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Table representation of search results timeline featuring number of search results per year.

Year Number of Results
1971 5
1972 7
1973 20
1974 14
1975 13
1976 22
1977 19
1978 16
1979 13
1980 17
1981 13
1982 20
1983 34
1984 28
1985 28
1986 26
1987 22
1988 34
1989 31
1990 25
1991 30
1992 26
1993 29
1994 30
1995 32
1996 27
1997 29
1998 33
1999 23
2000 31
2001 22
2002 27
2003 28
2004 39
2005 29
2006 26
2007 30
2008 19
2009 19
2010 19
2011 21
2012 23
2013 23
2014 23
2015 13
2016 11
2017 12
2018 12
2019 12
2020 12
2021 13
2022 1
2023 5
2024 4

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1,077 results

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Page 1
Intramuscular versus intravenous therapy for prehospital status epilepticus.
Silbergleit R, Durkalski V, Lowenstein D, Conwit R, Pancioli A, Palesch Y, Barsan W; NETT Investigators. Silbergleit R, et al. N Engl J Med. 2012 Feb 16;366(7):591-600. doi: 10.1056/NEJMoa1107494. N Engl J Med. 2012. PMID: 22335736 Free PMC article. Clinical Trial.
METHODS: This double-blind, randomized, noninferiority trial compared the efficacy of intramuscular midazolam with that of intravenous lorazepam for children and adults in status epilepticus treated by paramedics. ...The two treatment groups were similar with respect to ne …
METHODS: This double-blind, randomized, noninferiority trial compared the efficacy of intramuscular midazolam with that of intravenous lo
Comparison of the actions of diazepam and lorazepam.
Dundee JW, McGowan WA, Lilburn JK, McKay AC, Hegarty JE. Dundee JW, et al. Br J Anaesth. 1979 May;51(5):439-46. doi: 10.1093/bja/51.5.439. Br J Anaesth. 1979. PMID: 36117 Free article. Clinical Trial.
As a sedative, diazepam 10 mg is equivalent to lorazepam 2-2.5 mg. Diazepam is better absorbed after oral than after i.m. administrations but this does not apply to lorazepam. ...Lorazepam i.v. is followed by a lesser frequency of venous thrombosis....
As a sedative, diazepam 10 mg is equivalent to lorazepam 2-2.5 mg. Diazepam is better absorbed after oral than after i.m. administrat …
A comparison of four treatments for generalized convulsive status epilepticus. Veterans Affairs Status Epilepticus Cooperative Study Group.
Treiman DM, Meyers PD, Walton NY, Collins JF, Colling C, Rowan AJ, Handforth A, Faught E, Calabrese VP, Uthman BM, Ramsay RE, Mamdani MB. Treiman DM, et al. N Engl J Med. 1998 Sep 17;339(12):792-8. doi: 10.1056/NEJM199809173391202. N Engl J Med. 1998. PMID: 9738086 Free article. Clinical Trial.
Lorazepam was significantly superior to phenytoin in a pairwise comparison (P=0.002). ...CONCLUSIONS: As initial intravenous treatment for overt generalized convulsive status epilepticus, lorazepam is more effective than phenytoin. Although lorazepam is no mo
Lorazepam was significantly superior to phenytoin in a pairwise comparison (P=0.002). ...CONCLUSIONS: As initial intravenous treatmen
Lorazepam as a premedication.
Gale G, Galloon S. Gale G, et al. Can Anaesth Soc J. 1976 Jan;23(1):22-9. doi: 10.1007/BF03004991. Can Anaesth Soc J. 1976. PMID: 2377 Clinical Trial.
The patients who had lorazepam required higher doses of thiopentone for the operation, and this, in part, led to longer intervals in recovery times after lorazepam. However, it is suggested that lorazepam itself was partly responsible for the longer recovery. …
The patients who had lorazepam required higher doses of thiopentone for the operation, and this, in part, led to longer intervals in …
Making Sense of a Negative Clinical Trial Result: A Bayesian Analysis of a Clinical Trial of Lorazepam and Diazepam for Pediatric Status Epilepticus.
Chamberlain DB, Chamberlain JM. Chamberlain DB, et al. Ann Emerg Med. 2017 Jan;69(1):117-124. doi: 10.1016/j.annemergmed.2016.08.449. Ann Emerg Med. 2017. PMID: 27993298 Clinical Trial.
RESULTS: Consistent with the original study's classic analysis of study results, we did not demonstrate superiority of lorazepam over diazepam. There is a 95% probability that the true efficacy of lorazepam is in the range of 66% to 80%. ...In the case of pediatric …
