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1964 3
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65 results

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Page 1
Choosing a skeletal muscle relaxant.
See S, Ginzburg R. See S, et al. Am Fam Physician. 2008 Aug 1;78(3):365-70. Am Fam Physician. 2008. PMID: 18711953 Free article. Review.
The sedative properties of tizanidine and cyclobenzaprine may benefit patients with insomnia caused by severe muscle spasms. Methocarbamol and metaxalone are less sedating, although effectiveness evidence is limited. Adverse effects, particularly dizziness and drowsiness, …
The sedative properties of tizanidine and cyclobenzaprine may benefit patients with insomnia caused by severe muscle spasms. Methocarbamol a …
Metaxalone.
[No authors listed] [No authors listed] 2021 Sep 13. LiverTox: Clinical and Research Information on Drug-Induced Liver Injury [Internet]. Bethesda (MD): National Institute of Diabetes and Digestive and Kidney Diseases; 2012–. 2021 Sep 13. LiverTox: Clinical and Research Information on Drug-Induced Liver Injury [Internet]. Bethesda (MD): National Institute of Diabetes and Digestive and Kidney Diseases; 2012–. PMID: 31644145 Free Books & Documents. Review.
Metaxalone is a centrally acting skeletal muscle relaxant that has been in use for more than 40 years. Metaxalone has not been associated with serum aminotransferase elevations during therapy or with clinically apparent hepatic injury....
Metaxalone is a centrally acting skeletal muscle relaxant that has been in use for more than 40 years. Metaxalone has not been …
Comparative efficacy and safety of skeletal muscle relaxants for spasticity and musculoskeletal conditions: a systematic review.
Chou R, Peterson K, Helfand M. Chou R, et al. J Pain Symptom Manage. 2004 Aug;28(2):140-75. doi: 10.1016/j.jpainsymman.2004.05.002. J Pain Symptom Manage. 2004. PMID: 15276195 Free article.
There is very limited or inconsistent data regarding the effectiveness of metaxalone, methocarbamol, chlorzoxazone, baclofen, or dantrolene compared to placebo in patients with musculoskeletal conditions. There is insufficient evidence to determine the relative efficacy or …
There is very limited or inconsistent data regarding the effectiveness of metaxalone, methocarbamol, chlorzoxazone, baclofen, or dant …
Metaxalone (Skelaxin)-related death.
Poklis JL, Ropero-Miller JD, Garside D, Winecker RE. Poklis JL, et al. J Anal Toxicol. 2004 Sep;28(6):537-41. doi: 10.1093/jat/28.6.537. J Anal Toxicol. 2004. PMID: 15516312
Four additional cases in which metaxalone was present were analyzed for comparison. Two cases were probable drug-related deaths and had metaxalone aorta blood concentrations of 18 and 11 mg/L. The other two cases had therapeutic metaxalone concentrations in t …
Four additional cases in which metaxalone was present were analyzed for comparison. Two cases were probable drug-related deaths and h …
Metabolism of metaxalone.
Bruce RB, Turnbull L, Newman J, Pitts J. Bruce RB, et al. J Med Chem. 1966 May;9(3):286-8. doi: 10.1021/jm00321a004. J Med Chem. 1966. PMID: 5960889 No abstract available.
Metaxalone-induced Immune Hemolytic Anemia.
Onyechi A, Ohemeng-Dapaah J, Patel R, Onyechi E, Oyenuga M, Sartaj S, Mehta M, Lacasse A, Anyadibe IE. Onyechi A, et al. J Community Hosp Intern Med Perspect. 2023 Sep 2;13(5):86-89. doi: 10.55729/2000-9666.1236. eCollection 2023. J Community Hosp Intern Med Perspect. 2023. PMID: 37868679 Free PMC article.
We describe a patient presenting with yellow skin discoloration and orange-colored urine after starting metaxalone for treatment of lumbosacral sprain. Laboratory studies were consistent with warm hemolytic anemia. Symptoms improved remarkably after discontinuation of m …
We describe a patient presenting with yellow skin discoloration and orange-colored urine after starting metaxalone for treatment of l …
Biocatalytic Synthesis of Metaxalone and Its Analogues.
Wang ZX, Fu HK, Da XY, Wang HH, Cui BD, Han WY, Chen YZ, Wan NW. Wang ZX, et al. Org Lett. 2023 Jul 14;25(27):5049-5054. doi: 10.1021/acs.orglett.3c01752. Epub 2023 Jul 5. Org Lett. 2023. PMID: 37405417
A biocatalytic approach for the synthesis of metaxalone and its analogues was developed based on the reaction of epoxides and cyanate catalyzed by halohydrin dehalogenase. ...Additionally, various metaxalone analogues were synthesized at 28-40% yields (90-99% ee) fo …
A biocatalytic approach for the synthesis of metaxalone and its analogues was developed based on the reaction of epoxides and cyanate …
Pharmacotherapy for Spine-Related Pain in Older Adults.
Fu JL, Perloff MD. Fu JL, et al. Drugs Aging. 2022 Jul;39(7):523-550. doi: 10.1007/s40266-022-00946-x. Epub 2022 Jun 27. Drugs Aging. 2022. PMID: 35754070 Review.
Some muscle relaxants (carisoprodol, chlorzoxazone, cyclobenzaprine, metaxalone, methocarbamol, and orphenadrine) are avoided in older adults due to risk for sedation and falls. ...
Some muscle relaxants (carisoprodol, chlorzoxazone, cyclobenzaprine, metaxalone, methocarbamol, and orphenadrine) are avoided in olde …
The Relative Efficacy of Seven Skeletal Muscle Relaxants. An Analysis of Data From Randomized Studies.
Abril L, Zamora C, Cordero M, Williams AR, Friedman BW. Abril L, et al. J Emerg Med. 2022 Apr;62(4):455-461. doi: 10.1016/j.jemermed.2021.09.025. Epub 2022 Jan 20. J Emerg Med. 2022. PMID: 35067395
We compared the change in RMDQ among 8 groups: placebo, baclofen, metaxalone, tizanidine, diazepam, orphenadrine, methocarbamol, and cyclobenzaprine. All patients also received a nonsteroidal anti-inflammatory drug. ...RESULTS: The mean improvement in RMDQ per group was pl …
We compared the change in RMDQ among 8 groups: placebo, baclofen, metaxalone, tizanidine, diazepam, orphenadrine, methocarbamol, and …
MAO-A Inhibition by Metaxalone Reverts IL-1beta-Induced Inflammatory Phenotype in Microglial Cells.
Pallio G, D'Ascola A, Cardia L, Mannino F, Bitto A, Minutoli L, Picciolo G, Squadrito V, Irrera N, Squadrito F, Altavilla D. Pallio G, et al. Int J Mol Sci. 2021 Aug 5;22(16):8425. doi: 10.3390/ijms22168425. Int J Mol Sci. 2021. PMID: 34445126 Free PMC article.
The aim of this study was to investigate whether metaxalone might exert antioxidant and anti-inflammatory effects in HMC3 microglial cells. ...The present experimental study suggests that metaxalone has potential for the treatment of several neurological disorders a …
The aim of this study was to investigate whether metaxalone might exert antioxidant and anti-inflammatory effects in HMC3 microglial …
65 results