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Table representation of search results timeline featuring number of search results per year.

Year Number of Results
1965 2
1966 4
1967 7
1968 8
1969 13
1970 18
1971 15
1972 14
1973 6
1974 14
1975 13
1976 20
1977 12
1978 5
1979 21
1980 19
1981 15
1982 11
1983 9
1984 15
1985 16
1986 27
1987 20
1988 27
1989 21
1990 27
1991 32
1992 30
1993 42
1994 49
1995 69
1996 76
1997 68
1998 66
1999 59
2000 54
2001 56
2002 65
2003 85
2004 78
2005 81
2006 79
2007 73
2008 62
2009 72
2010 74
2011 59
2012 64
2013 62
2014 52
2015 54
2016 50
2017 52
2018 46
2019 48
2020 39
2021 41
2022 42
2023 27
2024 5

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2,139 results

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Page 1
Comparative Effectiveness of Levothyroxine, Desiccated Thyroid Extract, and Levothyroxine+Liothyronine in Hypothyroidism.
Shakir MKM, Brooks DI, McAninch EA, Fonseca TL, Mai VQ, Bianco AC, Hoang TD. Shakir MKM, et al. J Clin Endocrinol Metab. 2021 Oct 21;106(11):e4400-e4413. doi: 10.1210/clinem/dgab478. J Clin Endocrinol Metab. 2021. PMID: 34185829 Free PMC article. Clinical Trial.
INTRODUCTION: Studies comparing levothyroxine (LT4) therapy with LT4 + liothyronine (LT3) or desiccated thyroid extract (DTE) did not detect consistent superiority of either treatment. ...
INTRODUCTION: Studies comparing levothyroxine (LT4) therapy with LT4 + liothyronine (LT3) or desiccated thyroid extract (DTE) did not …
Intravenous Levothyroxine for Unstable Brain-Dead Heart Donors.
Dhar R, Marklin GF, Klinkenberg WD, Wang J, Goss CW, Lele AV, Kensinger CD, Lange PA, Lebovitz DJ. Dhar R, et al. N Engl J Med. 2023 Nov 30;389(22):2029-2038. doi: 10.1056/NEJMoa2305969. N Engl J Med. 2023. PMID: 38048188 Clinical Trial.
RESULTS: Of the 852 brain-dead donors who underwent randomization, 838 were included in the primary analysis: 419 in the levothyroxine group and 419 in the saline group. Hearts were transplanted from 230 donors (54.9%) in the levothyroxine group and 223 (53.2%) in t …
RESULTS: Of the 852 brain-dead donors who underwent randomization, 838 were included in the primary analysis: 419 in the levothyroxine
Treatment of Subclinical Hypothyroidism or Hypothyroxinemia in Pregnancy.
Casey BM, Thom EA, Peaceman AM, Varner MW, Sorokin Y, Hirtz DG, Reddy UM, Wapner RJ, Thorp JM Jr, Saade G, Tita AT, Rouse DJ, Sibai B, Iams JD, Mercer BM, Tolosa J, Caritis SN, VanDorsten JP; Eunice Kennedy Shriver National Institute of Child Health and Human Development Maternal–Fetal Medicine Units Network. Casey BM, et al. N Engl J Med. 2017 Mar 2;376(9):815-825. doi: 10.1056/NEJMoa1606205. N Engl J Med. 2017. PMID: 28249134 Free PMC article. Clinical Trial.
In separate trials for the two conditions, women were randomly assigned to receive levothyroxine or placebo. Thyroid function was assessed monthly, and the levothyroxine dose was adjusted to attain a normal thyrotropin or free T(4) level (depending on the trial), wi …
In separate trials for the two conditions, women were randomly assigned to receive levothyroxine or placebo. Thyroid function was ass …
Effect of initial levothyroxine dose on neurodevelopmental and growth outcomes in children with congenital hypothyroidism.
Esposito A, Vigone MC, Polizzi M, Wasniewska MG, Cassio A, Mussa A, Gastaldi R, Di Mase R, Vincenzi G, Pozzi C, Peroni E, Bravaccio C, Capalbo D, Bruzzese D, Salerno M. Esposito A, et al. Front Endocrinol (Lausanne). 2022 Sep 5;13:923448. doi: 10.3389/fendo.2022.923448. eCollection 2022. Front Endocrinol (Lausanne). 2022. PMID: 36133316 Free PMC article. Clinical Trial.
OBJECTIVES: We designed a multicentre open prospective randomized trial to evaluate the risk-benefit profile of two different initial treatment schemes with levothyroxine (L-T4), 10-12.5 mug/kg/day vs 12.6-15 mug/kg/day, on growth and neurodevelopmental outcomes in childre …
OBJECTIVES: We designed a multicentre open prospective randomized trial to evaluate the risk-benefit profile of two different initial treatm …
Levothyroxine in euthyroid thyroid peroxidase antibody positive women with recurrent pregnancy loss (T4LIFE trial): a multicentre, randomised, double-blind, placebo-controlled, phase 3 trial.