RESULTS: Consistent with the original study's classic analysis of study results, we did not demonstrate superiority of lorazepam over …
Lorazepam vs diazepam for pediatric status epilepticus: a randomized clinical trial.
Chamberlain JM, Okada P, Holsti M, Mahajan P, Brown KM, Vance C, Gonzalez V, Lichenstein R, Stanley R, Brousseau DC, Grubenhoff J, Zemek R, Johnson DW, Clemons TE, Baren J; Pediatric Emergency Care Applied Research Network (PECARN). Chamberlain JM, et al. JAMA. 2014 Apr 23-30;311(16):1652-60. doi: 10.1001/jama.2014.2625. JAMA. 2014. PMID: 24756515 Clinical Trial.
IMPORTANCE: Benzodiazepines are considered first-line therapy for pediatric status epilepticus. Some studies suggest that lorazepam may be more effective or safer than diazepam, but lorazepam is not Food and Drug Administration approved for this indication. ...There …
IMPORTANCE: Benzodiazepines are considered first-line therapy for pediatric status epilepticus. Some studies suggest that lorazepam m …
Intravenous promethazine versus lorazepam for the treatment of peripheral vertigo in the emergency department: A double blind, randomized clinical trial of efficacy and safety.
Amini A, Heidari K, Asadollahi S, Habibi T, Shahrami A, Mansouri B, Kariman H. Amini A, et al. J Vestib Res. 2014;24(1):39-47. doi: 10.3233/VES-130506. J Vestib Res. 2014. PMID: 24594499 Clinical Trial.
RESULTS: Promethazine was associated with significantly more reduction (46.5 mm) in vertigo than lorazepam (25.7 mm, p< 0.001). Mean change in nausea score 2 hours after drug injection on the VAS was 28.7 mm for promethazine and 22.8 for lorazepam (p=0.002). The …
RESULTS: Promethazine was associated with significantly more reduction (46.5 mm) in vertigo than lorazepam (25.7 mm, p< 0.001). Me …
Pharmacokinetics and clinical efficacy of lorazepam in children with severe malaria and convulsions.
Muchohi SN, Obiero K, Newton CR, Ogutu BR, Edwards G, Kokwaro GO. Muchohi SN, et al. Br J Clin Pharmacol. 2008 Jan;65(1):12-21. doi: 10.1111/j.1365-2125.2007.02966.x. Epub 2007 Jul 17. Br J Clin Pharmacol. 2008. PMID: 17635501 Free PMC article. Clinical Trial.
AIM: To investigate the pharmacokinetics and clinical efficacy of intravenous (i.v.) and intramuscular (i.m.) lorazepam (LZP) in children with severe malaria and convulsions. METHODS: Twenty-six children with severe malaria and convulsions lasting > or =5 min were studi …
AIM: To investigate the pharmacokinetics and clinical efficacy of intravenous (i.v.) and intramuscular (i.m.) lorazepam (LZP) in chil …
Sedative Plasma Concentrations and Delirium Risk in Critical Illness.
Stollings JL, Thompson JL, Ferrell BA, Scheinin M, Wilkinson GR, Hughes CG, Shintani AK, Ely EW, Girard TD, Pandharipande PP, Patel MB. Stollings JL, et al. Ann Pharmacother. 2018 Jun;52(6):513-521. doi: 10.1177/1060028017753480. Epub 2018 Jan 24. Ann Pharmacother. 2018. PMID: 29363356 Free PMC article. Clinical Trial.
OBJECTIVE: We hypothesized that higher plasma concentrations of lorazepam are associated with increased delirium risk, whereas higher plasma concentrations of dexmedetomidine are associated with reduced delirium risk. ...RESULTS: This critically ill cohort (n = 103) had a …
OBJECTIVE: We hypothesized that higher plasma concentrations of lorazepam are associated with increased delirium risk, whereas higher …
Transcranial Magnetic Stimulation and H(1)-Magnetic Resonance Spectroscopy Measures of Excitation and Inhibition Following Lorazepam Administration.
Ferland MC, Therrien-Blanchet JM, Proulx S, Klees-Themens G, Bacon BA, Dang Vu TT, Théoret H. Ferland MC, et al. Neuroscience. 2021 Jan 1;452:235-246. doi: 10.1016/j.neuroscience.2020.11.011. Epub 2020 Nov 24. Neuroscience. 2021. PMID: 33246064 Clinical Trial.
This study aimed at better understanding the neurochemistry underlying transcranial magnetic stimulation (TMS) and magnetic resonance spectroscopy (MRS) measurements as it pertains to GABAergic activity following administration of allosteric GABA(A) receptor agonist lorazepam
This study aimed at better understanding the neurochemistry underlying transcranial magnetic stimulation (TMS) and magnetic resonance spectr …
1,077 results