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192 results

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Page 1
Inhibition of Human Tyrosinase Requires Molecular Motifs Distinctively Different from Mushroom Tyrosinase.
Mann T, Gerwat W, Batzer J, Eggers K, Scherner C, Wenck H, Stäb F, Hearing VJ, Röhm KH, Kolbe L. Mann T, et al. J Invest Dermatol. 2018 Jul;138(7):1601-1608. doi: 10.1016/j.jid.2018.01.019. Epub 2018 Feb 7. J Invest Dermatol. 2018. PMID: 29427586 Free article. Clinical Trial.
Therefore, we used recombinant human tyrosinase to screen a library of 50,000 compounds and compared the active screening hits with well-known whitening ingredients. Hydroquinone and its derivative arbutin only weakly inhibited human tyrosinase with a half-maximal inhibito …
Therefore, we used recombinant human tyrosinase to screen a library of 50,000 compounds and compared the active screening hits with well-kno …
Efficacy and safety of topical isobutylamido thiazolyl resorcinol (Thiamidol) vs. 4% hydroquinone cream for facial melasma: an evaluator-blinded, randomized controlled trial.
Lima PB, Dias JAF, Cassiano DP, Esposito ACC, Miot LDB, Bagatin E, Miot HA. Lima PB, et al. J Eur Acad Dermatol Venereol. 2021 Sep;35(9):1881-1887. doi: 10.1111/jdv.17344. Epub 2021 Jun 7. J Eur Acad Dermatol Venereol. 2021. PMID: 33988887 Clinical Trial.
Patients were randomly assigned to apply a double layer of 0.2% Thiamidol twice a day or 4% hydroquinone cream at bedtime, for 90 days. Both groups received tinted sunscreen (sun protection factor 60, PPD 20). ...CONCLUSION: The melasma improvement achieved using 0.2% Thia …
Patients were randomly assigned to apply a double layer of 0.2% Thiamidol twice a day or 4% hydroquinone cream at bedtime, for 90 day …
Effective Tyrosinase Inhibition by Thiamidol Results in Significant Improvement of Mild to Moderate Melasma.
Arrowitz C, Schoelermann AM, Mann T, Jiang LI, Weber T, Kolbe L. Arrowitz C, et al. J Invest Dermatol. 2019 Aug;139(8):1691-1698.e6. doi: 10.1016/j.jid.2019.02.013. Epub 2019 Feb 27. J Invest Dermatol. 2019. PMID: 30825454 Free article. Clinical Trial.
To investigate new treatment options, we performed an exploratory double-blinded, randomized split-face study to assess the efficacy of the tyrosinase inhibitor Thiamidol compared to hydroquinone in women with mild to moderate melasma. After 12 weeks, modified Melasma Area …
To investigate new treatment options, we performed an exploratory double-blinded, randomized split-face study to assess the efficacy of the …
Superior even skin tone and anti-ageing benefit of a combination of 4-hexylresorcinol and niacinamide.
Shariff R, Du Y, Dutta M, Kumar S 5th, Thimmaiah S, Doraiswamy C, Kumari A, Kale V, Nair N, Zhang S, Joshi M, Santhanam U, Qiang Q, Damodaran A. Shariff R, et al. Int J Cosmet Sci. 2022 Feb;44(1):103-117. doi: 10.1111/ics.12759. Epub 2022 Feb 1. Int J Cosmet Sci. 2022. PMID: 34958693 Free PMC article. Clinical Trial.
This study demonstrates that a product designed to affect multiple pathways of melanogenesis, inflammation, and ageing may provide an additional treatment option, beyond hydroquinone and retinoids, for hyperpigmentation and ageing....
This study demonstrates that a product designed to affect multiple pathways of melanogenesis, inflammation, and ageing may provide an additi …
Melasma.
Kauh YC, Zachian TF. Kauh YC, et al. Adv Exp Med Biol. 1999;455:491-9. doi: 10.1007/978-1-4615-4857-7_72. Adv Exp Med Biol. 1999. PMID: 10599387 Clinical Trial.
