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Vericiguat in combination with isosorbide mononitrate in patients with chronic coronary syndromes: The randomized, phase Ib, VISOR study.
Boettcher M, Mikus G, Trenk D, Düngen HD, Donath F, Werner N, Karakas M, Besche N, Schulz-Burck D, Gerrits M, Hung J, Becker C. Boettcher M, et al. Clin Transl Sci. 2022 May;15(5):1204-1214. doi: 10.1111/cts.13238. Epub 2022 Mar 17. Clin Transl Sci. 2022. PMID: 35299288 Free PMC article. Clinical Trial.
This study evaluated safety, tolerability, and the pharmacodynamic (PD) interaction between co-administered vericiguat and isosorbide mononitrate in patients with CCS. ...Concomitant use of vericiguat with isosorbide mononitrate is unlikely to c …
This study evaluated safety, tolerability, and the pharmacodynamic (PD) interaction between co-administered vericiguat and isosorb …
Predicting the Pharmacokinetics of Orally Administered Drugs across BCS Classes 1-4 by Virtual Bioequivalence Model.
Zhang F, Wu X, Wu K, Yu M, Liu B, Wang H. Zhang F, et al. Mol Pharm. 2023 Jan 2;20(1):395-408. doi: 10.1021/acs.molpharmaceut.2c00688. Epub 2022 Dec 5. Mol Pharm. 2023. PMID: 36469444
As for the PK parameters, except for the time of peak concentration, T(max), of isosorbide mononitrate, other simulated PK parameters were all within a twofold error. The simulated PK behaviors were comparable to the observed ones, both for test (T) and reference (R …
As for the PK parameters, except for the time of peak concentration, T(max), of isosorbide mononitrate, other simulated PK par …
PD-1 Inhibitor-Induced Thyrotoxicosis Associated with Coronary Artery Spasm and Ventricular Tachycardia.
Guo K, Chen M, Li J. Guo K, et al. Cardiovasc Toxicol. 2022 Nov;22(10-11):892-897. doi: 10.1007/s12012-022-09756-4. Epub 2022 Jun 21. Cardiovasc Toxicol. 2022. PMID: 35727506
He was treated with antivasospasm drugs (isosorbide mononitrate and diltiazem). Thyroid function was reexamined and revealed elevated FT3 and FT4 levels, decreased TSH levels, and negative thyroid-associated antibodies. ...This case adds to our knowledge of the asso …
He was treated with antivasospasm drugs (isosorbide mononitrate and diltiazem). Thyroid function was reexamined and revealed e …
Organic nitrates favor regression of left ventricular hypertrophy in hypertensive patients on chronic peritoneal dialysis.
Li H, Wang S. Li H, et al. Int J Mol Sci. 2013 Jan 7;14(1):1069-79. doi: 10.3390/ijms14011069. Int J Mol Sci. 2013. PMID: 23296279 Free PMC article. Clinical Trial.
The aim of the study was to evaluate the effect of nitrates on left ventricular hypertrophy (LVH) in hypertensive patients on chronic peritoneal dialysis (PD). Sixty-four PD patients with hypertension were enrolled in this study. All patients accepted antihypertensi …
The aim of the study was to evaluate the effect of nitrates on left ventricular hypertrophy (LVH) in hypertensive patients on chronic perito …
Determination of Isosorbide-5-Mononitrate in Human Plasma by High-Performance Liquid Chromatography-Tandem Mass Spectrometry and Its Application to a Bioequivalence Study.
Zhou Y, Liu A, Jia R, Wu M, Wu N, Liu C, Han Z, Hu H, Wang H, He Q. Zhou Y, et al. J Anal Methods Chem. 2020 Jul 17;2020:1753265. doi: 10.1155/2020/1753265. eCollection 2020. J Anal Methods Chem. 2020. PMID: 32724701 Free PMC article.
Isosorbide-5-mononitrate (5-ISMN), an organic nitrate vasodilator, has been widely used worldwide to prevent angina pectoris for more than two decades. ...
Isosorbide-5-mononitrate (5-ISMN), an organic nitrate vasodilator, has been widely used worldwide to prevent angina pectoris f …