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Table representation of search results timeline featuring number of search results per year.

Year Number of Results
1971 5
1972 7
1973 20
1974 14
1975 13
1976 22
1977 19
1978 16
1979 13
1980 17
1981 13
1982 20
1983 34
1984 28
1985 28
1986 26
1987 22
1988 34
1989 31
1990 25
1991 30
1992 26
1993 29
1994 30
1995 32
1996 27
1997 29
1998 33
1999 23
2000 31
2001 22
2002 27
2003 28
2004 39
2005 29
2006 26
2007 30
2008 19
2009 19
2010 19
2011 21
2012 23
2013 23
2014 23
2015 13
2016 11
2017 12
2018 12
2019 12
2020 12
2021 13
2022 1
2023 0
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1,069 results
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Page 1
Intramuscular versus intravenous therapy for prehospital status epilepticus.
Silbergleit R, Durkalski V, Lowenstein D, Conwit R, Pancioli A, Palesch Y, Barsan W; NETT Investigators. Silbergleit R, et al. N Engl J Med. 2012 Feb 16;366(7):591-600. doi: 10.1056/NEJMoa1107494. N Engl J Med. 2012. PMID: 22335736 Free PMC article. Clinical Trial.
METHODS: This double-blind, randomized, noninferiority trial compared the efficacy of intramuscular midazolam with that of intravenous lorazepam for children and adults in status epilepticus treated by paramedics. ...The two treatment groups were similar with respect to ne …
METHODS: This double-blind, randomized, noninferiority trial compared the efficacy of intramuscular midazolam with that of intravenous lo …
Comparison of the actions of diazepam and lorazepam.
Dundee JW, McGowan WA, Lilburn JK, McKay AC, Hegarty JE. Dundee JW, et al. Br J Anaesth. 1979 May;51(5):439-46. doi: 10.1093/bja/51.5.439. Br J Anaesth. 1979. PMID: 36117 Free article. Clinical Trial.
As a sedative, diazepam 10 mg is equivalent to lorazepam 2-2.5 mg. Diazepam is better absorbed after oral than after i.m. administrations but this does not apply to lorazepam. ...Lorazepam i.v. is followed by a lesser frequency of venous thrombosis....
As a sedative, diazepam 10 mg is equivalent to lorazepam 2-2.5 mg. Diazepam is better absorbed after oral than after i.m. administrat …
Patterns of benzodiazepine underdosing in the Established Status Epilepticus Treatment Trial.
Sathe AG, Underwood E, Coles LD, Elm JJ, Silbergleit R, Chamberlain JM, Kapur J, Cock HR, Fountain NB, Shinnar S, Lowenstein DH, Rosenthal ES, Conwit RA, Bleck TP, Cloyd JC. Sathe AG, et al. Epilepsia. 2021 Mar;62(3):795-806. doi: 10.1111/epi.16825. Epub 2021 Feb 10. Epilepsia. 2021. PMID: 33567109 Free PMC article. Clinical Trial.
The first dose of the first benzodiazepine (N = 460) was lower than guideline recommendations in 76% of midazolam administrations and 81% of lorazepam administrations. Among all administrations, >85% of midazolam and >76% of lorazepam administrations were lowe …
The first dose of the first benzodiazepine (N = 460) was lower than guideline recommendations in 76% of midazolam administrations and 81% of …
Making Sense of a Negative Clinical Trial Result: A Bayesian Analysis of a Clinical Trial of Lorazepam and Diazepam for Pediatric Status Epilepticus.
Chamberlain DB, Chamberlain JM. Chamberlain DB, et al. Ann Emerg Med. 2017 Jan;69(1):117-124. doi: 10.1016/j.annemergmed.2016.08.449. Ann Emerg Med. 2017. PMID: 27993298 Clinical Trial.
RESULTS: Consistent with the original study's classic analysis of study results, we did not demonstrate superiority of lorazepam over diazepam. There is a 95% probability that the true efficacy of lorazepam is in the range of 66% to 80%. ...In the case of pediatric …
RESULTS: Consistent with the original study's classic analysis of study results, we did not demonstrate superiority of lorazepam over …
A comparison of four treatments for generalized convulsive status epilepticus. Veterans Affairs Status Epilepticus Cooperative Study Group.
Treiman DM, Meyers PD, Walton NY, Collins JF, Colling C, Rowan AJ, Handforth A, Faught E, Calabrese VP, Uthman BM, Ramsay RE, Mamdani MB. Treiman DM, et al. N Engl J Med. 1998 Sep 17;339(12):792-8. doi: 10.1056/NEJM199809173391202. N Engl J Med. 1998. PMID: 9738086 Free article. Clinical Trial.
