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Table representation of search results timeline featuring number of search results per year.

Year Number of Results
1965 2
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1969 13
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1972 14
1973 6
1974 14
1975 13
1976 20
1977 12
1978 5
1979 21
1980 19
1981 15
1982 11
1983 9
1984 15
1985 16
1986 27
1987 20
1988 27
1989 21
1990 27
1991 32
1992 30
1993 42
1994 49
1995 69
1996 76
1997 68
1998 66
1999 59
2000 54
2001 56
2002 65
2003 85
2004 78
2005 81
2006 79
2007 73
2008 62
2009 72
2010 74
2011 59
2012 64
2013 62
2014 52
2015 54
2016 50
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2018 45
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2,192 results

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Page 1
Comparative Effectiveness of Levothyroxine, Desiccated Thyroid Extract, and Levothyroxine+Liothyronine in Hypothyroidism.
Shakir MKM, Brooks DI, McAninch EA, Fonseca TL, Mai VQ, Bianco AC, Hoang TD. Shakir MKM, et al. J Clin Endocrinol Metab. 2021 Oct 21;106(11):e4400-e4413. doi: 10.1210/clinem/dgab478. J Clin Endocrinol Metab. 2021. PMID: 34185829 Free PMC article. Clinical Trial.
INTRODUCTION: Studies comparing levothyroxine (LT4) therapy with LT4 + liothyronine (LT3) or desiccated thyroid extract (DTE) did not detect consistent superiority of either treatment. ...
INTRODUCTION: Studies comparing levothyroxine (LT4) therapy with LT4 + liothyronine (LT3) or desiccated thyroid extract (DTE) did not …
Thyroid Hormone Therapy for Older Adults with Subclinical Hypothyroidism.
Stott DJ, Rodondi N, Kearney PM, Ford I, Westendorp RGJ, Mooijaart SP, Sattar N, Aubert CE, Aujesky D, Bauer DC, Baumgartner C, Blum MR, Browne JP, Byrne S, Collet TH, Dekkers OM, den Elzen WPJ, Du Puy RS, Ellis G, Feller M, Floriani C, Hendry K, Hurley C, Jukema JW, Kean S, Kelly M, Krebs D, Langhorne P, McCarthy G, McCarthy V, McConnachie A, McDade M, Messow M, O'Flynn A, O'Riordan D, Poortvliet RKE, Quinn TJ, Russell A, Sinnott C, Smit JWA, Van Dorland HA, Walsh KA, Walsh EK, Watt T, Wilson R, Gussekloo J; TRUST Study Group. Stott DJ, et al. N Engl J Med. 2017 Jun 29;376(26):2534-2544. doi: 10.1056/NEJMoa1603825. Epub 2017 Apr 3. N Engl J Med. 2017. PMID: 28402245 Free article. Clinical Trial.
BACKGROUND: The use of levothyroxine to treat subclinical hypothyroidism is controversial. We aimed to determine whether levothyroxine provided clinical benefits in older persons with this condition. ...CONCLUSIONS: Levothyroxine provided no apparent benefits …
BACKGROUND: The use of levothyroxine to treat subclinical hypothyroidism is controversial. We aimed to determine whether levothyro …
Phase II Clinical Trial of Intravenous Levothyroxine to Mitigate Pharyngocutaneous Fistula in Euthyroid Patients Undergoing Salvage Laryngectomy.
Heft Neal ME, Haring CT, Bellile E, Jaffe CC, Shuman AG, Chinn SB, Stucken CL, Malloy KM, Casper KA, Prince MEP, Chepeha DB, Rosko AJ, Spector ME. Heft Neal ME, et al. Clin Cancer Res. 2024 Jul 15;30(14):2910-2916. doi: 10.1158/1078-0432.CCR-24-0782. Clin Cancer Res. 2024. PMID: 38723280 Clinical Trial.
There were no observed adverse events related to levothyroxine supplementation. CONCLUSIONS: Postoperative intravenous levothyroxine supplementation reduced rates of acute hypothyroidism, fistula formation, and fistula requiring reoperation in patients undergoing sa …
There were no observed adverse events related to levothyroxine supplementation. CONCLUSIONS: Postoperative intravenous levothyroxi …
Discontinuation of levothyroxine therapy in patients with subclinical hypothyroidism: a pilot randomized clinical trial.
