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1977 1
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1986 11
1987 40
1988 25
1989 32
1990 29
1991 31
1992 35
1993 22
1994 37
1995 31
1996 16
1997 25
1998 21
1999 21
2000 25
2001 26
2002 27
2003 26
2004 20
2005 22
2006 16
2007 18
2008 18
2009 20
2010 20
2011 16
2012 18
2013 19
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2016 8
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2018 12
2019 3
2020 9
2021 4
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791 results
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Page 1
Isosorbide Mononitrate in Heart Failure with Preserved Ejection Fraction.
Redfield MM, Anstrom KJ, Levine JA, Koepp GA, Borlaug BA, Chen HH, LeWinter MM, Joseph SM, Shah SJ, Semigran MJ, Felker GM, Cole RT, Reeves GR, Tedford RJ, Tang WH, McNulty SE, Velazquez EJ, Shah MR, Braunwald E; NHLBI Heart Failure Clinical Research Network. Redfield MM, et al. N Engl J Med. 2015 Dec 10;373(24):2314-24. doi: 10.1056/NEJMoa1510774. Epub 2015 Nov 8. N Engl J Med. 2015. PMID: 26549714 Free PMC article. Clinical Trial.
BACKGROUND: Nitrates are commonly prescribed to enhance activity tolerance in patients with heart failure and a preserved ejection fraction. We compared the effect of isosorbide mononitrate or placebo on daily activity in such patients. ...During all dose regimens, …
BACKGROUND: Nitrates are commonly prescribed to enhance activity tolerance in patients with heart failure and a preserved ejection fraction. …
Long-acting isosorbide mononitrate.
Prakash A, Markham A. Prakash A, et al. Drugs. 1999 Jan;57(1):93-9; discussion 100. doi: 10.2165/00003495-199957010-00008. Drugs. 1999. PMID: 9951954 Review.
The antianginal effects of once-daily isosorbide mononitrate EL 50 to 100mg were generally similar to those of conventional isosorbide mononitrate or isosorbide dinitrate 10 to 20mg twice or 3 times daily, or sustained-release nifedipine 20mg tw …
The antianginal effects of once-daily isosorbide mononitrate EL 50 to 100mg were generally similar to those of conventional …
Comparative analysis of cost-effectiveness between isosorbide-5-mononitrate and isosorbide: a retrospective real-world evaluation.
Zhang G, Liu X, Xu J, Cheng G, Xu J. Zhang G, et al. J Comp Eff Res. 2020 Apr;9(6):405-412. doi: 10.2217/cer-2019-0099. Epub 2020 Apr 17. J Comp Eff Res. 2020. PMID: 32301331
Aim: The cost-effectiveness of isosorbide-5-mononitrate (5-ISMN) and isosorbide dinitrate (ISDN) in real-world use in patients with coronary heart disease (CHD; either angina pectoris or myocardial infarction) was retrospectively compared. ...Th …
Aim: The cost-effectiveness of isosorbide-5-mononitrate (5-ISMN) and isosorbide dinitrate (ISDN) in real- …
Intravaginal administration of isosorbide mononitrate for cervical ripening in prolonged pregnancy: a randomised clinical trial.
Mirteimouri M, Pourali L, Najaf Najafi M, Ghaffarian Omid M. Mirteimouri M, et al. J Obstet Gynaecol. 2020 Aug;40(6):792-796. doi: 10.1080/01443615.2019.1669546. Epub 2019 Dec 18. J Obstet Gynaecol. 2020. PMID: 31852287 Clinical Trial.
This study was performed to evaluate the efficacy of intravaginal isosorbide mononitrate (IMN) for cervical ripening in prolonged pregnancies. 122 pregnant women were recruited. ...According to results of the current study; using isosorbide mononitrate
This study was performed to evaluate the efficacy of intravaginal isosorbide mononitrate (IMN) for cervical ripening in prolon …
Pharmacokinetics of isosorbide mononitrate.
Abshagen UW. Abshagen UW. Am J Cardiol. 1992 Nov 27;70(17):61G-66G. doi: 10.1016/0002-9149(92)90028-w. Am J Cardiol. 1992. PMID: 1449102 Review.
Pharmacokinetic studies show that isosorbide mononitrate is rapidly absorbed after oral administration, reaches peak concentrations within an hour, undergoes no significant first-pass metabolism, and is virtually 100% bioavailable. ...Only 1-2% of an orally administ …
Pharmacokinetic studies show that isosorbide mononitrate is rapidly absorbed after oral administration, reaches peak concentra …
Isosorbide mononitrate versus alendronate for postmenopausal osteoporosis.
Nabhan AF, Rabie NH. Nabhan AF, et al. Int J Gynaecol Obstet. 2008 Dec;103(3):213-6. doi: 10.1016/j.ijgo.2008.07.011. Epub 2008 Sep 21. Int J Gynaecol Obstet. 2008. PMID: 18805524 Clinical Trial.
OBJECTIVE: To compare the effectiveness, safety, and affordability of isosorbide mononitrate with alendronate for postmenopausal osteoporosis. ...A 10.8% and 12.1% change in BMD after 12 months was seen for isosorbide mononitrate and alendronate, respe …
OBJECTIVE: To compare the effectiveness, safety, and affordability of isosorbide mononitrate with alendronate for postmenopaus …
Pharmacokinetics of isosorbide dinitrate and isosorbide-5-mononitrate.
Schaumann W. Schaumann W. Int J Clin Pharmacol Ther Toxicol. 1989 Sep;27(9):445-53. Int J Clin Pharmacol Ther Toxicol. 1989. PMID: 2681004 Review.
Among many organic nitrates developed for this purpose, ISDN became the most prominent. ISDN is metabolized to isosorbide-2-mononitrate (IS-2-MN) and isosorbide-5-mononitrate (IS-5-MN) which are pharmacologically active. ...After oral adm …
Among many organic nitrates developed for this purpose, ISDN became the most prominent. ISDN is metabolized to isosorbide-2-mononi
Isosorbide 5-mononitrate kinetics.
Major RM, Taylor T, Chasseaud LF, Darragh A, Lambe RF. Major RM, et al. Clin Pharmacol Ther. 1984 May;35(5):653-9. doi: 10.1038/clpt.1984.90. Clin Pharmacol Ther. 1984. PMID: 6713775
The kinetics of isosorbide 5-mononitrate (5-ISMN) were studied in 12 healthy subjects after intravenous infusion and oral doses of 20 mg. ...At the end of intravenous infusion of 5-ISMN at a rate of 8 mg/hr for 2.5 hr, mean plasma drug co …
The kinetics of isosorbide 5-mononitrate (5-ISMN) were studied in 12 healthy subjects after intravenous infusion …
Isosorbide 5-mononitrate: a review of a sustained-release formulation (Imdur) in stable angina pectoris.
Gunasekara NS, Noble S. Gunasekara NS, et al. Drugs. 1999 Feb;57(2):261-77. doi: 10.2165/00003495-199957020-00016. Drugs. 1999. PMID: 10188765 Review.
Imdur (IMD) is a sustained-release isosorbide 5-mononitrate preparation for the treatment of chronic stable angina pectoris. ...Preliminary data show that IMD 60 mg once daily has similar efficacy to diltiazem 60 mg 3 times daily and is at least as effective …
Imdur (IMD) is a sustained-release isosorbide 5-mononitrate preparation for the treatment of chronic stable angina pect …
791 results