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1995 1
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2003 1
2004 5
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2011 1
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Choosing a skeletal muscle relaxant.
See S, Ginzburg R. See S, et al. Am Fam Physician. 2008 Aug 1;78(3):365-70. Am Fam Physician. 2008. PMID: 18711953 Free article. Review.
The sedative properties of tizanidine and cyclobenzaprine may benefit patients with insomnia caused by severe muscle spasms. Methocarbamol and metaxalone are less sedating, although effectiveness evidence is limited. ...
The sedative properties of tizanidine and cyclobenzaprine may benefit patients with insomnia caused by severe muscle spasms. Methocarbamol a …
Comparative efficacy and safety of skeletal muscle relaxants for spasticity and musculoskeletal conditions: a systematic review.
Chou R, Peterson K, Helfand M. Chou R, et al. J Pain Symptom Manage. 2004 Aug;28(2):140-75. doi: 10.1016/j.jpainsymman.2004.05.002. J Pain Symptom Manage. 2004. PMID: 15276195 Free article. Review.
There is very limited or inconsistent data regarding the effectiveness of metaxalone, methocarbamol, chlorzoxazone, baclofen, or dantrolene compared to placebo in patients with musculoskeletal conditions. There is insufficient evidence to determine the relative efficacy or …
There is very limited or inconsistent data regarding the effectiveness of metaxalone, methocarbamol, chlorzoxazone, baclofen, or dant …
Pharmacotherapy for Spine-Related Pain in Older Adults.
Fu JL, Perloff MD. Fu JL, et al. Drugs Aging. 2022 Jul;39(7):523-550. doi: 10.1007/s40266-022-00946-x. Epub 2022 Jun 27. Drugs Aging. 2022. PMID: 35754070 Review.
Some muscle relaxants (carisoprodol, chlorzoxazone, cyclobenzaprine, metaxalone, methocarbamol, and orphenadrine) are avoided in older adults due to risk for sedation and falls. ...
Some muscle relaxants (carisoprodol, chlorzoxazone, cyclobenzaprine, metaxalone, methocarbamol, and orphenadrine) are avoided in olde …
The Relative Efficacy of Seven Skeletal Muscle Relaxants. An Analysis of Data From Randomized Studies.
Abril L, Zamora C, Cordero M, Williams AR, Friedman BW. Abril L, et al. J Emerg Med. 2022 Apr;62(4):455-461. doi: 10.1016/j.jemermed.2021.09.025. Epub 2022 Jan 20. J Emerg Med. 2022. PMID: 35067395
We compared the change in RMDQ among 8 groups: placebo, baclofen, metaxalone, tizanidine, diazepam, orphenadrine, methocarbamol, and cyclobenzaprine. ...RESULTS: The mean improvement in RMDQ per group was placebo 10.5 (95% confidence interval [CI] 9.5-11.5), baclofen 10.6 …
We compared the change in RMDQ among 8 groups: placebo, baclofen, metaxalone, tizanidine, diazepam, orphenadrine, methocarbamol, and …
Metaxalone.
[No authors listed] [No authors listed] 2021 Sep 13. LiverTox: Clinical and Research Information on Drug-Induced Liver Injury [Internet]. Bethesda (MD): National Institute of Diabetes and Digestive and Kidney Diseases; 2012–. 2021 Sep 13. LiverTox: Clinical and Research Information on Drug-Induced Liver Injury [Internet]. Bethesda (MD): National Institute of Diabetes and Digestive and Kidney Diseases; 2012–. PMID: 31644145 Free Books & Documents. Review.
Metaxalone is a centrally acting skeletal muscle relaxant that has been in use for more than 40 years. Metaxalone has not been associated with serum aminotransferase elevations during therapy or with clinically apparent hepatic injury....
Metaxalone is a centrally acting skeletal muscle relaxant that has been in use for more than 40 years. Metaxalone has not been …
Muscle relaxants for pain management in rheumatoid arthritis.
Richards BL, Whittle SL, Buchbinder R. Richards BL, et al. Cochrane Database Syst Rev. 2012 Jan 18;1:CD008922. doi: 10.1002/14651858.CD008922.pub2. Cochrane Database Syst Rev. 2012. PMID: 22258993 Review.
