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Year Number of Results
1985 1
1986 1
1987 3
1989 2
1990 3
1991 3
1992 1
1993 6
1994 7
1995 7
1996 11
1997 19
1998 18
1999 33
2000 32
2001 21
2002 18
2003 27
2004 24
2005 30
2006 41
2007 38
2008 39
2009 29
2010 27
2011 18
2012 25
2013 21
2014 8
2015 19
2016 18
2017 18
2018 16
2019 9
2020 5
2021 7
2022 5
2023 9
2024 6
2025 8

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578 results

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Page 1
The SANAD II study of the effectiveness and cost-effectiveness of levetiracetam, zonisamide, or lamotrigine for newly diagnosed focal epilepsy: an open-label, non-inferiority, multicentre, phase 4, randomised controlled trial.
Marson A, Burnside G, Appleton R, Smith D, Leach JP, Sills G, Tudur-Smith C, Plumpton C, Hughes DA, Williamson P, Baker GA, Balabanova S, Taylor C, Brown R, Hindley D, Howell S, Maguire M, Mohanraj R, Smith PE; SANAD II collaborators. Marson A, et al. Lancet. 2021 Apr 10;397(10282):1363-1374. doi: 10.1016/S0140-6736(21)00247-6. Lancet. 2021. PMID: 33838757 Free PMC article. Clinical Trial.
Patients were randomly assigned to receive lamotrigine (n=330), levetiracetam (n=332), or zonisamide (n=328). The ITT analysis included all participants and the PP analysis included 324 participants randomly assigned to lamotrigine, 320 participants randomly assigne …
Patients were randomly assigned to receive lamotrigine (n=330), levetiracetam (n=332), or zonisamide (n=328). The ITT analysis includ …
The SANAD study of effectiveness of valproate, lamotrigine, or topiramate for generalised and unclassifiable epilepsy: an unblinded randomised controlled trial.
Marson AG, Al-Kharusi AM, Alwaidh M, Appleton R, Baker GA, Chadwick DW, Cramp C, Cockerell OC, Cooper PN, Doughty J, Eaton B, Gamble C, Goulding PJ, Howell SJ, Hughes A, Jackson M, Jacoby A, Kellett M, Lawson GR, Leach JP, Nicolaides P, Roberts R, Shackley P, Shen J, Smith DF, Smith PE, Smith CT, Vanoli A, Williamson PR; SANAD Study group. Marson AG, et al. Lancet. 2007 Mar 24;369(9566):1016-26. doi: 10.1016/S0140-6736(07)60461-9. Lancet. 2007. PMID: 17382828 Free PMC article. Clinical Trial.
Patients were randomly assigned to valproate, lamotrigine, or topiramate between Jan 12, 1999, and Aug 31, 2004, and follow-up data were obtained up to Jan 13, 2006. ...FINDINGS: For time to treatment failure, valproate was significantly better than topiramate (hazard rati …
Patients were randomly assigned to valproate, lamotrigine, or topiramate between Jan 12, 1999, and Aug 31, 2004, and follow-up data w …
Ethosuximide, valproic acid, and lamotrigine in childhood absence epilepsy.
Glauser TA, Cnaan A, Shinnar S, Hirtz DG, Dlugos D, Masur D, Clark PO, Capparelli EV, Adamson PC; Childhood Absence Epilepsy Study Group. Glauser TA, et al. N Engl J Med. 2010 Mar 4;362(9):790-9. doi: 10.1056/NEJMoa0902014. N Engl J Med. 2010. PMID: 20200383 Free PMC article. Clinical Trial.
RESULTS: The 453 children who were randomly assigned to treatment with ethosuximide (156), lamotrigine (149), or valproic acid (148) were similar with respect to their demographic characteristics. After 16 weeks of therapy, the freedom-from-failure rates for ethosuximide a …
RESULTS: The 453 children who were randomly assigned to treatment with ethosuximide (156), lamotrigine (149), or valproic acid (148) …
Lamotrigine versus levetiracetam or zonisamide for focal epilepsy and valproate versus levetiracetam for generalised and unclassified epilepsy: two SANAD II non-inferiority RCTs.
Marson AG, Burnside G, Appleton R, Smith D, Leach JP, Sills G, Tudur-Smith C, Plumpton CO, Hughes DA, Williamson PR, Baker G, Balabanova S, Taylor C, Brown R, Hindley D, Howell S, Maguire M, Mohanraj R, Smith PE. Marson AG, et al. Health Technol Assess. 2021 Dec;25(75):1-134. doi: 10.3310/hta25750. Health Technol Assess. 2021. PMID: 34931602 Free article. Clinical Trial.
Levetiracetam did not meet the criteria for non-inferiority (hazard ratio 1.329) in the primary intention-to-treat analysis of time to 12-month remission (hazard ratio vs. lamotrigine 1.18, 97.5% confidence interval 0.95 to 1.47), but zonisamide did meet the criteria (haza …
Levetiracetam did not meet the criteria for non-inferiority (hazard ratio 1.329) in the primary intention-to-treat analysis of time to 12-mo …
The Clinical Effectiveness and Cost-Effectiveness of Lamotrigine in Borderline Personality Disorder: A Randomized Placebo-Controlled Trial.
