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Application of thrombin based fibrin glue and non-thrombin based batroxobin glue on intact human blood vessels: evidence for transmural thrombin activity.
Dascombe WH, Dumanian G, Hong C, Heil BV, Labadie K, Hessel B, Blombäck B, Johnson PC. Dascombe WH, et al. Thromb Haemost. 1997 Aug;78(2):947-51. Thromb Haemost. 1997. PMID: 9268200
An alternative method of uniting small diameter vessels to obtain tissue union while limiting the thrombogenic effect of suture placement at a vessel anastomosis involves the use of a thrombin based fibrin glue as a surgical sealant. This investigation addresses whether th …
An alternative method of uniting small diameter vessels to obtain tissue union while limiting the thrombogenic effect of suture placement at …
Parkinson's disease plasma biomarkers: an automated literature analysis followed by experimental validation.
Alberio T, Bucci EM, Natale M, Bonino D, Di Giovanni M, Bottacchi E, Fasano M. Alberio T, et al. J Proteomics. 2013 Sep 2;90:107-14. doi: 10.1016/j.jprot.2013.01.025. Epub 2013 Feb 4. J Proteomics. 2013. PMID: 23385359 Review.
The bioinformatic platform allowed us to analyze more than 51,000 scientific papers dealing with PD, containing information on 4121 proteins. Out of these, we could track back 35 PD-related proteins as present in at least two published 2-DE maps of human plas …
The bioinformatic platform allowed us to analyze more than 51,000 scientific papers dealing with PD, containing information on 4121 p …
Platycodin D inhibits platelet function and thrombus formation through inducing internalization of platelet glycoprotein receptors.
Luo Q, Wei G, Wu X, Tang K, Xu M, Wu Y, Liu Y, Li X, Sun Z, Ju W, Qi K, Chen C, Yan Z, Cheng H, Zhu F, Li Z, Zeng L, Xu K, Qiao J. Luo Q, et al. J Transl Med. 2018 Nov 15;16(1):311. doi: 10.1186/s12967-018-1688-z. J Transl Med. 2018. PMID: 30442147 Free PMC article.
Moreover, PD-treated mice platelets presented significantly impaired in vivo hemostasis and arterial thrombus formation. Interestingly, PD induced internalization of glycoprotein receptors alpha(IIb)beta(3), GPIbalpha and GPVI. ...
Moreover, PD-treated mice platelets presented significantly impaired in vivo hemostasis and arterial thrombus formation. Interestingl …
A novel method to quantify fibrin-fibrin and fibrin-alpha(2)-antiplasmin cross-links in thrombi formed from human trauma patient plasma.
Morrow GB, Flannery S, Charles PD, Heilig R, Feller T, McQuilten Z, Wake E, Ariens RAS, Winearls J, Mutch NJ, Fischer R, Laffan MA, Curry N. Morrow GB, et al. J Thromb Haemost. 2024 Jun;22(6):1758-1771. doi: 10.1016/j.jtha.2024.03.001. Epub 2024 Mar 9. J Thromb Haemost. 2024. PMID: 38462220 Free article.
OBJECTIVES: Here, we developed a method to quantify fibrin-fibrin and fibrin-alpha(2)AP cross-links that avoids the challenges posed by TXA in determining fibrinolytic resistance in conventional assays. METHODS: Fibrinogen alpha (FGA) chain (FGA-FGA), fibrinogen gam …
OBJECTIVES: Here, we developed a method to quantify fibrin-fibrin and fibrin-alpha(2)AP cross-links that avoids the challenges posed by TXA …
Pharmacokinetics and Pharmacodynamics of Emicizumab in Persons with Hemophilia A with Factor VIII Inhibitors: HAVEN 1 Study.
Schmitt C, Adamkewicz JI, Xu J, Petry C, Catalani O, Young G, Negrier C, Callaghan MU, Levy GG. Schmitt C, et al. Thromb Haemost. 2021 Mar;121(3):351-360. doi: 10.1055/s-0040-1717114. Epub 2020 Oct 21. Thromb Haemost. 2021. PMID: 33086400 Free PMC article. Clinical Trial.
Here we assess pharmacokinetic (PK) and pharmacodynamic (PD) biomarkers in PwHA with FVIII inhibitors in the Phase III HAVEN 1 study (NCT02622321). ...Emicizumab concentrations for PK analysis were measured via validated immunoassay. PD effects were assessed using F …
Here we assess pharmacokinetic (PK) and pharmacodynamic (PD) biomarkers in PwHA with FVIII inhibitors in the Phase III HAVEN 1 study …
Blood interactions with noble metals: coagulation and immune complement activation.
Hulander M, Hong J, Andersson M, Gervén F, Ohrlander M, Tengvall P, Elwing H. Hulander M, et al. ACS Appl Mater Interfaces. 2009 May;1(5):1053-62. doi: 10.1021/am900028e. ACS Appl Mater Interfaces. 2009. PMID: 20355891
In this article, we used whole blood in the "slide chamber model" to study the activation of the immune complement activation, generation of thrombin/antithrombin (TAT) complexes, and platelet depletion from blood upon contact with silver (Ag), palladium (Pd), gold …
In this article, we used whole blood in the "slide chamber model" to study the activation of the immune complement activation, generation of …
Multicenter Prospective Study of Grafting With Collagen Fleece TachoSil in Patients With Peyronie's Disease.
Fernández-Pascual E, Manfredi C, Torremadé J, Ibarra FP, Geli JS, Romero-Otero J, García-Baquero R, Poblador AF, Barbará MR, Campos-Juanatey F, Rojo AE, Iribarren IM, Rodríguez JC, Martínez-Salamanca JI. Fernández-Pascual E, et al. J Sex Med. 2020 Nov;17(11):2279-2286. doi: 10.1016/j.jsxm.2020.07.079. Epub 2020 Aug 20. J Sex Med. 2020. PMID: 32830078 Free article.
BACKGROUND: A xenograft consisting of equine collagen coated with human fibrinogen and thrombin (TachoSil; Baxter, CA) has recently been introduced in grafting procedures for Peyronie's disease (PD). ...METHODS: A prospective non-controlled multicenter …
BACKGROUND: A xenograft consisting of equine collagen coated with human fibrinogen and thrombin (TachoSil; Baxter, CA) …
Phase 1 dose-escalating study to evaluate the safety, pharmacokinetics, and pharmacodynamics of a recombinant factor Xa variant (FXaI16L ).
Parsons-Rich D, Hua F, Li G, Kantaridis C, Pittman DD, Arkin S. Parsons-Rich D, et al. J Thromb Haemost. 2017 May;15(5):931-937. doi: 10.1111/jth.13673. Epub 2017 Apr 25. J Thromb Haemost. 2017. PMID: 28294526 Free article. Clinical Trial.
Assessments included safety monitoring, pharmacokinetic and pharmacodynamic (PD) analyses, and immunogenicity testing. Results The trial enrolled 49 male volunteers. ...FXa(I16L) plasma levels appeared to increase dose-proportionally, with a half-life of ~ 4 min. Treatment …
Assessments included safety monitoring, pharmacokinetic and pharmacodynamic (PD) analyses, and immunogenicity testing. Results The tr …