Rational Tuning of Visual Cycle Modulator Pharmacodynamics.
Kiser PD, Zhang J, Badiee M, Kinoshita J, Peachey NS, Tochtrop GP, Palczewski K.
Kiser PD, et al.
J Pharmacol Exp Ther. 2017 Jul;362(1):131-145. doi: 10.1124/jpet.117.240721. Epub 2017 May 5.
J Pharmacol Exp Ther. 2017.
PMID: 28476927
Free PMC article.
The isopropyl derivative series produced discernible visual cycle suppression in vivo, albeit much less potently than compounds with a high affinity for the RPE65 active site. ...Except for one compound [3-amino-1-(3-isopropyl-5-((2,6,6-trimethylcyclohex-1-en-1-yl)m …
The isopropyl derivative series produced discernible visual cycle suppression in vivo, albeit much less potently than compounds with …