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Table representation of search results timeline featuring number of search results per year.

Year Number of Results
1946 1
1961 1
1964 5
1965 10
1966 16
1967 12
1968 13
1969 24
1970 13
1971 18
1972 11
1973 5
1974 16
1975 12
1976 7
1977 10
1978 10
1979 10
1980 9
1981 7
1982 7
1983 7
1984 12
1985 19
1986 18
1987 14
1988 27
1989 29
1990 51
1991 41
1992 35
1993 49
1994 55
1995 58
1996 55
1997 65
1998 73
1999 73
2000 68
2001 67
2002 53
2003 48
2004 57
2005 48
2006 58
2007 56
2008 67
2009 62
2010 52
2011 49
2012 66
2013 49
2014 47
2015 42
2016 39
2017 45
2018 47
2019 53
2020 51
2021 39
2022 37
2023 27
2024 20

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2,016 results

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Page 1
Dermal effects and pharmacokinetic evaluation of the lidocaine/prilocaine cream in healthy Chinese volunteers.
Li L, Cai B, Li H, Wei J, Tao L, Ma P. Li L, et al. BMC Pharmacol Toxicol. 2023 Oct 12;24(1):51. doi: 10.1186/s40360-023-00690-x. BMC Pharmacol Toxicol. 2023. PMID: 37828535 Free PMC article.
The change of temperature sensory sensitivity reached the peak value at 4.5-6 h.There was no statistically significant difference of the changes after application the lidocaine/prilocaine T or R cream in subjects. In general, the lidocaine/prilocaine T …
The change of temperature sensory sensitivity reached the peak value at 4.5-6 h.There was no statistically significant difference of the cha …
Blood concentration of prilocaine and lidocaine after the use of topical anesthesia (Oraqix() ) in lacerated wounds.
Al-Musawi A, Matar K, Kombian S, Andersson L. Al-Musawi A, et al. Dent Traumatol. 2016 Dec;32(6):502-506. doi: 10.1111/edt.12294. Epub 2016 Jul 10. Dent Traumatol. 2016. PMID: 27397548
RESULTS: Absorption of both lidocaine and prilocaine was rapid. C(max) and AUC values of lidocaine were significantly increased by fourfold and twofold, respectively, in lacerated mouse skin compared to intact skin. ...The present study, albeit in mice, indic …
RESULTS: Absorption of both lidocaine and prilocaine was rapid. C(max) and AUC values of lidocaine were significantly i …
Hybrid Hydrogel Composed of Polymeric Nanocapsules Co-Loading Lidocaine and Prilocaine for Topical Intraoral Anesthesia.
Muniz BV, Baratelli D, Di Carla S, Serpe L, da Silva CB, Guilherme VA, Ribeiro LNM, Cereda CMS, de Paula E, Volpato MC, Groppo FC, Fraceto LF, Franz-Montan M. Muniz BV, et al. Sci Rep. 2018 Dec 19;8(1):17972. doi: 10.1038/s41598-018-36382-4. Sci Rep. 2018. PMID: 30568251 Free PMC article.
This study reports the development of nanostructured hydrogels for the sustained release of the eutectic mixture of lidocaine and prilocaine (both at 2.5%) for intraoral topical use. ...
This study reports the development of nanostructured hydrogels for the sustained release of the eutectic mixture of lidocaine and …
Prilocaine/lidocaine spray for the treatment of premature ejaculation: a dose- and time-finding study for clinical practice use.
Cai T, Gallelli L, Verze P, Salonia A, Palmieri A. Cai T, et al. Int J Impot Res. 2023 Jun;35(4):378-384. doi: 10.1038/s41443-022-00554-8. Epub 2022 Mar 21. Int J Impot Res. 2023. PMID: 35314817 Clinical Trial.
A eutectic mixture of prilocaine/lidocaine spray (Fortacin, Recordati, Milan, Italy) has been approved for the management of patients affected by life-long premature ejaculation (PE), but to date, there is a lack of dose- or time-finding studies in the literature th …
A eutectic mixture of prilocaine/lidocaine spray (Fortacin, Recordati, Milan, Italy) has been approved for the management of p …
The effect of a lidocaine/prilocaine topical anesthetic on pain and discomfort associated with orthodontic elastomeric separator placement.
Al-Melh MA, Andersson L. Al-Melh MA, et al. Prog Orthod. 2017 Dec;18(1):1. doi: 10.1186/s40510-016-0156-7. Epub 2017 Jan 9. Prog Orthod. 2017. PMID: 28066874 Free PMC article. Clinical Trial.
