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Anticoagulant Decapeptide Interacts with Thrombin at the Active Site and Exosite-I.
Liu H, Tu M, Cheng S, Xu Z, Xu X, Du M. Liu H, et al. J Agric Food Chem. 2020 Jan 8;68(1):176-184. doi: 10.1021/acs.jafc.9b06450. Epub 2019 Dec 27. J Agric Food Chem. 2020. PMID: 31850760
At the same concentration, the fibrinogen clotting time prolonged from 25.5 0.7 to 38.3 1.3 s. The thrombin inhibitory efficiency in vitro (IC(50) value of 29.27 mM) and antithrombosis effect in vivo were determined. The secondary structure of thrombin, w …
At the same concentration, the fibrinogen clotting time prolonged from 25.5 0.7 to 38.3 1.3 s. The thrombin inhibitory eff …
Identification and inhibitory activity against alpha-thrombin of a novel anticoagulant peptide derived from oyster (Crassostrea gigas) protein.
Cheng S , Tu M , Chen H , Xu Z , Wang Z , Liu H , Zhao G , Zhu B , Du M . Cheng S , et al. Food Funct. 2018 Dec 13;9(12):6391-6400. doi: 10.1039/c8fo01635f. Food Funct. 2018. PMID: 30457135
The peptide specifically inhibited a vital blood coagulation factor: thrombin. The molecular docking energy scores of the anticoagulant peptide with the active site, exosite-I and exosite-II of thrombin were 132.355 kcal mol-1, 151.266 kcal mol-1 and 147.317 kcal mo …
The peptide specifically inhibited a vital blood coagulation factor: thrombin. The molecular docking energy scores of the anticoagula …
A thrombin assay based upon the release of fibrinopeptide A from fibrinogen: definition of a new thrombin unit.
Lewis SD, Shafer JA. Lewis SD, et al. Thromb Res. 1984 Jul 15;35(2):111-20. doi: 10.1016/0049-3848(84)90206-8. Thromb Res. 1984. PMID: 6474412 Free article.
In this assay one thrombin unit (TU) is defined as that amount of thrombin that will release half of the FPA in one min from one ml of a solution of greater than 90% clottable normal human fibrinogen (less than or equal to 0.35 microM) at 37 deg …
In this assay one thrombin unit (TU) is defined as that amount of thrombin that will release half of the FPA in one min …
Novel Anticoagulant Peptide from Lactoferrin Binding Thrombin at the Active Site and Exosite-I.
Xu S, Fan F, Liu H, Cheng S, Tu M, Du M. Xu S, et al. J Agric Food Chem. 2020 Mar 11;68(10):3132-3139. doi: 10.1021/acs.jafc.9b08094. Epub 2020 Feb 27. J Agric Food Chem. 2020. PMID: 32064873
Thrombin is currently one of the important targets for the treatment and prevention of thrombosis. ...LF-LR (5 mM) significantly prolonged activated partial thromboplastin time, prothrombin time, and thrombin time for 13.4, 1.7, and 5.1 s, respectively. It prolonged …
Thrombin is currently one of the important targets for the treatment and prevention of thrombosis. ...LF-LR (5 mM) significantly prol …
Copper-Induced Topology Switching and Thrombin Inhibition with Telomeric DNA G-Quadruplexes.
Engelhard DM, Nowack J, Clever GH. Engelhard DM, et al. Angew Chem Int Ed Engl. 2017 Sep 11;56(38):11640-11644. doi: 10.1002/anie.201705724. Epub 2017 Aug 10. Angew Chem Int Ed Engl. 2017. PMID: 28661023
Reversible control over a specific folding topology was achieved by the synthesis of a chiral, glycol-based pyridine ligand and its fourfold incorporation into human telomeric DNA by solid-phase synthesis. Square-planar coordination to a Cu(II) ion led to the formation of …
Reversible control over a specific folding topology was achieved by the synthesis of a chiral, glycol-based pyridine ligand and its fourfold …
Direct thrombin inhibitor-bivalirudin functionalized plasma polymerized allylamine coating for improved biocompatibility of vascular devices.
Yang Z, Tu Q, Maitz MF, Zhou S, Wang J, Huang N. Yang Z, et al. Biomaterials. 2012 Nov;33(32):7959-71. doi: 10.1016/j.biomaterials.2012.07.050. Epub 2012 Aug 9. Biomaterials. 2012. PMID: 22877639
The direct thrombin inhibitor of bivalirudin (BVLD), a short peptide derived from hirudin, has drawn an increasing attention in clinical application because it is safer and more effective than heparin for diabetic patients with moderate- or high-risk for acute coronary syn …
The direct thrombin inhibitor of bivalirudin (BVLD), a short peptide derived from hirudin, has drawn an increasing attention in clini …
A novel heptapeptide derived from Crassostrea gigas shows anticoagulant activity by targeting for thrombin active domain.
Cheng S, Tu M, Liu H, An Y, Du M, Zhu B. Cheng S, et al. Food Chem. 2021 Jan 1;334:127507. doi: 10.1016/j.foodchem.2020.127507. Epub 2020 Jul 10. Food Chem. 2021. PMID: 32688180
A novel food-derived anticoagulant heptapeptides (P-3-CG) was isolated and characterized from oyster (Crassostrea gigas) pepsin hydrolysate. P-3-CG competed with fibrinogen against thrombin active domain by a spontaneous and exothermic reaction which was entropicall …
A novel food-derived anticoagulant heptapeptides (P-3-CG) was isolated and characterized from oyster (Crassostrea gigas) pepsin hydrolysate. …
[Evaluation of Analytical Performance of HISCL TM, a Chemiluminescent Enzyme Immunoassay and the Use of Thrombomodulin as a Marker for Endothelial Dysfunction].
Nakanishi K, Masuda K, Mori N, Ishida A, Shiga S, Ichiyama S. Nakanishi K, et al. Rinsho Byori. 2014 Oct;62(10):942-7. Rinsho Byori. 2014. PMID: 27526539 Japanese.
Thrombomodulin (TM) is an endothelial receptor for thrombin. The thrombin-thrombomodulin complex activates protein C in the anticoagulant pathway. ...The assay showed excellent dilution linearity up to a TM level of 198 TU/mL with the lower limit of detection …
Thrombomodulin (TM) is an endothelial receptor for thrombin. The thrombin-thrombomodulin complex activates protein C in the an …