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202 results

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Page 1
Effective Tyrosinase Inhibition by Thiamidol Results in Significant Improvement of Mild to Moderate Melasma.
Arrowitz C, Schoelermann AM, Mann T, Jiang LI, Weber T, Kolbe L. Arrowitz C, et al. J Invest Dermatol. 2019 Aug;139(8):1691-1698.e6. doi: 10.1016/j.jid.2019.02.013. Epub 2019 Feb 27. J Invest Dermatol. 2019. PMID: 30825454 Free article. Clinical Trial.
To investigate new treatment options, we performed an exploratory double-blinded, randomized split-face study to assess the efficacy of the tyrosinase inhibitor Thiamidol compared to hydroquinone in women with mild to moderate melasma. After 12 weeks, modified Melasma Area …
To investigate new treatment options, we performed an exploratory double-blinded, randomized split-face study to assess the efficacy of the …
Inhibition of Human Tyrosinase Requires Molecular Motifs Distinctively Different from Mushroom Tyrosinase.
Mann T, Gerwat W, Batzer J, Eggers K, Scherner C, Wenck H, Stäb F, Hearing VJ, Röhm KH, Kolbe L. Mann T, et al. J Invest Dermatol. 2018 Jul;138(7):1601-1608. doi: 10.1016/j.jid.2018.01.019. Epub 2018 Feb 7. J Invest Dermatol. 2018. PMID: 29427586 Free article. Clinical Trial.
Therefore, we used recombinant human tyrosinase to screen a library of 50,000 compounds and compared the active screening hits with well-known whitening ingredients. Hydroquinone and its derivative arbutin only weakly inhibited human tyrosinase with a half-maximal inhibito …
Therefore, we used recombinant human tyrosinase to screen a library of 50,000 compounds and compared the active screening hits with well-kno …
Efficacy and safety of topical isobutylamido thiazolyl resorcinol (Thiamidol) vs. 4% hydroquinone cream for facial melasma: an evaluator-blinded, randomized controlled trial.
Lima PB, Dias JAF, Cassiano DP, Esposito ACC, Miot LDB, Bagatin E, Miot HA. Lima PB, et al. J Eur Acad Dermatol Venereol. 2021 Sep;35(9):1881-1887. doi: 10.1111/jdv.17344. Epub 2021 Jun 7. J Eur Acad Dermatol Venereol. 2021. PMID: 33988887 Clinical Trial.
Patients were randomly assigned to apply a double layer of 0.2% Thiamidol twice a day or 4% hydroquinone cream at bedtime, for 90 days. Both groups received tinted sunscreen (sun protection factor 60, PPD 20). ...CONCLUSION: The melasma improvement achieved using 0.2% Thia …
Patients were randomly assigned to apply a double layer of 0.2% Thiamidol twice a day or 4% hydroquinone cream at bedtime, for 90 day …
The effectiveness and safety of 3% tranexamic acid cream vs. 4% hydroquinone cream for mixed-type melasma in skin of color: a double-blind, split-face, randomized controlled trial.
Yasnova N, Sirait SP, Rahmayunita G. Yasnova N, et al. Acta Dermatovenerol Alp Pannonica Adriat. 2024 Jun;33(2):83-88. Acta Dermatovenerol Alp Pannonica Adriat. 2024. PMID: 38918942 Free article. Clinical Trial.
INTRODUCTION: Melasma, a chronic acquired skin pigmentation disorder, is characterized by the presence of irregular-edged brown to gray-brown patches with a symmetrical distribution, primarily on sun-exposed areas such as the face. Topical hydroquinone (HQ) is the gold sta …
INTRODUCTION: Melasma, a chronic acquired skin pigmentation disorder, is characterized by the presence of irregular-edged brown to gray-brow …
Melasma.
Kauh YC, Zachian TF. Kauh YC, et al. Adv Exp Med Biol. 1999;455:491-9. doi: 10.1007/978-1-4615-4857-7_72. Adv Exp Med Biol. 1999. PMID: 10599387 Clinical Trial.
With open studies of tretinoin cream and hydroquinone lotion followed by sun screen, we have found significant improvement within 5 months with a few side effects. ...We reconfirmed that a synergistic mechanism between tretinoin and hydroquinone is responsible for t …
With open studies of tretinoin cream and hydroquinone lotion followed by sun screen, we have found significant improvement within 5 m …
Melasma: treatment evaluation.
