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Table representation of search results timeline featuring number of search results per year.

Year Number of Results
1965 3
1966 2
1967 4
1968 10
1969 8
1970 9
1971 5
1972 13
1973 11
1974 19
1975 36
1976 41
1977 60
1978 60
1979 57
1980 59
1981 67
1982 73
1983 86
1984 111
1985 117
1986 119
1987 107
1988 133
1989 148
1990 155
1991 179
1992 214
1993 217
1994 308
1995 369
1996 343
1997 326
1998 294
1999 364
2000 343
2001 289
2002 332
2003 349
2004 394
2005 439
2006 465
2007 460
2008 453
2009 420
2010 501
2011 511
2012 526
2013 478
2014 413
2015 474
2016 387
2017 371
2018 365
2019 343
2020 342
2021 272
2022 226
2023 199
2024 244
2025 261
2026 160

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12,837 results

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Page 1
Neoadjuvant Modified FOLFOX6 With or Without Radiation Versus Fluorouracil Plus Radiation for Locally Advanced Rectal Cancer: Final Results of the Chinese FOWARC Trial.
Deng Y, Chi P, Lan P, Wang L, Chen W, Cui L, Chen D, Cao J, Wei H, Peng X, Huang Z, Cai G, Zhao R, Huang Z, Xu L, Zhou H, Wei Y, Zhang H, Zheng J, Huang Y, Zhou Z, Cai Y, Kang L, Huang M, Wu X, Peng J, Ren D, Wang J. Deng Y, et al. J Clin Oncol. 2019 Dec 1;37(34):3223-3233. doi: 10.1200/JCO.18.02309. Epub 2019 Sep 26. J Clin Oncol. 2019. PMID: 31557064 Free PMC article. Clinical Trial.
PURPOSE: In the multicenter, open-label, phase III FOWARC trial, modified infusional fluorouracil, leucovorin, and oxaliplatin (mFOLFOX6) plus radiotherapy resulted in a higher pathologic complete response rate than fluorouracil plus radiotherapy in Chinese patients …
PURPOSE: In the multicenter, open-label, phase III FOWARC trial, modified infusional fluorouracil, leucovorin, and oxaliplatin (mFOLF …
Clinical and Dermoscopic Comparison of the Efficacy and Safety of 5% Fluorouracil Topical Cream and 1% Niacinamide Topical Gel in the Treatment of Actinic Keratosis: A Randomized Controlled Trial.
Poostiyan N, Barati M, Shahmoradi Z, Saber M. Poostiyan N, et al. J Cosmet Dermatol. 2025 Feb;24(2):e16676. doi: 10.1111/jocd.16676. Epub 2024 Nov 26. J Cosmet Dermatol. 2025. PMID: 39587989 Free PMC article. Clinical Trial.
AIM: This study aimed to compare the effectiveness and safety of 5% fluorouracil topical cream and 1% niacinamide topical gel in patients with AK. METHODS: In a randomized clinical trial, 26 patients with 95 AK lesions were assigned to receive either 5% fluorouracil …
AIM: This study aimed to compare the effectiveness and safety of 5% fluorouracil topical cream and 1% niacinamide topical gel in pati …
Biochemical rationale for the 5-fluorouracil leucovorin combination and update of clinical experience.
Rustum YM. Rustum YM. J Chemother. 1990 Feb;2 Suppl 1:5-11. doi: 10.1080/1120009x.1990.11738998. J Chemother. 1990. PMID: 2195138 Review.
Although 5-fluorouracil has been the drug of choice for the treatment of patients with advanced adenocarcinoma of the colon, the reported response rate dose not exceed 20% with a median survival time less than 9 months. ...In this paper, the rationale for the modulation of …
Although 5-fluorouracil has been the drug of choice for the treatment of patients with advanced adenocarcinoma of the colon, the repo …
The results of a phase II randomized trial comparing 5-fluorouracil and 5-fluorouracil plus alpha-interferon: observations on the design of clinical trials for androgen-independent prostate cancer.
Daliani DD, Eisenberg PD, Weems J, Lord R, Fueger R, Logothetis CJ. Daliani DD, et al. J Urol. 1995 May;153(5):1587-91. J Urol. 1995. PMID: 7536271 Clinical Trial.
Although alpha-interferon is inactive as a single agent in prostate cancer, preclinical data indicate that it increases the in vitro cytotoxicity of 5-fluorouracil against a variety of malignant cells. We evaluated the relative antitumor activity and tolerance of 5-fluo …
Although alpha-interferon is inactive as a single agent in prostate cancer, preclinical data indicate that it increases the in vitro cytotox …
Fluorinated pyrimidines.
Heidelberger C. Heidelberger C. Prog Nucleic Acid Res Mol Biol. 1965;4:1-50. doi: 10.1016/s0079-6603(08)60783-7. Prog Nucleic Acid Res Mol Biol. 1965. PMID: 4226168 Review. No abstract available.
Fluorouracil Filtering Surgery Study One-Year Follow-up.
Fluorouracil Filtering Surgery Study Group. Fluorouracil Filtering Surgery Study Group. Am J Ophthalmol. 2018 Feb;186:xxxiii-xlii. doi: 10.1016/j.ajo.2017.12.021. Am J Ophthalmol. 2018. PMID: 29420951 Clinical Trial.
Two hundred thirteen patients participated in the Fluorouracil Filtering Surgery Study, a randomized clinical trial, to determine the efficacy and safety of subconjunctivally injected 5-fluorouracil after filtering surgery in eyes with poor prognoses. ...We recommen …
Two hundred thirteen patients participated in the Fluorouracil Filtering Surgery Study, a randomized clinical trial, to determine the …
Topical fluorouracil for actinic keratoses and photoaging: a clinical and molecular analysis.
Sachs DL, Kang S, Hammerberg C, Helfrich Y, Karimipour D, Orringer J, Johnson T, Hamilton TA, Fisher G, Voorhees JJ. Sachs DL, et al. Arch Dermatol. 2009 Jun;145(6):659-66. doi: 10.1001/archdermatol.2009.97. Arch Dermatol. 2009. PMID: 19528421 Clinical Trial.
OBJECTIVE: To examine clinical and molecular changes after topical fluorouracil treatment of photodamaged human facial skin for actinic keratoses. DESIGN: Nonrandomized, open-label 2-week treatment with fluorouracil cream, 5%, followed by clinical and molecular eval …
OBJECTIVE: To examine clinical and molecular changes after topical fluorouracil treatment of photodamaged human facial skin for actin …
Randomized trial of 5-fluorouracil, leucovorin and cisplatin in advanced pancreatic cancer.
Huguier M, Barrier A, Valinas R, Flahault A, Adloff M, Pezet D, Jaeck D, Millat B; French University Association for Surgical Research. Huguier M, et al. Hepatogastroenterology. 2001 May-Jun;48(39):875-8. Hepatogastroenterology. 2001. PMID: 11462946 Clinical Trial.
BACKGROUND/AIMS: Phase II trials of combined 5 fluorouracil, leucovorin and cisplatin have demonstrated an 18-28% response rate in advanced pancreatic carcinomas. ...RESULTS: Association of leucovorin, 5-fluorouracil and cisplatin failed to demonstrate any advantage …
BACKGROUND/AIMS: Phase II trials of combined 5 fluorouracil, leucovorin and cisplatin have demonstrated an 18-28% response rate in ad …
12,837 results
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