Maraka S, Owen RR, Singh Ospina NM, Knox M, Dodds T, Thostenson JD, Dishongh K, Raciborski RA, Albashaireh A, Shah A, Syed S, Naqvi S, Motahari H, Thumma S, Toloza F, Ambrogini E, Brito JP. Maraka S, et al. Endocrine. 2025 Nov;90(2):781-792. doi: 10.1007/s12020-025-04371-z. Epub 2025 Jul 30. Endocrine. 2025. PMID: 40736623 Clinical Trial.
Adults with SCH on levothyroxine 75 mcg daily were randomized to continue levothyroxine or switch to placebo. ...The low occurrence of adverse events suggests that levothyroxine discontinuation may be well-tolerated. These findings support conducting a larger …
Adults with SCH on levothyroxine 75 mcg daily were randomized to continue levothyroxine or switch to placebo. ...The low occur …
Association between levothyroxine treatment for maternal subclinical hypothyroidism with negative TPOAb and early child neurodevelopment: A prospective real-world clinical trial.
Zhao Z, Zhou Q, Zhao H, Xiong Y, Li X. Zhao Z, et al. Acta Obstet Gynecol Scand. 2023 Sep;102(9):1183-1192. doi: 10.1111/aogs.14602. Epub 2023 Jul 13. Acta Obstet Gynecol Scand. 2023. PMID: 37443452 Free PMC article. Clinical Trial.
Compared to women in the SCH-TPOAb (+) group, those in the SCH-TPOAb (-) group had lower thyroid-stimulating hormone (TSH) levels at enrollment and 12-16(+6) gestational weeks, and unexpectedly higher TSH levels at 30-34(+6) gestational weeks and delivery, with a correspondingly …
Compared to women in the SCH-TPOAb (+) group, those in the SCH-TPOAb (-) group had lower thyroid-stimulating hormone (TSH) levels at enrollm …
A feasibility double-blind trial of levothyroxine vs. levothyroxine-liothyronine in postsurgical hypothyroidism.
Phan GQ, Yavuz S, Stamatouli AM, Madan R, Chen S, Grover AC, Nilubol N, Bedoya P, Trankle C, Markley R, Abbate A, Celi FS. Phan GQ, et al. Front Endocrinol (Lausanne). 2025 Mar 10;16:1522753. doi: 10.3389/fendo.2025.1522753. eCollection 2025. Front Endocrinol (Lausanne). 2025. PMID: 40130156 Free PMC article. Clinical Trial.
CONTEXT: Despite normalization of Thyrotropin (TSH), some patients with hypothyroidism treated with Levothyroxine (LT4) report residual symptoms which may be attributable to loss of endogenous triiodothyronine (T3). ...
CONTEXT: Despite normalization of Thyrotropin (TSH), some patients with hypothyroidism treated with Levothyroxine (LT4) report residu …
Effects of levothyroxine in subclinical hypothyroidism and heart failure with reduced ejection fraction: An open-label randomized trial.
Wang W, Zhang X, Gao J, Meng X, Wang J, Zhang K, Chen J, Qi J, Shao C, Tang YD. Wang W, et al. Cell Rep Med. 2024 Apr 16;5(4):101473. doi: 10.1016/j.xcrm.2024.101473. Epub 2024 Mar 26. Cell Rep Med. 2024. PMID: 38537636 Free PMC article. Clinical Trial.
We report a randomized, multicenter, open-label trial (ClinicalTrials.gov: NCT03096613) to investigate the clinical benefits of levothyroxine (L-T4) administration in subclinical hypothyroidism (SCH) patients with heart failure with reduced ejection fraction (HFrEF). ...
We report a randomized, multicenter, open-label trial (ClinicalTrials.gov: NCT03096613) to investigate the clinical benefits of levothyro …
Effect of Levothyroxine on Left Ventricular Ejection Fraction in Patients With Subclinical Hypothyroidism and Acute Myocardial Infarction: A Randomized Clinical Trial.
Jabbar A, Ingoe L, Junejo S, Carey P, Addison C, Thomas H, Parikh JD, Austin D, Hollingsworth KG, Stocken DD, Pearce SHS, Greenwood JP, Zaman A, Razvi S. Jabbar A, et al. JAMA. 2020 Jul 21;324(3):249-258. doi: 10.1001/jama.2020.9389. JAMA. 2020. PMID: 32692386 Free PMC article. Clinical Trial.
OBJECTIVE: To evaluate the effect of levothyroxine treatment on left ventricular function in patients with acute myocardial infarction and subclinical hypothyroidism. ...None of the 6 secondary outcomes showed a significant difference between the levothyroxine and p …
OBJECTIVE: To evaluate the effect of levothyroxine treatment on left ventricular function in patients with acute myocardial infarctio …
2,192 results