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154 results

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Page 1
Effectiveness of norgestimate and ethinyl estradiol in treating moderate acne vulgaris.
Lucky AW, Henderson TA, Olson WH, Robisch DM, Lebwohl M, Swinyer LJ. Lucky AW, et al. J Am Acad Dermatol. 1997 Nov;37(5 Pt 1):746-54. doi: 10.1016/s0190-9622(97)70112-9. J Am Acad Dermatol. 1997. PMID: 9366821 Clinical Trial.
OBJECTIVE: Our purpose was to evaluate the efficacy of a triphasic, combination OC (ORTHO TRI-CYCLEN [Ortho-McNeil Pharmaceutical, Raritan, N.J.], norgestimate/ethinyl estradiol) compared with placebo in the treatment of moderate acne vulgaris. ...CONCLUSION: An OC contain …
OBJECTIVE: Our purpose was to evaluate the efficacy of a triphasic, combination OC (ORTHO TRI-CYCLEN [Ortho-McNeil Pharmaceutical, Raritan, …
Effects of rimegepant 75 mg daily on the pharmacokinetics of a combined oral contraceptive containing ethinyl estradiol and norgestimate in healthy female participants.
Bhardwaj R, Stringfellow JC, Morris B, Croop RS, Bertz RJ. Bhardwaj R, et al. Headache. 2023 May;63(5):652-662. doi: 10.1111/head.14512. Epub 2023 May 4. Headache. 2023. PMID: 37140071 Clinical Trial.
OBJECTIVE: To assess the effect of single and multiple doses of rimegepant 75 mg dose on the pharmacokinetics of an oral contraceptive containing ethinyl estradiol (EE)/norgestimate (NGM) in healthy females of childbearing potential or non-menopausal females with tubal lig …
OBJECTIVE: To assess the effect of single and multiple doses of rimegepant 75 mg dose on the pharmacokinetics of an oral contraceptive conta …
Disposition of norgestimate in the presence and absence of ethinyl estradiol after oral administration to humans.
Weintraub HS, Abrams LS, Patrick JE, McGuire JL. Weintraub HS, et al. J Pharm Sci. 1978 Oct;67(10):1406-8. doi: 10.1002/jps.2600671020. J Pharm Sci. 1978. PMID: 702290
The disposition of radioactivity following oral administration of 14C-norgestimate was compared to that following administration of the drug in combination with 3H-ethinyl estradiol in humans. ...Approximately 50% of the administered radioactivity due to carbon-14 was excr …
The disposition of radioactivity following oral administration of 14C-norgestimate was compared to that following administration of t …
Effect of the coadministration of daclatasvir on the pharmacokinetics of a combined oral contraceptive containing ethinyl estradiol and norgestimate.
Bifano M, Sevinsky H, Hwang C, Kandoussi H, Jiang H, Grasela D, Bertz R. Bifano M, et al. Antivir Ther. 2014;19(5):511-9. doi: 10.3851/IMP2718. Epub 2013 Dec 17. Antivir Ther. 2014. PMID: 24343001 Clinical Trial.
The primary objective of this study was to assess the effect of daclatasvir on the pharmacokinetics of a combined oral contraceptive containing ethinyl estradiol and norgestimate (Ortho Tri-Cyclen()). METHODS: In this open-label single-sequence study, 20 healthy female sub …
The primary objective of this study was to assess the effect of daclatasvir on the pharmacokinetics of a combined oral contraceptive contain …
Dolutegravir Has No Effect on the Pharmacokinetics of Oral Contraceptives With Norgestimate and Ethinyl Estradiol.
Song IH, Borland J, Chen S, Wajima T, Peppercorn AF, Piscitelli SC. Song IH, et al. Ann Pharmacother. 2015 Jul;49(7):784-9. doi: 10.1177/1060028015580637. Epub 2015 Apr 10. Ann Pharmacother. 2015. PMID: 25862012 Free PMC article. Clinical Trial.
OBJECTIVE: To determine the impact of DTG on the pharmacokinetics (PK) and pharmacodynamics (PD) of a common oral contraceptive, norgestimate/ethinyl estradiol (NGM/EE; Ortho-Cyclen; Ortho-McNeil-Janssen Pharmaceuticals, Inc, Raritan, NJ). ...CONCLUSIONS: DTG had no …
OBJECTIVE: To determine the impact of DTG on the pharmacokinetics (PK) and pharmacodynamics (PD) of a common oral contraceptive, n …
Influence of alitretinoin on the pharmacokinetics of the oral contraceptive ethinyl estradiol/norgestimate.
