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Page 1
Chronotoxicology of florfenicol.
Picco EJ, Díaz DC, Valtorta SE, Boggi JC. Picco EJ, et al. Chronobiol Int. 2001 May;18(3):567-72. doi: 10.1081/cbi-100103977. Chronobiol Int. 2001. PMID: 11475424
Sixty 3-month-old homozygote male mice were studied for circadian rhythmicity in the toxicity of florfenicol overdose. Animals were kept under a regimen of 12h light, 12h darkness (12:12 LD) with food and water available ad libitum. ...Cosinor analysis verified a statistic …
Sixty 3-month-old homozygote male mice were studied for circadian rhythmicity in the toxicity of florfenicol overdose. Animals were k …
A review on the antibiotic florfenicol: Occurrence, environmental fate, effects, and health risks.
Guo X, Chen H, Tong Y, Wu X, Tang C, Qin X, Guo J, Li P, Wang Z, Liu W, Mo J. Guo X, et al. Environ Res. 2024 Mar 1;244:117934. doi: 10.1016/j.envres.2023.117934. Epub 2023 Dec 16. Environ Res. 2024. PMID: 38109957 Review.
Due to the widespread use in aquaculture and veterinary medicine, florfenicol has been detected in the aquatic environment worldwide. Concerns over the effects and health risks of florfenicol on target and non-target organisms have been raised in recent years. Altho …
Due to the widespread use in aquaculture and veterinary medicine, florfenicol has been detected in the aquatic environment worldwide. …
Coexistence of optrA and fexA in Campylobacter.
Tang B, Wang Y, Luo Y, Zheng X, Qin X, Yang H, Shen Z. Tang B, et al. mSphere. 2021 May 12;6(3):e00125-21. doi: 10.1128/mSphere.00125-21. mSphere. 2021. PMID: 33980673 Free PMC article.
The emergence of optrA and fexA may support the spread of florfenicol-resistant Campylobacter strains of animal origin.IMPORTANCE Florfenicol is widely used for the treatment of respiratory infections and as a feed additive in food animal production. As a foodborne …
The emergence of optrA and fexA may support the spread of florfenicol-resistant Campylobacter strains of animal origin.IMPORTANCE …
Vibrio alginolyticus PEPCK Mediates Florfenicol Resistance through Lysine Succinylation Modification.
Pang H, Zhang W, Lin X, Zeng F, Xiao X, Wei Z, Wang S, Jian J, Wang N, Li W. Pang H, et al. J Proteome Res. 2024 Jul 5;23(7):2397-2407. doi: 10.1021/acs.jproteome.4c00085. Epub 2024 Jun 21. J Proteome Res. 2024. PMID: 38904328
In this study, quantitative analysis was conducted on the succinylated proteome of wild-type and florfenicol-resistant Vibrio alginolyticus to investigate the mechanism of succinylation regulating antibiotic resistance. ...The detection of site-directed mutagenesis strain …
In this study, quantitative analysis was conducted on the succinylated proteome of wild-type and florfenicol-resistant Vibrio alginol …
Determination of extractable and non-extractable florfenicol residues as florfenicol amine in eggs by UPLC-MS/MS.
Li X, Zhang Y, Sun Q, Ding M, Li Z, Yue H, Deng L, Chen L. Li X, et al. Food Addit Contam Part A Chem Anal Control Expo Risk Assess. 2022 Sep;39(9):1512-1520. doi: 10.1080/19440049.2022.2093988. Epub 2022 Jul 15. Food Addit Contam Part A Chem Anal Control Expo Risk Assess. 2022. PMID: 35838334
Some florfenicol (FF) metabolites have a strong binding affinity towards biomolecules in the edible tissues of some food animals. ...In this study, an ultra-performance liquid chromatography-tandem mass spectrometry (UPLC-MS/MS) method was established to detect the total r …
Some florfenicol (FF) metabolites have a strong binding affinity towards biomolecules in the edible tissues of some food animals. ... …
Formulation, pharmacokinetics, and antibacterial activity of florfenicol-loaded niosome.
