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Table representation of search results timeline featuring number of search results per year.

Year Number of Results
1980 6
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1985 48
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1987 55
1988 50
1989 65
1990 67
1991 79
1992 64
1993 45
1994 61
1995 68
1996 52
1997 52
1998 44
1999 36
2000 29
2001 33
2002 24
2003 21
2004 16
2005 18
2006 13
2007 12
2008 11
2009 16
2010 14
2011 8
2012 12
2013 16
2014 13
2015 13
2016 12
2017 8
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2019 5
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2022 3
2023 5
2024 6
2025 4
2026 1

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1,205 results

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Page 1
Calcium-channel blocking agents.
Leonard RG, Talbert RL. Leonard RG, et al. Clin Pharm. 1982 Jan-Feb;1(1):17-33. Clin Pharm. 1982. PMID: 6764159 Review.
Diltiazem's oral bioavailability is good (90% reaches systemic circulation), but there is significant interindividual variability between administered dose and resulting plasma concentration. Geriatric patients have delayed absorption and reduced clearance of diltiazem …
Diltiazem's oral bioavailability is good (90% reaches systemic circulation), but there is significant interindividual variability bet …
Efficacy of Diltiazem to Improve Coronary Vasomotor Dysfunction in ANOCA: The EDIT-CMD Randomized Clinical Trial.
Jansen TPJ, Konst RE, de Vos A, Paradies V, Teerenstra S, van den Oord SCH, Dimitriu-Leen A, Maas AHEM, Smits PC, Damman P, van Royen N, Elias-Smale SE. Jansen TPJ, et al. JACC Cardiovasc Imaging. 2022 Aug;15(8):1473-1484. doi: 10.1016/j.jcmg.2022.03.012. Epub 2022 Apr 2. JACC Cardiovasc Imaging. 2022. PMID: 35466050 Free article. Clinical Trial.
OBJECTIVES: The randomized, placebo-controlled EDIT-CMD (Efficacy of Diltiazem to Improve Coronary Microvascular Dysfunction: A Randomized Clinical Trial) evaluated the effect of diltiazem on CVDys, as assessed by repeated coronary function testing (CFT), angina, an …
OBJECTIVES: The randomized, placebo-controlled EDIT-CMD (Efficacy of Diltiazem to Improve Coronary Microvascular Dysfunction: A Rando …
Calcium-channel blocking agents for gastrointestinal disorders.
Castell DO. Castell DO. Am J Cardiol. 1985 Jan 25;55(3):210B-213B. doi: 10.1016/0002-9149(85)90633-2. Am J Cardiol. 1985. PMID: 3881916 Review.
In studies in man, oral doses of diltiazem and nifedipine have likewise been shown to have similar effects on the esophagus. ...In clinical trials, nifedipine has been shown to have a greater effect than placebo in improving symptoms in patients with achalasia, and dilt …
In studies in man, oral doses of diltiazem and nifedipine have likewise been shown to have similar effects on the esophagus. ...In cl …
Gallopamil and diltiazem: a double-blind, randomized, cross-over trial in effort ischaemia.
Marraccini P, Orsini E, Brunelli C, Nassi G, Ghigliotti G, Iannetti M, Caponnetto S, L'Abbate A. Marraccini P, et al. Eur Heart J. 1992 Mar;13(3):404-10. doi: 10.1093/oxfordjournals.eurheartj.a060181. Eur Heart J. 1992. PMID: 1597229 Clinical Trial.
At the end of each period a multistage bicycle exercise stress test was performed under placebo (first and third periods) and randomly under gallopamil (50 mg t.i.d.) or diltiazem (90 mg t.i.d.) in the second and fourth periods. Both drugs significantly increased time to i …
At the end of each period a multistage bicycle exercise stress test was performed under placebo (first and third periods) and randomly under …
Design of a placebo-controlled clinical trial of long-acting diltiazem and aspirin versus aspirin alone in patients receiving thrombolysis with a first acute myocardial infarction. Incomplete Infarction Trial of European Research Collaborators Evaluating Prognosis Post-Thrombolysis (diltiazem) (INTERCEPT) Research Group.
Boden WE, Scheldewaert R, Walters EG, Whitehead A, Coltart DJ, Santoni JP, Belgrave G, Starkey IR. Boden WE, et al. Am J Cardiol. 1995 Jun 1;75(16):1120-3. doi: 10.1016/s0002-9149(99)80742-5. Am J Cardiol. 1995. PMID: 7762497 Clinical Trial.
