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Table representation of search results timeline featuring number of search results per year.

Year Number of Results
1977 1
1978 3
1979 9
1980 53
1981 18
1982 31
1983 25
1984 39
1985 39
1986 34
1987 37
1988 20
1989 26
1990 23
1991 20
1992 26
1993 14
1994 17
1995 11
1996 14
1997 16
1998 11
1999 18
2000 10
2001 16
2002 15
2003 14
2004 22
2005 14
2006 24
2007 20
2008 17
2009 25
2010 30
2011 37
2012 39
2013 43
2014 49
2015 53
2016 49
2017 39
2018 51
2019 46
2020 53
2021 58
2022 56
2023 48
2024 58
2025 68
2026 53

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1,378 results

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Page 1
Nonstimulant Treatments for ADHD.
Newcorn JH, Krone B, Dittmann RW. Newcorn JH, et al. Child Adolesc Psychiatr Clin N Am. 2022 Jul;31(3):417-435. doi: 10.1016/j.chc.2022.03.005. Epub 2022 May 11. Child Adolesc Psychiatr Clin N Am. 2022. PMID: 35697393 Review.
We present detailed information regarding the 4 FDA-approved nonstimulant medications-the norepinephrine reuptake inhibitors, atomoxetine and viloxazine extended release, and the alpha-2 adrenergic agonists, clonidine XR and guanfacine XR. We additionally review evidence r …
We present detailed information regarding the 4 FDA-approved nonstimulant medications-the norepinephrine reuptake inhibitors, atomoxetine an …
Guanfacine for the Treatment of Attention-Deficit Hyperactivity Disorder: An Updated Systematic Review and Meta-Analysis.
Yu S, Shen S, Tao M. Yu S, et al. J Child Adolesc Psychopharmacol. 2023 Mar;33(2):40-50. doi: 10.1089/cap.2022.0038. J Child Adolesc Psychopharmacol. 2023. PMID: 36944092
Numerous randomized controlled trials (RCTs) have explored the efficacy of guanfacine in ADHD treatment. This meta-analysis combined data from selected RCTs to analyze the efficacy and safety of guanfacine in treating ADHD. ...The most common TEAEs in the guanfac …
Numerous randomized controlled trials (RCTs) have explored the efficacy of guanfacine in ADHD treatment. This meta-analysis combined …
Scientific rationale for the use of α2A-adrenoceptor agonists in treating neuroinflammatory cognitive disorders.
Arnsten AFT, Ishizawa Y, Xie Z. Arnsten AFT, et al. Mol Psychiatry. 2023 Nov;28(11):4540-4552. doi: 10.1038/s41380-023-02057-4. Epub 2023 Apr 7. Mol Psychiatry. 2023. PMID: 37029295 Free PMC article. Review.
Both basic and clinical studies show that alpha2A-AR agonists such as guanfacine can restore dlPFC network firing and cognitive function, through direct actions in the dlPFC, but also by reducing the activity of stress-related circuits, e.g. in the locus coeruleus and amyg …
Both basic and clinical studies show that alpha2A-AR agonists such as guanfacine can restore dlPFC network firing and cognitive funct …
Pharmacology of guanfacine.
Scholtysik G. Scholtysik G. Br J Clin Pharmacol. 1980;10 Suppl 1(Suppl 1):21S-24S. doi: 10.1111/j.1365-2125.1980.tb04900.x. Br J Clin Pharmacol. 1980. PMID: 6249333 Free PMC article.
Evidence is presented that guanfacine produces its antihypertensive action by a specific stimulation of central alpha-adrenoceptors. 4. Certain pharmacological differences between clonidine and guanfacine are discussed....
Evidence is presented that guanfacine produces its antihypertensive action by a specific stimulation of central alpha-adrenoceptors. …
Efficacy and Safety of Alpha-2 Agonists in Autism Spectrum Disorder: A Systematic Review.
Kaye AD, Green AM, Claude JT 2nd, Daniel CP, Cooley JF, Sala KR, Potharaju P, Rieger R, Patil S, Ahmadzadeh S, Shekoohi S. Kaye AD, et al. Adv Ther. 2024 Nov;41(11):4299-4311. doi: 10.1007/s12325-024-02980-0. Epub 2024 Sep 13. Adv Ther. 2024. PMID: 39269569
CONCLUSION: The present investigation encourages physicians to consider treatment outcomes of clonidine, guanfacine, and lofexidine to determine the most effective management of ASD-related symptoms and to minimize adverse effects. ...
CONCLUSION: The present investigation encourages physicians to consider treatment outcomes of clonidine, guanfacine, and lofexidine t …
Hyperadrenergic Postural Tachycardia Syndrome: Clinical Biomarkers and Response to Guanfacine.
Okamoto LE, Urechie V, Rigo S, Abner JJ, Giesecke M, Muldowney JAS, Furlan R, Shibao CA, Shirey-Rice JK, Pulley JM, Diedrich A, Biaggioni I. Okamoto LE, et al. Hypertension. 2024 Nov;81(11):2237-2247. doi: 10.1161/HYPERTENSIONAHA.124.23035. Epub 2024 Aug 7. Hypertension. 2024. PMID: 39109428 Free PMC article.
METHODS: We measured sympathetic function (supine muscle sympathetic nerve activity, upright plasma norepinephrine, and blood pressure responses to the Valsalva maneuver) in 28 patients with POTS (phenotyping cohort) to identify clinical biomarkers that are associated with respon …
METHODS: We measured sympathetic function (supine muscle sympathetic nerve activity, upright plasma norepinephrine, and blood pressure respo …
A thorough QT study of guanfacine.
Martin P, Satin L, Kahn RS, Robinson A, Corcoran M, Purkayastha J, Youcha S, Ermer JC. Martin P, et al. Int J Clin Pharmacol Ther. 2015 Apr;53(4):301-16. doi: 10.5414/CP202065. Int J Clin Pharmacol Ther. 2015. PMID: 25109412 Clinical Trial.
As part of the clinical development of GXR, and to further explore the effect of guanfacine on QT intervals, a thorough QT study of guanfacine was conducted (ClinicalTrials. gov identifier: NCT00672984). ...Guanfacine does not appear to interfere with cardiac …
As part of the clinical development of GXR, and to further explore the effect of guanfacine on QT intervals, a thorough QT study of …
Treating Hypertension During Breastfeeding.
Anderson PO. Anderson PO. Breastfeed Med. 2018 Mar;13(2):95-96. doi: 10.1089/bfm.2017.0236. Epub 2018 Jan 25. Breastfeed Med. 2018. PMID: 29369692 No abstract available.
1,378 results