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1997 1
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498 results

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Page 1
Comparison of amitriptyline supplemented with pregabalin, pregabalin supplemented with amitriptyline, and duloxetine supplemented with pregabalin for the treatment of diabetic peripheral neuropathic pain (OPTION-DM): a multicentre, double-blind, randomised crossover trial.
Tesfaye S, Sloan G, Petrie J, White D, Bradburn M, Julious S, Rajbhandari S, Sharma S, Rayman G, Gouni R, Alam U, Cooper C, Loban A, Sutherland K, Glover R, Waterhouse S, Turton E, Horspool M, Gandhi R, Maguire D, Jude EB, Ahmed SH, Vas P, Hariman C, McDougall C, Devers M, Tsatlidis V, Johnson M, Rice ASC, Bouhassira D, Bennett DL, Selvarajah D; OPTION-DM trial group. Tesfaye S, et al. Lancet. 2022 Aug 27;400(10353):680-690. doi: 10.1016/S0140-6736(22)01472-6. Epub 2022 Aug 22. Lancet. 2022. PMID: 36007534 Free PMC article. Clinical Trial.
Most guidelines recommend amitriptyline, duloxetine, pregabalin, or gabapentin as initial analgesic treatment for DPNP, but there is little comparative evidence on which one is best or whether they should be combined. ...Both treatments were titrated towards maximum tolera …
Most guidelines recommend amitriptyline, duloxetine, pregabalin, or gabapentin as initial analgesic treatment for DPNP, but there is …
Effect of duloxetine on pain, function, and quality of life among patients with chemotherapy-induced painful peripheral neuropathy: a randomized clinical trial.
Smith EM, Pang H, Cirrincione C, Fleishman S, Paskett ED, Ahles T, Bressler LR, Fadul CE, Knox C, Le-Lindqwister N, Gilman PB, Shapiro CL; Alliance for Clinical Trials in Oncology. Smith EM, et al. JAMA. 2013 Apr 3;309(13):1359-67. doi: 10.1001/jama.2013.2813. JAMA. 2013. PMID: 23549581 Free PMC article. Clinical Trial.
INTERVENTIONS: The initial treatment consisted of taking 1 capsule daily of either 30 mg of duloxetine or placebo for the first week and 2 capsules of either 30 mg of duloxetine or placebo daily for 4 additional weeks. ...The observed mean difference in the average …
INTERVENTIONS: The initial treatment consisted of taking 1 capsule daily of either 30 mg of duloxetine or placebo for the first week …
Duloxetine and pregabalin: high-dose monotherapy or their combination? The "COMBO-DN study"--a multinational, randomized, double-blind, parallel-group study in patients with diabetic peripheral neuropathic pain.
Tesfaye S, Wilhelm S, Lledo A, Schacht A, Tölle T, Bouhassira D, Cruccu G, Skljarevski V, Freynhagen R. Tesfaye S, et al. Pain. 2013 Dec;154(12):2616-2625. doi: 10.1016/j.pain.2013.05.043. Epub 2013 May 31. Pain. 2013. PMID: 23732189 Free article. Clinical Trial.
For initial 8-week therapy, either 60 mg/day duloxetine (groups 1, 2) or 300 mg/day pregabalin (groups 3, 4) was given. Thereafter, in the 8-week combination/high-dose therapy period, only nonresponders received 120 mg/day duloxetine (group 1), a combination of 60 m …
For initial 8-week therapy, either 60 mg/day duloxetine (groups 1, 2) or 300 mg/day pregabalin (groups 3, 4) was given. Thereafter, i …
A randomized, double-blinded, placebo-controlled clinical trial of duloxetine hydrochloride enteric-coated tablets in the treatment of refractory chronic cough.
Wang S, Li S, Wu H, Zhang T, Chen Y, Zhu Y, Wen S, Shi C, Yu L, Xu X. Wang S, et al. BMC Pulm Med. 2023 Aug 2;23(1):282. doi: 10.1186/s12890-023-02575-5. BMC Pulm Med. 2023. PMID: 37533019 Free PMC article. Clinical Trial.
A total of 98 individuals will be randomized in a 1:1 ratio to duloxetine group and placebo control group (starting with 20 mg QD, increasing 20 mg daily until 20 mg TID). ...DISCUSSION: This study is the first randomized, double-blind, and controlled clinical trial invest …
A total of 98 individuals will be randomized in a 1:1 ratio to duloxetine group and placebo control group (starting with 20 mg QD, in …
Efficacy of postoperative analgesia with duloxetine in posthemorrhoidectomy pain: a prospective, randomized, double-blind and placebo-controlled trial.
Gerber MT, Lyra HF Jr, Erdmann TR, Bomfati F, Gaspareto PB, de Oliveira Filho GR. Gerber MT, et al. BMC Anesthesiol. 2022 Dec 1;22(1):372. doi: 10.1186/s12871-022-01908-x. BMC Anesthesiol. 2022. PMID: 36457090 Free PMC article. Clinical Trial.