Although calcium antagonists have not been shown to alter post-AMI mortality, diltiazem has been shown to reduce recurrent nonfatal infarction and myocardial ischemia following non-Q-wave AMI. ...We have initiated a multicenter, randomized, placebo-controlled, double-blind …
Although calcium antagonists have not been shown to alter post-AMI mortality, diltiazem has been shown to reduce recurrent nonfatal i …
An assessment of diltiazem and hydrochlorothiazide in hypertension. Application of factorial trial design to a multicenter clinical trial of combination therapy.
Burris JF, Weir MR, Oparil S, Weber M, Cady WJ, Stewart WH. Burris JF, et al. JAMA. 1990 Mar 16;263(11):1507-12. JAMA. 1990. PMID: 2407872 Clinical Trial.
After a 4- to 6-week placebo run-in period, 297 qualifying patients were randomized to receive placebo, 1 of 4 doses of diltiazem SR monotherapy, 1 of 3 doses of hydrochlorothiazide monotherapy, or 1 of 12 possible combinations of diltiazem SR and hydrochlorothiazid …
After a 4- to 6-week placebo run-in period, 297 qualifying patients were randomized to receive placebo, 1 of 4 doses of diltiazem SR …
Randomized clinical trial with topical diltiazem for post-hemorrhoidectomy wound healing.
Rodríguez-Wong U, Rodríguez-Medina U, Medina-Murillo GR. Rodríguez-Wong U, et al. Rev Gastroenterol Mex (Engl Ed). 2019 Jan-Mar;84(1):119-122. doi: 10.1016/j.rgmx.2018.10.001. Epub 2018 Dec 24. Rev Gastroenterol Mex (Engl Ed). 2019. PMID: 30591198 Free article. Clinical Trial. English, Spanish.
Mean healing time for the group treated with diltiazem was 3.19 weeks (22.33 0.884 days) and 3.92 weeks (27.44 1.130 days) for the control group (p=0.012 95% CI). At week three, the wounds in 73.07% of the patients in the diltiazem group had healed, compared with 46 …
Mean healing time for the group treated with diltiazem was 3.19 weeks (22.33 0.884 days) and 3.92 weeks (27.44 1.130 days) for the co …
The diltiazem-digoxin interaction.
Rameis H, Magometschnigg D, Ganzinger U. Rameis H, et al. Clin Pharmacol Ther. 1984 Aug;36(2):183-9. doi: 10.1038/clpt.1984.160. Clin Pharmacol Ther. 1984. PMID: 6744777 Clinical Trial.
Diltiazem with digoxin induced an average increase of steady-state plasma digoxin concentration and AUC over 48 hr of 22.4%. ...Apparent volume of distribution was not relevantly altered. Diltiazem kinetics did not change significantly when digoxin was concurrently …
Diltiazem with digoxin induced an average increase of steady-state plasma digoxin concentration and AUC over 48 hr of 22.4%. ...Appar …
Clinical and medicoeconomic impact of the cyclosporine-diltiazem interaction in renal transplant recipients.
Smith CL, Hampton EM, Pederson JA, Pennington LR, Bourne DW. Smith CL, et al. Pharmacotherapy. 1994 Jul-Aug;14(4):471-81. Pharmacotherapy. 1994. PMID: 7937285 Clinical Trial.
The effect of the diltiazem-cyclosporine interaction on cyclosporine pharmacokinetics, pharmacodynamics, and pharmacoeconomics was studied in 10 recipients of renal allografts. ...After pharmacokinetic analysis, all patients were followed for 6 months during treatment with …
The effect of the diltiazem-cyclosporine interaction on cyclosporine pharmacokinetics, pharmacodynamics, and pharmacoeconomics was st …
Pharmacokinetic and pharmacodynamic interactions between diltiazem and methylprednisolone in healthy volunteers.
Booker BM, Magee MH, Blum RA, Lates CD, Jusko WJ. Booker BM, et al. Clin Pharmacol Ther. 2002 Oct;72(4):370-82. doi: 10.1067/mcp.2002.127944. Clin Pharmacol Ther. 2002. PMID: 12386639 Clinical Trial.
The AUC of diltiazem was unchanged in the presence of methylprednisolone. No significant intrinsic pharmacodynamic differences were observed for methylprednisolone versus methylprednisolone-diltiazem. ...However, significant differences between 50% inhibitory concen …
The AUC of diltiazem was unchanged in the presence of methylprednisolone. No significant intrinsic pharmacodynamic differences were o …
1,205 results