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34 results

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Page 1
Efficacy and Safety of Dihydropyridine Calcium Channel Blockers for Primary Hypertension: A Bayesian Network Meta-analysis.
Wang H, Yang H, Zhang Z, Guo H. Wang H, et al. Curr Hypertens Rev. 2025;21(2):117-128. doi: 10.2174/0115734021357729250214090452. Curr Hypertens Rev. 2025. PMID: 39995131
Felodipine had the highest probability of reducing 24-h ambulatory blood pressure (80.65%). Regarding safety, levamlodipine had the least impact on heart rate (85.71%). In terms of AEs, benidipine had the highest rate for cardiovascular (86.58%) and digestive system (93.57 …
Felodipine had the highest probability of reducing 24-h ambulatory blood pressure (80.65%). Regarding safety, levamlodipine had the l …
Clinical assessment of levamlodipine besylate combination therapy for essential hypertension: A protocol for systematic review and meta-analysis.
Dai GY, Zhu YH. Dai GY, et al. Medicine (Baltimore). 2022 Apr 1;101(13):e29148. doi: 10.1097/MD.0000000000029148. Medicine (Baltimore). 2022. PMID: 35421067 Free PMC article.
The current study's aim is to investigate the effectiveness as well as safety of levamlodipine besylate combination therapy in treating essential hypertension at varying degrees of severity. ...RESULTS: The analysis will evaluate the efficiency and level of safeness of …
The current study's aim is to investigate the effectiveness as well as safety of levamlodipine besylate combination therapy in treati …
Effect of low-dose Levamlodipine Besylate in the treatment of vascular dementia.
Yao KX, Lyu H, Liao MH, Yang L, Gao YP, Liu QB, Wang CK, Lu YM, Jiang GJ, Han F, Wang P. Yao KX, et al. Sci Rep. 2019 Dec 3;9(1):18248. doi: 10.1038/s41598-019-47868-0. Sci Rep. 2019. PMID: 31796756 Free PMC article.
Oral administration of levamlodipine besylate (0.1 mg/kg) could reduce the latency to find the hidden platform in the MWM test as compared to the vehicle group. Furthermore, vehicle-treated mice revealed reduced phospho-CaMKII (Thr286) levels in the hippocampus, which can …
Oral administration of levamlodipine besylate (0.1 mg/kg) could reduce the latency to find the hidden platform in the MWM test as com …
Bioequivalence of levamlodipine besylate tablets in healthy Chinese subjects: a single-dose and two-period crossover randomized study.
Li X, Wang C, Li T, Liu Y, Liu S, Tao Y, Ma Y, Gao X, Cao Y. Li X, et al. BMC Pharmacol Toxicol. 2020 Nov 19;21(1):80. doi: 10.1186/s40360-020-00459-6. BMC Pharmacol Toxicol. 2020. PMID: 33213527 Free PMC article. Clinical Trial.
BACKGROUND: Levamlodipine, a calcium channel blocker, has been show act as a cardiovascular drug. To compare the pharmacokinetic parameters between levamlodipine (test formulation) at a single dose of 5 mg and amlodipine (reference formulation) at a single dose of 1 …
BACKGROUND: Levamlodipine, a calcium channel blocker, has been show act as a cardiovascular drug. To compare the pharmacokinetic para …
Effect of administration of low-dose irbesartan and hydrochlorothiazide combined with levamlodipine at different times on the circadian rhythm of blood pressure and the levels of MMPs and TIMPs in non-dipper patients with grade 1 and 2 hypertension.
Yan P, Luo Y, Zhang J, Liu H, Chen J, Wang J, Dong G, Ge M. Yan P, et al. J Clin Hypertens (Greenwich). 2023 Feb;25(2):137-145. doi: 10.1111/jch.14630. Epub 2023 Jan 14. J Clin Hypertens (Greenwich). 2023. PMID: 36639984 Free PMC article. Clinical Trial.
