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Page 1
Therapy of ocular toxoplasmosis.
Rothova A, Buitenhuis HJ, Meenken C, Baarsma GS, Boen-Tan TN, de Jong PT, Schweitzer CM, Timmerman Z, de Vries J, Zaal MJ, et al. Rothova A, et al. Int Ophthalmol. 1989 Dec;13(6):415-9. doi: 10.1007/BF02306491. Int Ophthalmol. 1989. PMID: 2697708 Clinical Trial.
Patients with peripheral retinal lesions remained without systemic therapy (group 4, n = 32). Patients from group 1 received leucovorin 5 mg twice a week. No difference in the duration of inflammatory activity was observed between the treated and untreated patients or betw …
Patients with peripheral retinal lesions remained without systemic therapy (group 4, n = 32). Patients from group 1 received leucovorin …
A study for precision diagnosing and treatment strategies in difficult-to-treat AIDS cases and HIV-infected patients with highly fatal or highly disabling opportunistic infections.
Li Y, Zeng YM, Lu YQ, Qin YY, Chen YK. Li Y, et al. Medicine (Baltimore). 2020 May;99(20):e20146. doi: 10.1097/MD.0000000000020146. Medicine (Baltimore). 2020. PMID: 32443329 Free PMC article. Clinical Trial.
Several guidelines recommend the combination of pyrimethamine, sulfadiazine, and leucovorin as the preferred regimen for AIDS-associated toxoplasma encephalitis. However, it is not commonly used in China due to limited access to pyrimethamine and sulfadiazine …
Several guidelines recommend the combination of pyrimethamine, sulfadiazine, and leucovorin as the preferred regimen for AIDS- …
Primary prophylaxis with pyrimethamine for toxoplasmic encephalitis in patients with advanced human immunodeficiency virus disease: results of a randomized trial. Terry Beirn Community Programs for Clinical Research on AIDS.
Jacobson MA, Besch CL, Child C, Hafner R, Matts JP, Muth K, Wentworth DN, Neaton JD, Abrams D, Rimland D, et al. Jacobson MA, et al. J Infect Dis. 1994 Feb;169(2):384-94. doi: 10.1093/infdis/169.2.384. J Infect Dis. 1994. PMID: 8106772 Clinical Trial.
Pyrimethamine, 25 mg thrice weekly, was evaluated as primary prophylaxis for toxoplasmic encephalitis (TE) in a double-blind, randomized clinical trial in patients with human immunodeficiency virus (HIV) disease, absolute CD4 lymphocyte count of < 200/microL (or prior A …
Pyrimethamine, 25 mg thrice weekly, was evaluated as primary prophylaxis for toxoplasmic encephalitis (TE) in a double-blind, randomi …
Pyrimethamine for primary prophylaxis of toxoplasmic encephalitis in patients with human immunodeficiency virus infection: a double-blind, randomized trial. ANRS 005-ACTG 154 Group Members. Agence Nationale de Recherche sur le SIDA. AIDS Clinical Trial Group.
Leport C, Chêne G, Morlat P, Luft BJ, Rousseau F, Pueyo S, Hafner R, Miro J, Aubertin J, Salamon R, Vildé JL. Leport C, et al. J Infect Dis. 1996 Jan;173(1):91-7. doi: 10.1093/infdis/173.1.91. J Infect Dis. 1996. PMID: 8537688 Clinical Trial.

Rash was the only adverse event that appeared significantly more frequently in the pyrimethamine arm (7% vs. 1%). In the on-treatment analysis, the incidence of TE was lower in the pyrimethamine arm, 4%, than in the placebo arm, 12% (P < .006). Thus, pyrimetha

…
Rash was the only adverse event that appeared significantly more frequently in the pyrimethamine arm (7% vs. 1%). In the on-treatment …
Effectiveness of twice-weekly pyrimethamine-sulfadoxine as primary prophylaxis of Pneumocystis carinii pneumonia and toxoplasmic encephalitis in patients with advanced HIV infection.
Schürmann D, Bergmann F, Albrecht H, Padberg J, Wünsche T, Grünewald T, Schürmann M, Grobusch M, Vallée M, Ruf B, Suttorp N. Schürmann D, et al. Eur J Clin Microbiol Infect Dis. 2002 May;21(5):353-61. doi: 10.1007/s10096-002-0723-3. Epub 2002 May 18. Eur J Clin Microbiol Infect Dis. 2002. PMID: 12072919 Clinical Trial.
The safety and efficacy of a fixed 25 mg pyrimethamine-500 mg sulfadoxine combination supplemented with 15 mg folinic acid twice a week as primary prophylaxis of Pneumocystis carinii pneumonia (PCP) and toxoplasmic encephalitis was evaluated in 106 patients infected with t …
The safety and efficacy of a fixed 25 mg pyrimethamine-500 mg sulfadoxine combination supplemented with 15 mg folinic acid twice a we …
[Primary prophylaxis against cerebral toxoplasmosis. Efficacy of folinic acid in the prevention of hematologic toxicity of pyrimethamine].
Brossard G, Neau D, Barbeau P, Pellegrin JL, Leng B. Brossard G, et al. Presse Med. 1994 Apr 2;23(13):613-5. Presse Med. 1994. PMID: 8029191 Clinical Trial. French.
We evaluated the effect of adding folic acid to the standard treatment (including pyrimethamine) on preventing induced cytopenia in order to determine the optimal dose. METHODS: From January to September 1990, pyrimethamine (50 mg 3 times per week) was given as prim …
We evaluated the effect of adding folic acid to the standard treatment (including pyrimethamine) on preventing induced cytopenia in o …