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Cell-Type-Specific Causal Inference Unveils Novel Targets for Parkinson's Disease.
Gu SC, Sun QY, Zhang W, Shen CY, Su H, Xie F, Yuan CX, Zhou ZD, Tan EK, Ye Q. Gu SC, et al. Mov Disord. 2026 Feb 13. doi: 10.1002/mds.70223. Online ahead of print. Mov Disord. 2026. PMID: 41684331
BACKGROUND: Parkinson's disease (PD) involves heterogeneous neurodegenerative processes across brain cell types. The cell-type-specific effects of genetic risk remain unclear. ...Drug-gene interaction screen highlighted US Food and Drug Administration-approved agents inclu …
BACKGROUND: Parkinson's disease (PD) involves heterogeneous neurodegenerative processes across brain cell types. The cell-type-specif …
Risk factors for periorbital dermatitis in patients using dorzolamide/timolol eye drops.
Kim M, Jang H, Rho S. Kim M, et al. Sci Rep. 2021 Sep 9;11(1):17896. doi: 10.1038/s41598-021-97565-0. Sci Rep. 2021. PMID: 34504268 Free PMC article.
This study assessed the clinical risk factors for periorbital dermatitis (PD) after using dorzolamide/timolol eye drops in a total of 1282 glaucoma patients. Both the PD(+) group and the PD(-) group were evaluated using clinical data such as age, sex, …
This study assessed the clinical risk factors for periorbital dermatitis (PD) after using dorzolamide/timolol eye drops in a t …
Simultaneous determination of dorzolamide and timolol by first-order derivative UV spectroscopy in simulated biological fluid for in vitro drug release testing.
Tambe S, Jain D, Amin P. Tambe S, et al. Spectrochim Acta A Mol Biomol Spectrosc. 2021 Jul 5;255:119682. doi: 10.1016/j.saa.2021.119682. Epub 2021 Mar 13. Spectrochim Acta A Mol Biomol Spectrosc. 2021. PMID: 33770736
Dorzolamide hydrochloride and timolol maleate is a well-established fixed-dose combination for the treatment of glaucoma worldwide. ...No method has been reported so far for the simultaneous estimation of dorzolamide and timolol in simulated tear fluid. In the prese …
Dorzolamide hydrochloride and timolol maleate is a well-established fixed-dose combination for the treatment of glaucoma worldwide. . …
Hot-melt extruded in situ gelling systems (MeltDrops Technology): Formulation development, in silico modelling and in vivo studies.
Tambe SM, Jain DD, Hasmukh Mehta C, T A, Yogendra Nayak U, Amin PD. Tambe SM, et al. Eur J Pharm Biopharm. 2023 Jul;188:108-124. doi: 10.1016/j.ejpb.2023.05.008. Epub 2023 May 12. Eur J Pharm Biopharm. 2023. PMID: 37182553
In this study, we demonstrate novel application of hot-melt extrusion (HME) technology for continuous manufacturing of ISGS (MeltDrops Technology). Timolol maleate (TIM) and dorzolamide hydrochloride (DRZ) loaded MeltDrops were successfully developed using HME for glaucoma …
In this study, we demonstrate novel application of hot-melt extrusion (HME) technology for continuous manufacturing of ISGS (MeltDrops Techn …
Delayed periocular dermatitis as a rare side-effect of topical anti-glaucoma eyedrop instillation in two Shih-Tzu dogs with atopic dermatitis.
Shim J, Kim SA, Seo K, Kang S. Shim J, et al. J Vet Sci. 2023 Jan;24(1):e6. doi: 10.4142/jvs.22101. Epub 2022 Dec 5. J Vet Sci. 2023. PMID: 36560838 Free PMC article.
Two Shih-Tzu dogs with atopic dermatitis presented with delayed periocular dermatitis (PD) following the instillation of dorzolamide and dorzolamide/timolol combination eyedrops; the development of dermatologic signs took 94 and 104 d in cases 1 and 2, respec …
Two Shih-Tzu dogs with atopic dermatitis presented with delayed periocular dermatitis (PD) following the instillation of dorzolami …
Evaluation of retinal haemodynamics and retinal function after application of dorzolamide, timolol and latanoprost in newly diagnosed open-angle glaucoma patients.
Arend O, Harris A, Wolter P, Remky A. Arend O, et al. Acta Ophthalmol Scand. 2003 Oct;81(5):474-9. doi: 10.1034/j.1600-0420.2003.00122.x. Acta Ophthalmol Scand. 2003. PMID: 14510794 Free article. Clinical Trial.
Patients then randomly received timolol, dorzolamide or latanoprost treatment for 4 weeks. Patients then returned and all procedures were repeated and assessed. ...Contrast sensitivity testing at 6 cycles/degree (c.p.d.) revealed a significant rise after dorzolamide …
Patients then randomly received timolol, dorzolamide or latanoprost treatment for 4 weeks. Patients then returned and all procedures …
Navigating the Gene Co-Expression Network and Drug Repurposing Opportunities for Brain Disorders Associated with Neurocognitive Impairment.
Manuel MTA, Tayo LL. Manuel MTA, et al. Brain Sci. 2023 Nov 7;13(11):1564. doi: 10.3390/brainsci13111564. Brain Sci. 2023. PMID: 38002524 Free PMC article.
Herein, the microarray datasets AD (GSE5281), HAND (GSE35864), glioma (GSE15824), and PD (GSE7621) were used to perform Weighted Gene Co-expression Network Analysis (WGCNA) to identify highly preserved modules across the studied brain diseases. ...Drug repurposing based on …
Herein, the microarray datasets AD (GSE5281), HAND (GSE35864), glioma (GSE15824), and PD (GSE7621) were used to perform Weighted Gene …
The synthesis of novel sulfamides derived from β-benzylphenethylamines as acetylcholinesterase, butyrylcholinesterase and carbonic anhydrase enzymes inhibitors.
Akıncıoğlu A, Kocaman E, Akıncıoğlu H, Salmas RE, Durdagi S, Gülçin İ, Supuran CT, Göksu S. Akıncıoğlu A, et al. Bioorg Chem. 2017 Oct;74:238-250. doi: 10.1016/j.bioorg.2017.08.012. Epub 2017 Aug 23. Bioorg Chem. 2017. PMID: 28866249
In this study, a series of novel beta-benzylphenethylamines and their sulfamide derivatives were synthesized starting from (Z)-2,3-diphenylacrylonitriles. Pd-C catalysed hydrogenation of diphenylacrylonitriles, reduction of propanenitriles with LiAlH(4) in the presence of …
In this study, a series of novel beta-benzylphenethylamines and their sulfamide derivatives were synthesized starting from (Z)-2,3-diphenyla …