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94 results

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Page 1
Antihypertensive treatment with moexipril plus HCTZ vs metoprolol plus HCTZ in patients with mild-to-moderate hypertension.
Stimpel M, Koch B. Stimpel M, et al. J Hum Hypertens. 1997 Feb;11(2):133-7. doi: 10.1038/sj.jhh.1000390. J Hum Hypertens. 1997. PMID: 9140801 Clinical Trial.
At study endpoint adjusted mean reductions in sitting systolic/diastolic BP seen with both combinations were -17.6 mm Hg/-12.8 mm Hg and -17.2 mm Hg/-13.9 mm Hg in the moexipril/HCTZ and metoprolol/HCTZ groups, respectively. The response rate to both kinds of combinations …
At study endpoint adjusted mean reductions in sitting systolic/diastolic BP seen with both combinations were -17.6 mm Hg/-12.8 mm Hg and -17 …
Comparison of metoprolol as hydrochlorothiazide and antihypertensive agents.
Pedersen OL. Pedersen OL. Eur J Clin Pharmacol. 1976;10(6):381-5. doi: 10.1007/BF00563073. Eur J Clin Pharmacol. 1976. PMID: 793849 Clinical Trial.
A crossover comparison of metoprolol and hydrochlorothiazide has been performed in 20 patients with mild hypertension. ...The serum uric acid level was also significantly increased during hydrochlorothiazide treatment....
A crossover comparison of metoprolol and hydrochlorothiazide has been performed in 20 patients with mild hypertension. ...The …
Clinical evaluation of the antihypertensive effect of metoprolol in combination with hydrochlorothiazide and hydralazine in an unselected hypertensive population.
Tuomilehto J, Nissinen A, Honkavaara M. Tuomilehto J, et al. Acta Cardiol. 1980;35(4):289-301. Acta Cardiol. 1980. PMID: 7010854 Clinical Trial.
One hundred nineteen patients with essential hypertension (96 completing six months and 92 a one year study period) were randomized into four parallel groups and treated with one of four programs: 200 mg of metoprolol plus placebo; 200 mg of metoprolol plus 25 mg of …
One hundred nineteen patients with essential hypertension (96 completing six months and 92 a one year study period) were randomized into fou …
Lisinopril. A preliminary review of its pharmacodynamic and pharmacokinetic properties, and therapeutic use in hypertension and congestive heart failure.
Lancaster SG, Todd PA. Lancaster SG, et al. Drugs. 1988 Jun;35(6):646-69. doi: 10.2165/00003495-198835060-00003. Drugs. 1988. PMID: 2844497 Review.
It is at least as effective as usual therapeutic dosages of hydrochlorothiazide, atenolol, metoprolol and nifedipine while direct comparisons with other ACE inhibitors have not been reported. Many patients achieve an adequate blood pressure reduction with lisinopril …
It is at least as effective as usual therapeutic dosages of hydrochlorothiazide, atenolol, metoprolol and nifedipine while dir …
Fixed-dose Combination of Metoprolol, Telmisartan, and Chlorthalidone for Essential Hypertension in Adults with Stable Coronary Artery Disease: Phase III Study.
Sarkar G, Gaikwad VB, Sharma A, Halder SK, Kumar DA, Anand J, Agrawal S, Kumbhar A, Kinholkar B, Mathur R, Doshi M, Bachani D, Mehta S. Sarkar G, et al. Adv Ther. 2022 Feb;39(2):923-942. doi: 10.1007/s12325-021-01971-9. Epub 2021 Dec 17. Adv Ther. 2022. PMID: 34918194 Clinical Trial.
METHODS: In this phase III, open-label, multicenter study, 254 adults with stable CAD having uncontrolled hypertension despite being treated with FDC of metoprolol (25/50 mg) and telmisartan (40 mg) were included. Patients received either of the following FDC for 24 weeks: …
METHODS: In this phase III, open-label, multicenter study, 254 adults with stable CAD having uncontrolled hypertension despite being treated …
Effects of diltiazem, metoprolol, enalapril and hydrochlorothiazide on frequency of ventricular premature complexes.
