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1988 2
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284 results

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Page 1
Equine Protozoal Myeloencephalitis.
MacKay RJ, Howe DK. MacKay RJ, et al. Vet Clin North Am Equine Pract. 2022 Aug;38(2):249-268. doi: 10.1016/j.cveq.2022.05.003. Epub 2022 Jul 7. Vet Clin North Am Equine Pract. 2022. PMID: 35810151 Review.
Sulfadiazine/pyrimethamine (ReBalance) and the triazine compounds diclazuril (Protazil) and ponazuril (Marquis) are effective anticoccidial drugs that are now available as FDA-approved treatments for EPM....
Sulfadiazine/pyrimethamine (ReBalance) and the triazine compounds diclazuril (Protazil) and ponazuril (Marquis) are effective anticoc …
Plasma concentrations of diclazuril following oral administration of diclazuril and diclazuril sodium salt to cattle.
Dirikolu L, Lehner AF, Tobin T. Dirikolu L, et al. J Vet Pharmacol Ther. 2022 Jul;45(4):392-401. doi: 10.1111/jvp.13062. Epub 2022 Apr 30. J Vet Pharmacol Ther. 2022. PMID: 35488857
The present study reports on the bioavailability, pharmacokinetics, and metabolism of diclazuril and diclazuril sodium salt in cattle following administration of diclazuril suspended in water and by direct application of diclazuril sodium salt to the o …
The present study reports on the bioavailability, pharmacokinetics, and metabolism of diclazuril and diclazuril sodium salt in …
Interactions of diclazuril enantiomers with serum albumins: Multi-spectroscopic and molecular docking approaches.
Chen R, He RJ, Guo D, Zhang ZF, Zhang WG, Fan J. Chen R, et al. J Mol Recognit. 2022 Apr;35(4):e2948. doi: 10.1002/jmr.2948. Epub 2022 Jan 30. J Mol Recognit. 2022. PMID: 35094438
According to the thermodynamic study, binding of diclazuril enantiomers and SAs was an exothermic process driven by enthalpy change. Then, circular dichroism spectroscopy of SAs with diclazuril enantiomers revealed that the SAs conformation had changed in the presen …
According to the thermodynamic study, binding of diclazuril enantiomers and SAs was an exothermic process driven by enthalpy change. …
Diclazuril Inhibits Biofilm Formation and Hemolysis of Staphylococcus aureus.
Zheng J, Shang Y, Wu Y, Wu J, Chen J, Wang Z, Sun X, Xu G, Deng Q, Qu D, Yu Z. Zheng J, et al. ACS Infect Dis. 2021 Jun 11;7(6):1690-1701. doi: 10.1021/acsinfecdis.1c00030. Epub 2021 May 21. ACS Infect Dis. 2021. PMID: 34019393
The RNA levels of transcriptional regulatory genes (agrA, agrC, luxS, sarA, sigB, saeR, saeS), biofilm formation-related genes (aur, bap, ccpA, cidA, clfA, clfB, fnbA, fnbB, icaA, icaB, sasG), and virulence-related genes (hla, hlb, hld, hlg, lukDE, lukpvl-S, spa, sbi, alpha-3 PSM …
The RNA levels of transcriptional regulatory genes (agrA, agrC, luxS, sarA, sigB, saeR, saeS), biofilm formation-related genes (aur, bap, cc …
Equine protozoal myeloencephalitis.
MacKay RJ, Granstrom DE, Saville WJ, Reed SM. MacKay RJ, et al. Vet Clin North Am Equine Pract. 2000 Dec;16(3):405-25. doi: 10.1016/s0749-0739(17)30086-x. Vet Clin North Am Equine Pract. 2000. PMID: 11219340 Review.
In addition to standard SDZ/PYR therapy, toltrazuril, ponazuril, diclazuril, and NTZ have shown promise as possible alternatives....
In addition to standard SDZ/PYR therapy, toltrazuril, ponazuril, diclazuril, and NTZ have shown promise as possible alternatives....
Safety and efficacy of Coxiril() (diclazuril) for chickens reared for laying.
EFSA Panel on Additives and Products or Substances used in Animal Feed (FEEDAP); Rychen G, Aquilina G, Azimonti G, Bampidis V, Bastos ML, Bories G, Chesson A, Cocconcelli PS, Flachowsky G, Kolar B, Kouba M, López Alonso M, López Puente S, Mantovani A, Mayo B, Ramos F, Saarela M, Villa RE, Wallace RJ, Wester P, Brantom P, Halle I, van Beelen P, Holczknecht O, Vettori MV, Gropp J. EFSA Panel on Additives and Products or Substances used in Animal Feed (FEEDAP), et al. EFSA J. 2018 Mar 29;16(3):e05195. doi: 10.2903/j.efsa.2018.5195. eCollection 2018 Mar. EFSA J. 2018. PMID: 32625831 Free PMC article.
The FEEDAP Panel extended its previous assessment of consumer safety for the use of diclazuril from Coxiril() in chickens for fattening to chickens reared for laying. No measurable diclazuril residues were found in the first eggs laid from chickens reared for laying …
The FEEDAP Panel extended its previous assessment of consumer safety for the use of diclazuril from Coxiril() in chickens for fatteni …
HPLC semi-preparative separation of diclazuril enantiomers and racemization in solution.
Huang Z, Guo D, Fan J, Zhong Y, Zhang M, He L, Zhang W. Huang Z, et al. J Sep Sci. 2020 Apr;43(7):1240-1247. doi: 10.1002/jssc.201901201. Epub 2020 Jan 15. J Sep Sci. 2020. PMID: 31909564
Diclazuril has been widely used in poultry feed for prevention and treatment of coccidiosis, and its chiral separation is rarely reported. ...Racemization of diclazuril enantiomers was remarkably accelerated through adding triethylamine at high temperature. ...
Diclazuril has been widely used in poultry feed for prevention and treatment of coccidiosis, and its chiral separation is rarely repo …
Diclazuril Protects against Maternal Gastrointestinal Syndrome and Congenital Toxoplasmosis.
Oz HS, Tobin T. Oz HS, et al. Int J Clin Med. 2014 Jan 1;5(3):93-101. doi: 10.4236/ijcm.2014.53017. Int J Clin Med. 2014. PMID: 24851194 Free PMC article.