Crawford MJ, Sanatinia R, Barrett B, Cunningham G, Dale O, Ganguli P, Lawrence-Smith G, Leeson V, Lemonsky F, Lykomitrou G, Montgomery AA, Morriss R, Munjiza J, Paton C, Skorodzien I, Singh V, Tan W, Tyrer P, Reilly JG; LABILE study team. Crawford MJ, et al. Am J Psychiatry. 2018 Aug 1;175(8):756-764. doi: 10.1176/appi.ajp.2018.17091006. Epub 2018 Apr 6. Am J Psychiatry. 2018. PMID: 29621901 Free article. Clinical Trial.
OBJECTIVE: The authors examined whether lamotrigine is a clinically effective and cost-effective treatment for people with borderline personality disorder. ...CONCLUSIONS: The results suggest that treating people with borderline personality disorder with lamotrigine …
OBJECTIVE: The authors examined whether lamotrigine is a clinically effective and cost-effective treatment for people with borderline …
Bioequivalence Between Generic and Branded Lamotrigine in People With Epilepsy: The EQUIGEN Randomized Clinical Trial.
Berg M, Welty TE, Gidal BE, Diaz FJ, Krebill R, Szaflarski JP, Dworetzky BA, Pollard JR, Elder EJ Jr, Jiang W, Jiang X, Switzer RD, Privitera MD. Berg M, et al. JAMA Neurol. 2017 Aug 1;74(8):919-926. doi: 10.1001/jamaneurol.2017.0497. JAMA Neurol. 2017. PMID: 28654954 Free PMC article. Clinical Trial.
INTERVENTIONS: Participants received a single 25-mg dose of immediate-release lamotrigine at the start of each period, with the branded and the 2 most disparate generic products each studied twice. ...CONCLUSIONS AND RELEVANCE: This study provides evidence that the dispara …
INTERVENTIONS: Participants received a single 25-mg dose of immediate-release lamotrigine at the start of each period, with the brand …
Carbamazepine and lamotrigine in healthy volunteers: relevance to early tolerance and clinical trial dosage.
Hamilton MJ, Cohen AF, Yuen AW, Harkin N, Land G, Weatherley BC, Peck AW. Hamilton MJ, et al. Epilepsia. 1993 Jan-Feb;34(1):166-73. doi: 10.1111/j.1528-1157.1993.tb02393.x. Epilepsia. 1993. PMID: 8422853 Clinical Trial.
This study was conducted to examine the effects of acute doses of lamotrigine (LTG) and carbamazepine (CBZ) in healthy subjects and determine whether the low tendency to impairment with LTG observed in animals applied to humans. ...
This study was conducted to examine the effects of acute doses of lamotrigine (LTG) and carbamazepine (CBZ) in healthy subjects and d …
Biochemical and genetic predictors and correlates of response to lamotrigine and folic acid in bipolar depression: Analysis of the CEQUEL clinical trial.
Tunbridge EM, Attenburrow MJ, Gardiner A, Rendell JM, Hinds C, Goodwin GM, Harrison PJ, Geddes JR. Tunbridge EM, et al. Bipolar Disord. 2017 Sep;19(6):477-486. doi: 10.1111/bdi.12531. Epub 2017 Aug 20. Bipolar Disord. 2017. PMID: 28833962 Free PMC article. Clinical Trial.
OBJECTIVES: CEQUEL (Comparative Evaluation of QUEtiapine plus Lamotrigine combination versus quetiapine monotherapy [and folic acid versus placebo] in bipolar depression) was a double-blind, randomized, placebo-controlled, parallel group, 22 factorial trial that examined t …
OBJECTIVES: CEQUEL (Comparative Evaluation of QUEtiapine plus Lamotrigine combination versus quetiapine monotherapy [and folic acid v …
Comparative pre-emptive analgesic efficacy study of novel antiepileptic agents gabapentin, lamotrigine and topiramate in patients undergoing major surgeries at a tertiary care hospital: a randomized double blind clinical trial.
Bhosale UA, Yegnanarayan R, Gupta A, Shah P, Sardesai S. Bhosale UA, et al. J Basic Clin Physiol Pharmacol. 2017 Jan 1;28(1):59-66. doi: 10.1515/jbcpp-2016-0013. J Basic Clin Physiol Pharmacol. 2017. PMID: 27487492 Clinical Trial.
The present study is designed to study and compare the pre-emptive analgesic efficacy of lamotrigine, topiramate and gabapentin (as control) in postoperative pain control. METHODS: This randomized clinical trial included 90 patients of either sex, between 18 and 70 years u …
The present study is designed to study and compare the pre-emptive analgesic efficacy of lamotrigine, topiramate and gabapentin (as c …
Functional activity and connectivity signatures of ketamine and lamotrigine during negative emotional processing: a double-blind randomized controlled fMRI study.
Meiering MS, Weigner D, Gärtner M, Carstens L, Keicher C, Hertrampf R, Beckmann CF, Mennes M, Wunder A, Weigand A, Grimm S. Meiering MS, et al. Transl Psychiatry. 2024 Oct 14;14(1):436. doi: 10.1038/s41398-024-03120-6. Transl Psychiatry. 2024. PMID: 39402015 Free PMC article. Clinical Trial.
Interestingly, the effects of ketamine on brain measures are sensitive to modulation by pretreatment with lamotrigine, which inhibits glutamate release. Examining the antagonistic effects of ketamine and lamotrigine on glutamate transmission holds promise to identif …
Interestingly, the effects of ketamine on brain measures are sensitive to modulation by pretreatment with lamotrigine, which inhibits …
578 results