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Table representation of search results timeline featuring number of search results per year.

Year Number of Results
1960 1
1961 2
1962 7
1963 16
1964 60
1965 66
1966 61
1967 62
1968 75
1969 57
1970 70
1971 68
1972 62
1973 71
1974 94
1975 70
1976 64
1977 55
1978 56
1979 47
1980 74
1981 35
1982 70
1983 54
1984 42
1985 47
1986 37
1987 41
1988 33
1989 52
1990 46
1991 36
1992 26
1993 31
1994 23
1995 27
1996 13
1997 14
1998 15
1999 20
2000 16
2001 21
2002 14
2003 22
2004 14
2005 13
2006 19
2007 12
2008 16
2009 12
2010 9
2011 14
2012 17
2013 9
2014 8
2015 10
2016 14
2017 8
2018 10
2019 7
2020 8
2021 6
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2,047 results
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Page 1
Pharmacology and toxicology of ethinyl estradiol and norethindrone acetate in experimental animals.
Maier WE, Herman JR. Maier WE, et al. Regul Toxicol Pharmacol. 2001 Aug;34(1):53-61. doi: 10.1006/rtph.2001.1483. Regul Toxicol Pharmacol. 2001. PMID: 11502156 Review.
For over 30 years various combinations of synthetic estrogens and progestins have been used in oral contraceptive formulations. Ethinyl estradiol (EE) and norethindrone acetate (NA) are common synthetic hormones used in oral contraceptives such as Loestrin, B …
For over 30 years various combinations of synthetic estrogens and progestins have been used in oral contraceptive formulations. Ethinyl
The Primodos components Norethisterone acetate and Ethinyl estradiol induce developmental abnormalities in zebrafish embryos.
Brown S, Fraga LR, Cameron G, Erskine L, Vargesson N. Brown S, et al. Sci Rep. 2018 Feb 13;8(1):2917. doi: 10.1038/s41598-018-21318-9. Sci Rep. 2018. PMID: 29440757 Free PMC article.
The damage occurs rapidly after drug exposure, affecting multiple organ systems. Moreover, we found that the Norethisterone acetate and Ethinyl estradiol mixture can affect nerve outgrowth and blood vessel patterning directly and accumulates in the forming em …
The damage occurs rapidly after drug exposure, affecting multiple organ systems. Moreover, we found that the Norethisterone acetate a …
The effect of isotretinoin on the pharmacokinetics and pharmacodynamics of ethinyl estradiol and norethindrone.
Hendrix CW, Jackson KA, Whitmore E, Guidos A, Kretzer R, Liss CM, Shah LP, Khoo KC, McLane J, Trapnell CB. Hendrix CW, et al. Clin Pharmacol Ther. 2004 May;75(5):464-75. doi: 10.1016/j.clpt.2004.01.003. Clin Pharmacol Ther. 2004. PMID: 15116059 Clinical Trial.
RESULTS: The addition of isotretinoin to the oral contraceptive regimen resulted in small and inconsistent, although statistically significant (P <.04), decreases in the concentrations of both ethinyl estradiol (9% decrease in area under the plasma concentration- …
RESULTS: The addition of isotretinoin to the oral contraceptive regimen resulted in small and inconsistent, although statistically significa …
Simultaneous determination of norethindrone and ethinyl estradiol in human plasma by high performance liquid chromatography with tandem mass spectrometry--experiences on developing a highly selective method using derivatization reagent for enhancing sensitivity.
Li W, Li YH, Li AC, Zhou S, Naidong W. Li W, et al. J Chromatogr B Analyt Technol Biomed Life Sci. 2005 Oct 25;825(2):223-32. doi: 10.1016/j.jchromb.2005.01.012. J Chromatogr B Analyt Technol Biomed Life Sci. 2005. PMID: 16213451
Norethindrone, ethinyl estradiol, and their internal standards norethindrone-(13)C2, and ethinyl estradiol-d4, were extracted from human plasma matrix with n-butyl chloride. ...The inter-day precision and accuracy of the quality control s
Norethindrone, ethinyl estradiol, and their internal standards norethindrone-(13)C2, and ethinyl estra
Norethindrone acetate 1.0 milligram and ethinyl estradiol 10 micrograms as an ultra low-dose oral contraceptive.
Archer DF, Nakajima ST, Sawyer AT, Wentworth J, Trupin S, Koltun WD, Gilbert RD, Ellman H. Archer DF, et al. Obstet Gynecol. 2013 Sep;122(3):601-7. doi: 10.1097/AOG.0b013e3182a1741c. Obstet Gynecol. 2013. PMID: 23921878 Clinical Trial.