van Dijk MM, Vissenberg R, Fliers E, van der Post JAM, van der Hoorn MP, de Weerd S, Kuchenbecker WK, Hoek A, Sikkema JM, Verhoeve HR, Broeze KA, de Koning CH, Verpoest W, Christiansen OB, Koks C, de Bruin JP, Papatsonis DNM, Torrance H, van Wely M, Bisschop PH, Goddijn M. van Dijk MM, et al. Lancet Diabetes Endocrinol. 2022 May;10(5):322-329. doi: 10.1016/S2213-8587(22)00045-6. Epub 2022 Mar 14. Lancet Diabetes Endocrinol. 2022. PMID: 35298917 Clinical Trial.
The daily dose of levothyroxine was based on preconception TSH concentration and ranged from 0.5-1.0 mug/kg bodyweight. ...Seven (7%) women in the levothyroxine group and seven (8%) in the placebo group reported adverse events, none of them were directly related to …
The daily dose of levothyroxine was based on preconception TSH concentration and ranged from 0.5-1.0 mug/kg bodyweight. ...Seven (7%) …
Thyroid Hormone Therapy for Older Adults with Subclinical Hypothyroidism.
Stott DJ, Rodondi N, Kearney PM, Ford I, Westendorp RGJ, Mooijaart SP, Sattar N, Aubert CE, Aujesky D, Bauer DC, Baumgartner C, Blum MR, Browne JP, Byrne S, Collet TH, Dekkers OM, den Elzen WPJ, Du Puy RS, Ellis G, Feller M, Floriani C, Hendry K, Hurley C, Jukema JW, Kean S, Kelly M, Krebs D, Langhorne P, McCarthy G, McCarthy V, McConnachie A, McDade M, Messow M, O'Flynn A, O'Riordan D, Poortvliet RKE, Quinn TJ, Russell A, Sinnott C, Smit JWA, Van Dorland HA, Walsh KA, Walsh EK, Watt T, Wilson R, Gussekloo J; TRUST Study Group. Stott DJ, et al. N Engl J Med. 2017 Jun 29;376(26):2534-2544. doi: 10.1056/NEJMoa1603825. Epub 2017 Apr 3. N Engl J Med. 2017. PMID: 28402245 Free article. Clinical Trial.
BACKGROUND: The use of levothyroxine to treat subclinical hypothyroidism is controversial. We aimed to determine whether levothyroxine provided clinical benefits in older persons with this condition. ...CONCLUSIONS: Levothyroxine provided no apparent benefits …
BACKGROUND: The use of levothyroxine to treat subclinical hypothyroidism is controversial. We aimed to determine whether levothyro
Assessment of causal association between thyroid function and lipid metabolism: a Mendelian randomization study.
Wang JJ, Zhuang ZH, Shao CL, Yu CQ, Wang WY, Zhang K, Meng XB, Gao J, Tian J, Zheng JL, Huang T, Tang YD. Wang JJ, et al. Chin Med J (Engl). 2021 Apr 13;134(9):1064-1069. doi: 10.1097/CM9.0000000000001505. Chin Med J (Engl). 2021. PMID: 33942801 Free PMC article. Clinical Trial.
The clinical measures of thyroid function include thyrotropin (TSH), free triiodothyronine (FT3) and free thyroxine (FT4) levels, FT3:FT4 ratio and concentration of thyroid peroxidase antibodies (TPOAb). ...
The clinical measures of thyroid function include thyrotropin (TSH), free triiodothyronine (FT3) and free thyroxine (FT4) levels, FT3 …
Association between levothyroxine treatment for maternal subclinical hypothyroidism with negative TPOAb and early child neurodevelopment: A prospective real-world clinical trial.
Zhao Z, Zhou Q, Zhao H, Xiong Y, Li X. Zhao Z, et al. Acta Obstet Gynecol Scand. 2023 Sep;102(9):1183-1192. doi: 10.1111/aogs.14602. Epub 2023 Jul 13. Acta Obstet Gynecol Scand. 2023. PMID: 37443452 Free PMC article. Clinical Trial.
Compared to women in the SCH-TPOAb (+) group, those in the SCH-TPOAb (-) group had lower thyroid-stimulating hormone (TSH) levels at enrollment and 12-16(+6) gestational weeks, and unexpectedly higher TSH levels at 30-34(+6) gestational weeks and delivery, with a correspondingly …
Compared to women in the SCH-TPOAb (+) group, those in the SCH-TPOAb (-) group had lower thyroid-stimulating hormone (TSH) levels at enrollm …
Effect of Levothyroxine on Left Ventricular Ejection Fraction in Patients With Subclinical Hypothyroidism and Acute Myocardial Infarction: A Randomized Clinical Trial.
Jabbar A, Ingoe L, Junejo S, Carey P, Addison C, Thomas H, Parikh JD, Austin D, Hollingsworth KG, Stocken DD, Pearce SHS, Greenwood JP, Zaman A, Razvi S. Jabbar A, et al. JAMA. 2020 Jul 21;324(3):249-258. doi: 10.1001/jama.2020.9389. JAMA. 2020. PMID: 32692386 Clinical Trial.
The median serum thyrotropin level was 5.7 mU/L (interquartile range, 4.8-7.3 mU/L) and the mean (SD) free thyroxine level was 1.14 (0.16) ng/dL. The primary outcome measurements at 52 weeks were available in 85 patients (89.5%). ...None of the 6 secondary outcomes showed …
The median serum thyrotropin level was 5.7 mU/L (interquartile range, 4.8-7.3 mU/L) and the mean (SD) free thyroxine level was 1.14 ( …
2,139 results