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Ethosuximide, valproic acid, and lamotrigine in childhood absence epilepsy.
Glauser TA, Cnaan A, Shinnar S, Hirtz DG, Dlugos D, Masur D, Clark PO, Capparelli EV, Adamson PC; Childhood Absence Epilepsy Study Group. Glauser TA, et al. N Engl J Med. 2010 Mar 4;362(9):790-9. doi: 10.1056/NEJMoa0902014. N Engl J Med. 2010. PMID: 20200383 Free PMC article. Clinical Trial.
CONCLUSIONS: Ethosuximide and valproic acid are more effective than lamotrigine in the treatment of childhood absence epilepsy. Ethosuximide is associated with fewer adverse attentional effects. (ClinicalTrials.gov number, NCT00088452.)...
CONCLUSIONS: Ethosuximide and valproic acid are more effective than lamotrigine in the treatment of childhood absence epilepsy. Et
Pharmacogenetics of antiepileptic drug efficacy in childhood absence epilepsy.
Glauser TA, Holland K, O'Brien VP, Keddache M, Martin LJ, Clark PO, Cnaan A, Dlugos D, Hirtz DG, Shinnar S, Grabowski G; Childhood Absence Epilepsy Study Group. Glauser TA, et al. Ann Neurol. 2017 Mar;81(3):444-453. doi: 10.1002/ana.24886. Ann Neurol. 2017. PMID: 28165634 Free PMC article. Clinical Trial.
METHODS: Four hundred forty-six CAE children in a randomized double-blind trial of ethosuximide, lamotrigine, and valproate had short-term seizure outcome determined. ...In vitro electrophysiological studies showed no effect of the P640L polymorphism on channel physiology …
METHODS: Four hundred forty-six CAE children in a randomized double-blind trial of ethosuximide, lamotrigine, and valproate had short …
Assessment of the effectiveness and safety of Ethosuximide in the Treatment of non-Diabetic Peripheral Neuropathic Pain: EDONOT-protocol of a randomised, parallel, controlled, double-blinded and multicentre clinical trial.
Kerckhove N, Mallet C, Pereira B, Chenaf C, Duale C, Dubray C, Eschalier A. Kerckhove N, et al. BMJ Open. 2016 Dec 16;6(12):e013530. doi: 10.1136/bmjopen-2016-013530. BMJ Open. 2016. PMID: 27986742 Free PMC article. Clinical Trial.
Interestingly, ethosuximide, which has already been approved for treating epilepsy, is available on the European market for clinical use. Despite numerous preclinical data demonstrating an antinociceptive effect of ethosuximide in various animal models of neuropathi …
Interestingly, ethosuximide, which has already been approved for treating epilepsy, is available on the European market for clinical …
Second monotherapy in childhood absence epilepsy.
Cnaan A, Shinnar S, Arya R, Adamson PC, Clark PO, Dlugos D, Hirtz DG, Masur D, Glauser TA; Childhood Absence Epilepsy Study Group. Cnaan A, et al. Neurology. 2017 Jan 10;88(2):182-190. doi: 10.1212/WNL.0000000000003480. Epub 2016 Dec 16. Neurology. 2017. PMID: 27986874 Free PMC article. Clinical Trial.
At both time points, ethosuximide and valproic acid had superior seizure control compared to lamotrigine (p < 0.0001). ...Ethosuximide is the optimal second monotherapy for children with CAE not responding to initial therapy with other medications. ...

At both time points, ethosuximide and valproic acid had superior seizure control compared to lamotrigine (p < 0.0001). ...Ethos

Assessment of the effectiveness and safety of ethosuximide in the treatment of abdominal pain related to irritable bowel syndrome - IBSET: protocol of a randomised, parallel, controlled, double-blind and multicentre trial.
Kerckhove N, Scanzi J, Pereira B, Ardid D, Dapoigny M. Kerckhove N, et al. BMJ Open. 2017 Jul 18;7(7):e015380. doi: 10.1136/bmjopen-2016-015380. BMJ Open. 2017. PMID: 28720615 Free PMC article. Clinical Trial.
Recent studies have shown the involvement of T-type channel in abdominal pain. We aim to evaluate the therapeutic potential of ethosuximide, a T-type channel blocker, on the abdominal pain of patients presenting an IBS. ...It is the first clinical trial evaluating the effi …
Recent studies have shown the involvement of T-type channel in abdominal pain. We aim to evaluate the therapeutic potential of ethosuximi
Efficacy of anticonvulsant ethosuximide for major depressive disorder: a randomized, placebo-control clinical trial.
Zhang K, Jia G, Xia L, Du J, Gai G, Wang Z, Cao L, Zhang F, Tao R, Liu H, Hashimoto K, Wang G. Zhang K, et al. Eur Arch Psychiatry Clin Neurosci. 2021 Apr;271(3):487-493. doi: 10.1007/s00406-020-01103-4. Epub 2020 Feb 1. Eur Arch Psychiatry Clin Neurosci. 2021. PMID: 32006087 Clinical Trial.
