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Table representation of search results timeline featuring number of search results per year.

Year Number of Results
1967 1
1968 1
1969 2
1970 6
1971 3
1972 5
1973 16
1974 8
1975 14
1976 14
1977 14
1978 23
1979 31
1980 25
1981 16
1982 11
1983 29
1984 36
1985 30
1986 33
1987 30
1988 26
1989 27
1990 47
1991 43
1992 42
1993 33
1994 43
1995 42
1996 38
1997 44
1998 44
1999 40
2000 69
2001 45
2002 48
2003 49
2004 59
2005 49
2006 61
2007 58
2008 76
2009 64
2010 55
2011 69
2012 64
2013 67
2014 54
2015 53
2016 72
2017 94
2018 85
2019 78
2020 76
2021 90
2022 63
2023 38

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2,167 results

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Page 1
Ibuprofen versus paracetamol for treating fever in preschool children in Nigeria: a randomized clinical trial of effectiveness and safety.
Alaje EO, Udoh EE, Akande PA, Odey FA, Meremikwu MM. Alaje EO, et al. Pan Afr Med J. 2020 Aug 26;36:350. doi: 10.11604/pamj.2020.36.350.21393. eCollection 2020. Pan Afr Med J. 2020. PMID: 33224416 Free PMC article. Clinical Trial.
INTRODUCTION: fever is the primary symptom of most childhood illnesses and a cause of concern to their caregivers. The antipyretics commonly used to treat fever are ibuprofen and paracetamol. Most studies on the effectiveness of ibuprofen and paracetamol in treating …
INTRODUCTION: fever is the primary symptom of most childhood illnesses and a cause of concern to their caregivers. The antipyretics commonly …
Expectant Management or Early Ibuprofen for Patent Ductus Arteriosus.
Hundscheid T, Onland W, Kooi EMW, Vijlbrief DC, de Vries WB, Dijkman KP, van Kaam AH, Villamor E, Kroon AA, Visser R, Mulder-de Tollenaer SM, De Bisschop B, Dijk PH, Avino D, Hocq C, Zecic A, Meeus M, de Baat T, Derriks F, Henriksen TB, Kyng KJ, Donders R, Nuytemans DHGM, Van Overmeire B, Mulder AL, de Boode WP; BeNeDuctus Trial Investigators. Hundscheid T, et al. N Engl J Med. 2023 Mar 16;388(11):980-990. doi: 10.1056/NEJMoa2207418. Epub 2022 Dec 6. N Engl J Med. 2023. PMID: 36477458 Clinical Trial.
METHODS: In this multicenter, noninferiority trial, we randomly assigned infants with echocardiographically confirmed PDA (diameter, >1.5 mm, with left-to-right shunting) who were extremely preterm (<28 weeks' gestational age) to receive either expectant management or early …
METHODS: In this multicenter, noninferiority trial, we randomly assigned infants with echocardiographically confirmed PDA (diameter, >1.5 …
Pharmacokinetics and Bioavailability of a Fixed-Dose Combination of Ibuprofen and Paracetamol after Intravenous and Oral Administration.
Atkinson HC, Stanescu I, Frampton C, Salem II, Beasley CP, Robson R. Atkinson HC, et al. Clin Drug Investig. 2015 Oct;35(10):625-32. doi: 10.1007/s40261-015-0320-8. Clin Drug Investig. 2015. PMID: 26334726 Free PMC article. Clinical Trial.
Serial plasma samples were assayed for both paracetamol and ibuprofen concentrations, using validated liquid chromatography-tandem mass spectrometry methods. ...CONCLUSION: Concomitant administration of 3 mg/mL ibuprofen and 10 mg/mL paracetamol in a fixed-dose IV c …
Serial plasma samples were assayed for both paracetamol and ibuprofen concentrations, using validated liquid chromatography-tandem ma …
Paracetamol plus ibuprofen for the treatment of fever in children (PITCH): randomised controlled trial.
Hay AD, Costelloe C, Redmond NM, Montgomery AA, Fletcher M, Hollinghurst S, Peters TJ. Hay AD, et al. BMJ. 2008 Sep 2;337:a1302. doi: 10.1136/bmj.a1302. BMJ. 2008. PMID: 18765450 Free PMC article. Clinical Trial.
For less time with fever over 24 hours, paracetamol plus ibuprofen were superior to paracetamol (4.4 hours, 2.4 to 6.3; P<0.001) and to ibuprofen (2.5 hours, 0.6 to 4.4; P=0.008). ...CONCLUSION: Parents, nurses, pharmacists, and doctors wanting to use medicines t …
For less time with fever over 24 hours, paracetamol plus ibuprofen were superior to paracetamol (4.4 hours, 2.4 to 6.3; P<0.001) a …
Efficacy and safety of Curcuma domestica extracts compared with ibuprofen in patients with knee osteoarthritis: a multicenter study.
