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1981 7
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401 results

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Page 1
Isosorbide Mononitrate and Cilostazol Treatment in Patients With Symptomatic Cerebral Small Vessel Disease: The Lacunar Intervention Trial-2 (LACI-2) Randomized Clinical Trial.
Wardlaw JM, Woodhouse LJ, Mhlanga II, Oatey K, Heye AK, Bamford J, Cvoro V, Doubal FN, England T, Hassan A, Montgomery A, O'Brien JT, Roffe C, Sprigg N, Werring DJ, Bath PM; Lacunar Intervention Trial-2 (LACI-2) Investigator Group. Wardlaw JM, et al. JAMA Neurol. 2023 Jul 1;80(7):682-692. doi: 10.1001/jamaneurol.2023.1526. JAMA Neurol. 2023. PMID: 37222252 Free PMC article. Clinical Trial.
OBJECTIVE: To test the feasibility, drug tolerability, safety, and effects of 1-year isosorbide mononitrate (ISMN) and cilostazol treatment on vascular, functional, and cognitive outcomes in patients with lacunar stroke. ...Compared with those participants not recei …
OBJECTIVE: To test the feasibility, drug tolerability, safety, and effects of 1-year isosorbide mononitrate (ISMN) and cilosta …
Effects of Cilostazol and Isosorbide Mononitrate on Cerebral Hemodynamics in the LACI-1 Randomized Controlled Trial.
Blair GW, Janssen E, Stringer MS, Thrippleton MJ, Chappell F, Shi Y, Hamilton I, Flaherty K, Appleton JP, Doubal FN, Bath PM, Wardlaw JM. Blair GW, et al. Stroke. 2022 Jan;53(1):29-33. doi: 10.1161/STROKEAHA.121.034866. Epub 2021 Dec 1. Stroke. 2022. PMID: 34847709 Free PMC article. Clinical Trial.
BACKGROUND AND PURPOSE: Cerebral small vessel disease-a major cause of stroke and dementia-is associated with cerebrovascular dysfunction. We investigated whether short-term isosorbide mononitrate (ISMN) and cilostazol, alone or in combination, improved magnetic res …
BACKGROUND AND PURPOSE: Cerebral small vessel disease-a major cause of stroke and dementia-is associated with cerebrovascular dysfunction. W …
Cilostazol and isosorbide mononitrate for the prevention of progression of cerebral small vessel disease: baseline data and statistical analysis plan for the Lacunar Intervention Trial-2 (LACI-2) (ISRCTN14911850).
Bath PM, Mhlanga I, Woodhouse LJ, Doubal F, Oatey K, Montgomery AA, Wardlaw JM; LACI-2 Trial Investigators. Bath PM, et al. Stroke Vasc Neurol. 2023 Apr;8(2):134-143. doi: 10.1136/svn-2022-001816. Epub 2022 Sep 2. Stroke Vasc Neurol. 2023. PMID: 36219567 Free PMC article. Clinical Trial.
METHODS: The LACunar Intervention Trial-2 is an investigator-initiated prospective randomised open-label blinded-endpoint phase II feasibility study assessing cilostazol and isosorbide mononitrate for preventing SVD progression. We aimed to recruit 400 patients with …
METHODS: The LACunar Intervention Trial-2 is an investigator-initiated prospective randomised open-label blinded-endpoint phase II feasibili …
Long-acting cilostazol versus isosorbide mononitrate for patients with vasospastic angina: a randomized controlled trial.
Kang MG, Ahn JH, Hwang JY, Hwang SJ, Koh JS, Park Y, Bae JS, Chun KJ, Kim JS, Kim JH, Chon MK. Kang MG, et al. Coron Artery Dis. 2024 Sep 1;35(6):459-464. doi: 10.1097/MCA.0000000000001366. Epub 2024 Apr 9. Coron Artery Dis. 2024. PMID: 38595079 Clinical Trial.
We conducted a randomized, open-label, controlled trial to compare the efficacy and safety of long-acting cilostazol and isosorbide mononitrate (ISMN) for VSA. METHODS: The study included patients with confirmed VSA between September 2019 and May 2021. ...
We conducted a randomized, open-label, controlled trial to compare the efficacy and safety of long-acting cilostazol and isosorbide …
Intravaginal administration of isosorbide mononitrate for cervical ripening in prolonged pregnancy: a randomised clinical trial.
Mirteimouri M, Pourali L, Najaf Najafi M, Ghaffarian Omid M. Mirteimouri M, et al. J Obstet Gynaecol. 2020 Aug;40(6):792-796. doi: 10.1080/01443615.2019.1669546. Epub 2019 Dec 18. J Obstet Gynaecol. 2020. PMID: 31852287 Free article. Clinical Trial.
