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Table representation of search results timeline featuring number of search results per year.

Year Number of Results
1926 4
1927 2
1928 2
1929 1
1930 4
1931 2
1932 1
1933 2
1934 5
1935 3
1936 4
1937 2
1939 1
1940 1
1942 2
1943 1
1944 1
1945 16
1946 37
1947 31
1948 49
1949 45
1950 52
1951 106
1952 124
1953 165
1954 163
1955 186
1956 205
1957 204
1958 232
1959 260
1960 244
1961 261
1962 359
1963 481
1964 655
1965 482
1966 551
1967 576
1968 641
1969 708
1970 743
1971 759
1972 876
1973 950
1974 971
1975 940
1976 954
1977 1050
1978 1125
1979 1158
1980 1174
1981 1156
1982 1209
1983 1173
1984 1216
1985 1234
1986 1260
1987 1173
1988 1147
1989 1185
1990 1199
1991 1106
1992 1081
1993 1103
1994 1035
1995 956
1996 1000
1997 992
1998 931
1999 895
2000 919
2001 916
2002 888
2003 963
2004 987
2005 1088
2006 1065
2007 1113
2008 1116
2009 1155
2010 1181
2011 1136
2012 1160
2013 1310
2014 1254
2015 1295
2016 1330
2017 1370
2018 1355
2019 1386
2020 1532
2021 1632
2022 1515
2023 1421
2024 1120
2025 1

