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Year Number of Results
2003 1
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2012 5
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63 results

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Page 1
Combination Drug Therapy with Acetazolamide, Eszopiclone Venlafaxine for Obstructive Sleep Apnea (RESCUE-Combo): A Randomized, Double-Blind, Placebo-controlled Clinical Trial.
Schmickl CN, Orr JE, Alex RM, Gruenberg E, Parra G, White S, Spenceley A, DeSarkar T, Kong M, DeYoung PN, Sands SA, Owens RL, Malhotra A. Schmickl CN, et al. Ann Am Thorac Soc. 2025 Feb;22(2):263-273. doi: 10.1513/AnnalsATS.202407-736OC. Ann Am Thorac Soc. 2025. PMID: 39514000 Clinical Trial.
Rationale: Acetazolamide, eszopiclone, and venlafaxine may target different underlying mechanisms of obstructive sleep apnea (OSA) and individually may partially reduce OSA severity in select patients. We tested whether acetazolamide plus eszopiclone (DualRx) reduce …
Rationale: Acetazolamide, eszopiclone, and venlafaxine may target different underlying mechanisms of obstructive sleep apnea (OSA) an …
Efficacy and Safety of Transitioning to Lemborexant from Z-drug, Suvorexant, and Ramelteon in Japanese Insomnia Patients: An Open-label, Multicenter Study.
Ozone M, Hirota S, Ariyoshi Y, Hayashida K, Ikegami A, Habukawa M, Ohshima H, Harada D, Hiejima H, Kotorii N, Murotani K, Taninaga T, Uchimura N. Ozone M, et al. Adv Ther. 2024 Apr;41(4):1728-1745. doi: 10.1007/s12325-024-02811-2. Epub 2024 Mar 9. Adv Ther. 2024. PMID: 38460107 Free PMC article. Clinical Trial.
This prospective, non-randomized, open-label, interventional, multicenter study assessed whether Japanese patients with chronic insomnia dissatisfied with treatment could transition directly to lemborexant (LEM) from four cohorts-non-benzodiazepine sedative-hypnotic (zolpidem, zo …
This prospective, non-randomized, open-label, interventional, multicenter study assessed whether Japanese patients with chronic insomnia dis …
Eszopiclone improves overnight polysomnography and continuous positive airway pressure titration: a prospective, randomized, placebo-controlled trial.
Lettieri CJ, Quast TN, Eliasson AH, Andrada T. Lettieri CJ, et al. Sleep. 2008 Sep;31(9):1310-6. Sleep. 2008. PMID: 18788656 Free PMC article. Clinical Trial.
STUDY OBJECTIVES: To assess whether premedication with eszopiclone would improve sleep duration and continuity during polysomnography, thereby improving the quality of diagnostic and CPAP titration studies. ...PATIENTS: 226 adult subjects undergoing polysomnography for sus …
STUDY OBJECTIVES: To assess whether premedication with eszopiclone would improve sleep duration and continuity during polysomnography …
Effects of eszopiclone on sleep quality and cognitive function in elderly patients with Alzheimer's disease and sleep disorder: A randomized controlled trial.
Huo S, Cheng L, Li S, Xu F. Huo S, et al. Brain Behav. 2022 Feb;12(2):e2488. doi: 10.1002/brb3.2488. Epub 2022 Jan 18. Brain Behav. 2022. PMID: 35041261 Free PMC article. Clinical Trial.
OBJECTIVE: To investigate the effects of eszopiclone on sleep quality and cognitive function in elderly patients with Alzheimer's disease (AD) and sleep disorders. ...After treatment, the scores of the physical life self-care scale and instrumental activities of daily livi …
OBJECTIVE: To investigate the effects of eszopiclone on sleep quality and cognitive function in elderly patients with Alzheimer's dis …
The effects of eszopiclone on sleep spindles and memory consolidation in schizophrenia: a randomized placebo-controlled trial.
Wamsley EJ, Shinn AK, Tucker MA, Ono KE, McKinley SK, Ely AV, Goff DC, Stickgold R, Manoach DS. Wamsley EJ, et al. Sleep. 2013 Sep 1;36(9):1369-76. doi: 10.5665/sleep.2968. Sleep. 2013. PMID: 23997371 Free PMC article. Clinical Trial.
We investigated whether eszopiclone could increase spindles and thereby improve memory consolidation in schizophrenia. ...In the combined eszopiclone and placebo groups, spindle number and density predicted overnight MST improvement. ...
We investigated whether eszopiclone could increase spindles and thereby improve memory consolidation in schizophrenia. ...In the comb …