Kuptniratsaikul V, Dajpratham P, Taechaarpornkul W, Buntragulpoontawee M, Lukkanapichonchut P, Chootip C, Saengsuwan J, Tantayakom K, Laongpech S. Kuptniratsaikul V, et al. Clin Interv Aging. 2014 Mar 20;9:451-8. doi: 10.2147/CIA.S58535. eCollection 2014. Clin Interv Aging. 2014. PMID: 24672232 Free PMC article. Clinical Trial.
METHODS: 367 primary knee osteoarthritis patients with a pain score of 5 or higher were randomized to receive ibuprofen 1,200 mg/day or C. domestica extracts 1,500 mg/day for 4 weeks. ...However, the number of events of abdominal pain/discomfort was significantly higher in …
METHODS: 367 primary knee osteoarthritis patients with a pain score of 5 or higher were randomized to receive ibuprofen 1,200 mg/day …
Efficacy and safety of oral paracetamol versus oral ibuprofen for closure of patent ductus arteriosus in preterm infants: a randomized controlled trial.
El-Farrash RA, El Shimy MS, El-Sakka AS, Ahmed MG, Abdel-Moez DG. El-Farrash RA, et al. J Matern Fetal Neonatal Med. 2019 Nov;32(21):3647-3654. doi: 10.1080/14767058.2018.1470235. Epub 2018 May 9. J Matern Fetal Neonatal Med. 2019. PMID: 29695206 Clinical Trial.
Neonates were randomly assigned to two groups: 30 received oral ibuprofen and 30 received oral paracetamol. With failure of ductal closure, a second course of ibuprofen or paracetamol was given. ...Oral paracetamol was comparable with ibuprofen in terms of th …
Neonates were randomly assigned to two groups: 30 received oral ibuprofen and 30 received oral paracetamol. With failure of ductal cl …
Single- and Multiple-Dose Pharmacokinetics of Immediate-Release/Extended-Release Ibuprofen Tablets.
Legg T, Paluch E, Jayawardena S. Legg T, et al. Clin Pharmacol Drug Dev. 2017 Jan;6(1):36-43. doi: 10.1002/cpdd.288. Epub 2016 Sep 22. Clin Pharmacol Drug Dev. 2017. PMID: 27364900 Clinical Trial.
In both studies, the 2 formulations were bioequivalent to each other for the area under the plasma concentration-versus-time curve from time 0 to the last measurable concentration (AUCL), to infinity (AUC() ), and to 12 hours (AUC(0-12) ) and maximum concentration (C(max) ). In s …
In both studies, the 2 formulations were bioequivalent to each other for the area under the plasma concentration-versus-time curve from time …
Intravenous ibuprofen for acute treatment of migraine: A double-blind, randomized, placebo-controlled pilot study.
Yuan H, Curran JG, Keith SW, Hopkins MM, Silberstein SD. Yuan H, et al. Headache. 2021 Oct;61(9):1432-1440. doi: 10.1111/head.14214. Epub 2021 Oct 3. Headache. 2021. PMID: 34601736 Clinical Trial.
To date, only three IV NSAIDs (ketorolac, ibuprofen, and meloxicam) are available in the United States for use in moderate and severe pain, but no placebo-controlled trial is available for migraine. ...At 2 h posttreatment, pain relief was found in 74% (17/23) and 48% (10/ …
To date, only three IV NSAIDs (ketorolac, ibuprofen, and meloxicam) are available in the United States for use in moderate and severe …
Multicenter clinical trial of ibuprofen and acetaminophen in the treatment of postoperative dental pain.
Mehlisch DR, Sollecito WA, Helfrick JF, Leibold DG, Markowitz R, Schow CE Jr, Shultz R, Waite DE. Mehlisch DR, et al. J Am Dent Assoc. 1990 Aug;121(2):257-63. doi: 10.14219/jada.archive.1990.0237. J Am Dent Assoc. 1990. PMID: 2205641 Clinical Trial.
Oral surgery pain is a reliable model to reference the effectiveness of commonly used analgesics such as ibuprofen and acetaminophen. A total of 706 patients who were experiencing moderate to severe pain received a single dose of ibuprofen, acetaminophen, or placebo …
Oral surgery pain is a reliable model to reference the effectiveness of commonly used analgesics such as ibuprofen and acetaminophen. …
Ibuprofen and dysmenorrhea.
Dawood MY. Dawood MY. Am J Med. 1984 Jul 13;77(1A):87-94. doi: 10.1016/s0002-9343(84)80025-x. Am J Med. 1984. PMID: 6380282 Clinical Trial.
The condition may be treated by oral contraceptives, which reduce overall menstrual fluid volume, or by a prostaglandin synthetase inhibitor, such as ibuprofen. Unless the patient wishes to use oral contraceptives for birth control, ibuprofen (Motrin) is the drug of …
The condition may be treated by oral contraceptives, which reduce overall menstrual fluid volume, or by a prostaglandin synthetase inhibitor …
2,167 results