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65,635 results

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Page 1
Hypothyroidism.
Chaker L, Bianco AC, Jonklaas J, Peeters RP. Chaker L, et al. Lancet. 2017 Sep 23;390(10101):1550-1562. doi: 10.1016/S0140-6736(17)30703-1. Epub 2017 Mar 20. Lancet. 2017. PMID: 28336049 Free PMC article. Review.
The standard treatment is thyroid hormone replacement therapy with levothyroxine. However, a substantial proportion of patients who reach biochemical treatment targets have persistent complaints. ...
The standard treatment is thyroid hormone replacement therapy with levothyroxine. However, a substantial proportion of patients who r …
Primary hypothyroidism and quality of life.
Hegedüs L, Bianco AC, Jonklaas J, Pearce SH, Weetman AP, Perros P. Hegedüs L, et al. Nat Rev Endocrinol. 2022 Apr;18(4):230-242. doi: 10.1038/s41574-021-00625-8. Epub 2022 Jan 18. Nat Rev Endocrinol. 2022. PMID: 35042968 Free PMC article. Review.
In the 1970s, treatment with thyroid extract was superseded by levothyroxine, a synthetic L form of tetraiodothyronine. Since then, no major innovation has emerged for the treatment of hypothyroidism. ...However, neither studies combining levothyroxine and liothyron …
In the 1970s, treatment with thyroid extract was superseded by levothyroxine, a synthetic L form of tetraiodothyronine. Since then, n …
Levothyroxine for the Treatment of Subclinical Hypothyroidism and Cardiovascular Disease.
Sue LY, Leung AM. Sue LY, et al. Front Endocrinol (Lausanne). 2020 Oct 21;11:591588. doi: 10.3389/fendo.2020.591588. eCollection 2020. Front Endocrinol (Lausanne). 2020. PMID: 33193104 Free PMC article. Review.
In addition, evidence from multiple studies supports an association between subclinical hypothyroidism and cardiovascular disease. However, the use of levothyroxine in subclinical hypothyroidism to reduce cardiovascular disease risk is not clearly beneficial. Treatment wit …
In addition, evidence from multiple studies supports an association between subclinical hypothyroidism and cardiovascular disease. However, …
Optimal Thyroid Hormone Replacement.
Jonklaas J. Jonklaas J. Endocr Rev. 2022 Mar 9;43(2):366-404. doi: 10.1210/endrev/bnab031. Endocr Rev. 2022. PMID: 34543420 Free PMC article.
Hypothyroidism is a common endocrinopathy, and levothyroxine is frequently prescribed. Despite the basic tenets of initiating and adjusting levothyroxine being agreed on, there are many nuances and complexities to consistently maintaining euthyroidism. Understanding …
Hypothyroidism is a common endocrinopathy, and levothyroxine is frequently prescribed. Despite the basic tenets of initiating and adj …
Emerging Therapies in Hypothyroidism.
Bianco AC. Bianco AC. Annu Rev Med. 2024 Jan 29;75:307-319. doi: 10.1146/annurev-med-060622-101007. Epub 2023 Sep 22. Annu Rev Med. 2024. PMID: 37738506 Free PMC article. Review.
Levothyroxine (LT4) is effective for most patients with hypothyroidism. However, a minority of the patients remain symptomatic despite the normalization of serum thyrotropin levels. Randomized clinical trials including all types of patients with hypothyroidism revealed tha …
Levothyroxine (LT4) is effective for most patients with hypothyroidism. However, a minority of the patients remain symptomatic despit …
Evidence-Based Use of Levothyroxine/Liothyronine Combinations in Treating Hypothyroidism: A Consensus Document.
Jonklaas J, Bianco AC, Cappola AR, Celi FS, Fliers E, Heuer H, McAninch EA, Moeller LC, Nygaard B, Sawka AM, Watt T, Dayan CM. Jonklaas J, et al. Thyroid. 2021 Feb;31(2):156-182. doi: 10.1089/thy.2020.0720. Thyroid. 2021. PMID: 33276704 Free PMC article. Review.
Background: Fourteen clinical trials have not shown a consistent benefit of combination therapy with levothyroxine (LT4) and liothyronine (LT3). Despite the publication of these trials, combination therapy is widely used and patients reporting benefit continue to generate …
Background: Fourteen clinical trials have not shown a consistent benefit of combination therapy with levothyroxine (LT4) and liothyro …
Treatment of hypothyroidism in infants, children and adolescents.
Rodriguez L, Dinauer C, Francis G. Rodriguez L, et al. Trends Endocrinol Metab. 2022 Jul;33(7):522-532. doi: 10.1016/j.tem.2022.04.007. Epub 2022 May 7. Trends Endocrinol Metab. 2022. PMID: 35537910 Review.
In 2014, treatment guidelines from the American Thyroid Association reflected the general consensus that levothyroxine (LT4), adjusted to maintain a normal thyrotropin (TSH) level, is the preferred method for treatment of hypothyroidism. ...
In 2014, treatment guidelines from the American Thyroid Association reflected the general consensus that levothyroxine (LT4), adjuste …
Hypothyroidism: Diagnosis and Evidence-Based Treatment.
Davis MG, Phillippi JC. Davis MG, et al. J Midwifery Womens Health. 2022 May;67(3):394-397. doi: 10.1111/jmwh.13358. Epub 2022 Apr 5. J Midwifery Womens Health. 2022. PMID: 35384263
Diagnosis relies on simple-to-obtain, fairly inexpensive testing of thyroid-stimulating hormone (TSH) levels and confirmation with levels of thyroxine. Management of hypothyroidism usually involves monotherapy with levothyroxine taken on an empty stomach. There are …
Diagnosis relies on simple-to-obtain, fairly inexpensive testing of thyroid-stimulating hormone (TSH) levels and confirmation with levels of …
Management of Hypothyroidism and Hypothyroxinemia During Pregnancy.
Pearce EN. Pearce EN. Endocr Pract. 2022 Jul;28(7):711-718. doi: 10.1016/j.eprac.2022.05.004. Epub 2022 May 13. Endocr Pract. 2022. PMID: 35569735 Review.
Most women with pre-existing treated hypothyroidism require an increase in levothyroxine (LT4) dosing to maintain euthyroidism during gestation. LT4-treated pregnant patients need close monitoring of their serum TSH levels to avoid overtreatment or undertreatment. ...
Most women with pre-existing treated hypothyroidism require an increase in levothyroxine (LT4) dosing to maintain euthyroidism during …
[Levotyroxin].
Krátký J. Krátký J. Vnitr Lek. 2022 Winter;68(1):68-72. Vnitr Lek. 2022. PMID: 35459350 Czech.
Levothyroxine is a synthetic levoisomer of thyroxine. Currently, it is one of the most commonly prescribed drugs worldwide. ...Thyroxine is mainly a prohormone which is metabolized to the more active triiodothyronine. ...
Levothyroxine is a synthetic levoisomer of thyroxine. Currently, it is one of the most commonly prescribed drugs worldwide. .. …
65,635 results
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