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Table representation of search results timeline featuring number of search results per year.

Year Number of Results
1946 1
1947 32
1948 53
1949 22
1950 32
1951 17
1952 21
1953 26
1954 18
1955 15
1956 17
1957 13
1958 12
1959 9
1960 10
1961 8
1962 5
1963 14
1964 28
1965 16
1966 24
1967 26
1968 27
1969 45
1970 95
1971 131
1972 223
1973 475
1974 261
1975 267
1976 274
1977 199
1978 240
1979 218
1980 183
1981 176
1982 201
1983 171
1984 184
1985 146
1986 154
1987 139
1988 149
1989 190
1990 226
1991 220
1992 216
1993 222
1994 299
1995 245
1996 267
1997 272
1998 282
1999 292
2000 337
2001 356
2002 310
2003 384
2004 365
2005 437
2006 464
2007 528
2008 512
2009 531
2010 563
2011 562
2012 629
2013 683
2014 605
2015 629
2016 642
2017 680
2018 678
2019 740
2020 769
2021 808
2022 744
2023 673
2024 718
2025 788
2026 292

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20,712 results

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Page 1
Methadone for Pain Management: A Pharmacotherapeutic Review.
Kreutzwiser D, Tawfic QA. Kreutzwiser D, et al. CNS Drugs. 2020 Aug;34(8):827-839. doi: 10.1007/s40263-020-00743-3. CNS Drugs. 2020. PMID: 32564328 Review.
Methadone is increasingly being used for its analgesic properties. Despite the increasing popularity, many healthcare providers are not familiar with methadone's complex pharmacology and best practices surrounding its use. ...From an efficacy standpoint, limi …
Methadone is increasingly being used for its analgesic properties. Despite the increasing popularity, many healthcare providers are n …
[Methadone].
Madsen TB. Madsen TB. Ugeskr Laeger. 1994 Feb 21;156(8):1154-5. Ugeskr Laeger. 1994. PMID: 8116098 Danish. No abstract available.
Clinical use of methadone.
Layson-Wolf C, Goode JV, Small RE. Layson-Wolf C, et al. J Pain Palliat Care Pharmacother. 2002;16(1):29-59. J Pain Palliat Care Pharmacother. 2002. PMID: 14650449 Review.
Several characteristics make methadone a useful drug. However, these same characteristics and wide interpatient variability can make methadone difficult to use safely. ...Those publications were reviewed, and from them, other literature was identified and reviewed. …
Several characteristics make methadone a useful drug. However, these same characteristics and wide interpatient variability can make …
[Methadone treatment and its dangers].
Reingardiene D, Jodziūniene L, Lazauskas R. Reingardiene D, et al. Medicina (Kaunas). 2009;45(5):419-25. Medicina (Kaunas). 2009. PMID: 19535889 Free article. Review. Lithuanian.
Patients enrolled in a methadone maintenance treatment program may become physically dependent and may experience methadone withdrawal symptoms. In this review article, there are discussed about pharmacokinetic and pharmacodynamic properties of methadone, cli …
Patients enrolled in a methadone maintenance treatment program may become physically dependent and may experience methadone wi …
Methadone's effect on nAChRs--a link between methadone use and smoking?
Talka R, Tuominen RK, Salminen O. Talka R, et al. Biochem Pharmacol. 2015 Oct 15;97(4):542-549. doi: 10.1016/j.bcp.2015.07.031. Epub 2015 Jul 29. Biochem Pharmacol. 2015. PMID: 26231941 Review.
Almost all methadone maintenance patients are smokers, and there is a correlation between smoking habit and use of methadone. Methadone administration increases tobacco smoking, and heavy smokers use higher doses of methadone. ...
Almost all methadone maintenance patients are smokers, and there is a correlation between smoking habit and use of methadone. …
Interim methadone - Effective but underutilized: A scoping review.
McCarty D, Chan B, Bougatsos C, Grusing S, Chou R. McCarty D, et al. Drug Alcohol Depend. 2021 Aug 1;225:108766. doi: 10.1016/j.drugalcdep.2021.108766. Epub 2021 May 21. Drug Alcohol Depend. 2021. PMID: 34051546 Free PMC article.
BACKGROUND: Opioid treatment programs (OTPs) may provide interim methadone services - up to 120 days of methadone dosing without counseling. Regulatory requirements limit use of interim methadone services. ...Studies testing strategies to facilitate access to …
BACKGROUND: Opioid treatment programs (OTPs) may provide interim methadone services - up to 120 days of methadone dosing witho …
Methadone treatment for pain states.
Toombs JD, Kral LA. Toombs JD, et al. Am Fam Physician. 2005 Apr 1;71(7):1353-8. Am Fam Physician. 2005. PMID: 15832538 Free article. Review.
Methadone's unique pharmacokinetics and pharmacodynamics make it a valuable option in the management of cancer pain and other chronic pain, including neuropathic pain states. ...Some medications alter the absorption or metabolism of methadone, and their concu …
Methadone's unique pharmacokinetics and pharmacodynamics make it a valuable option in the management of cancer pain and other …
Analysis of Methadone-Related Poisoning Cases.
Li ZQ, Xing L, Zhang HG, He LR, Zhang JY, Wang JQ, Liu SH, Yang WH. Li ZQ, et al. Fa Yi Xue Za Zhi. 2025 Apr 25;41(2):160-167. doi: 10.12116/j.issn.1004-5619.2024.340303. Fa Yi Xue Za Zhi. 2025. PMID: 40813084 Free article. Chinese, English.
There were 6 cases (23.08%) caused by methadone alone, and 20 cases (76.92%) died from methadone combined with other substances or drugs. The mass concentration of methadone in blood ranged from 0.181 to 4.059 mg/L. CONCLUSIONS: The proportions of poisoning c …
There were 6 cases (23.08%) caused by methadone alone, and 20 cases (76.92%) died from methadone combined with other substance …
Methadone Destabilizes Cardiac Repolarization During Sleep.
Solhjoo S, Punjabi NM, Ivanescu AE, Crainiceanu C, Gaynanova I, Wicken C, Buckenmaier C 3rd, Haigney MC. Solhjoo S, et al. Clin Pharmacol Ther. 2021 Oct;110(4):1066-1074. doi: 10.1002/cpt.2368. Epub 2021 Aug 10. Clin Pharmacol Ther. 2021. PMID: 34287835 Free PMC article.
Most methadone-related deaths occur during sleep. The objective of this study was to determine whether methadone's arrhythmogenic effects increase during sleep, with a focus on cardiac repolarization instability using QT variability index (QTVI), a measure sh …
Most methadone-related deaths occur during sleep. The objective of this study was to determine whether methadone's arrh …
Anesthesia.
PAULSON JA, LUNDY JS. PAULSON JA, et al. Annu Rev Med. 1950;1:303-16. doi: 10.1146/annurev.me.01.020150.001511. Annu Rev Med. 1950. PMID: 14771856 No abstract available.
20,712 results
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