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Table representation of search results timeline featuring number of search results per year.

Year Number of Results
1946 1
1947 32
1948 53
1949 22
1950 32
1951 17
1952 21
1953 26
1954 18
1955 15
1956 17
1957 13
1958 12
1959 9
1960 10
1961 8
1962 5
1963 14
1964 28
1965 16
1966 24
1967 26
1968 27
1969 45
1970 95
1971 131
1972 223
1973 475
1974 261
1975 267
1976 274
1977 199
1978 240
1979 218
1980 183
1981 176
1982 201
1983 171
1984 184
1985 146
1986 154
1987 139
1988 149
1989 190
1990 226
1991 220
1992 216
1993 222
1994 299
1995 245
1996 267
1997 272
1998 282
1999 292
2000 337
2001 356
2002 310
2003 384
2004 365
2005 437
2006 464
2007 528
2008 512
2009 531
2010 563
2011 562
2012 629
2013 683
2014 605
2015 629
2016 642
2017 680
2018 678
2019 740
2020 769
2021 809
2022 744
2023 675
2024 708
2025 216

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19,958 results

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Page 1
Methadone for Pain Management: A Pharmacotherapeutic Review.
Kreutzwiser D, Tawfic QA. Kreutzwiser D, et al. CNS Drugs. 2020 Aug;34(8):827-839. doi: 10.1007/s40263-020-00743-3. CNS Drugs. 2020. PMID: 32564328 Review.
Methadone is increasingly being used for its analgesic properties. Despite the increasing popularity, many healthcare providers are not familiar with methadone's complex pharmacology and best practices surrounding its use. ...From an efficacy standpoint, limi …
Methadone is increasingly being used for its analgesic properties. Despite the increasing popularity, many healthcare providers are n …
Methadone--metabolism, pharmacokinetics and interactions.
Ferrari A, Coccia CP, Bertolini A, Sternieri E. Ferrari A, et al. Pharmacol Res. 2004 Dec;50(6):551-9. doi: 10.1016/j.phrs.2004.05.002. Pharmacol Res. 2004. PMID: 15501692 Review.
The activity of CYP3A4 varies considerably among individuals, and such variability is the responsible for the large differences in methadone bioavailability. CYP2D6 and probably CYP1A2 are also involved in methadone metabolism. ...In particular, antiretrovirals, whi …
The activity of CYP3A4 varies considerably among individuals, and such variability is the responsible for the large differences in methad …
Methadone's effect on nAChRs--a link between methadone use and smoking?
Talka R, Tuominen RK, Salminen O. Talka R, et al. Biochem Pharmacol. 2015 Oct 15;97(4):542-549. doi: 10.1016/j.bcp.2015.07.031. Epub 2015 Jul 29. Biochem Pharmacol. 2015. PMID: 26231941 Review.
Almost all methadone maintenance patients are smokers, and there is a correlation between smoking habit and use of methadone. Methadone administration increases tobacco smoking, and heavy smokers use higher doses of methadone. ...
Almost all methadone maintenance patients are smokers, and there is a correlation between smoking habit and use of methadone. …
Interim methadone - Effective but underutilized: A scoping review.
McCarty D, Chan B, Bougatsos C, Grusing S, Chou R. McCarty D, et al. Drug Alcohol Depend. 2021 Aug 1;225:108766. doi: 10.1016/j.drugalcdep.2021.108766. Epub 2021 May 21. Drug Alcohol Depend. 2021. PMID: 34051546 Free PMC article.
BACKGROUND: Opioid treatment programs (OTPs) may provide interim methadone services - up to 120 days of methadone dosing without counseling. Regulatory requirements limit use of interim methadone services. ...Studies testing strategies to facilitate access to …
BACKGROUND: Opioid treatment programs (OTPs) may provide interim methadone services - up to 120 days of methadone dosing witho …
Pharmacology corner. Methadone.
Lorman WJ. Lorman WJ. J Addict Nurs. 2014 Oct-Dec;25(4):209-10. doi: 10.1097/JAN.0000000000000051. J Addict Nurs. 2014. PMID: 25514692 No abstract available.
Methadone-related deaths.
Webster LR. Webster LR. J Opioid Manag. 2005 Sep-Oct;1(4):211-7. doi: 10.5055/jom.2005.0045. J Opioid Manag. 2005. PMID: 17315549 Review. No abstract available.
Methadone: a review of drug-drug and pathophysiological interactions.
Kapur BM, Hutson JR, Chibber T, Luk A, Selby P. Kapur BM, et al. Crit Rev Clin Lab Sci. 2011 Jul-Aug;48(4):171-95. doi: 10.3109/10408363.2011.620601. Crit Rev Clin Lab Sci. 2011. PMID: 22035341 Review.
Methadone users often have comorbidities and are prescribed drugs that may interact with methadone. ...The former can contribute to methadone's fatality. Prescribers of methadone and pharmacists should enquire about any new medications (includin …
Methadone users often have comorbidities and are prescribed drugs that may interact with methadone. ...The former can contribu …
Methadone: marvelous, malevolent, or merely misunderstood?
Martin CM. Martin CM. Consult Pharm. 2011 Jan;26(1):32-40. doi: 10.4140/TCP.n.2011.32. Consult Pharm. 2011. PMID: 21224197 Review.
However, many practitioners find methadone offers numerous benefits, including dosing options and duration of analgesia. Methadone may still have a place in pain management when practitioners are adequately educated about methadone's pharmacologic prop …
However, many practitioners find methadone offers numerous benefits, including dosing options and duration of analgesia. Methadone …
Methadone Destabilizes Cardiac Repolarization During Sleep.
Solhjoo S, Punjabi NM, Ivanescu AE, Crainiceanu C, Gaynanova I, Wicken C, Buckenmaier C 3rd, Haigney MC. Solhjoo S, et al. Clin Pharmacol Ther. 2021 Oct;110(4):1066-1074. doi: 10.1002/cpt.2368. Epub 2021 Aug 10. Clin Pharmacol Ther. 2021. PMID: 34287835 Free PMC article.
Most methadone-related deaths occur during sleep. The objective of this study was to determine whether methadone's arrhythmogenic effects increase during sleep, with a focus on cardiac repolarization instability using QT variability index (QTVI), a measure sh …
Most methadone-related deaths occur during sleep. The objective of this study was to determine whether methadone's arrh …
Anesthesia update - Incorporating methadone into companion animal anesthesia and analgesic protocols: A narrative review.
Kerr CL, Swanton WE. Kerr CL, et al. Can Vet J. 2023 Nov;64(11):1058-1065. Can Vet J. 2023. PMID: 37915778 Free PMC article. Review.
It has physiologic effects similar to other mu opioid agents, but fewer adverse gastrointestinal effects. This review discusses methadone's mechanism of action, pharmacologic characteristics, and clinical effects in dogs and cats. Current recommendations for using …
It has physiologic effects similar to other mu opioid agents, but fewer adverse gastrointestinal effects. This review discusses methadone …
19,958 results
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