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1,201 results

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Page 1
Calcium-channel blocking agents.
Leonard RG, Talbert RL. Leonard RG, et al. Clin Pharm. 1982 Jan-Feb;1(1):17-33. Clin Pharm. 1982. PMID: 6764159 Review.
Diltiazem's oral bioavailability is good (90% reaches systemic circulation), but there is significant interindividual variability between administered dose and resulting plasma concentration. Geriatric patients have delayed absorption and reduced clearance of diltiazem …
Diltiazem's oral bioavailability is good (90% reaches systemic circulation), but there is significant interindividual variability bet …
Calcium-channel blocking agents for gastrointestinal disorders.
Castell DO. Castell DO. Am J Cardiol. 1985 Jan 25;55(3):210B-213B. doi: 10.1016/0002-9149(85)90633-2. Am J Cardiol. 1985. PMID: 3881916 Review.
In studies in man, oral doses of diltiazem and nifedipine have likewise been shown to have similar effects on the esophagus. ...In clinical trials, nifedipine has been shown to have a greater effect than placebo in improving symptoms in patients with achalasia, and dilt …
In studies in man, oral doses of diltiazem and nifedipine have likewise been shown to have similar effects on the esophagus. ...In cl …
An assessment of diltiazem and hydrochlorothiazide in hypertension. Application of factorial trial design to a multicenter clinical trial of combination therapy.
Burris JF, Weir MR, Oparil S, Weber M, Cady WJ, Stewart WH. Burris JF, et al. JAMA. 1990 Mar 16;263(11):1507-12. JAMA. 1990. PMID: 2407872 Clinical Trial.
After a 4- to 6-week placebo run-in period, 297 qualifying patients were randomized to receive placebo, 1 of 4 doses of diltiazem SR monotherapy, 1 of 3 doses of hydrochlorothiazide monotherapy, or 1 of 12 possible combinations of diltiazem SR and hydrochlorothiazid …
After a 4- to 6-week placebo run-in period, 297 qualifying patients were randomized to receive placebo, 1 of 4 doses of diltiazem SR …
Antihypertensive safety and efficacy and physician and patient satisfaction: results from a phase 4 practice-based clinical experience trial with diltiazem LA.
Glasser SP. Glasser SP. Adv Ther. 2006 Mar-Apr;23(2):284-94. doi: 10.1007/BF02850134. Adv Ther. 2006. PMID: 16751161 Clinical Trial.
This study was undertaken to assess the safety and efficacy of a new long-acting formulation of diltiazem (DLA) (Cardizem LA; Biovail Pharmaceuticals, Inc., Bridgewater, NJ) in a large heterogeneous group of hypertensive patients, and to evaluate physician and patient trea …
This study was undertaken to assess the safety and efficacy of a new long-acting formulation of diltiazem (DLA) (Cardizem LA; Biovail …
Randomized clinical trial assessing the side-effects of glyceryl trinitrate and diltiazem hydrochloride in the treatment of chronic anal fissure.
Kocher HM, Steward M, Leather AJ, Cullen PT. Kocher HM, et al. Br J Surg. 2002 Apr;89(4):413-7. doi: 10.1046/j.0007-1323.2001.02042.x. Br J Surg. 2002. PMID: 11952579 Clinical Trial.
INTRODUCTION: Glyceryl trinitrate (GTN) ointment (0 small middle dot2 per cent) has an efficacy of up to 68 per cent in healing chronic anal fissure, but with headache as a major side-effect. Diltiazem hydrochloride (DTZ) cream (2 per cent) is expected to have fewer side-e …
INTRODUCTION: Glyceryl trinitrate (GTN) ointment (0 small middle dot2 per cent) has an efficacy of up to 68 per cent in healing chronic anal …
Pharmacokinetic and pharmacodynamic interactions between diltiazem and methylprednisolone in healthy volunteers.
Booker BM, Magee MH, Blum RA, Lates CD, Jusko WJ. Booker BM, et al. Clin Pharmacol Ther. 2002 Oct;72(4):370-82. doi: 10.1067/mcp.2002.127944. Clin Pharmacol Ther. 2002. PMID: 12386639 Clinical Trial.
The AUC of diltiazem was unchanged in the presence of methylprednisolone. No significant intrinsic pharmacodynamic differences were observed for methylprednisolone versus methylprednisolone-diltiazem. ...However, significant differences between 50% inhibitory concen …
The AUC of diltiazem was unchanged in the presence of methylprednisolone. No significant intrinsic pharmacodynamic differences were o …
Clinical experience with a once-daily, extended-release formulation of diltiazem in the treatment of hypertension.
Graney WF. Graney WF. Am J Med. 1992 Aug 31;93(2A):56S-64S. doi: 10.1016/0002-9343(92)90295-m. Am J Med. 1992. PMID: 1519637 Review.
Among the available calcium channel blockers, diltiazem hydrochloride appears to have a highly favorable side-effect profile. A new, extended-release formulation of diltiazem has been developed for the treatment of essential hypertension. ...Patients were randomly a …
Among the available calcium channel blockers, diltiazem hydrochloride appears to have a highly favorable side-effect profile. A new, …
Topical Minoxidil Versus Topical Diltiazem for Chemical Sphincterotomy of Chronic Anal Fissure: A Prospective, Randomized, Double-Blind, Clinical Trial.
Alvandipour M, Ala S, Khalvati M, Yazdanicharati J, Koulaeinejad N. Alvandipour M, et al. World J Surg. 2018 Jul;42(7):2252-2258. doi: 10.1007/s00268-017-4449-x. World J Surg. 2018. PMID: 29290068 Clinical Trial.
The objective of this study was evaluation of the efficacy and the adverse effects of topically applied minoxidil in chemical sphincterotomy of chronic anal fissure in comparison with topical diltiazem. METHODS: A total of 88 patients with chronic anal fissure aged between …
The objective of this study was evaluation of the efficacy and the adverse effects of topically applied minoxidil in chemical sphincterotomy …
Diltiazem: its place in the antihypertensive armamentarium.
Fagan TC. Fagan TC. J Cardiovasc Pharmacol. 1991;18 Suppl 9:S26-31. J Cardiovasc Pharmacol. 1991. PMID: 1725539 Review.
The total number of patients with adverse effects and those who drop out due to adverse effects are similar for diltiazem and the other drugs. Combination therapy with diltiazem and captopril showed additive effects, and combination of diltiazem with hydrochl …
The total number of patients with adverse effects and those who drop out due to adverse effects are similar for diltiazem and the oth …
Population Pharmacokinetic Modeling of Diltiazem in Chinese Renal Transplant Recipients.
Guan XF, Li DY, Yin WJ, Ding JJ, Zhou LY, Wang JL, Ma RR, Zuo XC. Guan XF, et al. Eur J Drug Metab Pharmacokinet. 2018 Feb;43(1):55-62. doi: 10.1007/s13318-017-0425-y. Eur J Drug Metab Pharmacokinet. 2018. PMID: 28646274 Clinical Trial.
Several population pharmacokinetic (PopPK) models had been established for cyclosporine A and tacrolimus but no specific PopPK model was established for diltiazem. The aim of the study is to develop a PopPK model for diltiazem in renal transplant recipients and prov …
Several population pharmacokinetic (PopPK) models had been established for cyclosporine A and tacrolimus but no specific PopPK model was est …
1,201 results