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1983 1
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158 results

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Page 1
Enalapril in heart failure.
Nicholls MG, Ikram H, Espiner EA, Webster MW, Fitzpatrick MA. Nicholls MG, et al. Br J Clin Pharmacol. 1984;18 Suppl 2(Suppl 2):163S-167S. doi: 10.1111/j.1365-2125.1984.tb02594.x. Br J Clin Pharmacol. 1984. PMID: 6099733 Free PMC article. Clinical Trial.
Pharmacokinetics and pharmacodynamics of enalapril and its active metabolite, enalaprilat, at four different doses in healthy horses.
Gómez-Díez M, Muñoz A, Caballero JM, Riber C, Castejón F, Serrano-Rodríguez JM. Gómez-Díez M, et al. Res Vet Sci. 2014 Aug;97(1):105-10. doi: 10.1016/j.rvsc.2014.06.006. Epub 2014 Jun 12. Res Vet Sci. 2014. PMID: 24972864 Clinical Trial.
Serum concentrations of enalapril and enalaprilat were determined for pharmacokinetic analysis. Angiotensin-converting enzyme (ACE) activity, serum ureic nitrogen (SUN), creatinine and electrolytes were measured, and blood pressure was monitored for pharmacodynamic analysi …
Serum concentrations of enalapril and enalaprilat were determined for pharmacokinetic analysis. Angiotensin-converting enzyme (ACE) a …
Pharmacokinetic comparison of a combination tablet of enalapril and hydrochlorothiazide with enalapril and hydrochlorothiazide tablets administered together and separately.
Howes LG, Conway EL, Phillips PA, Broadbear J, Drummer OH, Louis WJ. Howes LG, et al. Biopharm Drug Dispos. 1991 Aug-Sep;12(6):447-55. doi: 10.1002/bdd.2510120606. Biopharm Drug Dispos. 1991. PMID: 1932608 Clinical Trial.
Overall, HCT was bioequivalent under all conditions and enalaprilat was bioequivalent when given in combination with HCT either as one tablet or as two separate tablets. However, when given with HCT, the mean AUC and Cmax of enalaprilat were reduced up to 20 per cen …
Overall, HCT was bioequivalent under all conditions and enalaprilat was bioequivalent when given in combination with HCT either as on …
Comparison of the pharmacokinetics of fosinoprilat with enalaprilat and lisinopril in patients with congestive heart failure and chronic renal insufficiency.
Greenbaum R, Zucchelli P, Caspi A, Nouriel H, Paz R, Sclarovsky S, O'Grady P, Yee KF, Liao WC, Mangold B. Greenbaum R, et al. Br J Clin Pharmacol. 2000 Jan;49(1):23-31. doi: 10.1046/j.1365-2125.2000.00103.x. Br J Clin Pharmacol. 2000. PMID: 10606834 Free PMC article. Clinical Trial.
AIMS: To compare the serum pharmacokinetics of fosinoprilat with enalaprilat and lisinopril after 1 and 10 days of dosing with fosinopril, enalapril and lisinopril. ...The difference between the AI for fosinoprilat (1.41) and enalaprilat (1.96) was statistically sig …
AIMS: To compare the serum pharmacokinetics of fosinoprilat with enalaprilat and lisinopril after 1 and 10 days of dosing with fosino …
Determination of enalapril and enalaprilat by enzyme linked immunosorbent assays: application to pharmacokinetic and pharmacodynamic analysis.
Matalka K, Arafat T, Hamad M, Jehanli A. Matalka K, et al. Fundam Clin Pharmacol. 2002 Jun;16(3):237-44. doi: 10.1046/j.1472-8206.2002.00087.x. Fundam Clin Pharmacol. 2002. PMID: 12165071 Clinical Trial.
We have developed two enzyme linked immunosorbent assay (ELISA) methods for determining enalapril and enalaprilat in plasma. In this study, 48 healthy subjects received an oral dose of either 10 or 20 mg of enalapril and plasma concentrations of enalapril and enalaprila …
We have developed two enzyme linked immunosorbent assay (ELISA) methods for determining enalapril and enalaprilat in plasma. In this …
Pharmacokinetics and pharmacodynamics profiles of enalapril maleate in healthy volunteers following determination of enalapril and enalaprilat by two specific enzyme immunoassays.
Arafat T, Awad R, Hamad M, Azzam R, Al-Nasan A, Jehanli A, Matalka K. Arafat T, et al. J Clin Pharm Ther. 2005 Aug;30(4):319-28. doi: 10.1111/j.1365-2710.2005.00646.x. J Clin Pharm Ther. 2005. PMID: 15985045 Clinical Trial.
In these methods, enalapril has to be hydrolysed to enalaprilat first and then assayed. The purpose of this study was to re-estimate the PK parameters of enalapril and enalaprilat in healthy volunteers using two specific enzyme immunoassays for enalapril and enal …
In these methods, enalapril has to be hydrolysed to enalaprilat first and then assayed. The purpose of this study was to re-estimate …
Acute administration of metoprolol and enalaprilat reduces insulin-stimulated thermogenesis and skin blood flow.
Tuominen JA, Eriksson JG, Koivisto VA. Tuominen JA, et al. J Intern Med. 1996 May;239(5):399-406. doi: 10.1046/j.1365-2796.1996.473824000.x. J Intern Med. 1996. PMID: 8642232 Clinical Trial.

