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Table representation of search results timeline featuring number of search results per year.

Year Number of Results
1966 1
1967 1
1968 3
1969 4
1970 3
1971 3
1972 6
1973 11
1974 5
1975 9
1976 23
1977 9
1978 18
1979 14
1980 13
1981 19
1982 17
1983 18
1984 13
1985 13
1986 15
1987 9
1988 10
1989 18
1990 16
1991 17
1992 22
1993 16
1994 33
1995 36
1996 38
1997 40
1998 44
1999 43
2000 27
2001 35
2002 49
2003 50
2004 63
2005 62
2006 60
2007 62
2008 70
2009 60
2010 56
2011 67
2012 84
2013 93
2014 63
2015 65
2016 70
2017 57
2018 54
2019 47
2020 33
2021 37
2022 26
2023 40
2024 54
2025 47
2026 14

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1,806 results

Results by year

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Page 1
Epidural methadone and morphine pharmacokinetics and clinical effects in healthy volunteers: A randomized, crossover-design trial.
Hincker A, Reschke M, Ginosar Y, Kagan L, Kharasch ED, Siemiątkowska A, Park C, Bakos K, Ben-Abdallah A, Haroutounian S. Hincker A, et al. Br J Clin Pharmacol. 2024 Nov;90(11):2883-2896. doi: 10.1111/bcp.16178. Epub 2024 Jul 24. Br J Clin Pharmacol. 2024. PMID: 39049497 Free PMC article. Clinical Trial.
CONCLUSIONS: These results suggest that, with equal epidural doses, both methadone and morphine produced analgesia and methadone did not produce greater segmental effects than morphine. Epidural methadone provided a more favourable adverse effect profile....
CONCLUSIONS: These results suggest that, with equal epidural doses, both methadone and morphine produced analgesia and methadone …
Patient-centered methadone treatment: a randomized clinical trial.
Schwartz RP, Kelly SM, Mitchell SG, Gryczynski J, O'Grady KE, Gandhi D, Olsen Y, Jaffe JH. Schwartz RP, et al. Addiction. 2017 Mar;112(3):454-464. doi: 10.1111/add.13622. Epub 2016 Nov 10. Addiction. 2017. PMID: 27661788 Free PMC article. Clinical Trial.
We investigated whether a patient-centered approach to methadone treatment improved participant outcomes at 12 months following admission, compared with methadone treatment-as-usual. ...(Ps > 0.05). CONCLUSIONS: Patient-centered methadone treatment (with o …
We investigated whether a patient-centered approach to methadone treatment improved participant outcomes at 12 months following admis …
Opioid treatment program and community pharmacy collaboration for methadone maintenance treatment: results from a feasibility clinical trial.
Wu LT, John WS, Morse ED, Adkins S, Pippin J, Brooner RK, Schwartz RP. Wu LT, et al. Addiction. 2022 Feb;117(2):444-456. doi: 10.1111/add.15641. Epub 2021 Aug 16. Addiction. 2022. PMID: 34286886 Free PMC article. Clinical Trial.
BACKGROUND AND AIMS: Pharmacy administration and dispensing of methadone for methadone maintenance treatment (MMT) can expand treatment access for opioid use disorder (OUD). ...CONCLUSIONS: This feasibility trial has found pharmacy administration and dispensing of p …
BACKGROUND AND AIMS: Pharmacy administration and dispensing of methadone for methadone maintenance treatment (MMT) can expand …
Buprenorphine and methadone maintenance in jail and post-release: a randomized clinical trial.
Magura S, Lee JD, Hershberger J, Joseph H, Marsch L, Shropshire C, Rosenblum A. Magura S, et al. Drug Alcohol Depend. 2009 Jan 1;99(1-3):222-30. doi: 10.1016/j.drugalcdep.2008.08.006. Epub 2008 Oct 18. Drug Alcohol Depend. 2009. PMID: 18930603 Free PMC article. Clinical Trial.
Heroin-dependent men not enrolled in community methadone treatment and sentenced to 10-90 days in jail (N=116) were voluntarily randomly assigned either to buprenorphine or methadone maintenance, the latter being the standard of care for eligible inmates at Rikers. …
Heroin-dependent men not enrolled in community methadone treatment and sentenced to 10-90 days in jail (N=116) were voluntarily rando …
Methadone maintenance treatment.
Senay EC. Senay EC. Int J Addict. 1985 Jun-Jul;20(6-7):803-21. doi: 10.3109/10826088509047754. Int J Addict. 1985. PMID: 3908338 Review.
