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Page 1
Long-acting isosorbide mononitrate.
Prakash A, Markham A. Prakash A, et al. Drugs. 1999 Jan;57(1):93-9; discussion 100. doi: 10.2165/00003495-199957010-00008. Drugs. 1999. PMID: 9951954 Review.
The antianginal effects of once-daily isosorbide mononitrate EL 50 to 100mg were generally similar to those of conventional isosorbide mononitrate or isosorbide dinitrate 10 to 20mg twice or 3 times daily, or sustained-release nifedipine 20mg twice or …
The antianginal effects of once-daily isosorbide mononitrate EL 50 to 100mg were generally similar to those of conventional …
Pharmacokinetics of isosorbide dinitrate and isosorbide-5-mononitrate.
Schaumann W. Schaumann W. Int J Clin Pharmacol Ther Toxicol. 1989 Sep;27(9):445-53. Int J Clin Pharmacol Ther Toxicol. 1989. PMID: 2681004 Review.
ISDN is metabolized to isosorbide-2-mononitrate (IS-2-MN) and isosorbide-5-mononitrate (IS-5-MN) which are pharmacologically active. Since denitration is practically the only way of elimination, the denitration rate of the compounds is proportional to their t …
ISDN is metabolized to isosorbide-2-mononitrate (IS-2-MN) and isosorbide-5-mononitrate (IS-5-MN) which are pharmacologi …
Nitrates: why and how should they be used today? Current status of the clinical usefulness of nitroglycerin, isosorbide dinitrate and isosorbide-5-mononitrate.
Silber S. Silber S. Eur J Clin Pharmacol. 1990;38 Suppl 1:S35-51. doi: 10.1007/BF01417564. Eur J Clin Pharmacol. 1990. PMID: 2113003 Review.
Many studies with oral dosing of isosorbide dinitrate or isosorbide-5-mononitrate at least three times daily have proven nitrate tolerance in patients with coronary artery disease and/or congestive heart failure. ...The prolonged duration of action of once-da …
Many studies with oral dosing of isosorbide dinitrate or isosorbide-5-mononitrate at least three times daily have prove …
Vericiguat in combination with isosorbide mononitrate in patients with chronic coronary syndromes: The randomized, phase Ib, VISOR study.
Boettcher M, Mikus G, Trenk D, Düngen HD, Donath F, Werner N, Karakas M, Besche N, Schulz-Burck D, Gerrits M, Hung J, Becker C. Boettcher M, et al. Clin Transl Sci. 2022 May;15(5):1204-1214. doi: 10.1111/cts.13238. Epub 2022 Mar 17. Clin Transl Sci. 2022. PMID: 35299288 Free PMC article. Clinical Trial.
This study evaluated safety, tolerability, and the pharmacodynamic (PD) interaction between co-administered vericiguat and isosorbide mononitrate in patients with CCS. ...Concomitant use of vericiguat with isosorbide mononitrate is unlikely to c …
This study evaluated safety, tolerability, and the pharmacodynamic (PD) interaction between co-administered vericiguat and isosorb …
Pharmacokinetics of isosorbide mononitrate.
Abshagen UW. Abshagen UW. Am J Cardiol. 1992 Nov 27;70(17):61G-66G. doi: 10.1016/0002-9149(92)90028-w. Am J Cardiol. 1992. PMID: 1449102 Review.
Pharmacokinetic studies show that isosorbide mononitrate is rapidly absorbed after oral administration, reaches peak concentrations within an hour, undergoes no significant first-pass metabolism, and is virtually 100% bioavailable. ...An asymmetrical dosage regimen …
Pharmacokinetic studies show that isosorbide mononitrate is rapidly absorbed after oral administration, reaches peak concentra …
Isosorbide 5-mononitrate kinetics.
Major RM, Taylor T, Chasseaud LF, Darragh A, Lambe RF. Major RM, et al. Clin Pharmacol Ther. 1984 May;35(5):653-9. doi: 10.1038/clpt.1984.90. Clin Pharmacol Ther. 1984. PMID: 6713775
The kinetics of isosorbide 5-mononitrate (5-ISMN) were studied in 12 healthy subjects after intravenous infusion and oral doses of 20 mg. ...
The kinetics of isosorbide 5-mononitrate (5-ISMN) were studied in 12 healthy subjects after intravenous infusion and or …
Isosorbide mononitrate for cervical ripening during labour induction: A systematic review and meta-analysis of 23 randomized controlled trials.
Abu-Zaid A, Alshahrani MS, Al-Matary A, Khadawardi K, Miski NT, Abuzaid M, Alrasheed MA, Baradwan A, Salem A, Salem R, Albadawi MI, Jamjoom MZ, Almubarki AA, Abdulmalik NA, Almugbel M, Tulbah M, Baradwan S, Alomar O. Abu-Zaid A, et al. Eur J Obstet Gynecol Reprod Biol. 2022 Sep;276:38-46. doi: 10.1016/j.ejogrb.2022.06.028. Epub 2022 Jul 3. Eur J Obstet Gynecol Reprod Biol. 2022. PMID: 35803111 Review.
OBJECTIVE: To conduct a systematic review and meta-analysis of all randomized controlled trials (RCTs) that evaluated the efficacy and safety of isosorbide mononitrate (IMN) in promoting cervical ripening during labour induction. METHODS: Six major databases were se …
OBJECTIVE: To conduct a systematic review and meta-analysis of all randomized controlled trials (RCTs) that evaluated the efficacy and safet …
Isosorbide Mononitrate Versus Dinoprostone for Cervical Ripening During Labor Induction: a Systematic Review and Meta-analysis of Randomized Controlled Trials.
Abu-Zaid A, Khadawardi K, Al-Matary A, Alshahrani MS, Miski NT, Abuzaid M, Khalifa M, Almugbel M, Tulbah M, Baradwan S. Abu-Zaid A, et al. Reprod Sci. 2023 Feb;30(2):380-389. doi: 10.1007/s43032-022-00909-y. Epub 2022 Apr 19. Reprod Sci. 2023. PMID: 35441336 Review.
The objective of this study was to conduct a systematic review and meta-analysis of all randomized controlled trials (RCTs) that evaluated isosorbide mononitrate (ISMN) versus dinoprostone, a prostaglandin E2 (PGE2) analogue, in promoting cervical ripening during la …
The objective of this study was to conduct a systematic review and meta-analysis of all randomized controlled trials (RCTs) that evaluated …
Isosorbide Mononitrate in Heart Failure with Preserved Ejection Fraction.
Redfield MM, Anstrom KJ, Levine JA, Koepp GA, Borlaug BA, Chen HH, LeWinter MM, Joseph SM, Shah SJ, Semigran MJ, Felker GM, Cole RT, Reeves GR, Tedford RJ, Tang WH, McNulty SE, Velazquez EJ, Shah MR, Braunwald E; NHLBI Heart Failure Clinical Research Network. Redfield MM, et al. N Engl J Med. 2015 Dec 10;373(24):2314-24. doi: 10.1056/NEJMoa1510774. Epub 2015 Nov 8. N Engl J Med. 2015. PMID: 26549714 Free PMC article. Clinical Trial.
BACKGROUND: Nitrates are commonly prescribed to enhance activity tolerance in patients with heart failure and a preserved ejection fraction. We compared the effect of isosorbide mononitrate or placebo on daily activity in such patients. METHODS: In this multicenter, …
BACKGROUND: Nitrates are commonly prescribed to enhance activity tolerance in patients with heart failure and a preserved ejection fraction. …
821 results