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Table representation of search results timeline featuring number of search results per year.

Year Number of Results
1965 2
1966 4
1967 7
1968 8
1969 13
1970 18
1971 15
1972 14
1973 6
1974 14
1975 13
1976 20
1977 12
1978 5
1979 21
1980 19
1981 15
1982 11
1983 9
1984 15
1985 16
1986 27
1987 20
1988 27
1989 21
1990 27
1991 32
1992 30
1993 42
1994 49
1995 69
1996 76
1997 68
1998 66
1999 59
2000 54
2001 56
2002 65
2003 85
2004 78
2005 81
2006 79
2007 73
2008 62
2009 72
2010 74
2011 59
2012 64
2013 62
2014 52
2015 54
2016 50
2017 52
2018 46
2019 49
2020 41
2021 41
2022 43
2023 14

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2,125 results

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Page 1
Effect of Levothyroxine on Miscarriage Among Women With Normal Thyroid Function and Thyroid Autoimmunity Undergoing In Vitro Fertilization and Embryo Transfer: A Randomized Clinical Trial.
Wang H, Gao H, Chi H, Zeng L, Xiao W, Wang Y, Li R, Liu P, Wang C, Tian Q, Zhou Z, Yang J, Liu Y, Wei R, Mol BWJ, Hong T, Qiao J. Wang H, et al. JAMA. 2017 Dec 12;318(22):2190-2198. doi: 10.1001/jama.2017.18249. JAMA. 2017. PMID: 29234808 Clinical Trial.
The women in the control group (n = 300) did not receive levothyroxine. All participants received the same IVF-ET and follow-up protocols. ...CONCLUSIONS AND RELEVANCE: Among women in China who had intact thyroid function and tested positive for antithyroperoxidase antibod …
The women in the control group (n = 300) did not receive levothyroxine. All participants received the same IVF-ET and follow-up proto …
Comparative Effectiveness of Levothyroxine, Desiccated Thyroid Extract, and Levothyroxine+Liothyronine in Hypothyroidism.
Shakir MKM, Brooks DI, McAninch EA, Fonseca TL, Mai VQ, Bianco AC, Hoang TD. Shakir MKM, et al. J Clin Endocrinol Metab. 2021 Oct 21;106(11):e4400-e4413. doi: 10.1210/clinem/dgab478. J Clin Endocrinol Metab. 2021. PMID: 34185829 Free PMC article. Clinical Trial.
INTRODUCTION: Studies comparing levothyroxine (LT4) therapy with LT4 + liothyronine (LT3) or desiccated thyroid extract (DTE) did not detect consistent superiority of either treatment. ...
INTRODUCTION: Studies comparing levothyroxine (LT4) therapy with LT4 + liothyronine (LT3) or desiccated thyroid extract (DTE) did not …
Treatment of Subclinical Hypothyroidism or Hypothyroxinemia in Pregnancy.
Casey BM, Thom EA, Peaceman AM, Varner MW, Sorokin Y, Hirtz DG, Reddy UM, Wapner RJ, Thorp JM Jr, Saade G, Tita AT, Rouse DJ, Sibai B, Iams JD, Mercer BM, Tolosa J, Caritis SN, VanDorsten JP; Eunice Kennedy Shriver National Institute of Child Health and Human Development Maternal–Fetal Medicine Units Network. Casey BM, et al. N Engl J Med. 2017 Mar 2;376(9):815-825. doi: 10.1056/NEJMoa1606205. N Engl J Med. 2017. PMID: 28249134 Free PMC article. Clinical Trial.
In separate trials for the two conditions, women were randomly assigned to receive levothyroxine or placebo. Thyroid function was assessed monthly, and the levothyroxine dose was adjusted to attain a normal thyrotropin or free T(4) level (depending on the trial), wi …
In separate trials for the two conditions, women were randomly assigned to receive levothyroxine or placebo. Thyroid function was ass …
Effect of Levothyroxine on Left Ventricular Ejection Fraction in Patients With Subclinical Hypothyroidism and Acute Myocardial Infarction: A Randomized Clinical Trial.
