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Table representation of search results timeline featuring number of search results per year.

Year Number of Results
1965 6
1966 14
1967 8
1968 14
1969 7
1970 10
1971 13
1972 10
1973 12
1974 19
1975 17
1976 21
1977 28
1978 27
1979 46
1980 34
1981 48
1982 56
1983 71
1984 70
1985 80
1986 84
1987 86
1988 65
1989 94
1990 77
1991 83
1992 71
1993 70
1994 65
1995 62
1996 57
1997 53
1998 68
1999 55
2000 46
2001 48
2002 45
2003 56
2004 52
2005 44
2006 50
2007 60
2008 64
2009 78
2010 70
2011 80
2012 83
2013 67
2014 64
2015 52
2016 32
2017 44
2018 28
2019 21
2020 7
2021 14
2022 11
2023 13
2024 13
2025 14
2026 9

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2,655 results

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Page 1
Chlorthalidone vs Hydrochlorothiazide and Kidney Outcomes in Patients With Hypertension: A Secondary Analysis of a Randomized Clinical Trial.
Ishani A, Hau C, Raju S, Wise JK, Glassman PA, Taylor AA, Ferguson RE, Cushman WC, Leatherman SM. Ishani A, et al. JAMA Netw Open. 2024 Dec 2;7(12):e2449576. doi: 10.1001/jamanetworkopen.2024.49576. JAMA Netw Open. 2024. PMID: 39656458 Free PMC article. Clinical Trial.
Veterans 65 years or older with hypertension who were taking hydrochlorothiazide were included. INTERVENTION: The Diuretic Comparison Project randomized 13 523 participants to continue hydrochlorothiazide or switch to chlorthalidone. ...There was no difference in th …
Veterans 65 years or older with hypertension who were taking hydrochlorothiazide were included. INTERVENTION: The Diuretic Comparison …
Clinical trial of a new diuretic, furosemide: comparison with hydrochlorothiazide and mercaptomerin.
Godwin TF, Gunton RW. Godwin TF, et al. Can Med Assoc J. 1965 Dec 18;93(25):1296-300. Can Med Assoc J. 1965. PMID: 5320846 Free PMC article. Clinical Trial.
A clinical trial was carried out with the object of comparing the effects of furosemide, a new oral diuretic agent, with those of mercaptomerin and hydrochlorothiazide. Eleven edematous patients were chosen for the study and the diuretics were rotated, each drug being prec …
A clinical trial was carried out with the object of comparing the effects of furosemide, a new oral diuretic agent, with those of mercaptome …
Effects of Hydrochlorothiazide and Metformin on Aquaresis and Nephroprotection by a Vasopressin V2 Receptor Antagonist in ADPKD: A Randomized Crossover Trial.
Kramers BJ, Koorevaar IW, van Gastel MDA, van Goor H, Hallows KR, Heerspink HL, Li H, Leonhard WN, Peters DJM, Qiu J, Touw DJ, Gansevoort RT, Meijer E. Kramers BJ, et al. Clin J Am Soc Nephrol. 2022 Apr;17(4):507-517. doi: 10.2215/CJN.11260821. Epub 2022 Mar 21. Clin J Am Soc Nephrol. 2022. PMID: 35314480 Free PMC article. Clinical Trial.
Urine volume decreased to 5.1 L/24 h (P<0.001) with hydrochlorothiazide and to 5.4 L/24 h (P<0.001) on metformin. During hydrochlorothiazide treatment, plasma copeptin (surrogate for vasopressin) decreased, quality of life improved, and several markers of kidn …
Urine volume decreased to 5.1 L/24 h (P<0.001) with hydrochlorothiazide and to 5.4 L/24 h (P<0.001) on metformin. During hyd …
Hydrochlorothiazide and bendroflumethiazide in low doses--a comparative trial.
[No authors listed] [No authors listed] Acta Pharmacol Toxicol (Copenh). 1984;54 Suppl 1:47-51. Acta Pharmacol Toxicol (Copenh). 1984. PMID: 6369883 Clinical Trial.
The effect and tolerability of hydrochlorothiazide 12.5 mg and bendroflumethiazide 2.5 mg were compared in 36 previously untreated hypertensives in a double-blind randomized multicenter trial. The results show a significant blood pressure reduction with both hydrochloro …