With open studies of tretinoin cream and hydroquinone lotion followed by sun screen, we have found significant improvement within 5 months with a few side effects. ...We reconfirmed that a synergistic mechanism between tretinoin and hydroquinone is responsible for t …
With open studies of tretinoin cream and hydroquinone lotion followed by sun screen, we have found significant improvement within 5 m …
Comparison of 2% deoxyarbutin and 4% hydroquinone as a depigmenting agent in healthy individuals: A double-blind randomized controlled clinical trial.
Anwar AI, Asmarani Y, Madjid A, Patellongi I, Adriani A, As'ad S, Kurniadi I. Anwar AI, et al. J Cosmet Dermatol. 2021 Dec;20(12):3953-3959. doi: 10.1111/jocd.14050. Epub 2021 Mar 23. J Cosmet Dermatol. 2021. PMID: 33683782 Clinical Trial.
BACKGROUND: Hydroquinone, which is considered the gold standard skin depigmenting agent, has been associated with multiple side effects. Lately, deoxyarbutin has been suggested to be an alternative of hydroquinone with better safety profile. OBJECTIVE: To compare th …
BACKGROUND: Hydroquinone, which is considered the gold standard skin depigmenting agent, has been associated with multiple side effec …
The effectiveness and safety of 3% tranexamic acid cream vs. 4% hydroquinone cream for mixed-type melasma in skin of color: a double-blind, split-face, randomized controlled trial.
Yasnova N, Sirait SP, Rahmayunita G. Yasnova N, et al. Acta Dermatovenerol Alp Pannonica Adriat. 2024 Jun;33(2):83-88. Acta Dermatovenerol Alp Pannonica Adriat. 2024. PMID: 38918942 Free article. Clinical Trial.
INTRODUCTION: Melasma, a chronic acquired skin pigmentation disorder, is characterized by the presence of irregular-edged brown to gray-brown patches with a symmetrical distribution, primarily on sun-exposed areas such as the face. Topical hydroquinone (HQ) is the gold sta …
INTRODUCTION: Melasma, a chronic acquired skin pigmentation disorder, is characterized by the presence of irregular-edged brown to gray-brow …
Prospective, randomized, double-blind clinical study of split-body comparison of topical hydroquinone and hexylresorcinol for skin pigment appearance.
Wu H, Gabriel TA, Burney WA, Chambers CJ, Pan A, Sivamani RK. Wu H, et al. Arch Dermatol Res. 2023 Jul;315(5):1207-1214. doi: 10.1007/s00403-022-02514-0. Epub 2022 Dec 11. Arch Dermatol Res. 2023. PMID: 36502500 Clinical Trial.
Currently, the first line topical medication in the United States is hydroquinone. Hydroquinone use is associated with potential safety concerns including cytotoxicity to melanocytes, systemic absorption, metabolism in distant organs, and production of potentially c …
Currently, the first line topical medication in the United States is hydroquinone. Hydroquinone use is associated with potenti …
Melasma: treatment evaluation.
Salem A, Gamil H, Ramadan A, Harras M, Amer A. Salem A, et al. J Cosmet Laser Ther. 2009 Sep;11(3):146-50. doi: 10.1080/14764170902842549. J Cosmet Laser Ther. 2009. PMID: 19340686 Clinical Trial.
METHODS: A total of 45 patients with moderate-to-severe melasma were subjected to topical application of hydroquinone 4% cream, chemical peeling with 30% trichloroacetic acid (TCA) and/or frequency-doubled Q-switched Nd:YAG laser therapy for an average of 6 months. ...The …
METHODS: A total of 45 patients with moderate-to-severe melasma were subjected to topical application of hydroquinone 4% cream, chemi …
Clinical efficacy and safety of a multimodality skin brightener composition compared with 4% hydroquinone.
Makino ET, Mehta RC, Garruto J, Gotz V, Sigler ML, Herndon JH. Makino ET, et al. J Drugs Dermatol. 2013 Mar;12(3):s21-6. J Drugs Dermatol. 2013. PMID: 23545929 Clinical Trial.
While these conditions are of an aesthetic nature, there is great interest in newer, safer, and more effective treatment modalities. Topical hydroquinone (HQ) has been the gold standard of skin lighteners for many years. However, regulatory authorities around the world are …
While these conditions are of an aesthetic nature, there is great interest in newer, safer, and more effective treatment modalities. Topical …
192 results