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Table representation of search results timeline featuring number of search results per year.

Year Number of Results
1965 1
1966 5
1967 8
1968 2
1969 3
1970 3
1971 8
1972 10
1973 10
1974 14
1975 20
1976 19
1977 18
1978 12
1979 9
1980 12
1981 11
1982 11
1983 14
1984 20
1985 13
1986 21
1987 16
1988 21
1989 32
1990 14
1991 30
1992 21
1993 26
1994 22
1995 24
1996 24
1997 39
1998 33
1999 35
2000 23
2001 33
2002 36
2003 48
2004 73
2005 66
2006 84
2007 89
2008 85
2009 70
2010 71
2011 85
2012 81
2013 86
2014 77
2015 57
2016 70
2017 74
2018 57
2019 46
2020 54
2021 46
2022 35
2023 23
2024 28
2025 32
2026 0

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1,867 results

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Page 1
Methylphenidate, cognition, and epilepsy: A 1-month open-label trial.
Adams J, Alipio-Jocson V, Inoyama K, Bartlett V, Sandhu S, Oso J, Barry JJ, Loring DW, Meador KJ. Adams J, et al. Epilepsia. 2017 Dec;58(12):2124-2132. doi: 10.1111/epi.13917. Epub 2017 Oct 9. Epilepsia. 2017. PMID: 28990169 Clinical Trial.
We hypothesized that methylphenidate can safely improve cognition in adults with epilepsy. We detail here the open-label follow-up to a double-blind, placebo-controlled, single-dose study. ...Seizure frequency did not increase with methylphenidate treatment (2.8/mon …
We hypothesized that methylphenidate can safely improve cognition in adults with epilepsy. We detail here the open-label follow-up to …
Safety and efficacy of amantadine, modafinil, and methylphenidate for fatigue in multiple sclerosis: a randomised, placebo-controlled, crossover, double-blind trial.
Nourbakhsh B, Revirajan N, Morris B, Cordano C, Creasman J, Manguinao M, Krysko K, Rutatangwa A, Auvray C, Aljarallah S, Jin C, Mowry E, McCulloch C, Waubant E. Nourbakhsh B, et al. Lancet Neurol. 2021 Jan;20(1):38-48. doi: 10.1016/S1474-4422(20)30354-9. Epub 2020 Nov 23. Lancet Neurol. 2021. PMID: 33242419 Free PMC article. Clinical Trial.
FINDINGS: Between Oct 4, 2017, and Feb 27, 2019, of 169 patients screened, 141 patients were enrolled and randomly assigned to one of four medication administration sequences: 35 (25%) patients to the amantadine, placebo, modafinil, and methylphenidate sequence; 34 (24%) p …
FINDINGS: Between Oct 4, 2017, and Feb 27, 2019, of 169 patients screened, 141 patients were enrolled and randomly assigned to one of four m …
Improved cancer-related fatigue in a randomised clinical trial: methylphenidate no better than placebo.
Centeno C, Rojí R, Portela MA, De Santiago A, Cuervo MA, Ramos D, Gandara A, Salgado E, Gagnon B, Sanz A. Centeno C, et al. BMJ Support Palliat Care. 2022 Jun;12(2):226-234. doi: 10.1136/bmjspcare-2020-002454. Epub 2020 Nov 9. BMJ Support Palliat Care. 2022. PMID: 33168668 Clinical Trial.
RESULTS: 35 patients received placebo and 42 patients received methylphenidate. The populations of both groups were homogeneous. Patients receiving methylphenidate did not exhibit statistically significant improvement of fatigue in comparison to patients receiving p …
RESULTS: 35 patients received placebo and 42 patients received methylphenidate. The populations of both groups were homogeneous. Pati …
Carbamazepine and methylphenidate.
Gross-Tsur V. Gross-Tsur V. J Am Acad Child Adolesc Psychiatry. 1999 Jun;38(6):637. doi: 10.1097/00004583-199906000-00001. J Am Acad Child Adolesc Psychiatry. 1999. PMID: 10361775 Clinical Trial. No abstract available.
An Open-Label, Randomized Trial of Methylphenidate and Atomoxetine Treatment in Adults With ADHD.
Ni HC, Lin YJ, Gau SS, Huang HC, Yang LK. Ni HC, et al. J Atten Disord. 2017 Jan;21(1):27-39. doi: 10.1177/1087054713476549. Epub 2016 Jul 28. J Atten Disord. 2017. PMID: 23475825 Clinical Trial.
METHOD: This was an 8-to-10-week, open-label, head-to-head, randomized clinical trial with two treatment arms: immediate-release methylphenidate (IR-methylphenidate; n = 31) and atomoxetine once daily ( n = 32). The outcome measures included ADHD symptom severity, q …