This paper reviews the world literature on methadone. Methadone has been used in hundreds of thousands of patients, in disparate social, economic, cultural, and geographic situations; it has been evaluated in scores of studies. ...Despite the positive data, public o …
This paper reviews the world literature on methadone. Methadone has been used in hundreds of thousands of patients, in dispara …
Comparing the effect of buprenorphine and methadone in the reduction of methamphetamine craving: a randomized clinical trial.
Ahmadi J, Razeghian Jahromi L. Ahmadi J, et al. Trials. 2017 Jun 6;18(1):259. doi: 10.1186/s13063-017-2007-3. Trials. 2017. PMID: 28587620 Free PMC article. Clinical Trial.
BACKGROUND: We sought to test the effectiveness of methadone and buprenorphine in the treatment of methamphetamine withdrawal craving over a 17-day treatment period. ...Therefore, the conclusion may not be that methadone and buprenorphine both reduce the craving. Be …
BACKGROUND: We sought to test the effectiveness of methadone and buprenorphine in the treatment of methamphetamine withdrawal craving …
Single-dose Intraoperative Methadone for Pain Management in Pediatric Tonsillectomy: A Randomized Double-blind Clinical Trial.
Einhorn LM, Hoang J, La JO, Kharasch ED. Einhorn LM, et al. Anesthesiology. 2024 Sep 1;141(3):463-474. doi: 10.1097/ALN.0000000000005031. Anesthesiology. 2024. PMID: 38669011 Free PMC article. Clinical Trial.
Total 7-day opioid use (oral morphine equivalents per kg median [interquartile range]) was 1.5 [1.2, 2.1] in controls, 0.9 [0.1, 1.4] after methadone 0.1 mg/kg (P = 0.045), and 0.5 [0, 1.4] after methadone 0.15 mg/kg (P = 0.023). Postanesthesia care unit opioid use …
Total 7-day opioid use (oral morphine equivalents per kg median [interquartile range]) was 1.5 [1.2, 2.1] in controls, 0.9 [0.1, 1.4] after …
Oral and intravenous methadone use: some clinical and pharmacokinetic aspects.
Felder C, Uehlinger C, Baumann P, Powell K, Eap CB. Felder C, et al. Drug Alcohol Depend. 1999 Jun 1;55(1-2):137-43. doi: 10.1016/s0376-8716(98)00190-2. Drug Alcohol Depend. 1999. PMID: 10402158 Clinical Trial.
A sample of 15 patients participating in an injectable methadone trial and of 15 patients in an oral methadone maintenance treatment, who admitted injecting part or all of their methadone take-home doses, were compared to 20 patients in maintenance treatment …
A sample of 15 patients participating in an injectable methadone trial and of 15 patients in an oral methadone maintenance tre …
Clinical Effectiveness and Safety of Intraoperative Methadone in Patients Undergoing Posterior Spinal Fusion Surgery: A Randomized, Double-blinded, Controlled Trial.
Murphy GS, Szokol JW, Avram MJ, Greenberg SB, Shear TD, Deshur MA, Vender JS, Benson J, Newmark RL. Murphy GS, et al. Anesthesiology. 2017 May;126(5):822-833. doi: 10.1097/ALN.0000000000001609. Anesthesiology. 2017. PMID: 28418966 Clinical Trial.

Pain scores at rest, with movement, and with coughing were less in the methadone group at 21 of 27 assessments (all P = 0.001 to < 0.0001). Overall satisfaction with pain management was higher in the methadone group than in the hydromorphone group until the morni

…
Pain scores at rest, with movement, and with coughing were less in the methadone group at 21 of 27 assessments (all P = 0.001 to < …
A clinical trial of buprenorphine: comparison with methadone in the detoxification of heroin addicts.
Bickel WK, Stitzer ML, Bigelow GE, Liebson IA, Jasinski DR, Johnson RE. Bickel WK, et al. Clin Pharmacol Ther. 1988 Jan;43(1):72-8. doi: 10.1038/clpt.1988.13. Clin Pharmacol Ther. 1988. PMID: 3275523 Clinical Trial.
The efficacy of buprenorphine and methadone was compared in the outpatient detoxification of heroin addicts. Forty-five patients were randomized to receive either sublingual buprenorphine or oral methadone under double-dummy and double-blind conditions to study the …
The efficacy of buprenorphine and methadone was compared in the outpatient detoxification of heroin addicts. Forty-five patients were …
1,806 results