Treatment of insomnia in Parkinson's disease: a controlled trial of eszopiclone and placebo.
Menza M, Dobkin RD, Marin H, Gara M, Bienfait K, Dicke A, Comella CL, Cantor C, Hyer L. Menza M, et al. Mov Disord. 2010 Aug 15;25(11):1708-14. doi: 10.1002/mds.23168. Mov Disord. 2010. PMID: 20589875 Free PMC article. Clinical Trial.
We conducted a 6-week, randomized, controlled trial of eszopiclone and placebo in 30 patients with PD and insomnia. Patients with other primary sleep disorders (PSG defined) were excluded. ...Eszopiclone did not increase TST significantly but was superior to placebo …
We conducted a 6-week, randomized, controlled trial of eszopiclone and placebo in 30 patients with PD and insomnia. Patients with oth …
The effects of eszopiclone on sleep spindles and memory consolidation in schizophrenia: a randomized clinical trial.
Mylonas D, Baran B, Demanuele C, Cox R, Vuper TC, Seicol BJ, Fowler RA, Correll D, Parr E, Callahan CE, Morgan A, Henderson D, Vangel M, Stickgold R, Manoach DS. Mylonas D, et al. Neuropsychopharmacology. 2020 Dec;45(13):2189-2197. doi: 10.1038/s41386-020-00833-2. Epub 2020 Sep 12. Neuropsychopharmacology. 2020. PMID: 32919407 Free PMC article. Clinical Trial.
This larger double-blind crossover study that included healthy controls investigated whether eszopiclone could both increase N2 spindle density and improve memory. Twenty-six medicated schizophrenia outpatients and 29 healthy controls were randomly assigned to have a place …
This larger double-blind crossover study that included healthy controls investigated whether eszopiclone could both increase N2 spind …
The impact of eszopiclone on sleep and cognition in patients with schizophrenia and insomnia: a double-blind, randomized, placebo-controlled trial.
Tek C, Palmese LB, Krystal AD, Srihari VH, DeGeorge PC, Reutenauer EL, Guloksuz S. Tek C, et al. Schizophr Res. 2014 Dec;160(1-3):180-5. doi: 10.1016/j.schres.2014.10.002. Epub 2014 Oct 29. Schizophr Res. 2014. PMID: 25454802 Free PMC article. Clinical Trial.
Sleep remained improved during single-blind placebo phase after eszopiclone was stopped, but the working memory improvement in patients with schizophrenia was not durable. CONCLUSIONS: Eszopiclone stands as a safe and effective alternative for the treatment of insom …
Sleep remained improved during single-blind placebo phase after eszopiclone was stopped, but the working memory improvement in patien …
Lemborexant for the Treatment of Insomnia: Direct and Indirect Comparisons With Other Hypnotics Using Number Needed to Treat, Number Needed to Harm, and Likelihood to Be Helped or Harmed.
Citrome L, Juday T, Frech F, Atkins N Jr. Citrome L, et al. J Clin Psychiatry. 2021 Jun 1;82:20m13795. doi: 10.4088/JCP.20m13795. J Clin Psychiatry. 2021. PMID: 34077032 Free article. Clinical Trial.
Direct comparisons were made with zolpidem extended release (ER), and indirect comparisons were made with other hypnotic agents, including suvorexant, doxepin, ramelteon, zolpidem immediate release, eszopiclone, zaleplon, and selected benzodiazepines, using data from publi …
Direct comparisons were made with zolpidem extended release (ER), and indirect comparisons were made with other hypnotic agents, including s …
Eszopiclone improves insomnia and depressive and anxious symptoms in perimenopausal and postmenopausal women with hot flashes: a randomized, double-blinded, placebo-controlled crossover trial.
Joffe H, Petrillo L, Viguera A, Koukopoulos A, Silver-Heilman K, Farrell A, Yu G, Silver M, Cohen LS. Joffe H, et al. Am J Obstet Gynecol. 2010 Feb;202(2):171.e1-171.e11. doi: 10.1016/j.ajog.2009.10.868. Epub 2009 Dec 24. Am J Obstet Gynecol. 2010. PMID: 20035910 Clinical Trial.

RESULTS: Of 59 women, 46 (78%) completed the study. Eszopiclone reduced ISI scores by 8.7 + or - 1.4 more points than placebo (P < .0001). Eszopiclone improved (P < .05) all sleep parameters, depressive symptoms, anxiety symptoms, quality of life, and nighttim

…
RESULTS: Of 59 women, 46 (78%) completed the study. Eszopiclone reduced ISI scores by 8.7 + or - 1.4 more points than placebo (P < …
63 results