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Table representation of search results timeline featuring number of search results per year.

Year Number of Results
1976 1
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1978 8
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1980 44
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1983 64
1984 59
1985 69
1986 74
1987 57
1988 68
1989 64
1990 70
1991 55
1992 60
1993 41
1994 44
1995 40
1996 37
1997 45
1998 38
1999 32
2000 42
2001 25
2002 27
2003 55
2004 30
2005 25
2006 25
2007 32
2008 32
2009 35
2010 37
2011 32
2012 28
2013 40
2014 24
2015 25
2016 34
2017 29
2018 23
2019 32
2020 34
2021 30
2022 24
2023 28
2024 33
2025 26
2026 18

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1,805 results

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Page 1
Ketotifen.
Govil YC, Misra PK. Govil YC, et al. Indian Pediatr. 1992 Jan;29(1):85-9. Indian Pediatr. 1992. PMID: 1601503 Review. No abstract available.
Ketotifen-induced nocturnal bruxism.
Italiano D, Bramanti P, Militi D, Mondello S, Calabro RS. Italiano D, et al. Eur J Pediatr. 2014 Dec;173(12):1585-6. doi: 10.1007/s00431-013-2138-9. Epub 2013 Aug 16. Eur J Pediatr. 2014. PMID: 23949121
Herein, we describe a 4-year-old child who experienced nocturnal bruxism during treatment for bronchospasm and rhinitis with the antihistamine ketotifen. Drug rechallenge was also performed. CONCLUSION: The present case adds useful information to our knowledge of bruxism. …
Herein, we describe a 4-year-old child who experienced nocturnal bruxism during treatment for bronchospasm and rhinitis with the antihistami …
Ketotifen directly modifies the fibrotic response of human skin fibroblasts.
Leong E, Al-Bitar H, Marshall JS, Bezuhly M. Leong E, et al. Sci Rep. 2024 Mar 25;14(1):7076. doi: 10.1038/s41598-024-57776-7. Sci Rep. 2024. PMID: 38528089 Free PMC article.
In the skin, it is associated with systemic sclerosis and scarring with considerable health burden. Ketotifen is a clinical antihistamine and mast cell stabilizer. Studies have demonstrated mast cell-dependent anti-fibrotic effects of ketotifen but direct effects on …
In the skin, it is associated with systemic sclerosis and scarring with considerable health burden. Ketotifen is a clinical antihista …
Ketotifen is a Prodrug. Norketotifen is the active metabolite.
Aberg AKG, Arulnesan N, Bolger GT, Ciofalo VB, Pucaj K, Walle K, Walle T. Aberg AKG, et al. Drug Dev Res. 2022 Apr;83(2):362-367. doi: 10.1002/ddr.21865. Epub 2021 Aug 19. Drug Dev Res. 2022. PMID: 34410005
Evaluation of the in vitro human liver microsome and hepatocyte metabolism of ketotifen demonstrated that norketotifen (NK) is the major demethylated hepatic metabolite of ketotifen. ...Thus, when used as an anti-inflammatory drug, ketotifen is the sedating p …
Evaluation of the in vitro human liver microsome and hepatocyte metabolism of ketotifen demonstrated that norketotifen (NK) is the ma …
Ketotifen in asthma.
Dawson KP, Fergusson DM, Horwood LJ, Mogridge N. Dawson KP, et al. Aust Paediatr J. 1989 Apr;25(2):89-92. doi: 10.1111/j.1440-1754.1989.tb01423.x. Aust Paediatr J. 1989. PMID: 2660783 Clinical Trial.
Children receiving ketotifen showed significantly lower mean numbers of asthma attacks and less absence from school. ...In the second phase of study, additional therapy was withdrawn from both the ketotifen and placebo groups which resulted in a high (percentage) wi …
Children receiving ketotifen showed significantly lower mean numbers of asthma attacks and less absence from school. ...In the second …
An overview of ketotifen.
MacDonald GF. MacDonald GF. Chest. 1982 Jul;82(1 Suppl):30S-32S. doi: 10.1378/chest.82.1.30s. Chest. 1982. PMID: 6806019 No abstract available.
Ketotifen and chronic urticaria.
Taşkapan O, Harmanyeri Y. Taşkapan O, et al. Arch Dermatol. 1998 Feb;134(2):240-1. doi: 10.1001/archderm.134.2.240. Arch Dermatol. 1998. PMID: 9487221 No abstract available.
Enhancing nanomedicine efficacy in KPC pancreatic tumors through ketotifen-mediated tumor microenvironment remodeling.
Charalambous A, Mpekris F, Voutouri C, Neophytou C, Djamus J, Gupta A, Gabizon A, Stylianopoulos T. Charalambous A, et al. J Control Release. 2026 Feb 10;390:114541. doi: 10.1016/j.jconrel.2025.114541. Epub 2025 Dec 12. J Control Release. 2026. PMID: 41391724 Free PMC article.
These microenvironmental changes translated into greater anti-tumor efficacy and prolonged survival in groups that received a combination of ketotifen even at low doses. Cytokine analysis showed reduced IL-10 and an IFN-gamma increase in ketotifen combinations, sugg …
These microenvironmental changes translated into greater anti-tumor efficacy and prolonged survival in groups that received a combination of …
Ketotifen. A review of its pharmacodynamic and pharmacokinetic properties, and therapeutic use in asthma and allergic disorders.
Grant SM, Goa KL, Fitton A, Sorkin EM. Grant SM, et al. Drugs. 1990 Sep;40(3):412-48. doi: 10.2165/00003495-199040030-00006. Drugs. 1990. PMID: 2226222 Review.
Ketotifen is an orally active prophylactic agent for the management of bronchial asthma and allergic disorders. ...Patient acceptance of ketotifen is good, although sedation can be troublesome in older children and adults for the initial 2 weeks of treatment. ...
Ketotifen is an orally active prophylactic agent for the management of bronchial asthma and allergic disorders. ...Patient acceptance …
Ketotifen alone or as additional medication for long-term control of asthma and wheeze in children.
Schwarzer G, Bassler D, Mitra A, Ducharme FM, Forster J. Schwarzer G, et al. Cochrane Database Syst Rev. 2004;2004(1):CD001384. doi: 10.1002/14651858.CD001384.pub2. Cochrane Database Syst Rev. 2004. PMID: 14973969 Free PMC article.
BACKGROUND: Ketotifen is an antihistamine which may be used to treat asthma. Since administering inhaled therapy to younger children can be difficult, an oral agent such as ketotifen offers potential advantages. ...Reported side effects were more frequent in the …
BACKGROUND: Ketotifen is an antihistamine which may be used to treat asthma. Since administering inhaled therapy to younger children …
1,805 results