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Year Number of Results
1965 1
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1981 3
1982 2
1985 1
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1998 3
1999 5
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35 results

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Page 1
A controlled trial of glycopyrronium and l-hyoscyamine in the long-term treatment of duodenal ulcer.
Kaye MD, Rhodes J, Beck P, Sweetnam PM, Davies GT, Evans KT. Kaye MD, et al. Gut. 1970 Jul;11(7):559-66. doi: 10.1136/gut.11.7.559. Gut. 1970. PMID: 4916211 Free PMC article. Clinical Trial.
They received either glycopyrronium, or 1-hyoscyamine in a sustained-release form, or inert tablets for one year. Progress was judged on the basis of frequency and severity of symptoms, monthly assessments by patients, antacid consumption, and radiology. By all criteria, g …
They received either glycopyrronium, or 1-hyoscyamine in a sustained-release form, or inert tablets for one year. Progress was judged …
Pain relief during intrauterine device placement in nulligravid women with both oral ketorolac and an analgesic: a double-blinded randomised trial.
Marcelino AC, da Cunha Pereira P, Charles CM, Espejo-Arce X, Bahamondes L. Marcelino AC, et al. Eur J Contracept Reprod Health Care. 2024 Dec;29(6):276-281. doi: 10.1080/13625187.2024.2398440. Epub 2024 Sep 16. Eur J Contracept Reprod Health Care. 2024. PMID: 39279687 Free article. Clinical Trial.
We randomised participants who voluntarily agreed to participate to receive either one pill containing ketorolac 20 mg together with one pill containing dipyrone 300 mg, scopolamine 6.5 g, hyoscyamine 104 g, and homatropine 1 mg or placebo 60 min before IUD placement. Th …
We randomised participants who voluntarily agreed to participate to receive either one pill containing ketorolac 20 mg together with one pil …
Effect of Open-label Placebo on Children and Adolescents With Functional Abdominal Pain or Irritable Bowel Syndrome: A Randomized Clinical Trial.
Nurko S, Saps M, Kossowsky J, Zion SR, Di Lorenzo C, Vaz K, Hawthorne K, Wu R, Ciciora S, Rosen JM, Kaptchuk TJ, Kelley JM. Nurko S, et al. JAMA Pediatr. 2022 Apr 1;176(4):349-356. doi: 10.1001/jamapediatrics.2021.5750. JAMA Pediatr. 2022. PMID: 35099543 Free PMC article. Clinical Trial.
A standardized method for explaining the OLP was used, and the interaction with clinicians had the same duration and style for both time periods. Hyoscyamine was allowed as a rescue medication. MAIN OUTCOMES AND MEASURES: The primary outcome was the mean daily pain score d …
A standardized method for explaining the OLP was used, and the interaction with clinicians had the same duration and style for both time per …
Sublingual hyoscyamine for patient comfort during screening sigmoidoscopy: a randomized, double-blind, placebo-controlled clinical trial.
Dumot JA, Verzola E, Nicol S, Easley KA, Vargo JJ, van Stolk RU. Dumot JA, et al. Gastrointest Endosc. 1998 Sep;48(3):283-6. doi: 10.1016/s0016-5107(98)70192-0. Gastrointest Endosc. 1998. PMID: 9744605 Clinical Trial.
The possible benefit of a well-tolerated, low-cost antispasmodic medication, sublingual hyoscyamine, used before flexible sigmoidoscopy was assessed in a randomized, double-blinded, placebo-controlled trial. ...CONCLUSIONS: In this study, hyoscyamine administered in …
The possible benefit of a well-tolerated, low-cost antispasmodic medication, sublingual hyoscyamine, used before flexible sigmoidosco …
Systemic bioavailability of ocularly applied 1% atropine eyedrops.
Kaila T, Korte JM, Saari KM. Kaila T, et al. Acta Ophthalmol Scand. 1999 Apr;77(2):193-6. doi: 10.1034/j.1600-0420.1999.770215.x. Acta Ophthalmol Scand. 1999. PMID: 10321537 Free article. Clinical Trial.
The plasma concentrations of the biologically active atropine enantiomer, 1-hyoscyamine, were determined using a muscarinic cholinoceptor binding assay. RESULTS: The mean area under the curve from zero to infinitum (AUC0-infinity) for 1-hyoscyamine was 1.862+/-0.580 …
The plasma concentrations of the biologically active atropine enantiomer, 1-hyoscyamine, were determined using a muscarinic cholinoce …
Comparison of no medication, placebo, and hyoscyamine for reducing pain during a barium enema.
