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Table representation of search results timeline featuring number of search results per year.

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6,054 results

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Page 1
Donepezil for dementia due to Alzheimer's disease.
Birks JS, Harvey RJ. Birks JS, et al. Cochrane Database Syst Rev. 2018 Jun 18;6(6):CD001190. doi: 10.1002/14651858.CD001190.pub3. Cochrane Database Syst Rev. 2018. PMID: 29923184 Free PMC article.
OBJECTIVES: To assess the clinical efficacy and safety of donepezil in people with mild, moderate or severe dementia due to Alzheimer's disease; to compare the efficacy and safety of different doses of donepezil; and to assess the effect of donepezil on healt …
OBJECTIVES: To assess the clinical efficacy and safety of donepezil in people with mild, moderate or severe dementia due to Alzheimer …
Donepezil Regulates LPS and Abeta-Stimulated Neuroinflammation through MAPK/NLRP3 Inflammasome/STAT3 Signaling.
Kim J, Lee HJ, Park SK, Park JH, Jeong HR, Lee S, Lee H, Seol E, Hoe HS. Kim J, et al. Int J Mol Sci. 2021 Sep 30;22(19):10637. doi: 10.3390/ijms221910637. Int J Mol Sci. 2021. PMID: 34638977 Free PMC article.
In subsequent experiments in primary astrocytes, donepezil suppressed only LPS-stimulated iNOS mRNA levels. To identify the molecular mechanisms by which donepezil regulates LPS-induced neuroinflammation, we examined whether donepezil alters LPS-stimulated pr …
In subsequent experiments in primary astrocytes, donepezil suppressed only LPS-stimulated iNOS mRNA levels. To identify the molecular …
Efficacy and safety of donepezil, galantamine, and rivastigmine for the treatment of Alzheimer's disease: a systematic review and meta-analysis.
Hansen RA, Gartlehner G, Webb AP, Morgan LC, Moore CG, Jonas DE. Hansen RA, et al. Clin Interv Aging. 2008;3(2):211-25. Clin Interv Aging. 2008. PMID: 18686744 Free PMC article.
Three open-label trials and one double-blind randomized trial directly compared donepezil with galantamine and rivastigmine. Results are conflicting; two studies suggest no differences in efficacy between compared drugs, while one study found donepezil to be more ef …
Three open-label trials and one double-blind randomized trial directly compared donepezil with galantamine and rivastigmine. Results …
Donepezil.
Bryson HM, Benfield P. Bryson HM, et al. Drugs Aging. 1997 Mar;10(3):234-9; discussion 240-1. doi: 10.2165/00002512-199710030-00007. Drugs Aging. 1997. PMID: 9108896 Review.
Donepezil is a specific and potent acetylcholinesterase inhibitor according to in vitro data. ...Donepezil demonstrated efficacy in tests of reference memory in animals, but had less consistent activity in tests of working memory. ...
Donepezil is a specific and potent acetylcholinesterase inhibitor according to in vitro data. ...Donepezil demonstrated effica …
Donepezil: an update.
Seltzer B. Seltzer B. Expert Opin Pharmacother. 2007 May;8(7):1011-23. doi: 10.1517/14656566.8.7.1011. Expert Opin Pharmacother. 2007. PMID: 17472546 Review.
Donepezil hydrochloride is the most widely prescribed drug for Alzheimer's disease (AD). ...In addition, one study suggested that donepezil may delay the onset of AD in subjects with mild cognitive impairment, a prodrome to AD. ...
Donepezil hydrochloride is the most widely prescribed drug for Alzheimer's disease (AD). ...In addition, one study suggested that …
Donepezil-induced mania.
Leung JG. Leung JG. Consult Pharm. 2014 Mar;29(3):191-5. doi: 10.4140/TCP.n.2014.191. Consult Pharm. 2014. PMID: 24589768
CONCLUSION: The titration of donepezil was associated with the onset of mania. Previous trials involving off-label donepezil use in patients with bipolar disorder, but not schizophrenia, have reported the development of manic symptoms. Although rare, there is mounti …
CONCLUSION: The titration of donepezil was associated with the onset of mania. Previous trials involving off-label donepezil u …
Classics in Chemical Neuroscience: Donepezil.
Brewster JT 2nd, Dell'Acqua S, Thach DQ, Sessler JL. Brewster JT 2nd, et al. ACS Chem Neurosci. 2019 Jan 16;10(1):155-167. doi: 10.1021/acschemneuro.8b00517. Epub 2018 Nov 8. ACS Chem Neurosci. 2019. PMID: 30372021 Review.
The central role of the cholinergic system within human memory and learning, as well as its implication in Alzheimer's disease, has made it a point of focus within the neuropharmacology and medicinal chemistry communities. This review is focused on donepezil and covers the …
The central role of the cholinergic system within human memory and learning, as well as its implication in Alzheimer's disease, has made it …
A Novel Formulation: Donepezil Patch.
Adelman M, Louis L. Adelman M, et al. Sr Care Pharm. 2023 Jul 1;38(7):300-304. doi: 10.4140/TCP.n.2023.300. Sr Care Pharm. 2023. PMID: 37381137 Review.
The US FDA has approved three oral medications within this class- donepezil, galantamine, and rivastigmine. In 2022, the US Food and Drug Administration approved a novel patch formulation for donepezil that could be beneficial for patients with dysphagia as well as …
The US FDA has approved three oral medications within this class- donepezil, galantamine, and rivastigmine. In 2022, the US Food and …
Donepezil update.
[No authors listed] [No authors listed] Drug Ther Bull. 1998 Aug;36(8):60-1. Drug Ther Bull. 1998. PMID: 9876403 Review. No abstract available.
Donepezil: in vascular dementia.
Goldsmith DR, Scott LJ. Goldsmith DR, et al. Drugs Aging. 2003;20(15):1127-36. doi: 10.2165/00002512-200320150-00005. Drugs Aging. 2003. PMID: 14651435 Review.

Pooled data from two, randomised, double-blind, phase III trials showed that the least-squares mean change from baseline score effect size for the ADAS-cog was -1.79 for donepezil 5mg once daily (p < 0.001) and -2.28 for donepezil 10mg once daily (p < 0.001) a

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Pooled data from two, randomised, double-blind, phase III trials showed that the least-squares mean change from baseline score effect size f …
6,054 results