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Table representation of search results timeline featuring number of search results per year.

Year Number of Results
1946 1
1947 1
1952 8
1953 37
1954 27
1955 34
1956 72
1957 75
1958 98
1959 97
1960 97
1961 93
1962 147
1963 207
1964 265
1965 178
1966 203
1967 237
1968 220
1969 269
1970 270
1971 272
1972 363
1973 410
1974 471
1975 493
1976 510
1977 585
1978 669
1979 675
1980 730
1981 684
1982 684
1983 719
1984 749
1985 751
1986 782
1987 738
1988 704
1989 705
1990 730
1991 690
1992 633
1993 618
1994 599
1995 542
1996 567
1997 587
1998 511
1999 474
2000 469
2001 487
2002 459
2003 492
2004 461
2005 572
2006 489
2007 524
2008 514
2009 547
2010 539
2011 534
2012 527
2013 576
2014 527
2015 544
2016 578
2017 573
2018 550
2019 569
2020 621
2021 689
2022 629
2023 566
2024 560
2025 641
2026 376

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33,248 results

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Page 1
Comparative Effectiveness of Levothyroxine, Desiccated Thyroid Extract, and Levothyroxine+Liothyronine in Hypothyroidism.
Shakir MKM, Brooks DI, McAninch EA, Fonseca TL, Mai VQ, Bianco AC, Hoang TD. Shakir MKM, et al. J Clin Endocrinol Metab. 2021 Oct 21;106(11):e4400-e4413. doi: 10.1210/clinem/dgab478. J Clin Endocrinol Metab. 2021. PMID: 34185829 Free PMC article. Clinical Trial.
INTRODUCTION: Studies comparing levothyroxine (LT4) therapy with LT4 + liothyronine (LT3) or desiccated thyroid extract (DTE) did not detect consistent superiority of either treatment. ...
INTRODUCTION: Studies comparing levothyroxine (LT4) therapy with LT4 + liothyronine (LT3) or desiccated thyroid extract (DTE) …
Primary hypothyroidism and quality of life.
Hegedüs L, Bianco AC, Jonklaas J, Pearce SH, Weetman AP, Perros P. Hegedüs L, et al. Nat Rev Endocrinol. 2022 Apr;18(4):230-242. doi: 10.1038/s41574-021-00625-8. Epub 2022 Jan 18. Nat Rev Endocrinol. 2022. PMID: 35042968 Free PMC article. Review.
In the 1970s, treatment with thyroid extract was superseded by levothyroxine, a synthetic L form of tetraiodothyronine. Since then, no major innovation has emerged for the treatment of hypothyroidism. ...However, neither studies combining levothyroxine and liothy …
In the 1970s, treatment with thyroid extract was superseded by levothyroxine, a synthetic L form of tetraiodothyronine. Since then, n …
Hashimoto thyroiditis: an evidence-based guide to etiology, diagnosis and treatment.
Klubo-Gwiezdzinska J, Wartofsky L. Klubo-Gwiezdzinska J, et al. Pol Arch Intern Med. 2022 Mar 30;132(3):16222. doi: 10.20452/pamw.16222. Epub 2022 Mar 3. Pol Arch Intern Med. 2022. PMID: 35243857 Free PMC article.
The management of Hashitoxicosis is based on symptoms control usually with beta-blockers, euthyroidism requires periodical thyroid stimulating hormone measurements to assess for progression to hypothyroidism, and hypothyroidism is treated with thyroid hormone replacement therapy. …
The management of Hashitoxicosis is based on symptoms control usually with beta-blockers, euthyroidism requires periodical thyroid stimulati …
Optimal Thyroid Hormone Replacement.
Jonklaas J. Jonklaas J. Endocr Rev. 2022 Mar 9;43(2):366-404. doi: 10.1210/endrev/bnab031. Endocr Rev. 2022. PMID: 34543420 Free PMC article.
Hypothyroidism is a common endocrinopathy, and levothyroxine is frequently prescribed. Despite the basic tenets of initiating and adjusting levothyroxine being agreed on, there are many nuances and complexities to consistently maintaining euthyroidism. Understanding …
Hypothyroidism is a common endocrinopathy, and levothyroxine is frequently prescribed. Despite the basic tenets of initiating and adj …
Emerging Therapies in Hypothyroidism.
