nathan PJ, Okrasa K, Osborne G, Patel JC, Pickworth M, Robertson N, Shahabi S, Bundgaard C, Phillips K, Broad LM, Goonawardena AV, Morairty SR, Browning M, Perini F, Dawson GR, Deakin JFW, Smith RT, Sexton PM, Warneck J, Vinson M, Tasker T, Tehan BG, Teobald B, Christopoulos A, Langmead CJ, Jazayeri A, Cooke RM, Rucktooa P, Congreve MS, Weir M, Tobin AB. Brown AJH, et al. Cell. 2021 Nov 24;184(24):5886-5901.e22. doi: 10.1016/j.cell.2021.11.001. Cell. 2021. PMID: 34822784 Free PMC article. Clinical Trial.
Lecanemab Questions.
Nadeau SE. Nadeau SE. Neurology. 2024 Apr 9;102(7):e209320. doi: 10.1212/WNL.0000000000209320. Epub 2024 Mar 14. Neurology. 2024. PMID: 38484213
Classics in Chemical Neuroscience: Donepezil.
Brewster JT 2nd, Dell'Acqua S, Thach DQ, Sessler JL. Brewster JT 2nd, et al. ACS Chem Neurosci. 2019 Jan 16;10(1):155-167. doi: 10.1021/acschemneuro.8b00517. Epub 2018 Nov 8. ACS Chem Neurosci. 2019. PMID: 30372021 Review.
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