Bova JG, Bhattacharjee N, Jurdi R, Bennett WF. Bova JG, et al. AJR Am J Roentgenol. 1999 May;172(5):1285-7. doi: 10.2214/ajr.172.5.10227503. AJR Am J Roentgenol. 1999. PMID: 10227503 Clinical Trial.
SUBJECTS AND METHODS: Patients were randomized into three groups: no medication, placebo, and sublingual 1-hyoscyamine sulfate. The placebo or hyoscyamine tablet was placed under the tongue 15-30 min before the examination. ...CONCLUSION: Although safe, hyoscyami …
SUBJECTS AND METHODS: Patients were randomized into three groups: no medication, placebo, and sublingual 1-hyoscyamine sulfate. The p …
The effect of pirenzepine and L-hyoscyamine on gastric emptying and salivary secretion in healthy volunteers.
Jaup BH, Dotevall G. Jaup BH, et al. Scand J Gastroenterol. 1981;16(6):769-73. doi: 10.3109/00365528109181002. Scand J Gastroenterol. 1981. PMID: 6119766 Clinical Trial.
Gastric emptying was delayed during L-hyoscyamine, whereas the emptying was slightly accelerated by pirenzepine when compared with placebo. ...The salivation was significantly more inhibited by L-hyoscyamine than by pirenzepine. Pirenzepine in doses inhibiting gastr …
Gastric emptying was delayed during L-hyoscyamine, whereas the emptying was slightly accelerated by pirenzepine when compared with pl …
Intramuscular atropine in healthy volunteers: a pharmacokinetic and pharmacodynamic study.
Kentala E, Kaila T, Iisalo E, Kanto J. Kentala E, et al. Int J Clin Pharmacol Ther Toxicol. 1990 Sep;28(9):399-404. Int J Clin Pharmacol Ther Toxicol. 1990. PMID: 2228327 Clinical Trial.
The absorption rate and the elimination rate of dl-hyoscyamine and l-hyoscyamine were comparable (tmax = 8.40 vs 8.67 min, t1/2el = 2.95 vs 2.43 h, dose 0.02 mg/kg) but the mean maximum plasma concentration of dl-hyoscyamine was 2.9 times and the mean AUC val …
The absorption rate and the elimination rate of dl-hyoscyamine and l-hyoscyamine were comparable (tmax = 8.40 vs 8.67 min, t1/ …
Sublingual L-hyoscyamine for duodenal antimotility during ERCP: a prospective randomized double-blinded study.
Lynch CR, Khandekar S, Lynch SM, Disario JA. Lynch CR, et al. Gastrointest Endosc. 2007 Oct;66(4):748-52. doi: 10.1016/j.gie.2007.02.052. Gastrointest Endosc. 2007. PMID: 17905018 Clinical Trial.
OBJECTIVE: Demonstrate whether pre-ERCP sublingual L-hyoscyamine reduces the amount of glucagon required to complete ERCP. DESIGN: Randomized, double-blinded clinical trial of 200 participants assigned to receive L-hyoscyamine 0.5 mg or a placebo sublingually before …
OBJECTIVE: Demonstrate whether pre-ERCP sublingual L-hyoscyamine reduces the amount of glucagon required to complete ERCP. DESIGN: Ra …
Prospective study comparing hyoscyamine, doxazosin, and combination therapy for the treatment of urgency and frequency in women.
Serels S, Stein M. Serels S, et al. Neurourol Urodyn. 1998;17(1):31-6. doi: 10.1002/(sici)1520-6777(1998)17:1<31::aid-nau6>3.0.co;2-e. Neurourol Urodyn. 1998. PMID: 9453690 Clinical Trial.
Between September 1994 and October 1995, 34 women aged 28-91 (mean age, 62) received either 0.375 mg of sustained-release hyoscyamine twice a day or 2 mg doxazosin QHS prior to being crossed over to the other drug and/or the combination. ...By urodynamic evaluation, a grea …
Between September 1994 and October 1995, 34 women aged 28-91 (mean age, 62) received either 0.375 mg of sustained-release hyoscyamine …
35 results