Gabapentin for Pain Management after Major Surgery: A Placebo-controlled, Double-blinded, Randomized Clinical Trial (the GAP Study).
Baos S, Lui M, Walker-Smith T, Pufulete M, Messenger D, Abbadi R, Batchelor T, Casali G, Edwards M, Goddard N, Abu Hilal M, Alzetani A, Vaida M, Martinovsky P, Saravanan P, Cook T, Malhotra R, Simpson A, Little R, Wordsworth S, Stokes E, Jiang J, Reeves B, Culliford L, Collett L, Maishman R, Chauhan N, McCullagh L, McKeon H, Abbs S, Lamb J, Gilbert A, Hughes C, Wynick D, Angelini G, Grocott M, Gibbison B, Rogers CA; GAP Investigators.
Baos S, et al.
Anesthesiology. 2025 Oct 1;143(4):851-861. doi: 10.1097/ALN.0000000000005655. Epub 2025 Jul 15.
Anesthesiology. 2025.
PMID: 40663783
Free PMC article.
Clinical Trial.
BACKGROUND: Gabapentin is an anticonvulsant medication with approval for use in neuropathic pain and epileptic disorders. ...Overall, 384 participants experienced one or more serious adverse events (gabapentin, 189 of 596 [31.7%]; placebo, 195 of 599 [32.6%]), with …
BACKGROUND: Gabapentin is an anticonvulsant medication with approval for use in neuropathic pain and epileptic disorders. ...Overall, …