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Page 1
DMT1 polymorphism and risk of Parkinson's disease.
He Q, Du T, Yu X, Xie A, Song N, Kang Q, Yu J, Tan L, Xie J, Jiang H. He Q, et al. Neurosci Lett. 2011 Sep 1;501(3):128-31. doi: 10.1016/j.neulet.2011.07.001. Epub 2011 Jul 12. Neurosci Lett. 2011. PMID: 21777657
Growing evidence suggests that iron accumulation in the substantia nigra (SN) is involved in the pathology of Parkinson's diseases (PD). Divalent metal transporter 1 (DMT1) is an endogenous transporter for ferrous iron, the levels of which are significantly increase …
Growing evidence suggests that iron accumulation in the substantia nigra (SN) is involved in the pathology of Parkinson's diseases (PD …
Interplay of Ferritin Accumulation and Ferroportin Loss in Ageing Brain: Implication for Protein Aggregation in Down Syndrome Dementia, Alzheimer's, and Parkinson's Diseases.
Raha AA, Biswas A, Henderson J, Chakraborty S, Holland A, Friedland RP, Mukaetova-Ladinska E, Zaman S, Raha-Chowdhury R. Raha AA, et al. Int J Mol Sci. 2022 Jan 19;23(3):1060. doi: 10.3390/ijms23031060. Int J Mol Sci. 2022. PMID: 35162984 Free PMC article.
The transporter of ferrous iron, Divalent metal protein 1 (DMT1), was observed solely in the capillary endothelium and in astrocytes close to the ventricles with unchanged expression in PD. ...Membrane damage and subsequent impairment of ferroportin and hepcidin cau …
The transporter of ferrous iron, Divalent metal protein 1 (DMT1), was observed solely in the capillary endothelium and in astrocytes …
Up-regulation of divalent metal transporter 1 is involved in 1-methyl-4-phenylpyridinium (MPP(+))-induced apoptosis in MES23.5 cells.
Zhang S, Wang J, Song N, Xie J, Jiang H. Zhang S, et al. Neurobiol Aging. 2009 Sep;30(9):1466-76. doi: 10.1016/j.neurobiolaging.2007.11.025. Epub 2008 Jan 8. Neurobiol Aging. 2009. PMID: 18191877
Apoptosis has been identified as one of the important mechanisms involved in the degeneration of dopaminergic neurons in Parkinson's disease (PD). Our previous study showed increased iron levels in the substantia nigra as well as loss of dopaminergic neurons in 1-methyl-4- …
Apoptosis has been identified as one of the important mechanisms involved in the degeneration of dopaminergic neurons in Parkinson's disease …
Ceruloplasmin is Involved in the Nigral Iron Accumulation of 6-OHDA-Lesioned Rats.
Wang J, Bi M, Xie J. Wang J, et al. Cell Mol Neurobiol. 2015 Jul;35(5):661-8. doi: 10.1007/s10571-015-0161-2. Epub 2015 Feb 6. Cell Mol Neurobiol. 2015. PMID: 25656940 Free PMC article.
Elevated iron levels in the substantia nigra (SN) participate in neuronal death in Parkinson's disease (PD), while the mechanisms underlying the increased iron are still unknown. Ceruloplasmin (CP), a ferroxidase, converts highly toxic ferrous iron to its non-toxic …
Elevated iron levels in the substantia nigra (SN) participate in neuronal death in Parkinson's disease (PD), while the mechanisms und …
Genetic iron chelation protects against proteasome inhibition-induced dopamine neuron degeneration.
Zhu W, Li X, Xie W, Luo F, Kaur D, Andersen JK, Jankovic J, Le W. Zhu W, et al. Neurobiol Dis. 2010 Feb;37(2):307-13. doi: 10.1016/j.nbd.2009.09.024. Epub 2009 Oct 8. Neurobiol Dis. 2010. PMID: 19818853
Impairment of the ubiquitin proteasome system (UPS) and iron accumulation in the substantia nigra (SN) have both been implicated in the pathogenesis of Parkinson's disease (PD). We previously reported that chemical iron chelation can protect against proteasome inhibitor la …
Impairment of the ubiquitin proteasome system (UPS) and iron accumulation in the substantia nigra (SN) have both been implicated in the path …
A sensitive electrochemiluminescence immunosensor based on luminophore capped Pd@Au core-shell nanoparticles as signal tracers and ferrocenyl compounds as signal enhancers.