This study was performed to evaluate the efficacy of intravaginal isosorbide mononitrate (IMN) for cervical ripening in prolonged pregnancies. 122 pregnant women were recruited. ...According to results of the current study; using isosorbide mononitrate …
This study was performed to evaluate the efficacy of intravaginal isosorbide mononitrate (IMN) for cervical ripening in prolon …
Oral misoprostol and vaginal isosorbide mononitrate for labor induction: a randomized controlled trial.
Collingham JP, Fuh KC, Caughey AB, Pullen KM, Lyell DJ, El-Sayed YY. Collingham JP, et al. Obstet Gynecol. 2010 Jul;116(1):121-126. doi: 10.1097/AOG.0b013e3181e408f2. Obstet Gynecol. 2010. PMID: 20567177 Clinical Trial.
OBJECTIVE: To estimate whether vaginal isosorbide mononitrate, added to oral misoprostol for cervical ripening and labor induction, shortens time to vaginal delivery. ...Seventy-eight women received misoprostol, and 78 received misoprostol with isosorbide …
OBJECTIVE: To estimate whether vaginal isosorbide mononitrate, added to oral misoprostol for cervical ripening and labor induc …
Mononitrate Isosorbide as an Adjunctive Therapy in Schizophrenia: A Randomized Controlled Crossover Trial.
Guimarães TM, Guimarães MRC, Oliveira ÍAF, Leoni RF, Santos AC, Dursun SM, Crippa JAS, Bressan RA, Machado-de-Sousa JP, Lacerda ALT, Hallak JEC. Guimarães TM, et al. J Clin Psychopharmacol. 2021 May-Jun 01;41(3):260-266. doi: 10.1097/JCP.0000000000001388. J Clin Psychopharmacol. 2021. PMID: 33857028 Clinical Trial.
The aim of this study was to test the efficacy of isosorbide mononitrate (ISMN) as an adjunctive therapy for symptomatic outpatients with schizophrenia. ...CONCLUSIONS: Schizophrenia patients with persistent symptoms showed significant improvement after 4 weeks of t …
The aim of this study was to test the efficacy of isosorbide mononitrate (ISMN) as an adjunctive therapy for symptomatic outpa …
Isosorbide mononitrate increases bone formation and decreases bone resorption in postmenopausal women: a randomized trial.
Jamal SA, Cummings SR, Hawker GA. Jamal SA, et al. J Bone Miner Res. 2004 Sep;19(9):1512-7. doi: 10.1359/JBMR.040716. Epub 2004 Jul 26. J Bone Miner Res. 2004. PMID: 15312252 Free article. Clinical Trial.
MATERIALS AND METHODS: We randomly assigned 144 healthy postmenopausal women with a hip BMD T score between 0 and -2.5 to 5 or 20 mg/day of isosorbide mononitrate (ISMO) or placebo for 12 weeks. We measured urine N-telopeptide (NTx), a marker of bone resorption, and …
MATERIALS AND METHODS: We randomly assigned 144 healthy postmenopausal women with a hip BMD T score between 0 and -2.5 to 5 or 20 mg/day of …
Comparison of the efficacy of isosorbide mononitrate and doxazosin in the treatment of lower urinary tract symptoms and benign prostatic hyperplasia: a randomized clinical trial.
Tarhan F, Çelik O, Tosun Ç, Faydacı G, Eryıldırım B. Tarhan F, et al. Urol Int. 2014;93(1):17-21. doi: 10.1159/000357034. Epub 2014 Mar 13. Urol Int. 2014. PMID: 24643055 Clinical Trial.
OBJECTIVE: We aimed to compare the efficacy of isosorbide mononitrate and doxazosin in the treatment of lower urinary tract symptoms (LUTS). ...All patients were evaluated with uroflowmetry, post-void residual (PVR) urine, prostate volume, International Prostate Sym …
OBJECTIVE: We aimed to compare the efficacy of isosorbide mononitrate and doxazosin in the treatment of lower urinary tract sy …
Preventing cognitive decline and dementia from cerebral small vessel disease: The LACI-1 Trial. Protocol and statistical analysis plan of a phase IIa dose escalation trial testing tolerability, safety and effect on intermediary endpoints of isosorbide mononitrate and cilostazol, separately and in combination.
Blair GW, Appleton JP, Law ZK, Doubal F, Flaherty K, Dooley R, Shuler K, Richardson C, Hamilton I, Shi Y, Stringer M, Boyd J, Thrippleton MJ, Sprigg N, Bath PM, Wardlaw JM. Blair GW, et al. Int J Stroke. 2018 Jul;13(5):530-538. doi: 10.1177/1747493017731947. Epub 2017 Sep 14. Int J Stroke. 2018. PMID: 28906205 Clinical Trial.
Aim LACI-1 will assess the tolerability, safety, and efficacy, by dose, of isosorbide mononitrate and cilostazol, alone and in combination, in patients with ischemic lacunar stroke. ...Discussion This study will inform the design of a larger phase III trial of is …
Aim LACI-1 will assess the tolerability, safety, and efficacy, by dose, of isosorbide mononitrate and cilostazol, alone and in …
401 results