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257 results

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Page 1
Isosorbide Mononitrate and Cilostazol Treatment in Patients With Symptomatic Cerebral Small Vessel Disease: The Lacunar Intervention Trial-2 (LACI-2) Randomized Clinical Trial.
Wardlaw JM, Woodhouse LJ, Mhlanga II, Oatey K, Heye AK, Bamford J, Cvoro V, Doubal FN, England T, Hassan A, Montgomery A, O'Brien JT, Roffe C, Sprigg N, Werring DJ, Bath PM; Lacunar Intervention Trial-2 (LACI-2) Investigator Group. Wardlaw JM, et al. JAMA Neurol. 2023 Jul 1;80(7):682-692. doi: 10.1001/jamaneurol.2023.1526. JAMA Neurol. 2023. PMID: 37222252 Free PMC article. Clinical Trial.
OBJECTIVE: To test the feasibility, drug tolerability, safety, and effects of 1-year isosorbide mononitrate (ISMN) and cilostazol treatment on vascular, functional, and cognitive outcomes in patients with lacunar stroke. ...Compared with those participants no …
OBJECTIVE: To test the feasibility, drug tolerability, safety, and effects of 1-year isosorbide mononitrate (ISMN) and …
Methods for the induction of labor: efficacy and safety.
Sanchez-Ramos L, Levine LD, Sciscione AC, Mozurkewich EL, Ramsey PS, Adair CD, Kaunitz AM, McKinney JA. Sanchez-Ramos L, et al. Am J Obstet Gynecol. 2024 Mar;230(3S):S669-S695. doi: 10.1016/j.ajog.2023.02.009. Epub 2023 Jul 13. Am J Obstet Gynecol. 2024. PMID: 38462252 Review.
Concerning the vaginal administration of nitric oxide donors, including isosorbide mononitrate, isosorbide, nitroglycerin, and sodium nitroprusside, the higher incidence of side effects with these agents has limited their use. ...
Concerning the vaginal administration of nitric oxide donors, including isosorbide mononitrate, isosorbide, nitroglycerin, and …
Isosorbide mononitrate for cervical ripening during labour induction: A systematic review and meta-analysis of 23 randomized controlled trials.
Abu-Zaid A, Alshahrani MS, Al-Matary A, Khadawardi K, Miski NT, Abuzaid M, Alrasheed MA, Baradwan A, Salem A, Salem R, Albadawi MI, Jamjoom MZ, Almubarki AA, Abdulmalik NA, Almugbel M, Tulbah M, Baradwan S, Alomar O. Abu-Zaid A, et al. Eur J Obstet Gynecol Reprod Biol. 2022 Sep;276:38-46. doi: 10.1016/j.ejogrb.2022.06.028. Epub 2022 Jul 3. Eur J Obstet Gynecol Reprod Biol. 2022. PMID: 35803111 Review.
OBJECTIVE: To conduct a systematic review and meta-analysis of all randomized controlled trials (RCTs) that evaluated the efficacy and safety of isosorbide mononitrate (IMN) in promoting cervical ripening during labour induction. METHODS: Six major databases were se …
OBJECTIVE: To conduct a systematic review and meta-analysis of all randomized controlled trials (RCTs) that evaluated the efficacy and safet …
Isosorbide Mononitrate Versus Dinoprostone for Cervical Ripening During Labor Induction: a Systematic Review and Meta-analysis of Randomized Controlled Trials.
Abu-Zaid A, Khadawardi K, Al-Matary A, Alshahrani MS, Miski NT, Abuzaid M, Khalifa M, Almugbel M, Tulbah M, Baradwan S. Abu-Zaid A, et al. Reprod Sci. 2023 Feb;30(2):380-389. doi: 10.1007/s43032-022-00909-y. Epub 2022 Apr 19. Reprod Sci. 2023. PMID: 35441336 Review.
The objective of this study was to conduct a systematic review and meta-analysis of all randomized controlled trials (RCTs) that evaluated isosorbide mononitrate (ISMN) versus dinoprostone, a prostaglandin E2 (PGE2) analogue, in promoting cervical ripening during la …
The objective of this study was to conduct a systematic review and meta-analysis of all randomized controlled trials (RCTs) that evaluated …
Isosorbide Mononitrate in Heart Failure with Preserved Ejection Fraction.