Schmitt-Hoffmann AH, Roos B, Sauer J, Schleimer M, Schoetzau A, Leese PT, Weidekamm E, Maares J. Schmitt-Hoffmann AH, et al. Clin Exp Dermatol. 2011 Apr;36 Suppl 2:4-11. doi: 10.1111/j.1365-2230.2011.04031.x. Clin Exp Dermatol. 2011. PMID: 21443598 Clinical Trial.
Similarly, the influence of ethinyl estradiol/norgestimate on systemic exposure to alitretinoin and 4-oxo-alitretinoin was not clinically relevant. Alitretinoin was well tolerated when given either alone or with ethinyl estradiol/norgestimate. CONCLUSIONS: There was …
Similarly, the influence of ethinyl estradiol/norgestimate on systemic exposure to alitretinoin and 4-oxo-alitretinoin was not clinic …
Evaluation of Potential Drug-Drug Interaction Between Delayed-Release Dimethyl Fumarate and a Commonly Used Oral Contraceptive (Norgestimate/Ethinyl Estradiol) in Healthy Women.
Zhu B, Nestorov I, Zhao G, Meka V, Leahy M, Kam J, Sheikh SI. Zhu B, et al. Clin Pharmacol Drug Dev. 2017 Nov;6(6):604-613. doi: 10.1002/cpdd.377. Epub 2017 Aug 7. Clin Pharmacol Drug Dev. 2017. PMID: 28783872 Free PMC article. Clinical Trial.
This 2-period crossover study was conducted to evaluate the potential for drug-drug interaction between DMF (240 mg twice daily) and a combined oral contraceptive (OC; norgestimate 250 mug, ethinyl estradiol 35 mug). Forty-six healthy women were enrolled; 32 completed the …
This 2-period crossover study was conducted to evaluate the potential for drug-drug interaction between DMF (240 mg twice daily) and a combi …
The duration of response to norgestimate and ethinyl estradiol in the treatment of acne vulgaris.
Olson WH, Lippman JS, Robisch DM. Olson WH, et al. Int J Fertil Womens Med. 1998 Nov-Dec;43(6):286-90. Int J Fertil Womens Med. 1998. PMID: 9920537 Clinical Trial.
Subjects received either 3 weeks of active OC treatment (i.e., 0.035 mg ethinyl estradiol plus increasing doses of norgestimate [0.180 mg, 0.215 mg, 0.250 mg]) and 1 week of inactive tablets, or 4 weeks of color-matched placebo tablets. ...CONCLUSION: A triphasic combinati …
Subjects received either 3 weeks of active OC treatment (i.e., 0.035 mg ethinyl estradiol plus increasing doses of norgestimate [0.18 …
Lack of a clinically important pharmacokinetic interaction between sofosbuvir or ledipasvir and hormonal oral contraceptives norgestimate/ethinyl estradiol in HCV-uninfected female subjects.
German P, Moorehead L, Pang P, Vimal M, Mathias A. German P, et al. J Clin Pharmacol. 2014 Nov;54(11):1290-8. doi: 10.1002/jcph.346. Epub 2014 Jun 24. J Clin Pharmacol. 2014. PMID: 24925712
This study evaluated the potential for a drug-drug interaction between HCV direct-acting antivirals sofosbuvir or ledipasvir and oral hormonal contraceptive (OC) norgestimate/ethinyl estradiol (norgestimate 0.18/0.215/0.25 mg with ethinyl estradiol 25 mug). ...Admin …
This study evaluated the potential for a drug-drug interaction between HCV direct-acting antivirals sofosbuvir or ledipasvir and oral hormon …
The effect of atazanavir/ritonavir on the pharmacokinetics of an oral contraceptive containing ethinyl estradiol and norgestimate in healthy women.
Zhang J, Chung E, Yones C, Persson A, Mahnke L, Eley T, Xu X, Bertz R. Zhang J, et al. Antivir Ther. 2011;16(2):157-64. doi: 10.3851/IMP1724. Antivir Ther. 2011. PMID: 21447864
An open-label three-period single-sequence study assessed the effect of coadministration of atazanavir (ATV)/ritonavir (RTV) with Ortho Tri-Cyclen() and with Ortho Tri-Cyclen() LO (Ortho-McNeil-Janssen Pharmaceuticals, Inc., Raritan, NJ, USA) on the pharmacokinetics (PK) of ethin …
An open-label three-period single-sequence study assessed the effect of coadministration of atazanavir (ATV)/ritonavir (RTV) with Ortho Tri- …
154 results