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1966 1
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2005 2
2008 2
2009 1
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2012 1
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2015 4
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Page 1
Choosing a skeletal muscle relaxant.
See S, Ginzburg R. See S, et al. Am Fam Physician. 2008 Aug 1;78(3):365-70. Am Fam Physician. 2008. PMID: 18711953 Free article. Review.
The sedative properties of tizanidine and cyclobenzaprine may benefit patients with insomnia caused by severe muscle spasms. Methocarbamol and metaxalone are less sedating, although effectiveness evidence is limited. Adverse effects, particularly dizziness and drowsiness, …
The sedative properties of tizanidine and cyclobenzaprine may benefit patients with insomnia caused by severe muscle spasms. Methocarbamol a …
Comparative efficacy and safety of skeletal muscle relaxants for spasticity and musculoskeletal conditions: a systematic review.
Chou R, Peterson K, Helfand M. Chou R, et al. J Pain Symptom Manage. 2004 Aug;28(2):140-75. doi: 10.1016/j.jpainsymman.2004.05.002. J Pain Symptom Manage. 2004. PMID: 15276195 Free article. Review.
There is very limited or inconsistent data regarding the effectiveness of metaxalone, methocarbamol, chlorzoxazone, baclofen, or dantrolene compared to placebo in patients with musculoskeletal conditions. There is insufficient evidence to determine the relative efficacy or …
There is very limited or inconsistent data regarding the effectiveness of metaxalone, methocarbamol, chlorzoxazone, baclofen, or dant …
Pharmacotherapy for Spine-Related Pain in Older Adults.
Fu JL, Perloff MD. Fu JL, et al. Drugs Aging. 2022 Jul;39(7):523-550. doi: 10.1007/s40266-022-00946-x. Epub 2022 Jun 27. Drugs Aging. 2022. PMID: 35754070 Review.
Whenever possible, beneficial geriatric spine pain pharmacotherapy should employ the lowest therapeutic doses with consideration of polypharmacy, potentially decreased renal and hepatic metabolism, and co-morbid medical disorders. ...Some muscle relaxants (carisoprodol, ch …
Whenever possible, beneficial geriatric spine pain pharmacotherapy should employ the lowest therapeutic doses with consideration of p …
Metaxalone (Skelaxin)-related death.
Poklis JL, Ropero-Miller JD, Garside D, Winecker RE. Poklis JL, et al. J Anal Toxicol. 2004 Sep;28(6):537-41. doi: 10.1093/jat/28.6.537. J Anal Toxicol. 2004. PMID: 15516312
Four additional cases in which metaxalone was present were analyzed for comparison. Two cases were probable drug-related deaths and had metaxalone aorta blood concentrations of 18 and 11 mg/L. The other two cases had therapeutic metaxalone concentratio …
Four additional cases in which metaxalone was present were analyzed for comparison. Two cases were probable drug-related deaths and h …
Commonly used muscle relaxant therapies for acute low back pain: a review of carisoprodol, cyclobenzaprine hydrochloride, and metaxalone.
Toth PP, Urtis J. Toth PP, et al. Clin Ther. 2004 Sep;26(9):1355-67. doi: 10.1016/j.clinthera.2004.09.008. Clin Ther. 2004. PMID: 15530999 Review.
Carisoprodol, cyclobenzaprine hydrochloride, and metaxalone represented >45% of all such prescriptions. Cochrane Library, MEDLINE, and EMBASE databases were searched (time frame: 1960 through January 2004; search terms: back pain, carisoprodol, cyclobenzaprine, metax …
Carisoprodol, cyclobenzaprine hydrochloride, and metaxalone represented >45% of all such prescriptions. Cochrane Library, MEDLINE, …
Postmortem Metaxalone (Skelaxin) Data from North Carolina.
Bishop-Freeman SC, Miller A, Hensel EM, Winecker RE. Bishop-Freeman SC, et al. J Anal Toxicol. 2015 Oct;39(8):629-36. doi: 10.1093/jat/bkv066. J Anal Toxicol. 2015. PMID: 26378137
The mean metaxalone concentration for the additive deaths was 14.2 mg/L with a median value of 11 mg/L (n = 18) and a mean metaxalone concentration of 36.7 mg/L with a median value of 32 mg/L (n = 9) for primary deaths. For unattributed metaxalone concentrati …
The mean metaxalone concentration for the additive deaths was 14.2 mg/L with a median value of 11 mg/L (n = 18) and a mean metaxal …
Monoamine oxidase A inhibition by toxic concentrations of metaxalone.
Cherrington B, Englich U, Niruntari S, Grant W, Hodgman M. Cherrington B, et al. Clin Toxicol (Phila). 2020 May;58(5):383-387. doi: 10.1080/15563650.2019.1648815. Epub 2019 Aug 2. Clin Toxicol (Phila). 2020. PMID: 31373522
Context: Serotonin toxicity is a reported complication associated with both therapeutic use and overdose of metaxalone while on therapeutic doses of serotonergic drugs such as serotonin reuptake inhibitors. Monoamine oxidase A (MAO-A) inhibition by …
Context: Serotonin toxicity is a reported complication associated with both therapeutic use and overdose of metaxalone …
A fatality involving metaxalone.
Moore KA, Levine B, Fowler D. Moore KA, et al. Forensic Sci Int. 2005 May 10;149(2-3):249-51. doi: 10.1016/j.forsciint.2004.07.017. Forensic Sci Int. 2005. PMID: 15749367
Postmortem toxicologic analysis of the heart blood identified acetaminophen (97 mg/L), citalopram (0.4 mg/L), gabapentin (24 mg/L) and metaxalone (21 mg/L). The metaxalone concentration is within the range of previously reported fatalities involving metaxalone …
Postmortem toxicologic analysis of the heart blood identified acetaminophen (97 mg/L), citalopram (0.4 mg/L), gabapentin (24 mg/L) and me …
Serotonin syndrome associated with metaxalone overdose.
Bosak AR, Skolnik AB. Bosak AR, et al. J Med Toxicol. 2014 Dec;10(4):402-5. doi: 10.1007/s13181-014-0404-5. J Med Toxicol. 2014. PMID: 24805103 Free PMC article.
INTRODUCTION: Serotonin syndrome is a potentially life-threatening entity associated with pro-serotonergic medications in therapeutic use, in overdose, or when co-administered with other drugs. A broad range of drugs and drug combinations have been associated with s …
INTRODUCTION: Serotonin syndrome is a potentially life-threatening entity associated with pro-serotonergic medications in therapeutic …
A Randomized, Placebo-Controlled Trial of Ibuprofen Plus Metaxalone, Tizanidine, or Baclofen for Acute Low Back Pain.
Friedman BW, Irizarry E, Solorzano C, Zias E, Pearlman S, Wollowitz A, Jones MP, Shah PD, Gallagher EJ. Friedman BW, et al. Ann Emerg Med. 2019 Oct;74(4):512-520. doi: 10.1016/j.annemergmed.2019.02.017. Epub 2019 Apr 5. Ann Emerg Med. 2019. PMID: 30955985 Free PMC article. Clinical Trial.
Additionally, they were randomized to baclofen 10 mg, metaxalone 400 mg, tizanidine 2 mg, or placebo. Participants were instructed to take 1 or 2 of these capsules 3 times a day as needed. ...CONCLUSION: Adding baclofen, metaxalone, or tizanidine to ibuprofen does n …
Additionally, they were randomized to baclofen 10 mg, metaxalone 400 mg, tizanidine 2 mg, or placebo. Participants were instructed to …
35 results