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Table representation of search results timeline featuring number of search results per year.

Year Number of Results
1965 1
1967 5
1968 11
1969 19
1970 56
1971 141
1972 166
1973 193
1974 194
1975 181
1976 154
1977 179
1978 188
1979 164
1980 178
1981 158
1982 186
1983 173
1984 210
1985 206
1986 220
1987 239
1988 229
1989 296
1990 333
1991 306
1992 264
1993 282
1994 316
1995 312
1996 298
1997 317
1998 314
1999 342
2000 391
2001 393
2002 401
2003 411
2004 453
2005 479
2006 472
2007 515
2008 563
2009 558
2010 647
2011 691
2012 803
2013 836
2014 932
2015 1066
2016 1033
2017 1137
2018 1216
2019 1283
2020 1498
2021 1625
2022 1616
2023 1782
2024 1455

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26,455 results

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Page 1
Mechanisms of ketamine action as an antidepressant.
Zanos P, Gould TD. Zanos P, et al. Mol Psychiatry. 2018 Apr;23(4):801-811. doi: 10.1038/mp.2017.255. Epub 2018 Mar 13. Mol Psychiatry. 2018. PMID: 29532791 Free PMC article. Review.
Recent preclinical research has focused on unraveling the molecular mechanisms underlying the antidepressant actions of ketamine in an effort to develop novel pharmacotherapies, which will mimic ketamine's antidepressant actions but lack its undesirable effec …
Recent preclinical research has focused on unraveling the molecular mechanisms underlying the antidepressant actions of ketamine in a …
Ketamine and Ketamine Metabolite Pharmacology: Insights into Therapeutic Mechanisms.
Zanos P, Moaddel R, Morris PJ, Riggs LM, Highland JN, Georgiou P, Pereira EFR, Albuquerque EX, Thomas CJ, Zarate CA Jr, Gould TD. Zanos P, et al. Pharmacol Rev. 2018 Jul;70(3):621-660. doi: 10.1124/pr.117.015198. Pharmacol Rev. 2018. PMID: 29945898 Free PMC article. Review.
Ketamine, a racemic mixture consisting of (S)- and (R)-ketamine, has been in clinical use since 1970. ...Dissociative, psychotomimetic, cognitive, and peripheral side effects associated with short-term or prolonged exposure, as well as recreational ketamine u …
Ketamine, a racemic mixture consisting of (S)- and (R)-ketamine, has been in clinical use since 1970. ...Dissociative, psychot …
Long-term safety of ketamine and esketamine in treatment of depression.
Nikayin S, Murphy E, Krystal JH, Wilkinson ST. Nikayin S, et al. Expert Opin Drug Saf. 2022 Jun;21(6):777-787. doi: 10.1080/14740338.2022.2066651. Epub 2022 Apr 19. Expert Opin Drug Saf. 2022. PMID: 35416105 Review.
INTRODUCTION: Ketamine can produce rapid-acting antidepressant effects. Esketamine (Spravato), the S-enantiomer of racemic ketamine, was approved by the FDA for treatment-resistant depression in 2019. Here we review what is known about the long-term safety of …
INTRODUCTION: Ketamine can produce rapid-acting antidepressant effects. Esketamine (Spravato), the S-enantiomer of racemic …
Pharmacotherapy: Ketamine and Esketamine.
Feeney A, Papakostas GI. Feeney A, et al. Psychiatr Clin North Am. 2023 Jun;46(2):277-290. doi: 10.1016/j.psc.2023.02.003. Epub 2023 Mar 10. Psychiatr Clin North Am. 2023. PMID: 37149345 Review.
Ketamine and esketamine have rapid-onset antidepressant effects and may be considered for the management of treatment-resistant depression. ...The long-term safety and efficacy of ketamine/esketamine as antidepressants require further study....
Ketamine and esketamine have rapid-onset antidepressant effects and may be considered for the management of treatment-resistan …
Ketamine for the treatment of addiction: Evidence and potential mechanisms.
Ivan Ezquerra-Romano I, Lawn W, Krupitsky E, Morgan CJA. Ivan Ezquerra-Romano I, et al. Neuropharmacology. 2018 Nov;142:72-82. doi: 10.1016/j.neuropharm.2018.01.017. Epub 2018 Jan 12. Neuropharmacology. 2018. PMID: 29339294 Review.
