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Page 1
Secukinumab in plaque psoriasis--results of two phase 3 trials.
Langley RG, Elewski BE, Lebwohl M, Reich K, Griffiths CE, Papp K, Puig L, Nakagawa H, Spelman L, Sigurgeirsson B, Rivas E, Tsai TF, Wasel N, Tyring S, Salko T, Hampele I, Notter M, Karpov A, Helou S, Papavassilis C; ERASURE Study Group; FIXTURE Study Group. Langley RG, et al. N Engl J Med. 2014 Jul 24;371(4):326-38. doi: 10.1056/NEJMoa1314258. Epub 2014 Jul 9. N Engl J Med. 2014. PMID: 25007392 Free article. Clinical Trial.
BACKGROUND: Interleukin-17A is considered to be central to the pathogenesis of psoriasis. We evaluated secukinumab, a fully human anti-interleukin-17A monoclonal antibody, in patients with moderate-to-severe plaque psoriasis. ...
BACKGROUND: Interleukin-17A is considered to be central to the pathogenesis of psoriasis. We evaluated secukinumab, a fully human ant …
Precision targeting of autoantigen-specific B cells in muscle-specific tyrosine kinase myasthenia gravis with chimeric autoantibody receptor T cells.
Oh S, Mao X, Manfredo-Vieira S, Lee J, Patel D, Choi EJ, Alvarado A, Cottman-Thomas E, Maseda D, Tsao PY, Ellebrecht CT, Khella SL, Richman DP, O'Connor KC, Herzberg U, Binder GK, Milone MC, Basu S, Payne AS. Oh S, et al. Nat Biotechnol. 2023 Sep;41(9):1229-1238. doi: 10.1038/s41587-022-01637-z. Epub 2023 Jan 19. Nat Biotechnol. 2023. PMID: 36658341 Free PMC article.
Specific off-target interactions of MuSK-CAART were not identified in vivo, in primary human cell screens or by high-throughput human membrane proteome array. These data contributed to an investigational new drug application and phase 1 clinical study design for MuS …
Specific off-target interactions of MuSK-CAART were not identified in vivo, in primary human cell screens or by high-throughput hu
Humoral IgG1 responses to tumor antigens underpin clinical outcomes in immune checkpoint blockade.
Gonzalez-Kozlova E, Sweeney R, Figueiredo I, Tuballes K, Ozbey S, Hamon P, Park MD, Ioannou G, Nose Y, Guo R, Restrepo P, Buckup M, Roudko V, Hennequin C, Le Berichel J, Venturini N, Halasz L, Troncoso L, Tabachnikova A, Chang C, Reid A, Brown H, Chin T, Cabal R, Mattiuz R, Eikawa S, Del Valle DM, Gonsalves TR, LaMarche NM, Jamal H, Lansky A, Yi N, Nelson D, Morgenroth-Rebin J, Merand R, Villagomez B, D'Souza D, Radkevich E, Nie K, Chen Z, Tada Y, Nishikawa H, Ward SC, Fiel MI, Brody R, Tabrizian P, Gunasekaran G, Kamphorst AO, Cohen N, Curotto de Lafaille M, Hapanowicz O, Lucas N, Wu K, James N, Lin JC, Thurston G, Schwartz M, Fiaschi N, Kim-Schulze S, Merad M, Marron TU, Gnjatic S. Gonzalez-Kozlova E, et al. Nat Med. 2026 Mar;32(3):978-991. doi: 10.1038/s41591-025-04177-6. Epub 2026 Jan 27. Nat Med. 2026. PMID: 41593194 Free PMC article.
Bullous Pemphigoid Severity and Levels of Antibodies to BP180 and BP230: A Systematic Review and Meta-Analysis.
Chou PY, Yu CL, Wen CN, Tu YK, Chi CC. Chou PY, et al. JAMA Dermatol. 2024 Nov 1;160(11):1192-1200. doi: 10.1001/jamadermatol.2024.3425. JAMA Dermatol. 2024. PMID: 39356527 Free PMC article.
OBJECTIVE: To investigate the correlation of anti-BP180 and anti-BP230 immunoglobulin G (IgG) antibody levels with BP disease severity. DATA SOURCES: A search was performed of the Cochrane Central Register of Controlled Trials, Embase, and PubMed databases from thei …
OBJECTIVE: To investigate the correlation of anti-BP180 and anti-BP230 immunoglobulin G (IgG) antibody levels with BP disease …
[Tick-Borne Encephalitis (TBE) - Fundamentals].
