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Table representation of search results timeline featuring number of search results per year.

Year Number of Results
1959 1
1960 2
1961 1
1962 3
1963 10
1964 12
1965 10
1966 7
1967 6
1968 20
1969 27
1970 16
1971 28
1972 29
1973 12
1974 13
1975 15
1976 19
1977 28
1978 34
1979 30
1980 24
1981 17
1982 12
1983 26
1984 25
1985 17
1986 18
1987 29
1988 27
1989 29
1990 28
1991 50
1992 42
1993 48
1994 51
1995 76
1996 100
1997 97
1998 145
1999 192
2000 203
2001 227
2002 333
2003 375
2004 411
2005 486
2006 588
2007 652
2008 725
2009 805
2010 981
2011 1115
2012 1309
2013 1452
2014 1765
2015 1886
2016 1982
2017 2100
2018 2227
2019 2337
2020 2746
2021 2923
2022 2712
2023 2625
2024 1530
2025 1

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32,114 results

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Page 1
Metformin: Is it a drug for all reasons and diseases?
Triggle CR, Mohammed I, Bshesh K, Marei I, Ye K, Ding H, MacDonald R, Hollenberg MD, Hill MA. Triggle CR, et al. Metabolism. 2022 Aug;133:155223. doi: 10.1016/j.metabol.2022.155223. Epub 2022 May 29. Metabolism. 2022. PMID: 35640743 Free article. Review.
The objectives for this review are to: 1) evaluate the putative mechanism(s) of action of metformin; 2) analyze the controversial evidence for metformin's effectiveness in the treatment of diseases other than type 2 diabetes; 3) assess the reproducibility of …
The objectives for this review are to: 1) evaluate the putative mechanism(s) of action of metformin; 2) analyze the controversial evi …
Cellular and Molecular Mechanisms of Metformin Action.
LaMoia TE, Shulman GI. LaMoia TE, et al. Endocr Rev. 2021 Jan 28;42(1):77-96. doi: 10.1210/endrev/bnaa023. Endocr Rev. 2021. PMID: 32897388 Free PMC article. Review.
However, despite decades of research, the mechanism by which metformin inhibits this process is still highly debated. A key reason for these discrepant effects is likely due to the inconsistency in dosage of metformin across studies. ...Here, we review the current l …
However, despite decades of research, the mechanism by which metformin inhibits this process is still highly debated. A key reason fo …
Metformin--mode of action and clinical implications for diabetes and cancer.
Pernicova I, Korbonits M. Pernicova I, et al. Nat Rev Endocrinol. 2014 Mar;10(3):143-56. doi: 10.1038/nrendo.2013.256. Epub 2014 Jan 7. Nat Rev Endocrinol. 2014. PMID: 24393785 Review.
Metformin has been the mainstay of therapy for diabetes mellitus for many years; however, the mechanistic aspects of metformin action remained ill-defined. ...The knowledge gained from dissecting the principal mechanisms by which metformin works can help us t
Metformin has been the mainstay of therapy for diabetes mellitus for many years; however, the mechanistic aspects of metformin
Metformin: from mechanisms of action to therapies.
Foretz M, Guigas B, Bertrand L, Pollak M, Viollet B. Foretz M, et al. Cell Metab. 2014 Dec 2;20(6):953-66. doi: 10.1016/j.cmet.2014.09.018. Epub 2014 Oct 30. Cell Metab. 2014. PMID: 25456737 Free article. Review.
Metformin is currently the first-line drug treatment for type 2 diabetes. ...However, the underlying mechanisms of action remain elusive. Convincing data place energy metabolism at the center of metformin's mechanism of action in diabetes and may also be of i
Metformin is currently the first-line drug treatment for type 2 diabetes. ...However, the underlying mechanisms of action remain elus
Benefits of Metformin in Attenuating the Hallmarks of Aging.
Kulkarni AS, Gubbi S, Barzilai N. Kulkarni AS, et al. Cell Metab. 2020 Jul 7;32(1):15-30. doi: 10.1016/j.cmet.2020.04.001. Epub 2020 Apr 24. Cell Metab. 2020. PMID: 32333835 Free PMC article. Review.