Jabbar A, Ingoe L, Junejo S, Carey P, Addison C, Thomas H, Parikh JD, Austin D, Hollingsworth KG, Stocken DD, Pearce SHS, Greenwood JP, Zaman A, Razvi S. Jabbar A, et al. JAMA. 2020 Jul 21;324(3):249-258. doi: 10.1001/jama.2020.9389. JAMA. 2020. PMID: 32692386 Clinical Trial.
The median serum thyrotropin level was 5.7 mU/L (interquartile range, 4.8-7.3 mU/L) and the mean (SD) free thyroxine level was 1.14 (0.16) ng/dL. The primary outcome measurements at 52 weeks were available in 85 patients (89.5%). ...None of the 6 secondary outcomes showed …
The median serum thyrotropin level was 5.7 mU/L (interquartile range, 4.8-7.3 mU/L) and the mean (SD) free thyroxine level was 1.14 ( …
Levothyroxine in euthyroid thyroid peroxidase antibody positive women with recurrent pregnancy loss (T4LIFE trial): a multicentre, randomised, double-blind, placebo-controlled, phase 3 trial.
van Dijk MM, Vissenberg R, Fliers E, van der Post JAM, van der Hoorn MP, de Weerd S, Kuchenbecker WK, Hoek A, Sikkema JM, Verhoeve HR, Broeze KA, de Koning CH, Verpoest W, Christiansen OB, Koks C, de Bruin JP, Papatsonis DNM, Torrance H, van Wely M, Bisschop PH, Goddijn M. van Dijk MM, et al. Lancet Diabetes Endocrinol. 2022 May;10(5):322-329. doi: 10.1016/S2213-8587(22)00045-6. Epub 2022 Mar 14. Lancet Diabetes Endocrinol. 2022. PMID: 35298917 Clinical Trial.
The daily dose of levothyroxine was based on preconception TSH concentration and ranged from 0.5-1.0 mug/kg bodyweight. ...Seven (7%) women in the levothyroxine group and seven (8%) in the placebo group reported adverse events, none of them were directly related to …
The daily dose of levothyroxine was based on preconception TSH concentration and ranged from 0.5-1.0 mug/kg bodyweight. ...Seven (7%) …
Effect of Levothyroxine Therapy on the Development of Depressive Symptoms in Older Adults With Subclinical Hypothyroidism: An Ancillary Study of a Randomized Clinical Trial.
Wildisen L, Feller M, Del Giovane C, Moutzouri E, Du Puy RS, Mooijaart SP, Collet TH, Poortvliet RKE, Kearney P, Quinn TJ, Klöppel S, Bauer DC, Peeters RP, Westendorp R, Aujesky D, Gussekloo J, Rodondi N. Wildisen L, et al. JAMA Netw Open. 2021 Feb 1;4(2):e2036645. doi: 10.1001/jamanetworkopen.2020.36645. JAMA Netw Open. 2021. PMID: 33566107 Free PMC article. Clinical Trial.
At baseline, the mean (SD) GDS-15 score was 1.26 (1.85) in the levothyroxine group and 0.96 (1.58) in the placebo group. The mean (SD) GDS-15 score at 12 months was 1.39 (2.13) in the levothyroxine and 1.07 (1.67) in the placebo group with an adjusted between-group …
At baseline, the mean (SD) GDS-15 score was 1.26 (1.85) in the levothyroxine group and 0.96 (1.58) in the placebo group. The mean (SD …
Thyroid Hormone Therapy for Older Adults with Subclinical Hypothyroidism.
Stott DJ, Rodondi N, Kearney PM, Ford I, Westendorp RGJ, Mooijaart SP, Sattar N, Aubert CE, Aujesky D, Bauer DC, Baumgartner C, Blum MR, Browne JP, Byrne S, Collet TH, Dekkers OM, den Elzen WPJ, Du Puy RS, Ellis G, Feller M, Floriani C, Hendry K, Hurley C, Jukema JW, Kean S, Kelly M, Krebs D, Langhorne P, McCarthy G, McCarthy V, McConnachie A, McDade M, Messow M, O'Flynn A, O'Riordan D, Poortvliet RKE, Quinn TJ, Russell A, Sinnott C, Smit JWA, Van Dorland HA, Walsh KA, Walsh EK, Watt T, Wilson R, Gussekloo J; TRUST Study Group. Stott DJ, et al. N Engl J Med. 2017 Jun 29;376(26):2534-2544. doi: 10.1056/NEJMoa1603825. Epub 2017 Apr 3. N Engl J Med. 2017. PMID: 28402245 Free article. Clinical Trial.