Results of a preclinical study suggested that the anticonvulsant drug ethosuximide may elicit ketamine-like rapid-acting antidepressant actions. ...Patients in the acute single study received three doses (500, 1000, or 1500 mg) of ethosuximide or placebo. Patients i …
Results of a preclinical study suggested that the anticonvulsant drug ethosuximide may elicit ketamine-like rapid-acting antidepressa …
Ethosuximide, valproic acid, and lamotrigine in childhood absence epilepsy: initial monotherapy outcomes at 12 months.
Glauser TA, Cnaan A, Shinnar S, Hirtz DG, Dlugos D, Masur D, Clark PO, Adamson PC; Childhood Absence Epilepsy Study Team. Glauser TA, et al. Epilepsia. 2013 Jan;54(1):141-55. doi: 10.1111/epi.12028. Epub 2012 Nov 21. Epilepsia. 2013. PMID: 23167925 Free PMC article. Clinical Trial.
At the month 12 visit, the freedom-from-failure rates for ethosuximide and valproic acid were similar (45% and 44%, respectively; odds ratio [OR]with valproic acid vs. ethosuximide 0.94; 95% confidence interval [CI] 0.58-1.52; p = 0.82) and were higher than the rate …
At the month 12 visit, the freedom-from-failure rates for ethosuximide and valproic acid were similar (45% and 44%, respectively; odd …
Efficacy and safety of a T-type calcium channel blocker in patients with neuropathic pain: A proof-of-concept, randomized, double-blind and controlled trial.
Kerckhove N, Pereira B, Soriot-Thomas S, Alchaar H, Deleens R, Hieng VS, Serra E, Lanteri-Minet M, Arcagni P, Picard P, Lefebvre-Kuntz D, Maindet C, Mick G, Balp L, Lucas C, Creach C, Letellier M, Martinez V, Navez M, Delbrouck D, Kuhn E, Piquet E, Bozzolo E, Brosse C, Lietar B, Marcaillou F, Hamdani A, Leroux-Bromberg N, Perier Y, Vergne-Salle P, Gov C, Delage N, Gillet D, Romettino S, Richard D, Mallet C, Bernard L, Lambert C, Dubray C, Duale C, Eschalier A. Kerckhove N, et al. Eur J Pain. 2018 Aug;22(7):1321-1330. doi: 10.1002/ejp.1221. Epub 2018 Apr 18. Eur J Pain. 2018. PMID: 29577519 Clinical Trial.
BACKGROUND: T-type calcium channels have been shown to play an important role in the initiation and maintenance of neuropathic pain and represent a promising therapeutic target for new analgesic treatments. Ethosuximide (ETX), an anticonvulsant and a T-type channel blocker …
BACKGROUND: T-type calcium channels have been shown to play an important role in the initiation and maintenance of neuropathic pain and repr …
Pretreatment behavior and subsequent medication effects in childhood absence epilepsy.
Shinnar RC, Shinnar S, Cnaan A, Clark P, Dlugos D, Hirtz DG, Hu F, Liu C, Masur D, Weiss EF, Glauser TA; Childhood Absence Epilepsy Study Group. Shinnar RC, et al. Neurology. 2017 Oct 17;89(16):1698-1706. doi: 10.1212/WNL.0000000000004514. Epub 2017 Sep 15. Neurology. 2017. PMID: 28916534 Free PMC article. Clinical Trial.
Valproic acid is associated with worse behavioral outcomes than ethosuximide or lamotrigine, further reinforcing ethosuximide as the preferred initial therapy for CAE. ...CLASSIFICATION OF EVIDENCE: This study provides Class II evidence that for children with CAE, v …
Valproic acid is associated with worse behavioral outcomes than ethosuximide or lamotrigine, further reinforcing ethosuximide
Clinical spectrum and medical treatment of children with electrical status epilepticus in sleep (ESES).
Kramer U, Sagi L, Goldberg-Stern H, Zelnik N, Nissenkorn A, Ben-Zeev B. Kramer U, et al. Epilepsia. 2009 Jun;50(6):1517-24. doi: 10.1111/j.1528-1167.2008.01891.x. Epub 2008 Nov 19. Epilepsia. 2009. PMID: 19054417 Free article. Clinical Trial.
The antiepileptic drugs that were found to be efficacious were: levetiracetam (41%), clobazam (31%), and sulthiame (17%). Valproic acid, lamotrigine, topiramate, and ethosuximide showed no efficacy. Steroids were efficacious in 65%; immunoglobulins were efficacious in 33%. …
The antiepileptic drugs that were found to be efficacious were: levetiracetam (41%), clobazam (31%), and sulthiame (17%). Valproic acid, lam …
45 results