Kollaritsch H, Dobler G, Schmidt AJ, Krech T, Steffen R. Kollaritsch H, et al. Ther Umsch. 2022 Nov;79(9):463-470. doi: 10.1024/0040-5930/a001389. Ther Umsch. 2022. PMID: 36303530 German.
Fcγ-receptor-activation by circulating immune complexes in systemic autoimmune diseases and its reduction by CD19-CAR T cell therapy.
Freitag M, Kolb P, Falcone V, Claus M, Schröder P, Andreeva I, Rodon L, Ewald M, Deicher FS, Stütz AN, Distler JHW, Blank N, Grieshaber-Bouyer R, Muñoz LE, Lorenz HM, Schett G, Merkt W. Freitag M, et al. Rheumatology (Oxford). 2026 Mar 5;65(3):keaf627. doi: 10.1093/rheumatology/keaf627. Rheumatology (Oxford). 2026. PMID: 41335463 Free PMC article.
Lithium suppresses the Ras-Raf-MEK-ERK signaling in CD4 T cells and impairs the humoral immune system.
Wu J, Zhao Y, Zhang J, Tu L, Liu Y, Wang C, Liu T, Wang W, Luo Y, Ju Y, Xue P, Xu Y, Gu M, Qu W, Zhang Y. Wu J, et al. Food Chem Toxicol. 2025 Oct;204:115661. doi: 10.1016/j.fct.2025.115661. Epub 2025 Jul 23. Food Chem Toxicol. 2025. PMID: 40712771
Lithium (Li) is a metal that broadly exists in human bodies. To date, the impact of Li on the humoral immune system remains to be defined. ...In line with this, in vitro treatment with Li on human PBMC decreased the production of IgG, but not IgM in the supernatants …
Lithium (Li) is a metal that broadly exists in human bodies. To date, the impact of Li on the humoral immune system remains to be def …
Streamlined human antibody generation and optimization by exploiting designed immunoglobulin loci in a B cell line.
Seo H, Masuda H, Asagoshi K, Uchiki T, Kawata S, Sasaki G, Yabuki T, Miyai S, Takahashi N, Hashimoto SI, Sawada A, Takaiwa A, Koyama C, Tamai K, Kurosawa K, Lin KY, Ohta K, Nakazaki Y. Seo H, et al. Cell Mol Immunol. 2021 Jun;18(6):1545-1561. doi: 10.1038/s41423-020-0440-9. Epub 2020 May 26. Cell Mol Immunol. 2021. PMID: 32457406 Free PMC article.
Using the avian-derived B cell line DT40, we previously developed an antibody display technology, namely, the ADLib system, which rapidly generates antigen-specific mAbs. Here, we report the development of a human version of the ADLib system and showcase the streamlined ge …
Using the avian-derived B cell line DT40, we previously developed an antibody display technology, namely, the ADLib system, which rapidly ge …
The European AntibotABE Framework Program and Its Update: Development of Innovative Botulinum Antibodies.
Rasetti-Escargueil C, Avril A, Miethe S, Mazuet C, Derman Y, Selby K, Thullier P, Pelat T, Urbain R, Fontayne A, Korkeala H, Sesardic D, Hust M, Popoff MR. Rasetti-Escargueil C, et al. Toxins (Basel). 2017 Oct 2;9(10):309. doi: 10.3390/toxins9100309. Toxins (Basel). 2017. PMID: 28974033 Free PMC article. Review.
These serotypes are lethal and responsible for most human botulinum cases. To improve therapeutic efficacy, the heavy and light chains (HC and LC) of the three BoNT serotypes were targeted to achieve a synergistic effect (oligoclonal antibodies). ...For each library, the b …
These serotypes are lethal and responsible for most human botulinum cases. To improve therapeutic efficacy, the heavy and light chain …
Tegument protein UL16 of herpes simplex virus 1 suppresses the innate immune response by downregulating MAVS abundance via mitophagy.
Wang J, Zhu R, Yi P, Gan M, Long F. Wang J, et al. Autophagy. 2026 Jul 8:1-22. doi: 10.1080/15548627.2026.2698747. Online ahead of print. Autophagy. 2026. PMID: 42391028
This study provides critical insights into host-pathogen interactions and establishes a rational foundation for developing novel therapeutics against HSV-1 infection.Abbreviations: 3-MA: 3-methyladenine; BNIP3L/NIX: BCL2 interacting protein 3 like; BSA: bovine serum albumin; CALC …
This study provides critical insights into host-pathogen interactions and establishes a rational foundation for developing novel therapeutic …
104 results