The effect and tolerability of hydrochlorothiazide 12.5 mg and bendroflumethiazide 2.5 mg were compared in 36 previously untreated hy …
Double-blind factorial trial of prindolol and hydrochlorothiazide in hypertension.
Chalmers JP, Korner PI, Tiller DJ, Bune AJ, Steiner JD, West MJ, Wing LM, Uther JF. Chalmers JP, et al. Med J Aust. 1976 May 1;1(18):650-3. Med J Aust. 1976. PMID: 781495 Clinical Trial.
There were four eight-week phases in which patients received prindolol alone, hydrochlorothiazide alone, prindolol plus hydrochlorothiazide in combination, and no treatment. ...Supine mean arterial pressure (MAP) in resting patients fell from 127 mm Hg in the placeb …
There were four eight-week phases in which patients received prindolol alone, hydrochlorothiazide alone, prindolol plus hydrochlor …
Effects of timolol and hydrochlorothiazide on blood-pressure and plasma renin activity. Double-blind factorial trial.
Chalmers J, Tiller D, Horvath J, Bune A. Chalmers J, et al. Lancet. 1976 Aug 14;2(7981):328-31. doi: 10.1016/s0140-6736(76)92589-7. Lancet. 1976. PMID: 60566 Clinical Trial.
There were four randomised test phases of 8 weeks each during which patients received timolol alone, hydrochlorothiazide alone, timolol plus hydrochlorothiazide, and no treatment (placebo). Blood-pressure was measured weekly, alternately at the outpatient clinic and …
There were four randomised test phases of 8 weeks each during which patients received timolol alone, hydrochlorothiazide alone, timol …
Slow-release furosemide and hydrochlorothiazide in congestive cardiac failure: a controlled trial.
Vermeulen A, Chadha DR. Vermeulen A, et al. J Clin Pharmacol. 1982 Nov-Dec;22(11-12):513-9. doi: 10.1002/j.1552-4604.1982.tb02644.x. J Clin Pharmacol. 1982. PMID: 6761370 Clinical Trial.
Thirty-eight ambulatory patients with congestive cardiac failure took part in a double-blind clinical trial of 50 mg hydrochlorothiazide orally daily and slow-release formulation of 60 mg furosemide orally daily. ...Both treatments were clinically well tolerated; however, …
Thirty-eight ambulatory patients with congestive cardiac failure took part in a double-blind clinical trial of 50 mg hydrochlorothiazide …
An assessment of diltiazem and hydrochlorothiazide in hypertension. Application of factorial trial design to a multicenter clinical trial of combination therapy.
Burris JF, Weir MR, Oparil S, Weber M, Cady WJ, Stewart WH. Burris JF, et al. JAMA. 1990 Mar 16;263(11):1507-12. JAMA. 1990. PMID: 2407872 Clinical Trial.
This multicenter, factorial-design trial assessed the safety and additive antihypertensive efficacy of a slow-release (SR) formulation of diltiazem hydrochloride given alone or in combination with hydrochlorothiazide for treatment of mild to moderate hypertension. After a …
This multicenter, factorial-design trial assessed the safety and additive antihypertensive efficacy of a slow-release (SR) formulation of di …
A multifactorial trial design to assess combination therapy in hypertension. Treatment with bisoprolol and hydrochlorothiazide.
Frishman WH, Bryzinski BS, Coulson LR, DeQuattro VL, Vlachakis ND, Mroczek WJ, Dukart G, Goldberg JD, Alemayehu D, Koury K. Frishman WH, et al. Arch Intern Med. 1994 Jul 11;154(13):1461-8. Arch Intern Med. 1994. PMID: 8018001 Clinical Trial.
The addition of hydrochlorothiazide (or bisoprolol) to therapy with bisoprolol (or hydrochlorothiazide) produced an incremental reduction in blood pressure. Dosages of hydrochlorothiazide as low as 6.25 mg/d contributed a significant antihypertensive effect. …
The addition of hydrochlorothiazide (or bisoprolol) to therapy with bisoprolol (or hydrochlorothiazide) produced an incrementa …
2,655 results