Redfield MM, Anstrom KJ, Levine JA, Koepp GA, Borlaug BA, Chen HH, LeWinter MM, Joseph SM, Shah SJ, Semigran MJ, Felker GM, Cole RT, Reeves GR, Tedford RJ, Tang WH, McNulty SE, Velazquez EJ, Shah MR, Braunwald E; NHLBI Heart Failure Clinical Research Network. Redfield MM, et al. N Engl J Med. 2015 Dec 10;373(24):2314-24. doi: 10.1056/NEJMoa1510774. Epub 2015 Nov 8. N Engl J Med. 2015. PMID: 26549714 Free PMC article. Clinical Trial.
BACKGROUND: Nitrates are commonly prescribed to enhance activity tolerance in patients with heart failure and a preserved ejection fraction. We compared the effect of isosorbide mononitrate or placebo on daily activity in such patients. METHODS: In this multicenter, …
BACKGROUND: Nitrates are commonly prescribed to enhance activity tolerance in patients with heart failure and a preserved ejection fraction. …
Long-acting cilostazol versus isosorbide mononitrate for patients with vasospastic angina: a randomized controlled trial.
Kang MG, Ahn JH, Hwang JY, Hwang SJ, Koh JS, Park Y, Bae JS, Chun KJ, Kim JS, Kim JH, Chon MK. Kang MG, et al. Coron Artery Dis. 2024 Sep 1;35(6):459-464. doi: 10.1097/MCA.0000000000001366. Epub 2024 Apr 9. Coron Artery Dis. 2024. PMID: 38595079 Clinical Trial.
We conducted a randomized, open-label, controlled trial to compare the efficacy and safety of long-acting cilostazol and isosorbide mononitrate (ISMN) for VSA. METHODS: The study included patients with confirmed VSA between September 2019 and May 2021. ...CONCLUSION …
We conducted a randomized, open-label, controlled trial to compare the efficacy and safety of long-acting cilostazol and isosorbide …
Cilostazol and isosorbide mononitrate for the prevention of progression of cerebral small vessel disease: baseline data and statistical analysis plan for the Lacunar Intervention Trial-2 (LACI-2) (ISRCTN14911850).
Bath PM, Mhlanga I, Woodhouse LJ, Doubal F, Oatey K, Montgomery AA, Wardlaw JM; LACI-2 Trial Investigators. Bath PM, et al. Stroke Vasc Neurol. 2023 Apr;8(2):134-143. doi: 10.1136/svn-2022-001816. Epub 2022 Sep 2. Stroke Vasc Neurol. 2023. PMID: 36219567 Free PMC article. Clinical Trial.
METHODS: The LACunar Intervention Trial-2 is an investigator-initiated prospective randomised open-label blinded-endpoint phase II feasibility study assessing cilostazol and isosorbide mononitrate for preventing SVD progression. We aimed to recruit 400 patients with …
METHODS: The LACunar Intervention Trial-2 is an investigator-initiated prospective randomised open-label blinded-endpoint phase II feasibili …
Vericiguat in combination with isosorbide mononitrate in patients with chronic coronary syndromes: The randomized, phase Ib, VISOR study.
Boettcher M, Mikus G, Trenk D, Düngen HD, Donath F, Werner N, Karakas M, Besche N, Schulz-Burck D, Gerrits M, Hung J, Becker C. Boettcher M, et al. Clin Transl Sci. 2022 May;15(5):1204-1214. doi: 10.1111/cts.13238. Epub 2022 Mar 17. Clin Transl Sci. 2022. PMID: 35299288 Free PMC article. Clinical Trial.
This study evaluated safety, tolerability, and the pharmacodynamic (PD) interaction between co-administered vericiguat and isosorbide mononitrate in patients with CCS. In this phase Ib, double-blind, multicenter study, patients were randomized 2:1 to receive vericig …
This study evaluated safety, tolerability, and the pharmacodynamic (PD) interaction between co-administered vericiguat and isosorbide …
Use of nitrates in ischemic heart disease.
Giuseppe C, Paul J, Hans-Ulrich I. Giuseppe C, et al. Expert Opin Pharmacother. 2015;16(11):1567-72. doi: 10.1517/14656566.2015.1052742. Epub 2015 Jun 1. Expert Opin Pharmacother. 2015. PMID: 26027641 Review.
Multivariate analysis data from large nonrandomized studies suggested that long-acting nitrates increase the incidence of acute coronary syndromes, while data from another multivariate study indicate that they have positive effects. Because of methodological differences an …
Multivariate analysis data from large nonrandomized studies suggested that long-acting nitrates increase the incidence of acute coronary syn …
257 results