Muscle relaxants include drugs that reduce muscle spasm (for example benzodiazepines such as diazepam (Valium), alprazolam (Xanax), lorazepam (Ativan) and non-benzodiazepines such as metaxalone (Skelaxin) or a combination of paracetamol and orphenadrine (Muscol)) and drugs …
Muscle relaxants include drugs that reduce muscle spasm (for example benzodiazepines such as diazepam (Valium), alprazolam (Xanax), lorazepa …
A Randomized, Placebo-Controlled Trial of Ibuprofen Plus Metaxalone, Tizanidine, or Baclofen for Acute Low Back Pain.
Friedman BW, Irizarry E, Solorzano C, Zias E, Pearlman S, Wollowitz A, Jones MP, Shah PD, Gallagher EJ. Friedman BW, et al. Ann Emerg Med. 2019 Oct;74(4):512-520. doi: 10.1016/j.annemergmed.2019.02.017. Epub 2019 Apr 5. Ann Emerg Med. 2019. PMID: 30955985 Free PMC article. Clinical Trial.
At 1-week follow-up, 30% of placebo patients (95% CI 21% to 41%) reported moderate to severe low back pain versus 33% of baclofen patients (95% CI 24% to 44%), 37% of metaxalone patients (95% CI 27% to 48%), and 33% of tizanidine patients (95% CI 23% to 44%). CONCLUSION: A …
At 1-week follow-up, 30% of placebo patients (95% CI 21% to 41%) reported moderate to severe low back pain versus 33% of baclofen patients ( …
Monoamine oxidase A inhibition by toxic concentrations of metaxalone.
Cherrington B, Englich U, Niruntari S, Grant W, Hodgman M. Cherrington B, et al. Clin Toxicol (Phila). 2020 May;58(5):383-387. doi: 10.1080/15563650.2019.1648815. Epub 2019 Aug 2. Clin Toxicol (Phila). 2020. PMID: 31373522
Monoamine oxidase A (MAO-A) inhibition by metaxalone has been proposed as the etiology of this toxicity. Metaxalone concentrations reported with cases of serotonin toxicity range from 31 to 61 mcg/ml (140-276 M). We investigated the effect of metaxalone on MA …
Monoamine oxidase A (MAO-A) inhibition by metaxalone has been proposed as the etiology of this toxicity. Metaxalone concentrat …
MAO-A Inhibition by Metaxalone Reverts IL-1β-Induced Inflammatory Phenotype in Microglial Cells.
Pallio G, D'Ascola A, Cardia L, Mannino F, Bitto A, Minutoli L, Picciolo G, Squadrito V, Irrera N, Squadrito F, Altavilla D. Pallio G, et al. Int J Mol Sci. 2021 Aug 5;22(16):8425. doi: 10.3390/ijms22168425. Int J Mol Sci. 2021. PMID: 34445126 Free PMC article.
The aim of this study was to investigate whether metaxalone might exert antioxidant and anti-inflammatory effects in HMC3 microglial cells. ...The present experimental study suggests that metaxalone has potential for the treatment of several neurological disorders a …
The aim of this study was to investigate whether metaxalone might exert antioxidant and anti-inflammatory effects in HMC3 microglial …
Metaxalone Suppresses Production of Inflammatory Cytokines Associated with Painful Conditions in Mouse Macrophages RAW264.7 Cells in Vitro: Synergistic Effect with β-caryophyllene.
Yamaguchi M, Levy RM. Yamaguchi M, et al. Curr Mol Med. 2020;20(8):643-652. doi: 10.2174/1566524020666200217102508. Curr Mol Med. 2020. PMID: 32065089
Inflammatory cytokines with painful conditions are well known as biomarkers in human muscle pain, and they are produced by macrophages. Metaxalone is used as a skeletal muscle relaxant, but the mechanism by which metaxalone acts is unknown. ...CONCLUSION: Metaxal …
Inflammatory cytokines with painful conditions are well known as biomarkers in human muscle pain, and they are produced by macrophages. M …
56 results