Forearm blood flow (plethysmography) was lower with metoprolol compared to enalaprilat (2.1 +/- 0.2 vs. 2.8 +/- 0.4 mL per 100 mL min-1; P < 0.05). Glucose-plus-insulin-stimulated thermogenesis and total energy expenditures were reduced both by metoprolol (71 and 5.2%;

…
Forearm blood flow (plethysmography) was lower with metoprolol compared to enalaprilat (2.1 +/- 0.2 vs. 2.8 +/- 0.4 mL per 100 mL min …
Angiotensin II and sympathetic activity in patients with congestive heart failure.
Goldsmith SR, Hasking GJ, Miller E. Goldsmith SR, et al. J Am Coll Cardiol. 1993 Apr;21(5):1107-13. doi: 10.1016/0735-1097(93)90232-p. J Am Coll Cardiol. 1993. PMID: 8384645 Free article. Clinical Trial.
OBJECTIVES: This study was designed to determine the effects of intravenous angiotensin II infusions and the short-term effects of enalaprilat on venous plasma norepinephrine and norepinephrine spillover in patients with stable chronic congestive heart failure. ...Norepine …
OBJECTIVES: This study was designed to determine the effects of intravenous angiotensin II infusions and the short-term effects of enalap …
Chronopharmacology of enalapril in hypertensive patients.
Sunaga K, Fujimura A, Shiga T, Ebihara A. Sunaga K, et al. Eur J Clin Pharmacol. 1995;48(6):441-5. doi: 10.1007/BF00194332. Eur J Clin Pharmacol. 1995. PMID: 8582461 Clinical Trial.
Serum concentrations of total drug (enalapril + enalaprilat, its active metabolite) during the day and night trials did not differ significantly at any time. However, serum enalaprilat tended to be higher and its maximum concentration greater in the day trial than i …
Serum concentrations of total drug (enalapril + enalaprilat, its active metabolite) during the day and night trials did not differ si …
Substance P increases sympathetic activity during combined angiotensin-converting enzyme and dipeptidyl peptidase-4 inhibition.
Devin JK, Pretorius M, Nian H, Yu C, Billings FT 4th, Brown NJ. Devin JK, et al. Hypertension. 2014 May;63(5):951-7. doi: 10.1161/HYPERTENSIONAHA.113.02767. Epub 2014 Feb 10. Hypertension. 2014. PMID: 24516103 Free PMC article. Clinical Trial.
Substance P and bradykinin were infused via brachial artery before and during intra-arterial enalaprilat. Sitagliptin and enalaprilat each reduced forearm vascular resistance and increased forearm blood flow without affecting mean arterial pressure, but there was no …
Substance P and bradykinin were infused via brachial artery before and during intra-arterial enalaprilat. Sitagliptin and enalapri …
158 results