METHODS: This open-label, uncontrolled, multicenter study used an ultra low-dose OCP (1.0 mg norethindrone acetate and 10 micrograms ethinyl E2). The OCP was administered in a regimen of 24 days of a 28-day cycle followed by 10 micrograms ethinyl E2 for 2 day …
METHODS: This open-label, uncontrolled, multicenter study used an ultra low-dose OCP (1.0 mg norethindrone acetate and 10 micrograms …
Dissolution testing of norethindrone:ethinyl estradiol, norethindrone:mestranol, and norethindrone acetate:ethinyl estradiol combination tablets.
Nguyen HT, Shiu GK, Worsley WN, Skelly JP. Nguyen HT, et al. J Pharm Sci. 1990 Feb;79(2):163-7. doi: 10.1002/jps.2600790217. J Pharm Sci. 1990. PMID: 2324966
Dissolution of oral contraceptive combination products from six manufacturing firms was studied utilizing the rotating basket method at 100 rpm in 600 mL of 0.1 M HCl and 0.02% sodium lauryl sulfate (SLS). Most of the combination products of norethindrone (NE):ethinyl
Dissolution of oral contraceptive combination products from six manufacturing firms was studied utilizing the rotating basket method at 100 …
Pharmacokinetic interaction between bosentan and the oral contraceptives norethisterone and ethinyl estradiol.
van Giersbergen PL, Halabi A, Dingemanse J. van Giersbergen PL, et al. Int J Clin Pharmacol Ther. 2006 Mar;44(3):113-8. doi: 10.5414/cpp44113. Int J Clin Pharmacol Ther. 2006. PMID: 16550733 Clinical Trial.
Treatment A consisted of a single dose of OrthoNovum containing 1 mg norethisterone (norethindrone) and 35 microg ethinyl estradiol. Treatment B consisted of bosentan, 125 mg b.i.d. for 7 days plus concomitant norethisterone and ethinyl
Treatment A consisted of a single dose of OrthoNovum containing 1 mg norethisterone (norethindrone) and 35 microg ethinyl
The effect of food on the bioavailability of norethindrone and ethinyl estradiol from norethindrone acetate/ethinyl estradiol tablets intended for continuous hormone replacement therapy.
Boyd RA, Zegarac EA, Eldon MA. Boyd RA, et al. J Clin Pharmacol. 2003 Jan;43(1):52-8. doi: 10.1177/0091270002239706. J Clin Pharmacol. 2003. PMID: 12520628 Clinical Trial.
As part of the development of a combination product containing norethindrone acetate and low-dose ethinyl estradiol for continuous hormone replacement therapy in postmenopausal women, a study was conducted to determine the effect of a high-fat meal on the bio …
As part of the development of a combination product containing norethindrone acetate and low-dose ethinyl estradiol for …
A comparative study of two contraceptive vaginal rings releasing norethindrone acetate and differing doses of ethinyl estradiol.
Weisberg E, Fraser IS, Mishell DR Jr, Lacarra M, Darney P, Jackanicz TM. Weisberg E, et al. Contraception. 1999 May;59(5):305-10. doi: 10.1016/s0010-7824(99)00036-0. Contraception. 1999. PMID: 10494484 Clinical Trial.
Two combined contraceptive vaginal rings (CVR) each releasing approximately 1 mg norethindrone acetate (NET-Ac) and either 20 micrograms or 15 micrograms ethinyl estradiol over 24 h were tested at three clinic sites in Los Angeles, San Francisco, and Sydney. …
Two combined contraceptive vaginal rings (CVR) each releasing approximately 1 mg norethindrone acetate (NET-Ac) and either 20 microgr …
Thalidomide does not alter the pharmacokinetics of ethinyl estradiol and norethindrone.
Trapnell CB, Donahue SR, Collins JM, Flockhart DA, Thacker D, Abernethy DR. Trapnell CB, et al. Clin Pharmacol Ther. 1998 Dec;64(6):597-602. doi: 10.1016/S0009-9236(98)90050-9. Clin Pharmacol Ther. 1998. PMID: 9871424 Clinical Trial.
OBJECTIVE: To evaluate the effect of thalidomide on the plasma pharmacokinetics of ethinyl estradiol (INN, ethinylestradiol) and norethindrone (INN, norethisterone). ...An open-label crossover study was conducted to evaluate the effect of thalidomide o …
OBJECTIVE: To evaluate the effect of thalidomide on the plasma pharmacokinetics of ethinyl estradiol (INN, ethinylestradiol) a …
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