BACKGROUND: The use of levothyroxine to treat subclinical hypothyroidism is controversial. We aimed to determine whether levothyroxine provided clinical benefits in older persons with this condition. ...CONCLUSIONS: Levothyroxine provided no apparent benefits …
BACKGROUND: The use of levothyroxine to treat subclinical hypothyroidism is controversial. We aimed to determine whether levothyro …
Levothyroxine in Women with Thyroid Peroxidase Antibodies before Conception.
Dhillon-Smith RK, Middleton LJ, Sunner KK, Cheed V, Baker K, Farrell-Carver S, Bender-Atik R, Agrawal R, Bhatia K, Edi-Osagie E, Ghobara T, Gupta P, Jurkovic D, Khalaf Y, MacLean M, McCabe C, Mulbagal K, Nunes N, Overton C, Quenby S, Rai R, Raine-Fenning N, Robinson L, Ross J, Sizer A, Small R, Tan A, Underwood M, Kilby MD, Boelaert K, Daniels J, Thangaratinam S, Chan SY, Coomarasamy A. Dhillon-Smith RK, et al. N Engl J Med. 2019 Apr 4;380(14):1316-1325. doi: 10.1056/NEJMoa1812537. Epub 2019 Mar 23. N Engl J Med. 2019. PMID: 30907987 Clinical Trial.
We randomly assigned 952 women to receive either 50 mug once daily of levothyroxine (476 women) or placebo (476 women) before conception through the end of pregnancy. ...There were no significant between-group differences in other pregnancy outcomes, including pregnancy lo …
We randomly assigned 952 women to receive either 50 mug once daily of levothyroxine (476 women) or placebo (476 women) before concept …
Levothyroxine treatment for subclinical hypothyroidism improves the rate of live births in pregnant women with recurrent pregnancy loss: a randomized clinical trial.
Leng T, Li X, Zhang H. Leng T, et al. Gynecol Endocrinol. 2022 Jun;38(6):488-494. doi: 10.1080/09513590.2022.2063831. Epub 2022 Apr 15. Gynecol Endocrinol. 2022. PMID: 35426326 Clinical Trial.
Objective: This study aimed to assess whether the use of levothyroxine was beneficial in pregnant women with subclinical hypothyroidism (SCH) or women who were positive for thyroid peroxidase antibody (TPOAb(+)).Study design: This was a randomized clinical trial involving …
Objective: This study aimed to assess whether the use of levothyroxine was beneficial in pregnant women with subclinical hypothyroidi …
The Impact of Levothyroxine on Cardiac Function in Older Adults With Mild Subclinical Hypothyroidism: A Randomized Clinical Trial.
Gencer B, Moutzouri E, Blum MR, Feller M, Collet TH, Delgiovane C, da Costa BR, Buffle E, Monney P, Gabus V, Müller H, Sykiotis GP, Kearney P, Gussekloo J, Westendorp R, Stott DJ, Bauer DC, Rodondi N. Gencer B, et al. Am J Med. 2020 Jul;133(7):848-856.e5. doi: 10.1016/j.amjmed.2020.01.018. Epub 2020 Mar 12. Am J Med. 2020. PMID: 32171774 Free article. Clinical Trial.
BACKGROUND: Subclinical hypothyroidism has been associated with heart failure, but only small trials assessed whether treatment with levothyroxine has an impact on cardiac function. METHODS: In a randomized, double-blind, placebo-controlled, trial nested within the TRUST t …
BACKGROUND: Subclinical hypothyroidism has been associated with heart failure, but only small trials assessed whether treatment with levo …
2,125 results