METHOD: This was an 8-to-10-week, open-label, head-to-head, randomized clinical trial with two treatment arms: immediate-release methylph …
Safety and efficacy of methylphenidate for apathy in Alzheimer's disease: a randomized, placebo-controlled trial.
Rosenberg PB, Lanctôt KL, Drye LT, Herrmann N, Scherer RW, Bachman DL, Mintzer JE, ADMET Investigators. Rosenberg PB, et al. J Clin Psychiatry. 2013 Aug;74(8):810-6. doi: 10.4088/JCP.12m08099. J Clin Psychiatry. 2013. PMID: 24021498 Free PMC article. Clinical Trial.
OBJECTIVE: In a recent crossover trial, methylphenidate treatment decreased apathy in Alzheimer's disease. We further assessed this finding in the Apathy in Dementia Methylphenidate Trial (ADMET). ...NPI apathy score improvement was 1.8 points (95% CI, 0.3 to 3.4) g …
OBJECTIVE: In a recent crossover trial, methylphenidate treatment decreased apathy in Alzheimer's disease. We further assessed this f …
The Role of Methylphenidate and Aripiprazole in the Treatment of Emotion Dysregulation in Children With ADHD.
Pan PY, Yeh CB. Pan PY, et al. J Clin Psychopharmacol. 2025 Jul-Aug 01;45(4):356-363. doi: 10.1097/JCP.0000000000002002. Epub 2025 Apr 16. J Clin Psychopharmacol. 2025. PMID: 40238929 Clinical Trial.
RESULTS: Among the 30 enrolled patients, 22 (73.3%) responded to methylphenidate (group MR), while 8 entered step 2 (aripiprazole treatment for methylphenidate nonresponders; group MN). ...Aripiprazole could be effective and safe for methylphenidate nonrespon …
RESULTS: Among the 30 enrolled patients, 22 (73.3%) responded to methylphenidate (group MR), while 8 entered step 2 (aripiprazole tre …
Minimizing adverse events while maintaining clinical improvement in a pediatric attention-deficit/hyperactivity disorder crossover trial with dextroamphetamine and methylphenidate.
Ramtvedt BE, Aabech HS, Sundet K. Ramtvedt BE, et al. J Child Adolesc Psychopharmacol. 2014 Apr;24(3):130-9. doi: 10.1089/cap.2013.0114. Epub 2014 Mar 25. J Child Adolesc Psychopharmacol. 2014. PMID: 24666268 Free PMC article. Clinical Trial.
Furthermore, dextroamphetamine and methylphenidate did not differ from each other on any SERS item, except that dextroamphetamine was associated with higher severity of "insomnia" and a higher prevalence of "unusually happy." ...CONCLUSIONS: The availability of both dextro …
Furthermore, dextroamphetamine and methylphenidate did not differ from each other on any SERS item, except that dextroamphetamine was …
Clinical effects of methylphenidate and thioridazine in intellectually subaverage children.
Aman MG, Marks RE, Turbott SH, Wilsher CP, Merry SN. Aman MG, et al. J Am Acad Child Adolesc Psychiatry. 1991 Mar;30(2):246-56. doi: 10.1097/00004583-199103000-00013. J Am Acad Child Adolesc Psychiatry. 1991. PMID: 2016229 Clinical Trial.
Thirty children with subaverage IQs and psychiatric diagnoses of attention deficit disorder and/or or conduct disorder took part in a double-blind study of placebo, methylphenidate, and thioridazine, which were given for 3 weeks each. The results showed a consistent and hi …
Thirty children with subaverage IQs and psychiatric diagnoses of attention deficit disorder and/or or conduct disorder took part in a double …
Efficacy and safety of add-on dextromethorphan on irritability in children with ADHD treated with methylphenidate: A randomized double-blind controlled trial.
Pan PY, Yeh CB. Pan PY, et al. J Affect Disord. 2025 Oct 15;387:119546. doi: 10.1016/j.jad.2025.119546. Epub 2025 May 27. J Affect Disord. 2025. PMID: 40441647 Clinical Trial.
This trial aimed to investigate the efficacy and safety of add-on dextromethorphan on irritability in children with attention-deficit/hyperactivity disorder (ADHD) receiving methylphenidate treatment. METHODS: This randomized, double-blind, parallel-group trial evaluated d …
This trial aimed to investigate the efficacy and safety of add-on dextromethorphan on irritability in children with attention-deficit/hypera …
1,867 results