Animals became anemic and showed hydrothorax, and ascities. Diclazuril effectively protected dams from ascities and anemia (p < 0.05). Infected dams showed splenomegaly, with massive infiltration of epithelioid cells compared with the protective effect of diclazuril

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Animals became anemic and showed hydrothorax, and ascities. Diclazuril effectively protected dams from ascities and anemia (p < 0.

…
Diclazuril-induced expression of CDK-related kinase 2 in the second-generation merozoites of Eimeria tenella.
Zhou BH, Ding HY, Yang JY, Chai J, Guo HW, Tian EJ. Zhou BH, et al. Mol Biochem Parasitol. 2023 Sep;255:111575. doi: 10.1016/j.molbiopara.2023.111575. Epub 2023 Jun 9. Mol Biochem Parasitol. 2023. PMID: 37302489
Diclazuril is a classic anticoccidial drug. The key molecules of diclazuril in anticoccidial action allows target screening for the development of anticoccidial drugs. ...The fluorescence intensity of EtCRK2 in the infected/diclazuril group was significantly …
Diclazuril is a classic anticoccidial drug. The key molecules of diclazuril in anticoccidial action allows target screening fo …
Review of triazine antiprotozoal drugs used in veterinary medicine.
Stock ML, Elazab ST, Hsu WH. Stock ML, et al. J Vet Pharmacol Ther. 2018 Apr;41(2):184-194. doi: 10.1111/jvp.12450. Epub 2017 Aug 17. J Vet Pharmacol Ther. 2018. PMID: 28833212 Review.
In this article, we discuss the pharmacological characteristics of five triazines, toltrazuril, ponazuril, clazuril, diclazuril, and nitromezuril which are used in veterinary medicine to control protozoal diseases which include coccidiosis, equine protozoal myeloencephalit …
In this article, we discuss the pharmacological characteristics of five triazines, toltrazuril, ponazuril, clazuril, diclazuril, and …
284 results