The purpose of this study was to investigate the effect of a lidocaine/prilocaine topical anesthetic on pain and discomfort associated with the placement of orthodontic elastomeric separators. ...CONCLUSIONS: The discomfort and pain resulting from the initial placem …
The purpose of this study was to investigate the effect of a lidocaine/prilocaine topical anesthetic on pain and discomfort as …
Pharmacokinetic and pharmacodynamic evaluation of a nanotechnological topical formulation of lidocaine/prilocaine (nanorap) in healthy volunteers.
Gagliano-Jucá T, Castelli MR, Mendes GD, Arruda AM, Chen LS, de Oliveira MA, Costa SF, Lopes AG, de Souza W, De Nucci G. Gagliano-Jucá T, et al. Ther Drug Monit. 2015 Jun;37(3):362-8. doi: 10.1097/FTD.0000000000000156. Ther Drug Monit. 2015. PMID: 25525759 Clinical Trial.
BACKGROUND: Nanorap is a new nanotechnological formulation for topical anesthesia composed of lidocaine (2.5%) and prilocaine (2.5%). This study evaluated the pharmacokinetics of Nanorap. ...Mean Cmax was 6.62 and 1.72 ng/mL for lidocaine and prilocaine
BACKGROUND: Nanorap is a new nanotechnological formulation for topical anesthesia composed of lidocaine (2.5%) and prilocaine
Use of a topical mix of lidocaine and prilocaine during split-thickness skin graft harvest improves postoperative recovery-A prospective randomized controlled trial.
Chang DH, Lin YT, Chang CW, Chen YS, Hsieh CY, Chang KC. Chang DH, et al. Burns. 2022 Sep;48(6):1396-1404. doi: 10.1016/j.burns.2021.08.023. Epub 2021 Aug 31. Burns. 2022. PMID: 34893371 Clinical Trial.
MATERIALS AND METHODS: Patients with well-granulating wounds with skin grafting were randomized into TA or general anesthesia (GA) groups. In the TA group, an eutectic mixture of lidocaine and prilocaine (EMLA) was applied. Perioperative heart rate, postoperative do …
MATERIALS AND METHODS: Patients with well-granulating wounds with skin grafting were randomized into TA or general anesthesia (GA) groups. I …
Effect of lidocaine- and prilocaine-based topical anesthetics on the inflammatory exudates in subcutaneous tissue of rats.
Pochapski MT, Neto JL, Jassen JL, Farago PV, Santos FA. Pochapski MT, et al. Anesth Prog. 2012 Summer;59(2):57-61. doi: 10.2344/11-23.1. Anesth Prog. 2012. PMID: 22822991 Free PMC article.
Sixty animals were divided into 4 groups: group 1, saline solution (control); group 2, poloxamer gel (thermosetting vehicle); group 3, lidocaine and prilocaine poloxamer thermosetting gel; group 4: EMLA, a lidocaine and prilocaine dermatological cream. …
Sixty animals were divided into 4 groups: group 1, saline solution (control); group 2, poloxamer gel (thermosetting vehicle); group 3, li
Use of lidocaine-prilocaine patch for the mantoux test: Influence on pain and reading.
Dubus JC, Mely L, Lanteaume A. Dubus JC, et al. Int J Pharm. 2006 Dec 11;327(1-2):78-80. doi: 10.1016/j.ijpharm.2006.07.037. Epub 2006 Jul 25. Int J Pharm. 2006. PMID: 16959450 Clinical Trial.
Reading of the test were not affected by the lidocaine-prilocaine application (p=0.26). Four subjects had 6mm or more difference between their two tests, two of them having an induration greater than 15mm with lidocaine-prilocaine. ...However, when the …
Reading of the test were not affected by the lidocaine-prilocaine application (p=0.26). Four subjects had 6mm or more differen …
Phase diagram and aqueous solubility of the lidocaine-prilocaine binary system.
Brodin A, Nyqvist-Mayer A, Wadsten T, Forslund B, Broberg F. Brodin A, et al. J Pharm Sci. 1984 Apr;73(4):481-4. doi: 10.1002/jps.2600730413. J Pharm Sci. 1984. PMID: 6726632
The phase behavior of the lidocaine-prilocaine binary system has been studied by X-ray diffraction, differential thermal analysis, hot-stage microscopy, and IR spectrometry. ...Investigations of various lidocaine-prilocaine ratios indicate that the two …
The phase behavior of the lidocaine-prilocaine binary system has been studied by X-ray diffraction, differential thermal analy …
2,016 results