Bianco AC. Bianco AC. Annu Rev Med. 2024 Jan 29;75:307-319. doi: 10.1146/annurev-med-060622-101007. Epub 2023 Sep 22. Annu Rev Med. 2024. PMID: 37738506 Free PMC article. Review.
Levothyroxine (LT4) is effective for most patients with hypothyroidism. However, a minority of the patients remain symptomatic despite the normalization of serum thyrotropin levels. Randomized clinical trials including all types of patients with hypothyroidism revealed tha …
Levothyroxine (LT4) is effective for most patients with hypothyroidism. However, a minority of the patients remain symptomatic despit …
Evidence-Based Use of Levothyroxine/Liothyronine Combinations in Treating Hypothyroidism: A Consensus Document.
Jonklaas J, Bianco AC, Cappola AR, Celi FS, Fliers E, Heuer H, McAninch EA, Moeller LC, Nygaard B, Sawka AM, Watt T, Dayan CM. Jonklaas J, et al. Thyroid. 2021 Feb;31(2):156-182. doi: 10.1089/thy.2020.0720. Thyroid. 2021. PMID: 33276704 Free PMC article. Review.
Background: Fourteen clinical trials have not shown a consistent benefit of combination therapy with levothyroxine (LT4) and liothyronine (LT3). Despite the publication of these trials, combination therapy is widely used and patients reporting benefit continue to ge …
Background: Fourteen clinical trials have not shown a consistent benefit of combination therapy with levothyroxine (LT4) and lioth …
Treatment Preferences in Patients With Hypothyroidism.
de Lima Beltrão FE, Carvalhal G, de Almeida Beltrão DC, de Lima Beltrão FE, Ribeiro MO, Ettleson MD, Ramos HE, Bianco AC. de Lima Beltrão FE, et al. J Clin Endocrinol Metab. 2025 Feb 18;110(3):887-900. doi: 10.1210/clinem/dgae651. J Clin Endocrinol Metab. 2025. PMID: 39290156 Free PMC article.
CONTEXT: Levothyroxine (L-T4) monotherapy is the standard of care for the treatment of hypothyroidism. A minority of L-T4-treated patients remain symptomatic and report better outcomes with combination therapy that contains liothyronine (L-T3) or with desiccated thy …
CONTEXT: Levothyroxine (L-T4) monotherapy is the standard of care for the treatment of hypothyroidism. A minority of L-T4-treated pat …
[Levotyroxin].
Krátký J. Krátký J. Vnitr Lek. 2022 Winter;68(1):68-72. Vnitr Lek. 2022. PMID: 35459350 Czech.
Levothyroxine is a synthetic levoisomer of thyroxine. Currently, it is one of the most commonly prescribed drugs worldwide. ...Thyroxine is mainly a prohormone which is metabolized to the more active triiodothyronine. ...
Levothyroxine is a synthetic levoisomer of thyroxine. Currently, it is one of the most commonly prescribed drugs worldwide. .. …
Combined therapy with levothyroxine and liothyronine for hypothyroidism.
Fischman A, Domínguez JM. Fischman A, et al. Medwave. 2018 Dec 14;18(8):e7376. doi: 10.5867/medwave.2018.08.7375. Medwave. 2018. PMID: 30550536 English, Spanish.
INTRODUCTION: The usual supplementation for hypothyroidism is based on monotherapy with levothyroxine. However, some patients persist with symptoms attributable to the deficit of thyroid hormone. It has been suggested that the a combined treatment with liothyronine …
INTRODUCTION: The usual supplementation for hypothyroidism is based on monotherapy with levothyroxine. However, some patients persist …
[Autoimmune thyroid disease].
Koehler VF, Bojunga J. Koehler VF, et al. Dtsch Med Wochenschr. 2021 Oct;146(20):1329-1336. doi: 10.1055/a-1258-5674. Epub 2021 Oct 13. Dtsch Med Wochenschr. 2021. PMID: 34644793 German.
Subclinical hypothyroidism is characterized by elevated TSH with normal serum free thyroxine (fT(4)) and triiodothyronine (fT(3)) levels, while in manifest hypothyroidism serum fT(4) and fT(3) levels are reduced. Levothyroxine (LT(4)) treatment in subclinical …
Subclinical hypothyroidism is characterized by elevated TSH with normal serum free thyroxine (fT(4)) and triiodothyronine (fT( …
33,248 results
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