Abonashey SG, Hassan HAFM, Shalaby MA, Fouad AG, Mobarez E, El-Banna HA. Abonashey SG, et al. Drug Deliv Transl Res. 2024 Apr;14(4):1077-1092. doi: 10.1007/s13346-023-01459-9. Epub 2023 Nov 13. Drug Deliv Transl Res. 2024. PMID: 37957473 Free PMC article.
In vitro antibacterial testing demonstrated the niosomal capacity to significantly reduce florfenicol minimum inhibitory concentration (MIC) against E. coli and S. aureus. Pharmacokinetic profiles of free florfenicol and FLN were assessed following oral administrati …
In vitro antibacterial testing demonstrated the niosomal capacity to significantly reduce florfenicol minimum inhibitory concentratio …
Unveiling synergism of polymyxin B with chloramphenicol derivatives against multidrug-resistant (MDR) Klebsiella pneumoniae.
Idris N, Leong KH, Wong EH, Abdul Rahim N. Idris N, et al. J Antibiot (Tokyo). 2023 Dec;76(12):711-719. doi: 10.1038/s41429-023-00659-2. Epub 2023 Oct 11. J Antibiot (Tokyo). 2023. PMID: 37821539
Furthermore, the combination of polymyxin B with florfenicol had the lowest cytotoxic effect on the HS-5 cells compared to polymyxin B combination with chloramphenicol and thiamphenicol. Overall, the combination of polymyxin B with florfenicol enhanced bacterial kil …
Furthermore, the combination of polymyxin B with florfenicol had the lowest cytotoxic effect on the HS-5 cells compared to polymyxin …
Recovery of intestinal microbial community in Penaeus vannamei after florfenicol perturbation.
Luo K, Yang Z, Wen X, Wang D, Liu J, Wang L, Fan R, Tian X. Luo K, et al. J Hazard Mater. 2024 Dec 5;480:136158. doi: 10.1016/j.jhazmat.2024.136158. Epub 2024 Oct 12. J Hazard Mater. 2024. PMID: 39405716
Meanwhile, the basal diet was supplemented with florfenicol for 7 days, followed by a period without florfenicol (natural recovery, FB), or with live strain W2 (probiotic recovery, FM), for a duration of 35 days. Results indicated that dietary supplementation of str …
Meanwhile, the basal diet was supplemented with florfenicol for 7 days, followed by a period without florfenicol (natural reco …
Florfenicol administration in piglets co-selects for multiple antimicrobial resistance genes.
Holman DB, Gzyl KE, Kommadath A. Holman DB, et al. mSystems. 2024 Dec 17;9(12):e0125024. doi: 10.1128/msystems.01250-24. Epub 2024 Nov 25. mSystems. 2024. PMID: 39584815 Free PMC article.
In addition to selecting for florfenicol resistance genes (floR, fexA, and fexB), florfenicol also selected for genes conferring resistance to the aminoglycosides, beta-lactams, or sulfonamides up until weaning at 21 days of age. ...In addition, florfenicol s …
In addition to selecting for florfenicol resistance genes (floR, fexA, and fexB), florfenicol also selected for genes conferri …
Impacts of florfenicol on the microbiota landscape and resistome as revealed by metagenomic analysis.
Zeng Q, Liao C, Terhune J, Wang L. Zeng Q, et al. Microbiome. 2019 Dec 9;7(1):155. doi: 10.1186/s40168-019-0773-8. Microbiome. 2019. PMID: 31818316 Free PMC article.
These bacteria with increased abundance either harbor florfenicol-resistant genes (FRGs) or had beneficial mutations. The florfenicol treatment promoted the proliferation of florfenicol-resistant genes. ...In addition to horizontal gene transfer, bacteria cou …
These bacteria with increased abundance either harbor florfenicol-resistant genes (FRGs) or had beneficial mutations. The florfeni …
2,033 results