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Year Number of Results
1980 1
1990 1
2003 1
2004 4
2005 2
2008 1
2009 1
2010 2
2012 1
2014 1
2015 4
2016 1
2019 1
2020 1
2021 1
2022 4
2024 2

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26 results

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Page 1
Choosing a skeletal muscle relaxant.
See S, Ginzburg R. See S, et al. Am Fam Physician. 2008 Aug 1;78(3):365-70. Am Fam Physician. 2008. PMID: 18711953 Free article. Review.
The sedative properties of tizanidine and cyclobenzaprine may benefit patients with insomnia caused by severe muscle spasms. Methocarbamol and metaxalone are less sedating, although effectiveness evidence is limited. Adverse effects, particularly dizziness an …
The sedative properties of tizanidine and cyclobenzaprine may benefit patients with insomnia caused by severe muscle spasms. Methocarbamol a …
Comparative efficacy and safety of skeletal muscle relaxants for spasticity and musculoskeletal conditions: a systematic review.
Chou R, Peterson K, Helfand M. Chou R, et al. J Pain Symptom Manage. 2004 Aug;28(2):140-75. doi: 10.1016/j.jpainsymman.2004.05.002. J Pain Symptom Manage. 2004. PMID: 15276195 Free article. Review.
Randomized trials (for comparative efficacy and adverse events) and observational studies (for adverse events only) that included oral medications classified as skeletal muscle relaxants by the FDA were sought using electronic databases, reference lists, and pharmac …
Randomized trials (for comparative efficacy and adverse events) and observational studies (for adverse events only) that inclu …
Pharmacotherapy for Spine-Related Pain in Older Adults.
Fu JL, Perloff MD. Fu JL, et al. Drugs Aging. 2022 Jul;39(7):523-550. doi: 10.1007/s40266-022-00946-x. Epub 2022 Jun 27. Drugs Aging. 2022. PMID: 35754070 Review.
Some muscle relaxants (carisoprodol, chlorzoxazone, cyclobenzaprine, metaxalone, methocarbamol, and orphenadrine) are avoided in older adults due to risk for sedation and falls. ...Older antidepressants are typically avoided in older adults due to their side effects …
Some muscle relaxants (carisoprodol, chlorzoxazone, cyclobenzaprine, metaxalone, methocarbamol, and orphenadrine) are avoided in olde …
Metaxalone (Skelaxin)-related death.
Poklis JL, Ropero-Miller JD, Garside D, Winecker RE. Poklis JL, et al. J Anal Toxicol. 2004 Sep;28(6):537-41. doi: 10.1093/jat/28.6.537. J Anal Toxicol. 2004. PMID: 15516312
Four additional cases in which metaxalone was present were analyzed for comparison. Two cases were probable drug-related deaths and had metaxalone aorta blood concentrations of 18 and 11 mg/L. The other two cases had therapeutic metaxalone concentrations in t …
Four additional cases in which metaxalone was present were analyzed for comparison. Two cases were probable drug-related deaths and h …
Commonly used muscle relaxant therapies for acute low back pain: a review of carisoprodol, cyclobenzaprine hydrochloride, and metaxalone.
Toth PP, Urtis J. Toth PP, et al. Clin Ther. 2004 Sep;26(9):1355-67. doi: 10.1016/j.clinthera.2004.09.008. Clin Ther. 2004. PMID: 15530999 Review.
Carisoprodol, cyclobenzaprine hydrochloride, and metaxalone represented >45% of all such prescriptions. Cochrane Library, MEDLINE, and EMBASE databases were searched (time frame: 1960 through January 2004; search terms: back pain, carisoprodol, cyclobenzaprine, metax …
Carisoprodol, cyclobenzaprine hydrochloride, and metaxalone represented >45% of all such prescriptions. Cochrane Library, MEDLINE, …
Monoamine oxidase A inhibition by toxic concentrations of metaxalone.
Cherrington B, Englich U, Niruntari S, Grant W, Hodgman M. Cherrington B, et al. Clin Toxicol (Phila). 2020 May;58(5):383-387. doi: 10.1080/15563650.2019.1648815. Epub 2019 Aug 2. Clin Toxicol (Phila). 2020. PMID: 31373522
Monoamine oxidase A (MAO-A) inhibition by metaxalone has been proposed as the etiology of this toxicity. Metaxalone concentrations reported with cases of serotonin toxicity range from 31 to 61 mcg/ml (140-276 M). We investigated the effect of metaxalone on MA …
Monoamine oxidase A (MAO-A) inhibition by metaxalone has been proposed as the etiology of this toxicity. Metaxalone concentrat …
Postmortem Metaxalone (Skelaxin) Data from North Carolina.
Bishop-Freeman SC, Miller A, Hensel EM, Winecker RE. Bishop-Freeman SC, et al. J Anal Toxicol. 2015 Oct;39(8):629-36. doi: 10.1093/jat/bkv066. J Anal Toxicol. 2015. PMID: 26378137
The mean metaxalone concentration for the additive deaths was 14.2 mg/L with a median value of 11 mg/L (n = 18) and a mean metaxalone concentration of 36.7 mg/L with a median value of 32 mg/L (n = 9) for primary deaths. For unattributed metaxalone concentrati …
The mean metaxalone concentration for the additive deaths was 14.2 mg/L with a median value of 11 mg/L (n = 18) and a mean metaxal …
A fatality involving metaxalone.
Moore KA, Levine B, Fowler D. Moore KA, et al. Forensic Sci Int. 2005 May 10;149(2-3):249-51. doi: 10.1016/j.forsciint.2004.07.017. Forensic Sci Int. 2005. PMID: 15749367
Postmortem toxicologic analysis of the heart blood identified acetaminophen (97 mg/L), citalopram (0.4 mg/L), gabapentin (24 mg/L) and metaxalone (21 mg/L). The metaxalone concentration is within the range of previously reported fatalities involving metaxalone …
Postmortem toxicologic analysis of the heart blood identified acetaminophen (97 mg/L), citalopram (0.4 mg/L), gabapentin (24 mg/L) and me …
Serotonin syndrome associated with metaxalone overdose.
Bosak AR, Skolnik AB. Bosak AR, et al. J Med Toxicol. 2014 Dec;10(4):402-5. doi: 10.1007/s13181-014-0404-5. J Med Toxicol. 2014. PMID: 24805103 Free PMC article.
A broad range of drugs and drug combinations have been associated with serotonin syndrome. Metaxalone overdose associated with serotonin syndrome has not been previously reported. ...Non-depolarizing neuromuscular blockade and cooling blankets were required to control hype …
A broad range of drugs and drug combinations have been associated with serotonin syndrome. Metaxalone overdose associated with seroto …
Isostructural cocrystals of metaxalone with improved dissolution characteristics.
Gohel SK, Palanisamy V, Sanphui P, Prakash M, Singh GP, Chernyshev V. Gohel SK, et al. RSC Adv. 2021 Sep 15;11(49):30689-30700. doi: 10.1039/d1ra05959a. eCollection 2021 Sep 14. RSC Adv. 2021. PMID: 35479860 Free PMC article.
Muscle relaxant and pain reliever metaxalone (MET) is a biopharmaceutical classification systems (BCS) class II drug with poor aqueous solubility and high permeability. ...A high dose (800 mg) of the drug often creates adverse side effects on the central nerv …
Muscle relaxant and pain reliever metaxalone (MET) is a biopharmaceutical classification systems (BCS) class II drug with poor aqueou …
26 results