Salem A, Gamil H, Ramadan A, Harras M, Amer A. Salem A, et al. J Cosmet Laser Ther. 2009 Sep;11(3):146-50. doi: 10.1080/14764170902842549. J Cosmet Laser Ther. 2009. PMID: 19340686 Clinical Trial.
METHODS: A total of 45 patients with moderate-to-severe melasma were subjected to topical application of hydroquinone 4% cream, chemical peeling with 30% trichloroacetic acid (TCA) and/or frequency-doubled Q-switched Nd:YAG laser therapy for an average of 6 months. ...The …
METHODS: A total of 45 patients with moderate-to-severe melasma were subjected to topical application of hydroquinone 4% cream, chemi …
Efficacy of Botulinum Toxin A for the Management of Melasma: A Split-Face, Randomized Control Study.
Chaijaras S, Boonpethkaew S, Chirasuthat S, Sakpuwadol N, Yongpisarn T, Anansiripun P, Vachiramon V. Chaijaras S, et al. J Cosmet Dermatol. 2025 Aug;24(8):e70376. doi: 10.1111/jocd.70376. J Cosmet Dermatol. 2025. PMID: 40747795 Free PMC article. Clinical Trial.
OBJECTIVE: To evaluate the effectiveness of adjunctive incoBoNT-A injection combined with triple combination cream (TCC, 4% hydroquinone, 0.05% tretinoin, and 0.01% fluocinolone acetonide) for treating and preventing melasma recurrence compared to topical therapy alone. .. …
OBJECTIVE: To evaluate the effectiveness of adjunctive incoBoNT-A injection combined with triple combination cream (TCC, 4% hydroquinone …
Safety and efficacy of niosomal and conventional tranexamic acid/niacinamide vs. hydroquinone creams in melasma: A randomized, double-blind, case-controlled clinical trial.
Ghasemiyeh P, Haghighi NF, Dastgheib L, Ranjbar S, Mohammadi-Samani S. Ghasemiyeh P, et al. Sci Rep. 2025 Nov 28;15(1):42739. doi: 10.1038/s41598-025-26693-8. Sci Rep. 2025. PMID: 41315336 Free PMC article. Clinical Trial.
This randomized, double-blind, case-controlled clinical trial compared the efficacy of niosomal tranexamic acid (TXA) 2%/niacinamide (NCA) 2% cream and conventional TXA 5%/NCA 4% cream with topical hydroquinone (HQ) 4% cream as a gold standard in melasma patients. A total …
This randomized, double-blind, case-controlled clinical trial compared the efficacy of niosomal tranexamic acid (TXA) 2%/niacinamide (NCA) 2 …
A randomized, double-blind, placebo-controlled clinical trial on the efficacy and safety of 3% Rumex occidentalis cream versus 4% hydroquinone cream in the treatment of melasma among Filipinos.
Mendoza CG, Singzon IA, Handog EB. Mendoza CG, et al. Int J Dermatol. 2014 Nov;53(11):1412-6. doi: 10.1111/ijd.12690. Epub 2014 Sep 30. Int J Dermatol. 2014. PMID: 25265986 Clinical Trial.
The skin-lightening properties of Rumex occidentalis make it a therapeutic alternative to the reference standard treatment of hydroquinone (HQ). OBJECTIVES: This study was conducted to evaluate the safety and efficacy of 3% R. occidentalis cream versus 4% HQ cream in the m …
The skin-lightening properties of Rumex occidentalis make it a therapeutic alternative to the reference standard treatment of hydroquinon …
Efficacy of overnight leave-on sandwich therapy with 5% cysteamine and ectoine cream compared to hydroquinone 4% cream for treatment of melasma: a double-blind randomized controlled trial.
Kusumawardani A, Murasmita A, Rosmarwati E, Norawati Ashadi L, Setiawan SV, Murlistyarini S, Wahyu Fitriyani N. Kusumawardani A, et al. Acta Dermatovenerol Alp Pannonica Adriat. 2025 Mar;34(1):1-4. Acta Dermatovenerol Alp Pannonica Adriat. 2025. PMID: 40127492 Free article. Clinical Trial.
Participants were randomly assigned to Group A (5% cysteamine + ectoine) or Group B (4% hydroquinone + ectoine). Efficacy was evaluated using the modified Melasma Area and Severity Index (mMASI) and the JANUS-I skin analyzer. ...Either 5% cysteamine with ectoine or 4% h …
Participants were randomly assigned to Group A (5% cysteamine + ectoine) or Group B (4% hydroquinone + ectoine). Efficacy was evaluat …
202 results