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97 results

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Page 1
Carbonic anhydrases--an overview.
Supuran CT. Supuran CT. Curr Pharm Des. 2008;14(7):603-14. doi: 10.2174/138161208783877884. Curr Pharm Des. 2008. PMID: 18336305 Review.
These enzymes are efficient catalysts for the reversible hydration of carbon dioxide to bicarbonate, but at least the alpha-CAs possess a high versatility, being able to catalyze different other hydrolytic processes The catalytic mechanism of the alpha-CAs is understood in detail …
These enzymes are efficient catalysts for the reversible hydration of carbon dioxide to bicarbonate, but at least the alpha-CAs possess a hi …
Crystal structure of Zn2(HTeO3)(AsO4).
Eder F, Weil M. Eder F, et al. Acta Crystallogr E Crystallogr Commun. 2021 Apr 27;77(Pt 5):555-558. doi: 10.1107/S2056989021004333. eCollection 2021 May 1. Acta Crystallogr E Crystallogr Commun. 2021. PMID: 34026264 Free PMC article.
The Zn(II) atom exhibits a coordination number of 5 and is coordinated by four oxygen atoms and a hydroxide group, forming a distorted trigonal bipyramid. The hydroxide ion is positioned at a significantly larger distance on one of the axial positions of the bipyram …
The Zn(II) atom exhibits a coordination number of 5 and is coordinated by four oxygen atoms and a hydroxide group, forming a distorted trigo …
Carbonic anhydrases as drug targets--an overview.
Supuran CT. Supuran CT. Curr Top Med Chem. 2007;7(9):825-33. doi: 10.2174/156802607780636690. Curr Top Med Chem. 2007. PMID: 17504127 Review.
These enzymes are very efficient catalysts for the reversible hydration of carbon dioxide to bicarbonate, but at least the alpha-CAs possess a high versatility, being able to catalyze different other hydrolytic processes The catalytic mechanism of the alpha-CAs is understood in d …
These enzymes are very efficient catalysts for the reversible hydration of carbon dioxide to bicarbonate, but at least the alpha-CAs possess …
Carbonic anhydrases as targets for medicinal chemistry.
Supuran CT, Scozzafava A. Supuran CT, et al. Bioorg Med Chem. 2007 Jul 1;15(13):4336-50. doi: 10.1016/j.bmc.2007.04.020. Epub 2007 Apr 19. Bioorg Med Chem. 2007. PMID: 17475500 Review.
The catalytic mechanism of the alpha-CAs is understood in detail: the active site consists of a Zn(II) ion co-ordinated by three histidine residues and a water molecule/hydroxide ion. The latter is the active species, acting as a potent nucleophile. For beta- and ga …
The catalytic mechanism of the alpha-CAs is understood in detail: the active site consists of a Zn(II) ion co-ordinated by three histidine r …
Long-range proton and hydroxide ion transfer dynamics at the water/CeO(2) interface in the nanosecond regime: reactive molecular dynamics simulations and kinetic analysis.
Kobayashi T, Ikeda T, Nakayama A. Kobayashi T, et al. Chem Sci. 2024 Apr 2;15(18):6816-6832. doi: 10.1039/d4sc01422g. eCollection 2024 May 8. Chem Sci. 2024. PMID: 38725504 Free PMC article.
The water interfaces with two low-index surfaces of (111) and (110) are explored with these NNPs, and the structure and long-range proton and hydroxide ion transfer dynamics are examined with unprecedented system sizes and long simulation times. ...Furthermore, in o …
The water interfaces with two low-index surfaces of (111) and (110) are explored with these NNPs, and the structure and long-range proton an …
The aqueous stability of bupropion.
O'Byrne PM, Williams R, Walsh JJ, Gilmer JF. O'Byrne PM, et al. J Pharm Biomed Anal. 2010 Nov 2;53(3):376-81. doi: 10.1016/j.jpba.2010.04.024. Epub 2010 May 4. J Pharm Biomed Anal. 2010. PMID: 20547024
The effects of hydrogen ion, solvent and hydroxide ion concentration are discussed with particular emphasis on the kinetics of degradation of bupropion. ...The inherent instability of bupropion above pH 5 has implications for its therapeutic use, formu …
The effects of hydrogen ion, solvent and hydroxide ion concentration are discussed with particular emphasis on the kinetics of …
Bioactive heterocycles containing endocyclic N-hydroxy groups.
Rani R, Granchi C. Rani R, et al. Eur J Med Chem. 2015 Jun 5;97:505-24. doi: 10.1016/j.ejmech.2014.11.031. Epub 2014 Nov 18. Eur J Med Chem. 2015. PMID: 25466924 Free PMC article. Review.
Nevertheless, heterocycles bearing endocyclic N-hydroxy portions have so far been poorly studied as chemical classes that may provide new therapeutic agents. This review provides an overview of N-OH-containing heterocycles with reported bioactivities that may be considered …
Nevertheless, heterocycles bearing endocyclic N-hydroxy portions have so far been poorly studied as chemical classes that may provide new …
The influence of sample dimensions on hydroxyl ion release from calcium hydroxide products.
Murray PE, Lumley PJ, Smith AJ, Ross HF. Murray PE, et al. Endod Dent Traumatol. 2000 Dec;16(6):251-7. doi: 10.1034/j.1600-9657.2000.016006251.x. Endod Dent Traumatol. 2000. PMID: 11202890
The range in hydroxide activity between products was found to be 298%. In rank order of hydroxide ion release, from the most to the least active was: Hypocal, Calasept, Life and Dycal. ...It is suggested that in cases where the oral healing responses have been poore …
The range in hydroxide activity between products was found to be 298%. In rank order of hydroxide ion release, from the most t …
97 results