This study aimed to probe the effects of low-dose irbesartan and hydrochlorothiazide in combination with levamlodipine at different times on the circadian rhythm of blood pressure, matrix metalloproteinases (MMPs), and tissue inhibitors of metalloproteinases (TIMPs) levels …
This study aimed to probe the effects of low-dose irbesartan and hydrochlorothiazide in combination with levamlodipine at different t …
Model-Informed Precision Dosing of Levamlodipine Besylate in Smoking Patients.
Li G, Guan Y, Yang Y, Xiang Q, Chen S, Shao J, Chen Y, Yu X. Li G, et al. Drug Des Devel Ther. 2025 Apr 24;19:3193-3207. doi: 10.2147/DDDT.S501762. eCollection 2025. Drug Des Devel Ther. 2025. PMID: 40297316 Free PMC article.
METHODS: A prospective study (NCT05126381) enrolled 43 patients receiving levamlodipine monotherapy. Pop PK/PD model of levamlodipine besylate was established to investigate the effects of nicotine concentration, demographics (age, sex, height, weight, BMI), biochem …
METHODS: A prospective study (NCT05126381) enrolled 43 patients receiving levamlodipine monotherapy. Pop PK/PD model of levamlodip
Evaluation of levamlodipine benzenesulfonate compound I for embryo-fetal developmental toxicity in SD rats and genotoxicity.
Tian Y, Shi W, Liu F, Li H, Zhang T, Zhu Y. Tian Y, et al. Reprod Toxicol. 2024 Oct;129:108676. doi: 10.1016/j.reprotox.2024.108676. Epub 2024 Jul 31. Reprod Toxicol. 2024. PMID: 39094807
In the present study, the effects of levamlodipine benzenesulfonate on the development of fertile Sprague-Dawley (SD) rats, their embryos, and littermates were assessed using an embryo-fetal developmental toxicity test. ...Levamlodipine benzenesulfonate did not exhi …
In the present study, the effects of levamlodipine benzenesulfonate on the development of fertile Sprague-Dawley (SD) rats, their emb …
Affinity and specificity of levamlodipine-human serum albumin interactions: insights into its carrier function.
Liu Z, Zheng X, Yang X, Wang E, Wang J. Liu Z, et al. Biophys J. 2009 May 20;96(10):3917-25. doi: 10.1016/j.bpj.2008.12.3965. Biophys J. 2009. PMID: 19450464 Free PMC article.
To gain insight into the carrier function of HSA, the binding of levamlodipine with HSA has been investigated as a model system by a combined experimental and theoretical/computational approach. ...As indicated by the thermodynamic analysis, hydrophobic interaction is the …
To gain insight into the carrier function of HSA, the binding of levamlodipine with HSA has been investigated as a model system by a …
Sensitive and effective method with 96-well plate for determination of levamlodipine in human plasma using LC-MS/MS.
Dong L, Li K, Gao S, Wang W, Feng Y, Zhang J, Yang J, Dong W, Zhang W. Dong L, et al. Anal Biochem. 2024 Aug;691:115556. doi: 10.1016/j.ab.2024.115556. Epub 2024 May 3. Anal Biochem. 2024. PMID: 38705226
we developed an effective protein precipitation method for determination of levamlodipine in human plasma using LC-MS/MS. Sample extraction was carried out by using liquid-liquid extraction in 96-well plate format. ...This method was applied to a bioequivalence study of …
we developed an effective protein precipitation method for determination of levamlodipine in human plasma using LC-MS/MS. Sample extr …
Probing the interaction between levamlodipine and hemoglobin based on spectroscopic and molecular docking methods.
Xu L, Liu Z, Liao T, Tuo X. Xu L, et al. Spectrochim Acta A Mol Biomol Spectrosc. 2019 Dec 5;223:117306. doi: 10.1016/j.saa.2019.117306. Epub 2019 Jun 22. Spectrochim Acta A Mol Biomol Spectrosc. 2019. PMID: 31255862
In recent years, levamlodipine (LAML) has been widely used as a common drug for the treatment of hypertension. ...
In recent years, levamlodipine (LAML) has been widely used as a common drug for the treatment of hypertension. ...
34 results