Lorazepam was significantly superior to phenytoin in a pairwise comparison (P=0.002). ...CONCLUSIONS: As initial intravenous treatment for overt generalized convulsive status epilepticus, lorazepam is more effective than phenytoin. Although lorazepam is no mo …
Lorazepam was significantly superior to phenytoin in a pairwise comparison (P=0.002). ...CONCLUSIONS: As initial intravenous treatmen …
Intravenous promethazine versus lorazepam for the treatment of peripheral vertigo in the emergency department: A double blind, randomized clinical trial of efficacy and safety.
Amini A, Heidari K, Asadollahi S, Habibi T, Shahrami A, Mansouri B, Kariman H. Amini A, et al. J Vestib Res. 2014;24(1):39-47. doi: 10.3233/VES-130506. J Vestib Res. 2014. PMID: 24594499 Clinical Trial.
RESULTS: Promethazine was associated with significantly more reduction (46.5 mm) in vertigo than lorazepam (25.7 mm, p< 0.001). Mean change in nausea score 2 hours after drug injection on the VAS was 28.7 mm for promethazine and 22.8 for lorazepam (p=0.002). The …
RESULTS: Promethazine was associated with significantly more reduction (46.5 mm) in vertigo than lorazepam (25.7 mm, p< 0.001). Me …
Clinical efficacy of lorazepam in prophylaxis of anticipatory, acute, and delayed nausea and vomiting induced by high doses of cisplatin. A prospective randomized trial.
Malik IA, Khan WA, Qazilbash M, Ata E, Butt A, Khan MA. Malik IA, et al. Am J Clin Oncol. 1995 Apr;18(2):170-5. doi: 10.1097/00000421-199504000-00017. Am J Clin Oncol. 1995. PMID: 7900711 Clinical Trial.
We conducted a randomized trial to evaluate the efficacy of lorazepam in managing anticipatory, acute, and delayed emesis induced by high doses of cisplatin. ...Side effects were few except for mild sedation and amnesia, which were significantly more common in those receiv …
We conducted a randomized trial to evaluate the efficacy of lorazepam in managing anticipatory, acute, and delayed emesis induced by …
Lorazepam vs diazepam for pediatric status epilepticus: a randomized clinical trial.
Chamberlain JM, Okada P, Holsti M, Mahajan P, Brown KM, Vance C, Gonzalez V, Lichenstein R, Stanley R, Brousseau DC, Grubenhoff J, Zemek R, Johnson DW, Clemons TE, Baren J; Pediatric Emergency Care Applied Research Network (PECARN). Chamberlain JM, et al. JAMA. 2014 Apr 23-30;311(16):1652-60. doi: 10.1001/jama.2014.2625. JAMA. 2014. PMID: 24756515 Clinical Trial.
IMPORTANCE: Benzodiazepines are considered first-line therapy for pediatric status epilepticus. Some studies suggest that lorazepam may be more effective or safer than diazepam, but lorazepam is not Food and Drug Administration approved for this indication. ...There …
IMPORTANCE: Benzodiazepines are considered first-line therapy for pediatric status epilepticus. Some studies suggest that lorazepam m …
Pharmacokinetics and clinical efficacy of lorazepam in children with severe malaria and convulsions.
Muchohi SN, Obiero K, Newton CR, Ogutu BR, Edwards G, Kokwaro GO. Muchohi SN, et al. Br J Clin Pharmacol. 2008 Jan;65(1):12-21. doi: 10.1111/j.1365-2125.2007.02966.x. Epub 2007 Jul 17. Br J Clin Pharmacol. 2008. PMID: 17635501 Free PMC article. Clinical Trial.
AIM: To investigate the pharmacokinetics and clinical efficacy of intravenous (i.v.) and intramuscular (i.m.) lorazepam (LZP) in children with severe malaria and convulsions. METHODS: Twenty-six children with severe malaria and convulsions lasting > or =5 min were studi …
AIM: To investigate the pharmacokinetics and clinical efficacy of intravenous (i.v.) and intramuscular (i.m.) lorazepam (LZP) in chil …
Haloperidol and lorazepam combined: clinical effects and drug plasma levels in the treatment of acute schizophrenic psychosis.
Stevens A, Stevens I, Mahal A, Gaertner HJ. Stevens A, et al. Pharmacopsychiatry. 1992 Nov;25(6):273-7. doi: 10.1055/s-2007-1014421. Pharmacopsychiatry. 1992. PMID: 1494594 Clinical Trial.
A significant linear relationship between lorazepam serum levels and oral dosage was found, but none between lorazepam serum levels and BPRS total score, subscore reduction, or extrapyramidal side-effects. The authors conclude that beneficial effects of lorazepam …
A significant linear relationship between lorazepam serum levels and oral dosage was found, but none between lorazepam serum l …
1,069 results