Papademetriou V, Narayan P, Kokkinos P. Papademetriou V, et al. Am J Cardiol. 1994 Feb 1;73(4):242-6. doi: 10.1016/0002-9149(94)90227-5. Am J Cardiol. 1994. PMID: 7507638 Clinical Trial.
Patients were assessed at baseline (after 3 weeks of placebo treatment) and after treatment with each of 4 monotherapies: diltiazem 120 or 240 mg/day, metoprolol 100 or 200 mg/day, enalapril 10 or 20 mg/day and hydrochlorothiazide 50 or 100 mg/day. ...In the group a …
Patients were assessed at baseline (after 3 weeks of placebo treatment) and after treatment with each of 4 monotherapies: diltiazem 120 or 2 …
Effects of six anti-hypertensive medications on cognitive performance.
Muldoon MF, Waldstein SR, Ryan CM, Jennings JR, Polefrone JM, Shapiro AP, Manuck SB. Muldoon MF, et al. J Hypertens. 2002 Aug;20(8):1643-52. doi: 10.1097/00004872-200208000-00028. J Hypertens. 2002. PMID: 12172327 Clinical Trial.
INTERVENTIONS: Six-week treatment periods with atenolol, metoprolol, hydrochlorothiazide, methyldopa, enalapril and verapamil, and 2-week placebo baseline and wash-out periods. ...Manual dexterity declined somewhat with metoprolol and methyldopa (P = 0.01). I …
INTERVENTIONS: Six-week treatment periods with atenolol, metoprolol, hydrochlorothiazide, methyldopa, enalapril and verapamil, …
Metabolic effects of carvedilol vs metoprolol in patients with type 2 diabetes mellitus and hypertension: a randomized controlled trial.
Bakris GL, Fonseca V, Katholi RE, McGill JB, Messerli FH, Phillips RA, Raskin P, Wright JT Jr, Oakes R, Lukas MA, Anderson KM, Bell DS; GEMINI Investigators. Bakris GL, et al. JAMA. 2004 Nov 10;292(18):2227-36. doi: 10.1001/jama.292.18.2227. JAMA. 2004. PMID: 15536109 Clinical Trial.
DESIGN, SETTING, AND PARTICIPANTS: A randomized, double-blind, parallel-group trial (The Glycemic Effects in Diabetes Mellitus: Carvedilol-Metoprolol Comparison in Hypertensives [GEMINI]) conducted between June 1, 2001, and April 6, 2004, at 205 US sites that compared the …
DESIGN, SETTING, AND PARTICIPANTS: A randomized, double-blind, parallel-group trial (The Glycemic Effects in Diabetes Mellitus: Carvedilol- …
Factorial antihypertensive study of an extended-release metoprolol and hydrochlorothiazide combination.
Papademetriou V, Hainer JW, Sugg J, Munzer D; ATTACH Study Group. Papademetriou V, et al. Am J Hypertens. 2006 Dec;19(12):1217-25. doi: 10.1016/j.amjhyper.2006.05.007. Am J Hypertens. 2006. PMID: 17161766 Clinical Trial.
METHODS: This multicenter, randomized, double-blind, placebo-controlled, unbalanced factorial study (N = 1571) was designed to determine whether hydrochlorothiazide (HCT) and extended release (ER) metoprolol both contribute to an antihypertensive effect. ...Serum po …
METHODS: This multicenter, randomized, double-blind, placebo-controlled, unbalanced factorial study (N = 1571) was designed to determine whe …
Effects of long-term treatment with metoprolol and hydrochlorothiazide on plasma lipids and lipoproteins.
Monmany J, Domingo P, Gomez JA, Sanz F, Roca-Cusachs A, Nolla J, Jane F. Monmany J, et al. J Intern Med. 1990 Oct;228(4):323-31. doi: 10.1111/j.1365-2796.1990.tb00240.x. J Intern Med. 1990. PMID: 2266340 Clinical Trial.
In order to evaluate the effects of one-year antihypertensive treatment on plasma lipids and lipoproteins, 65 patients whose diastolic blood pressure was in the range 95-120 mmHg were randomly allocated to groups that received either hydrochlorothiazide or metoprolol …
In order to evaluate the effects of one-year antihypertensive treatment on plasma lipids and lipoproteins, 65 patients whose diastolic blood …
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