This review focuses on metformin's mechanisms in attenuating hallmarks of aging and their interconnectivity, by improving nutrient sensing, enhancing autophagy and intercellular communication, protecting against macromolecular damage, delaying stem cell aging, modul …
This review focuses on metformin's mechanisms in attenuating hallmarks of aging and their interconnectivity, by improving nutr …
Metformin: historical overview.
Bailey CJ. Bailey CJ. Diabetologia. 2017 Sep;60(9):1566-1576. doi: 10.1007/s00125-017-4318-z. Epub 2017 Aug 3. Diabetologia. 2017. PMID: 28776081
Metformin's future was precarious, its reputation tarnished by association with other biguanides despite evident differences. ...Long-term cardiovascular benefits of metformin were identified by the UK Prospective Diabetes Study (UKPDS) in 1998, providing a n
Metformin's future was precarious, its reputation tarnished by association with other biguanides despite evident differences.
Metformin - its potential anti-cancer and anti-aging effects.
Podhorecka M, Ibanez B, Dmoszyńska A. Podhorecka M, et al. Postepy Hig Med Dosw (Online). 2017 Mar 2;71(0):170-175. doi: 10.5604/01.3001.0010.3801. Postepy Hig Med Dosw (Online). 2017. PMID: 28258677 Free article. Review.
The generally accepted mechanism of metformin's effect is stimulation of adenosine monophosphate (AMP)-activated protein kinase (AMPK). ...Lately, many novel pathways, besides AMPK induction, have been revealed, which can explain some of metformin's be …
The generally accepted mechanism of metformin's effect is stimulation of adenosine monophosphate (AMP)-activated protein kinas …
Metformin: clinical use in type 2 diabetes.
Sanchez-Rangel E, Inzucchi SE. Sanchez-Rangel E, et al. Diabetologia. 2017 Sep;60(9):1586-1593. doi: 10.1007/s00125-017-4336-x. Epub 2017 Aug 2. Diabetologia. 2017. PMID: 28770321 Review.
Metformin is one of the most popular oral glucose-lowering medications, widely considered to be the optimal initial therapy for patients with type 2 diabetes mellitus. ...With no long-term studies comparing it against newer glucose-lowering drugs, some of which have more r
Metformin is one of the most popular oral glucose-lowering medications, widely considered to be the optimal initial therapy for patie
The intersection of metformin and inflammation.
Bharath LP, Nikolajczyk BS. Bharath LP, et al. Am J Physiol Cell Physiol. 2021 May 1;320(5):C873-C879. doi: 10.1152/ajpcell.00604.2020. Epub 2021 Mar 10. Am J Physiol Cell Physiol. 2021. PMID: 33689478 Free PMC article. Review.
Additionally, metformin's action on mitochondrial function and cellular homeostasis processes such as autophagy is of particular interest because of the importance of these mechanisms in maintaining cellular health. ...Thus, dysregulation of autophagy or mitochondri …
Additionally, metformin's action on mitochondrial function and cellular homeostasis processes such as autophagy is of particul …
Human trials exploring anti-aging medicines.
Guarente L, Sinclair DA, Kroemer G. Guarente L, et al. Cell Metab. 2024 Feb 6;36(2):354-376. doi: 10.1016/j.cmet.2023.12.007. Epub 2024 Jan 4. Cell Metab. 2024. PMID: 38181790 Review.
Here, we summarize the current knowledge on eight promising drugs and natural compounds that have been tested in the clinic: metformin, NAD(+) precursors, glucagon-like peptide-1 receptor agonists, TORC1 inhibitors, spermidine, senolytics, probiotics, and anti-inflammatori …
Here, we summarize the current knowledge on eight promising drugs and natural compounds that have been tested in the clinic: metformin
32,114 results
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