This review explores the preclinical and clinical research into ketamine's ability to treat addiction. Despite methodological limitations and the relative infancy of the field, results thus far are promising. ...However, further randomised controlled trials are urge …
This review explores the preclinical and clinical research into ketamine's ability to treat addiction. Despite methodological …
Comparative efficacy of racemic ketamine and esketamine for depression: A systematic review and meta-analysis.
Bahji A, Vazquez GH, Zarate CA Jr. Bahji A, et al. J Affect Disord. 2021 Jan 1;278:542-555. doi: 10.1016/j.jad.2020.09.071. Epub 2020 Sep 23. J Affect Disord. 2021. PMID: 33022440 Free PMC article. Review.
FINDINGS: 24 trials representing 1877 participants were pooled. Racemic ketamine relative to esketamine demonstrated greater overall response (RR = 3.01 vs. RR = 1.38) and remission rates (RR = 3.70 vs. RR = 1.47), as well as lower dropouts (RR = 0.76 vs. RR = 1.37) …
FINDINGS: 24 trials representing 1877 participants were pooled. Racemic ketamine relative to esketamine demonstrated greater o …
Ketamine use in current clinical practice.
Gao M, Rejaei D, Liu H. Gao M, et al. Acta Pharmacol Sin. 2016 Jul;37(7):865-72. doi: 10.1038/aps.2016.5. Epub 2016 Mar 28. Acta Pharmacol Sin. 2016. PMID: 27018176 Free PMC article. Review.
After nearly half a century on the market, ketamine still occupies a unique corner in the medical armamentarium of anesthesiologists or clinicians treating pain. ...Recently, new insights have been gained on ketamine's potential anti-depressive and antisuicid …
After nearly half a century on the market, ketamine still occupies a unique corner in the medical armamentarium of anesthesiologists …
Esketamine for treatment resistant depression.
Swainson J, Thomas RK, Archer S, Chrenek C, MacKay MA, Baker G, Dursun S, Klassen LJ, Chokka P, Demas ML. Swainson J, et al. Expert Rev Neurother. 2019 Oct;19(10):899-911. doi: 10.1080/14737175.2019.1640604. Epub 2019 Jul 16. Expert Rev Neurother. 2019. PMID: 31282772 Review.
Introduction: Treatment Resistant Depression (TRD) is a common and burdensome condition with poor outcomes and few treatment options. Esketamine is the S-enantiomer of ketamine and has recently been FDA approved in the United States for treating depression that has …
Introduction: Treatment Resistant Depression (TRD) is a common and burdensome condition with poor outcomes and few treatment options. Esk …
Ketamine: a versatile tool for anesthesia and analgesia.
Barrett W, Buxhoeveden M, Dhillon S. Barrett W, et al. Curr Opin Anaesthesiol. 2020 Oct;33(5):633-638. doi: 10.1097/ACO.0000000000000916. Curr Opin Anaesthesiol. 2020. PMID: 32826629 Review.
Ketamine's role in the ongoing opioid crisis has been of particular interest, with multiple studies evaluating its potential role in managing both acute and chronic pain conditions. ...Ongoing research is needed to further elucidate ketamine's effects …
Ketamine's role in the ongoing opioid crisis has been of particular interest, with multiple studies evaluating its potential r …
Ketamine applications beyond anesthesia - A literature review.
Nowacka A, Borczyk M. Nowacka A, et al. Eur J Pharmacol. 2019 Oct 5;860:172547. doi: 10.1016/j.ejphar.2019.172547. Epub 2019 Jul 23. Eur J Pharmacol. 2019. PMID: 31348905 Review.
Ketamine's clinical use began in the 1970s. Physicians benefited from its safety and ability to induce short-term anesthesia and analgesia. ...This review aims to discuss the well-known and new promising applications of ketamine....
Ketamine's clinical use began in the 1970s. Physicians benefited from its safety and ability to induce short-term anesthesia a …
26,455 results
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