Liu Y, Wang H, Xiong C, Yuan Y, Chai Y, Yuan R. Liu Y, et al. Biosens Bioelectron. 2016 Jul 15;81:334-340. doi: 10.1016/j.bios.2016.03.014. Epub 2016 Mar 9. Biosens Bioelectron. 2016. PMID: 26985586
In order to enhance the luminescence efficiency, ferrocene monocarboxylic acid (Fc) as catalyzer is grafted on the surface of ABEI-Pd@AuNPs with the aid of l-cysteine (l-Cys). When the Fc is electrochemically oxidized to ferricinium cation species (Fc(+)), the decom …
In order to enhance the luminescence efficiency, ferrocene monocarboxylic acid (Fc) as catalyzer is grafted on the surface of ABEI-Pd …
Heteroleptic dipyrrinato complexes containing 5-ferrocenyldipyrromethene and dithiocarbamates as coligands: selective chromogenic and redox probes.
Gupta RK, Pandey R, Singh R, Srivastava N, Maiti B, Saha S, Li P, Xu Q, Pandey DS. Gupta RK, et al. Inorg Chem. 2012 Aug 20;51(16):8916-30. doi: 10.1021/ic300900m. Epub 2012 Aug 7. Inorg Chem. 2012. PMID: 22871172
Six heteroleptic dipyrrinato complexes [Ni(fcdpm)(dedtc)] (1), [Ni(fcdpm)(dipdtc)] (2), [Ni(fcdpm)(dbdtc)] (3), [Pd(fcdpm)(dedtc)] (4), [Pd(fcdpm)(dipdtc)] (5), and [Pd(fcdpm)(dbdtc)] (6) (fcdpm = 5-ferrocenyldipyrromethene; dedtc = diethyldithiocarbamate; di …
Six heteroleptic dipyrrinato complexes [Ni(fcdpm)(dedtc)] (1), [Ni(fcdpm)(dipdtc)] (2), [Ni(fcdpm)(dbdtc)] (3), [Pd(fcdpm)(dedtc)] (4 …
Rg1 protects the MPP+-treated MES23.5 cells via attenuating DMT1 up-regulation and cellular iron uptake.
Xu H, Jiang H, Wang J, Xie J. Xu H, et al. Neuropharmacology. 2010 Feb;58(2):488-94. doi: 10.1016/j.neuropharm.2009.09.002. Epub 2009 Sep 8. Neuropharmacology. 2010. PMID: 19744503
Our previous study observed the protective effect of Rg1 on iron accumulation in the substantia nigra (SN) in 1-methyl-4-phenyl-1,2,3,6- tetrahydropyridine (MPTP)-treated Parkinson's disease (PD) mice. However, the mechanisms of this neuroprotective effect of Rg1 are unkno …
Our previous study observed the protective effect of Rg1 on iron accumulation in the substantia nigra (SN) in 1-methyl-4-phenyl-1,2,3,6- tet …
Divalent metal transporter 1 up-regulation is involved in the 6-hydroxydopamine-induced ferrous iron influx.
Song N, Jiang H, Wang J, Xie JX. Song N, et al. J Neurosci Res. 2007 Nov 1;85(14):3118-26. doi: 10.1002/jnr.21430. J Neurosci Res. 2007. PMID: 17663481
The reasons underlying the high iron content found in the substantia nigra (SN) of Parkinson's disease (PD) are largely unknown. We suppose, based on our previous studies, that the newly discovered iron transporter divalent metal transporter 1 (DMT1) might be involved in t …
The reasons underlying the high iron content found in the substantia nigra (SN) of Parkinson's disease (PD) are largely unknown. We s …
Pro-inflammatory cytokines modulate iron regulatory protein 1 expression and iron transportation through reactive oxygen/nitrogen species production in ventral mesencephalic neurons.
Wang J, Song N, Jiang H, Wang J, Xie J. Wang J, et al. Biochim Biophys Acta. 2013 May;1832(5):618-25. doi: 10.1016/j.bbadis.2013.01.021. Epub 2013 Jan 31. Biochim Biophys Acta. 2013. PMID: 23376588 Free article.
Both inflammatory processes associated with microglia activation and abnormal iron deposit in dopaminergic neurons are involved in the pathogenesis of Parkinson's disease (PD). However, the relationship between neuroinflammation and iron accumulation was not fully elucidat …
Both inflammatory processes associated with microglia activation and abnormal iron deposit in dopaminergic neurons are involved in the patho …
11 results