Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation

Search Page

Filters

My Custom Filters

Results by year

Table representation of search results timeline featuring number of search results per year.

Year Number of Results
1980 7
1981 5
1982 3
1983 15
1984 12
1985 13
1986 14
1987 18
1988 15
1989 15
1990 12
1991 8
1992 12
1993 11
1994 14
1995 10
1996 18
1997 11
1998 19
1999 19
2000 21
2001 29
2002 32
2003 12
2004 17
2005 20
2006 20
2007 23
2008 28
2009 20
2010 19
2011 16
2012 15
2013 18
2014 16
2015 18
2016 25
2017 15
2018 13
2019 21
2020 30
2021 30
2022 27
2023 27
2024 28
2025 29
2026 0

Publication date

Text availability

Article attribute

Article type

Additional filters

Article Language

Species

Sex

Age

Other

Search Results

751 results

Results by year

Filters applied: . Clear all
Page 1
Comparing N-acetylcysteine and 4-methylpyrazole as antidotes for acetaminophen overdose.
Akakpo JY, Ramachandran A, Curry SC, Rumack BH, Jaeschke H. Akakpo JY, et al. Arch Toxicol. 2022 Feb;96(2):453-465. doi: 10.1007/s00204-021-03211-z. Epub 2022 Jan 3. Arch Toxicol. 2022. PMID: 34978586 Free PMC article. Review.
In addition, fomepizole treatment, unlike NAC, prevented APAP-induced kidney damage and promoted hepatic regeneration in mice. ...Furthermore, the formation of oxidative metabolites was eliminated in healthy volunteers using the established treatment protocol for fomepi …
In addition, fomepizole treatment, unlike NAC, prevented APAP-induced kidney damage and promoted hepatic regeneration in mice. ...Fur …
Fomepizole.
[No authors listed] [No authors listed] Dimens Crit Care Nurs. 2001 Sep-Oct;20(5):29. doi: 10.1097/00003465-200109000-00007. Dimens Crit Care Nurs. 2001. PMID: 22076517 No abstract available.
4-Methylpyrazole--present status.
Jacobsen D, McMartin K. Jacobsen D, et al. J Toxicol Clin Toxicol. 1996;34(4):379-81. doi: 10.3109/15563659609013807. J Toxicol Clin Toxicol. 1996. PMID: 8699551 No abstract available.
Bridging the Gap.
Lee JT, Lechner MG, Vaidya A, Weinmann M. Lee JT, et al. N Engl J Med. 2019 Jan 31;380(5):e6. doi: 10.1056/NEJMimc1716605. N Engl J Med. 2019. PMID: 30699317 No abstract available.
[Antidote update].
Kiyota K. Kiyota K. Nihon Rinsho. 2016 Feb;74(2):236-40. Nihon Rinsho. 2016. PMID: 26915245 Review. Japanese.
Japanese Society for Clinical Toxicology and Japan Poison Information Center applied some candidates including methyleneblue (MB) and fomepizole, both of them were authorized in clinical market in 2015. MB is the medicine for methemoglobinemia, caused by variety of chemica …
Japanese Society for Clinical Toxicology and Japan Poison Information Center applied some candidates including methyleneblue (MB) and fom …
Fomepizole for the treatment of pediatric ethylene and diethylene glycol, butoxyethanol, and methanol poisonings.
Brent J. Brent J. Clin Toxicol (Phila). 2010 Jun;48(5):401-6. doi: 10.3109/15563650.2010.495347. Clin Toxicol (Phila). 2010. PMID: 20586570 Review.
FOMEPIZOLE REGIMEN: Most cases used the current U.S.-approved regimen. ADVERSE EFFECTS OF FOMEPIZOLE: The one adverse effect reported during fomepizole therapy was transient nystagmus in a 6-year-old with a serum ethylene glycol concentration of 130 mg/L and …
FOMEPIZOLE REGIMEN: Most cases used the current U.S.-approved regimen. ADVERSE EFFECTS OF FOMEPIZOLE: The one adverse effect r …
[Fomepizole].
Endo Y. Endo Y. Chudoku Kenkyu. 2015 Mar;28(1):31-6. Chudoku Kenkyu. 2015. PMID: 26399012 Japanese. No abstract available.
Use of fomepizole (4-methylpyrazole) for acetaminophen poisoning: A scoping review.
Pourbagher-Shahri AM, Schimmel J, Shirazi FM, Nakhaee S, Mehrpour O. Pourbagher-Shahri AM, et al. Toxicol Lett. 2022 Feb 1;355:47-61. doi: 10.1016/j.toxlet.2021.11.005. Epub 2021 Nov 14. Toxicol Lett. 2022. PMID: 34785186
RESULTS: Reports on fomepizole as a therapeutic adjunct for APAP toxicity span heterogeneous types of evidence. ...The marginal clinical benefit of fomepizole adjunct therapy beyond NAC monotherapy remains to be clearly defined, and routine use for APAP overdose is …
RESULTS: Reports on fomepizole as a therapeutic adjunct for APAP toxicity span heterogeneous types of evidence. ...The marginal clini …
Diethylene glycol poisoning.
Schep LJ, Slaughter RJ, Temple WA, Beasley DM. Schep LJ, et al. Clin Toxicol (Phila). 2009 Jul;47(6):525-35. doi: 10.1080/15563650903086444. Clin Toxicol (Phila). 2009. PMID: 19586352 Review.
MANAGEMENT: Initial treatment consists of appropriate airway management and attention to acid-base abnormalities. Prompt use of fomepizole or ethanol is important in preventing the formation of the toxic metabolite HEAA; hemodialysis can also be critical, and assisted vent …
MANAGEMENT: Initial treatment consists of appropriate airway management and attention to acid-base abnormalities. Prompt use of fomepizol …
Clinical and forensic toxicology of methanol.
Jones AW. Jones AW. Forensic Sci Rev. 2021 Jul;33(2):117-143. Forensic Sci Rev. 2021. PMID: 34247144 Review.
Effective antidotes for treatment of methanol poisoning are administration of ethanol or the therapeutic drug fomepizole (Antizol), which is 4-methyl pyrazole (4-MP). Both treatments work by blocking the metabolism of methanol by liver alcohol dehydrogenase (ADH). ...
Effective antidotes for treatment of methanol poisoning are administration of ethanol or the therapeutic drug fomepizole (Antizol), w …
751 results