BACKGROUND: To evaluate the effect of duloxetine when added to a multimodal analgesia regimen on posthemorrhoidectomy pain, opioid consumption, and side effects. ...RESULTS: Fifty-two patients completed the study (25 in the duloxetine group and 27 in the placebo gro …
BACKGROUND: To evaluate the effect of duloxetine when added to a multimodal analgesia regimen on posthemorrhoidectomy pain, opioid co …
Duloxetine in OsteoArthritis (DOA) study: effects of duloxetine on pain and function in end-stage hip and knee OA - a pragmatic enriched randomized controlled trial.
Blikman T, Rienstra W, van Raaij TM, Ten Hagen AJ, Dijkstra B, Zijlstra WP, Bulstra SK, Stevens M, van den Akker-Scheek I. Blikman T, et al. BMC Musculoskelet Disord. 2022 Feb 5;23(1):115. doi: 10.1186/s12891-022-05034-0. BMC Musculoskelet Disord. 2022. PMID: 35123461 Free PMC article. Clinical Trial.
OBJECTIVES: Assess the efficacy of an 8-week duloxetine treatment compared to usual care in end-stage knee and hip OA patients with a level of centralized pain. ...Nearly 44% felt much to very much better after duloxetine usage compared to 0% in the care-as-usual gr …
OBJECTIVES: Assess the efficacy of an 8-week duloxetine treatment compared to usual care in end-stage knee and hip OA patients with a …
Fixed dose combination of low dose pregabalin and duloxetine, or pregabalin monotherapy for neuropathic pain: A double-blind, randomized, parallel-group study.
K K, Dutt S, Rattan P, Dadhania A, Gupta R, Joshi D, Kakkad A, Makwana A, Jha P. K K, et al. F1000Res. 2023 Mar 30;12:353. doi: 10.12688/f1000research.130345.1. eCollection 2023. F1000Res. 2023. PMID: 38618021 Free PMC article. Clinical Trial.
Three hundred and twenty-eight adult patients with moderate to severe neuropathic pain were randomized in a ratio of 1:1 to receive a FDC of pregabalin and duloxetine or pregabalin monotherapy for 7 weeks followed by a one-week follow-up. The pregabalin-duloxetine c …
Three hundred and twenty-eight adult patients with moderate to severe neuropathic pain were randomized in a ratio of 1:1 to receive a FDC of …
PPARgamma and AKt gene modulation following pregabalin and duloxetine combination for painful diabetic polyneuropathy.
Saxena AK, Thanikkal N, Chilkoti GT, Gondode PG, Sharma T, Banerjee BD. Saxena AK, et al. Pain Manag. 2024 Jun 2;14(5-6):273-281. doi: 10.1080/17581869.2024.2370758. Epub 2024 Jul 12. Pain Manag. 2024. PMID: 38995181 Free PMC article. Clinical Trial.
Current treatments like pregabalin and duloxetine offer limited efficacy. This study evaluates combining pregabalin and duloxetine versus pregabalin alone for DPN pain relief, and explores gene modulation (PPARgamma and Akt) to understand neuropathic pain's molecula …
Current treatments like pregabalin and duloxetine offer limited efficacy. This study evaluates combining pregabalin and duloxetine …
Comparison of Duloxetine Supplemented With Pregabalin and Amitriptyline Supplemented With Pregabalin for the Treatment of Postherpetic Neuralgia: A Double-Blind, Randomized Crossover Trial.
Wang Y, Wu C, Liu Y, Lou Y, Chen C, Chen Q, Li X, Ma C, Li J, Huang Y. Wang Y, et al. CNS Neurosci Ther. 2025 May;31(5):e70460. doi: 10.1111/cns.70460. CNS Neurosci Ther. 2025. PMID: 40418104 Free PMC article. Clinical Trial.
About 220 participants were randomly assigned (1:1) to either the duloxetine combined with pregabalin or the amitriptyline combined with pregabalin. The patient takes duloxetine or amitriptyline orally before bedtime for 6 weeks each time. ...In the reported adverse …
About 220 participants were randomly assigned (1:1) to either the duloxetine combined with pregabalin or the amitriptyline combined w …
The effect of duloxetine on mechanistic pain profiles, cognitive factors and clinical pain in patients with painful knee osteoarthritis-A randomized, double-blind, placebo-controlled, crossover study.
Petersen KK, Drewes AM, Olesen AE, Ammitzbøll N, Bertoli D, Brock C, Arendt-Nielsen L. Petersen KK, et al. Eur J Pain. 2022 Sep;26(8):1650-1664. doi: 10.1002/ejp.1988. Epub 2022 Jun 13. Eur J Pain. 2022. PMID: 35638317 Free PMC article. Clinical Trial.
BACKGROUND: Duloxetine is indicated in the management of pain in osteoarthritis. Evidence suggests that duloxetine modulates central pain mechanisms and cognitive factors, and these factors are assumed contributing to the analgesic effect. ...Linear regression model …
BACKGROUND: Duloxetine is indicated in the management of pain in osteoarthritis. Evidence suggests that duloxetine modulates c …
498 results